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Science 22 April 1994:
Vol. 264. no. 5158, pp. 561 - 563
DOI: 10.1126/science.8160012
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Articles

Science, Vol 264, Issue 5158, 561-563
Copyright © 1994 by American Association for the Advancement of Science

articles

The role of interleukin-6 in mucosal IgA antibody responses in vivo

AJ Ramsay, AJ Husband, IA Ramshaw, S Bao, KI Matthaei, G Koehler, and M Kopf

John Curtin School of Medical Research, Australian National University, Canberra.

In mice with targeted disruption of the gene that encodes interleukin-6 (IL-6), greatly reduced numbers of immunoglobulin A (IgA)-producing cells were observed at mucosae and grossly deficient local antibody responses were recorded after mucosal challenge with either ovalbumin or vaccinia virus. The IgA response in the lungs was completely restored after intranasal infection with recombinant vaccinia viruses engineered to express IL-6. These findings demonstrate a critical role for IL-6 in vivo in the development of local IgA antibody responses and illustrate the effectiveness of vector-directed cytokine gene therapy.


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