Science 22 April 1994: Vol. 264. no. 5158, pp. 582 - 586 DOI: 10.1126/science.8160017

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Articles

{beta}1-Adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.

B. Yoo, A. Lemaire, S. Mangmool, M. J. Wolf, A. Curcio, L. Mao, and H. A. Rockman (2009)
Am J Physiol Heart Circ Physiol 297, H1377-H1386
 |  Abstract »  |  Full Text »  |  PDF »

Chronic prenatal hypoxia sensitizes {beta}-adrenoceptors in the embryonic heart but causes postnatal desensitization.

I. Lindgren and J. Altimiras (2009)
Am J Physiol Regulatory Integrative Comp Physiol 297, R258-R264
 |  Abstract »  |  Full Text »  |  PDF »

Dynamic Protein Kinase A Activities Induced by {beta}-Adrenoceptors Dictate Signaling Propagation for Substrate Phosphorylation and Myocyte Contraction.

D. Soto, V. De Arcangelis, J. Zhang, and Y. Xiang (2009)
Circ. Res. 104, 770-779
 |  Abstract »  |  Full Text »  |  PDF »

Chronic partial unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in failing rat hearts..

J. Wang, M. Tsukashita, T. Nishina, A. Marui, E. Yoshikawa, H. Muranaka, S. Matsuoka, and T. Ikeda (2009)
J. Thorac. Cardiovasc. Surg. 137, 465-470
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure.

P. W. Raake, L. E. Vinge, E. Gao, M. Boucher, G. Rengo, X. Chen, B. R. DeGeorge Jr, S. Matkovich, S. R. Houser, P. Most, et al. (2008)
Circ. Res. 103, 413-422
 |  Abstract »  |  Full Text »  |  PDF »

Gene Therapy in Heart Failure.

L. E. Vinge, P. W. Raake, and W. J. Koch (2008)
Circ. Res. 102, 1458-1470
 |  Abstract »  |  Full Text »  |  PDF »

Arrhythmogenic Effects of {beta}2-Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load.

J. DeSantiago, X. Ai, M. Islam, G. Acuna, M. T. Ziolo, D. M. Bers, and S. M. Pogwizd (2008)
Circ. Res. 102, 1389-1397
 |  Abstract »  |  Full Text »  |  PDF »

Restricted Collision Coupling of the A2A Receptor Revisited: EVIDENCE FOR PHYSICAL SEPARATION OF TWO SIGNALING CASCADES.

C. Charalambous, I. Gsandtner, S. Keuerleber, L. Milan-Lobo, O. Kudlacek, M. Freissmuth, and J. Zezula (2008)
J. Biol. Chem. 283, 9276-9288
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis machinery is required for {beta}1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.

C. Morisco, C. Marrone, J. Galeotti, D. Shao, D. E. Vatner, S. F. Vatner, and J. Sadoshima (2008)
Cardiovasc Res 78, 36-44
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22.

N. Hedhli, L. Wang, Q. Wang, E. Rashed, Y. Tian, X. Sui, K. Madura, and C. Depre (2008)
Cardiovasc Res 77, 497-505
 |  Abstract »  |  Full Text »  |  PDF »

Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose.

D. D. Belke, E. Swanson, J. Suarez, B. T. Scott, A. E. Stenbit, and W. H. Dillmann (2007)
Am J Physiol Heart Circ Physiol 292, H1755-H1763
 |  Abstract »  |  Full Text »  |  PDF »

Principles of Genetic Murine Models for Cardiac Disease.

K. E. Yutzey and J. Robbins (2007)
Circulation 115, 792-799
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching {beta}1-Adrenergic but Locally Confined {beta}2-Adrenergic Receptor-Mediated Signaling.

V. O. Nikolaev, M. Bunemann, E. Schmitteckert, M. J. Lohse, and S. Engelhardt (2006)
Circ. Res. 99, 1084-1091
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional response to persistent {beta}2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility.

D. W. McGraw, K. M. Fogel, S. Kong, A. A. Litonjua, E. G. Kranias, B. J. Aronow, and S. B. Liggett (2006)
Physiol Genomics 27, 171-177
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic {alpha}1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival.

X.-J. Du, X.-M. Gao, H. Kiriazis, X.-L. Moore, Z. Ming, Y. Su, A. M. Finch, R. A. Hannan, A. M. Dart, and R. M. Graham (2006)
Cardiovasc Res 71, 735-743
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac-Directed Expression of Adenylyl Cyclase VI Facilitates Atrioventricular Nodal Conduction.

A. Sastry, E. Arnold, H. Gurji, A. Iwasa, H. Bui, A. Hassankhani, H. H. Patel, J. R. Feramisco, D. M. Roth, N. C. Lai, et al. (2006)
J. Am. Coll. Cardiol. 48, 559-565
 |  Abstract »  |  Full Text »  |  PDF »

Signal Switching, Crosstalk, and Arrestin Scaffolds: Novel G Protein-Coupled Receptor Signaling in Cardiovascular Disease.

N. J. Smith and L. M. Luttrell (2006)
Hypertension 48, 173-179
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Enhancement of the Recycling and Activation of beta-Adrenergic Receptor by Rab4 GTPase in Cardiac Myocytes.

C. M. Filipeanu, F. Zhou, M. L. Lam, K. E. Kerut, W. C. Claycomb, and G. Wu (2006)
J. Biol. Chem. 281, 11097-11103
 |  Abstract »  |  Full Text »  |  PDF »

cAMP-Binding Protein Epac Induces Cardiomyocyte Hypertrophy.

E. Morel, A. Marcantoni, M. Gastineau, R. Birkedal, F. Rochais, A. Garnier, A.-M. Lompre, G. Vandecasteele, and F. Lezoualc'h (2005)
Circ. Res. 97, 1296-1304
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian G Proteins and Their Cell Type Specific Functions.

N. Wettschureck and S. Offermanns (2005)
Physiol Rev 85, 1159-1204
 |  Abstract »  |  Full Text »  |  PDF »

Heterodimerization of {beta}1- and {beta}2-Adrenergic Receptor Subtypes Optimizes {beta}-Adrenergic Modulation of Cardiac Contractility.

W.-Z. Zhu, K. Chakir, S. Zhang, D. Yang, C. Lavoie, M. Bouvier, T. E. Hebert, E. G. Lakatta, H. Cheng, and R.-P. Xiao (2005)
Circ. Res. 97, 244-251
 |  Abstract »  |  Full Text »  |  PDF »

The Cytosolic Phospholipase A2 Pathway, a Safeguard of {beta}2-Adrenergic Cardiac Effects in Rat.

B. Ait-Mamar, M. Cailleret, C. Rucker-Martin, A. Bouabdallah, G. Candiani, C. Adamy, P. Duvaldestin, F. Pecker, N. Defer, and C. Pavoine (2005)
J. Biol. Chem. 280, 18881-18890
 |  Abstract »  |  Full Text »  |  PDF »

{beta}2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle.

J. G. Burniston, L.-B. Tan, and D. F. Goldspink (2005)
J Appl Physiol 98, 1379-1386
 |  Abstract »  |  Full Text »  |  PDF »

cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform.

R. Nassar, N. N. Malouf, L. Mao, H. A. Rockman, A. E. Oakeley, J. R. Frye, J. R. Herlong, S. P. Sanders, and P. A. W. Anderson (2005)
Am J Physiol Heart Circ Physiol 288, H1147-H1156
 |  Abstract »  |  Full Text »  |  PDF »

{beta}2 Adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery.

J. M. Jones, J. A. Petrofski, K. H. Wilson, C. Steenbergen, W. J. Koch, and C. A. Milano (2004)
Eur. J. Cardiothorac. Surg. 26, 1161-1168
 |  Abstract »  |  Full Text »  |  PDF »

Abnormal Myocardial Presynaptic Norepinephrine Recycling in Patients With Brugada Syndrome.

P. Kies, T. Wichter, M. Schafers, M. Paul, K. P. Schafers, L. Eckardt, L. Stegger, E. Schulze-Bahr, O. Rimoldi, G. Breithardt, et al. (2004)
Circulation 110, 3017-3022
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of {beta}2-Adrenergic Receptors cAMP-dependent Protein Kinase Phosphorylates and Modulates Slow Delayed Rectifier Potassium Channels Expressed in Murine Heart: EVIDENCE FOR RECEPTOR/CHANNEL CO-LOCALIZATION.

K. W. Dilly, J. Kurokawa, C. Terrenoire, S. Reiken, W. J. Lederer, A. R. Marks, and R. S. Kass (2004)
J. Biol. Chem. 279, 40778-40787
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of human {beta}2-adrenergic receptors increases gain of excitation-contraction coupling in mouse ventricular myocytes.

S. A. Grandy, E. M. Denovan-Wright, G. R. Ferrier, and S. E. Howlett (2004)
Am J Physiol Heart Circ Physiol 287, H1029-H1038
 |  Abstract »  |  Full Text »  |  PDF »

Network integration of the adrenergic system in cardiac hypertrophy.

L. Barki-Harrington, C. Perrino, and H. A Rockman (2004)
Cardiovasc Res 63, 391-402
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta}1 and angiotensin networking in cardiac remodeling.

S. Rosenkranz (2004)
Cardiovasc Res 63, 423-432
 |  Abstract »  |  Full Text »  |  PDF »

Alterations of adenylyl cyclase and G proteins in aortocaval shunt-induced heart failure.

X. Wang, E. Sentex, D. Chapman, and N. S. Dhalla (2004)
Am J Physiol Heart Circ Physiol 287, H118-H125
 |  Abstract »  |  Full Text »  |  PDF »

Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A3 adenosine receptors.

L. Fabritz, P. Kirchhof, L. Fortmuller, J. A Auchampach, H. A Baba, G. Breithardt, J. Neumann, P. Boknik, and W. Schmitz (2004)
Cardiovasc Res 62, 500-508
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of cardiac contractility by Rab4-modulated {beta}2-adrenergic receptor recycling.

A. Odley, H. S. Hahn, R. A. Lynch, Y. Marreez, H. Osinska, J. Robbins, and G. W. Dorn II (2004)
PNAS 101, 7082-7087
 |  Abstract »  |  Full Text »  |  PDF »

Epinephrine Activates Both Gs and Gi Pathways, but Norepinephrine Activates Only the Gs Pathway through Human {beta}2-Adrenoceptors Overexpressed in Mouse Heart.

J. F. Heubach, U. Ravens, and A. J. Kaumann (2004)
Mol. Pharmacol. 65, 1313-1322
 |  Abstract »  |  Full Text »

Determination of cardiac contractility in awake unsedated mice with a fluid-filled catheter.

Q. Wang, H. R. Brunner, and M. Burnier (2004)
Am J Physiol Heart Circ Physiol 286, H806-H814
 |  Abstract »  |  Full Text »  |  PDF »

Manipulating Cardiac Contractility in Heart Failure: Data From Mice and Men.

G. W. Dorn II and J. D. Molkentin (2004)
Circulation 109, 150-158
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The Adrenergic Pathway and Heart Failure.

J.R. Keys and W.J. Koch (2004)
Recent Prog. Horm. Res. 59, 13-30
 |  Abstract »  |  Full Text »

Common Genomic Response in Different Mouse Models of {beta}-Adrenergic-Induced Cardiomyopathy.

V. Gaussin, J. E. Tomlinson, C. Depre, S. Engelhardt, C. L. Antos, G. Takagi, L. Hein, J. N. Topper, S. B. Liggett, E. N. Olson, et al. (2003)
Circulation 108, 2926-2933
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activity and Inverse Agonists of G Protein-Coupled Receptors: a Current Perspective.

G. Milligan (2003)
Mol. Pharmacol. 64, 1271-1276
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.

A. El-Armouche, O. Zolk, T. Rau, and T. Eschenhagen (2003)
Cardiovasc Res 60, 478-487
 |  Abstract »  |  Full Text »  |  PDF »

Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through {beta}2-adrenoceptors.

K. Foerster, F. Groner, J. Matthes, W. J. Koch, L. Birnbaumer, and S. Herzig (2003)
PNAS 100, 14475-14480
 |  Abstract »  |  Full Text »  |  PDF »

What Is the Role of {beta}-Adrenergic Signaling in Heart Failure?.

M. J. Lohse, S. Engelhardt, and T. Eschenhagen (2003)
Circ. Res. 93, 896-906
 |  Abstract »  |  Full Text »  |  PDF »

The Third Intracellular Loop and the Carboxyl Terminus of {beta}2-Adrenergic Receptor Confer Spontaneous Activity of the Receptor.

K. Chakir, Y. Xiang, D. Yang, S.-J. Zhang, H. Cheng, B. K. Kobilka, and R.-P. Xiao (2003)
Mol. Pharmacol. 64, 1048-1058
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Gi Signaling Selectively Negates {beta}2-Adrenergic Receptor (AR)- but Not {beta}1-AR-Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts.

R.-P. Xiao, S.-J. Zhang, K. Chakir, P. Avdonin, W. Zhu, R. A. Bond, C. W. Balke, E. G. Lakatta, and H. Cheng (2003)
Circulation 108, 1633-1639
 |  Abstract »  |  Full Text »  |  PDF »

Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following {beta}2-adrenergic stimulation of ICa,L in frog ventricular myocytes.

J. Jurevicius, V A. Skeberdis, and R. Fischmeister (2003)
J. Physiol. 551, 239-252
 |  Abstract »  |  Full Text »  |  PDF »

{beta}3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human {beta}3-adrenergic receptor.

G. Tavernier, G. Toumaniantz, M. Erfanian, M.-F. Heymann, K. Laurent, D. Langin, and C. Gauthier (2003)
Cardiovasc Res 59, 288-296
 |  Abstract »  |  Full Text »  |  PDF »

Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor.

P. Kirchhof, L. Fabritz, L. Fortmuller, G. P. Matherne, A. Lankford, H. A. Baba, W. Schmitz, G. Breithardt, J. Neumann, and P. Boknik (2003)
Am J Physiol Heart Circ Physiol 285, H145-H153
 |  Abstract »  |  Full Text »  |  PDF »

Bridge to recovery with the use of left ventricular assist device and clenbuterol.

J. K. F. Hon and M. H. Yacoub (2003)
Ann. Thorac. Surg. 75, S36-41
 |  Abstract »  |  Full Text »  |  PDF »

Use of echocardiography for the phenotypic assessment of genetically altered mice.

K. A. Collins, C. E. Korcarz, and R. M. Lang (2003)
Physiol Genomics 13, 227-239
 |  Abstract »  |  Full Text »  |  PDF »

Altered calcium transient and development of hypertrophy in {beta}2-adrenoceptor overexpressing mice with and without pressure overload.

B. Schwarz, E. Percy, X.-M. Gao, A. M. Dart, G. Richardt, and X.-J. Du (2003)
Eur J Heart Fail 5, 131-136
 |  Abstract »  |  Full Text »  |  PDF »

Alterations of beta -adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta 1.

S. Rosenkranz, M. Flesch, K. Amann, C. Haeuseler, H. Kilter, U. Seeland, K.-D. Schluter, and M. Bohm (2002)
Am J Physiol Heart Circ Physiol 283, H1253-H1262
 |  Abstract »  |  Full Text »  |  PDF »

Myocardial Gene Transfer and Overexpression of {beta}2-Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts.

H. T. Tevaearai, A. D. Eckhart, G. B. Walton, J. R. Keys, K. Wilson, and W. J. Koch (2002)
Circulation 106, 124-129
 |  Abstract »  |  Full Text »  |  PDF »

Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification.

B. J. A. Janssen and J. F. M. Smits (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R1545-R1564
 |  Abstract »  |  Full Text »  |  PDF »

Specific {beta}2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the {beta}2AR in Myocytes From Failing Human Heart.

H. Gong, H. Sun, W. J. Koch, T. Rau, T. Eschenhagen, U. Ravens, J. F. Heubach, D. L. Adamson, and S. E. Harding (2002)
Circulation 105, 2497-2503
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Receptor Binding and Activation Associated with a Human Prostacyclin Receptor Polymorphism.

J. Stitham, A. Stojanovic, and J. Hwa (2002)
J. Biol. Chem. 277, 15439-15444
 |  Abstract »  |  Full Text »  |  PDF »

Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression.

J.M. Jones, K.H. Wilson, W.J. Koch, and C.A. Milano (2002)
Eur. J. Cardiothorac. Surg. 21, 847-852
 |  Abstract »  |  Full Text »  |  PDF »

Male and female mice overexpressing the {beta}2-adrenergic receptor exhibit differences in ischemia/reperfusion injury: role of nitric oxide.

H. R Cross, E. Murphy, W. J Koch, and C. Steenbergen (2002)
Cardiovasc Res 53, 662-671
 |  Abstract »  |  Full Text »  |  PDF »

The MLP Family of Cytoskeletal Z Disc Proteins and Dilated Cardiomyopathy: A Stress Pathway Model for Heart Failure Progression.

M. HOSHIJIMA, M. PASHMFOROUSH, R. KNOLL, and K.R. CHIEN (2002)
Cold Spring Harb Symp Quant Biol 67, 399-408
 |  Abstract »  |  PDF »

Modulation of {beta}-adrenergic receptor subtype activities in perioperative medicine: mechanisms and sites of action.

M. Zaugg, M. C. Schaub, T. Pasch, and D. R. Spahn (2002)
Br. J. Anaesth. 88, 101-123
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-Coupled Receptor Kinases and Beta Arrestins Are Relocalized and Attenuate Cyclic 3',5'-Adenosine Monophosphate Response to Follicle-Stimulating Hormone in Rat Primary Sertoli Cells.

S. Marion, F. Robert, P. Crepieux, N. Martinat, C. Troispoux, F. Guillou, and E. Reiter (2002)
Biol Reprod 66, 70-76
 |  Abstract »  |  Full Text »

Protein Kinase A Transgenes: The Many Faces of cAMP.

M. J. Lohse and S. Engelhardt (2001)
Circ. Res. 89, 938-940
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Augmentation of Cardiac Contractility Mediated by the Human {beta}3-Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice.

T. A. Kohout, H. Takaoka, P. H. McDonald, S. J. Perry, L. Mao, R. J. Lefkowitz, and H. A. Rockman (2001)
Circulation 104, 2485-2491
 |  Abstract »  |  Full Text »  |  PDF »

Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a {beta}-Adrenergic Receptor Kinase Inhibitor.

H. T. Tevaearai, A. D. Eckhart, K. F. Shotwell, K. Wilson, and W. J. Koch (2001)
Circulation 104, 2069-2074
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Studies of Cardiac Adrenergic Receptor Regulation.

A. D. Eckhart and W. J. Koch (2001)
J. Pharmacol. Exp. Ther. 299, 1-5
 |  Abstract »  |  Full Text »  |  PDF »

Influence of clenbuterol treatment during six weeks of chronic right ventricular pressure overload as studied with pressure-volume analysis.

J. K.F. Hon, P. Steendijk, M. Petrou, K. Wong, and M. H. Yacoub (2001)
J. Thorac. Cardiovasc. Surg. 122, 767-774
 |  Abstract »  |  Full Text »  |  PDF »

beta -Adrenergic Receptors, Transgenic Mice, and Pharmacological Model Systems.

J. D. Port and M. R. Bristow (2001)
Mol. Pharmacol. 60, 629-631
 |  Full Text »  |  PDF »

Constitutive Activity of the Human beta 1-Adrenergic Receptor in beta 1-Receptor Transgenic Mice.

S. Engelhardt, Y. Grimmer, G.-H. Fan, and M. J. Lohse (2001)
Mol. Pharmacol. 60, 712-717
 |  Abstract »  |  Full Text »  |  PDF »

Targeted transgenic expression of {beta}2-adrenergic receptors to type II cells increases alveolar fluid clearance.

D. W. McGraw, N. Fukuda, P. F. James, S. L. Forbes, A. L. Woo, J. B. Lingrel, D. P. Witte, M. A. Matthay, and S. B. Liggett (2001)
Am J Physiol Lung Cell Mol Physiol 281, L895-L903
 |  Abstract »  |  Full Text »  |  PDF »

Sympathoadrenergic mechanisms in functional regulation and development of cardiac hypertrophy and failure: findings from genetically engineered mice.

X.-J. Du (2001)
Cardiovasc Res 50, 443-453
 |  Full Text »  |  PDF »

Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice.

M. Palmen, M.J.A.P. Daemen, R. Bronsaer, W.R.M. Dassen, H.R. Zandbergen, M. Kockx, J.F.M. Smits, R. van der Zee, and P.A. Doevendans (2001)
Cardiovasc Res 50, 516-524
 |  Abstract »  |  Full Text »  |  PDF »

Anesthetic inhibition in ischemic and nonischemic murine heart: comparison with conscious echocardiographic approach.

S. Takuma, K. Suehiro, C. Cardinale, T. Hozumi, H. Yano, J. Shimizu, S. Mullis-Jansson, R. Sciacca, J. Wang, D. Burkhoff, et al. (2001)
Am J Physiol Heart Circ Physiol 280, H2364-H2370
 |  Abstract »  |  Full Text »  |  PDF »

Stimulating G Protein-Coupled Receptors : Cure or Cause for Heart Failure?.

D. E. Vatner (2001)
Circ. Res. 88, 645-647
 |  Full Text »  |  PDF »

Dobutamine-Stress Magnetic Resonance Microimaging in Mice : Acute Changes of Cardiac Geometry and Function in Normal and Failing Murine Hearts.

F. Wiesmann, J. Ruff, S. Engelhardt, L. Hein, C. Dienesch, A. Leupold, R. Illinger, A. Frydrychowicz, K.-H. Hiller, E. Rommel, et al. (2001)
Circ. Res. 88, 563-569
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of {beta}3-Adrenoceptors and Altered Contractile Response to Inotropic Amines in Human Failing Myocardium.

S. Moniotte, L. Kobzik, O. Feron, J.-N. Trochu, C. Gauthier, and J.-L. Balligand (2001)
Circulation 103, 1649-1655
 |  Abstract »  |  Full Text »  |  PDF »

Dual modulation of cell survival and cell death by beta 2-adrenergic signaling in adult mouse cardiac myocytes.

W.-Z. Zhu, M. Zheng, W. J. Koch, R. J. Lefkowitz, B. K. Kobilka, and R.-P. Xiao (2001)
PNAS 98, 1607-1612
 |  Abstract »  |  Full Text »  |  PDF »

Prospects for Cardiovascular Research.

R. J. Lefkowitz and J. T. Willerson (2001)
JAMA 285, 581-587
 |  Abstract »  |  Full Text »  |  PDF »

Differential effects of carvedilol and metoprolol on isoprenaline-induced changes in {beta}-adrenoceptor density and systolic function in rat cardiac myocytes.

M. Flesch, S. Ettelbruck, S. Rosenkranz, C. Maack, B. Cremers, K.-D. Schluter, O. Zolk, and M. Bohm (2001)
Cardiovasc Res 49, 371-380
 |  Abstract »  |  Full Text »  |  PDF »

Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.

K. Freeman, C. Colon-Rivera, M. C. Olsson, R. L. Moore, H. D. Weinberger, I. L. Grupp, K. L. Vikstrom, G. Iaccarino, W. J. Koch, and L. A. Leinwand (2001)
Am J Physiol Heart Circ Physiol 280, H151-H159
 |  Abstract »  |  Full Text »  |  PDF »

Nucleoside diphosphate kinase: a new player in heart failure?.

Y.-Y. Zhou and M. Artman (2001)
Cardiovasc Res 49, 7-10
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The Cellular Actions of {beta}-Adrenergic Receptor Agonists : Looking Beyond cAMP.

S. F. Steinberg (2000)
Circ. Res. 87, 1079-1082
 |  Full Text »  |  PDF »

Age-dependent cardiomyopathy and heart failure phenotype in mice overexpressing {beta}2-adrenergic receptors in the heart.

X.-J. Du, X.-M. Gao, B. Wang, G. L Jennings, E. A Woodcock, and A. M Dart (2000)
Cardiovasc Res 48, 448-454
 |  Abstract »  |  Full Text »  |  PDF »

Spontaneous Activation of beta 2- but Not beta 1-Adrenoceptors Expressed in Cardiac Myocytes from beta 1beta 2 Double Knockout Mice.

Y.-Y. Zhou, D. Yang, W.-Z. Zhu, S.-J. Zhang, D.-J. Wang, D. K. Rohrer, E. Devic, B. K. Kobilka, E. G. Lakatta, H. Cheng, et al. (2000)
Mol. Pharmacol. 58, 887-894
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Preserved ventricular contractility in infarcted mouse heart overexpressing beta 2-adrenergic receptors.

X.-J. Du, X.-M. Gao, G. L. Jennings, A. M. Dart, and E. A. Woodcock (2000)
Am J Physiol Heart Circ Physiol 279, H2456-H2463
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Cell Logic for Dual Coupling of a Single Class of Receptors to Gs and Gi Proteins.

R.-P. Xiao (2000)
Circ. Res. 87, 635-637
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Relation of tissue Doppler derived myocardial velocities to myocardial structure and beta-adrenergic receptor density in humans.

K. Shan, R. J. Bick, B. J. Poindexter, S. Shimoni, G. V. Letsou, M. J. Reardon, J. F. Howell, W. A. Zoghbi, and S. F. Nagueh (2000)
J. Am. Coll. Cardiol. 36, 891-896
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Adenovirus-mediated genetic manipulation of the myocardial {beta}-adrenergic signaling system in transplanted hearts.

A. S. Shah, D. C. White, O. Tai, J. A. Hata, K. H. Wilson, A. Pippen, A. P. Kypson, D. D. Glower, R. J. Lefkowitz, and W. J. Koch (2000)
J. Thorac. Cardiovasc. Surg. 120, 581-588
 |  Abstract »  |  Full Text »  |  PDF »

Stoichiometry and Compartmentation in G Protein-Coupled Receptor Signaling: Implications for Therapeutic Interventions Involving Gs.

R. S. Ostrom, S. R. Post, and P. A. Insel (2000)
J. Pharmacol. Exp. Ther. 294, 407-412
 |  Abstract »  |  Full Text »

Transgenic overexpression of beta 2-adrenergic receptors in airway epithelial cells decreases bronchoconstriction.

D. W. McGraw, S. L. Forbes, J. C. W. Mak, D. P. Witte, P. E. Carrigan, G. D. Leikauf, and S. B. Liggett (2000)
Am J Physiol Lung Cell Mol Physiol 279, L379-L389
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{beta}-Adrenergic Receptor Subtypes Differentially Affect Apoptosis in Adult Rat Ventricular Myocytes.

M. Zaugg, W. Xu, E. Lucchinetti, S. A. Shafiq, N. Z. Jamali, and M. A. Q. Siddiqui (2000)
Circulation 102, 344-350
 |  Abstract »  |  Full Text »  |  PDF »

{beta}2-Adrenergic receptor overexpression driven by {alpha}-MHC promoter is downregulated in hypertrophied and failing myocardium.

D. J. Sheridan, D. J. Autelitano, B. Wang, E. Percy, E. A. Woodcock, and X.-J. Du (2000)
Cardiovasc Res 47, 133-141
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Coupling Function of Endogenous {alpha}1- and {beta}-Adrenergic Receptors in Mouse Cardiomyocytes.

A. Sabri, E. Pak, S. A. Alcott, B. A. Wilson, and S. F. Steinberg (2000)
Circ. Res. 86, 1047-1053
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Selective Enhancement of beta -Adrenergic Receptor Signaling by Overexpression of Adenylyl Cyclase Type 6: Colocalization of Receptor and Adenylyl Cyclase in Caveolae of Cardiac Myocytes.

R. S. Ostrom, J. D. Violin, S. Coleman, and P. A. Insel (2000)
Mol. Pharmacol. 57, 1075-1079
 |  Abstract »  |  Full Text »

Enhanced Cardiac Function in Transgenic Mice Expressing a Ca2+-Stimulated Adenylyl Cyclase.

L. Lipskaia, N. Defer, G. Esposito, I. Hajar, M.-C. Garel, H. A. Rockman, and J. Hanoune (2000)
Circ. Res. 86, 795-801
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Catecholamines, Cardiac {beta}-Adrenergic Receptors, and Heart Failure.

R. J. Lefkowitz, H. A. Rockman, and W. J. Koch (2000)
Circulation 101, 1634-1637
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Early and Delayed Consequences of {beta}2-Adrenergic Receptor Overexpression in Mouse Hearts : Critical Role for Expression Level.

S. B. Liggett, N. M. Tepe, J. N. Lorenz, A. M. Canning, T. D. Jantz, S. Mitarai, A. Yatani, and G. W. Dorn II (2000)
Circulation 101, 1707-1714
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{beta}-Adrenergic Receptor Signaling: An Acute Compensatory Adjustment--Inappropriate for the Chronic Stress of Heart Failure? : Insights from Gs{alpha} Overexpression and Other Genetically Engineered Animal Models.

S. F. Vatner, D. E. Vatner, and C. J. Homcy (2000)
Circ. Res. 86, 502-506
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Modulation of mouse cardiac function in vivo by eNOS and ANP.

R. Gyurko, P. Kuhlencordt, M. C. Fishman, and P. L. Huang (2000)
Am J Physiol Heart Circ Physiol 278, H971-H981
 |  Abstract »  |  Full Text »  |  PDF »

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