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Science 8 April 1994:
Vol. 264. no. 5156, pp. 258 - 260
DOI: 10.1126/science.8146657
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Articles

Science, Vol 264, Issue 5156, 258-260
Copyright © 1994 by American Association for the Advancement of Science

articles

Recombination in adaptive mutation

RS Harris, S Longerich, and SM Rosenberg

Department of Genetics, University of Alberta, Edmonton, Canada.

The genetic requirements for adaptive mutation in Escherichia coli parallel those for homologous recombination in the RecBCD pathway. Recombination-deficient recA and recB null mutant strains are deficient in adaptive reversion. A hyper-recombinagenic recD strain is hypermutable, and its hypermutation depends on functional recA and recB genes. Genes of subsidiary recombination systems are not required. These results indicate that the molecular mechanism by which adaptive mutation occurs includes recombination. No such association is seen for spontaneous mutation in growing cells.


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