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Science 1 April 1994:
Vol. 264. no. 5155, pp. 98 - 101
DOI: 10.1126/science.8140423
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Articles

Science, Vol 264, Issue 5155, 98-101
Copyright © 1994 by American Association for the Advancement of Science

articles

Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium

MH Soonpaa, GY Koh, MG Klug, and LJ Field

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis 46202-4800.

Fetal cardiomyocytes isolated from transgenic mice carrying a fusion gene of the alpha-cardiac myosin heavy chain promoter with a beta-galactosidase reporter were examined for their ability to form stable intracardiac grafts. Embryonic day 15 transgenic cardiomyocytes delivered directly into the myocardium of syngeneic hosts formed stable grafts, as identified by nuclear beta-galactosidase activity. Grafted cardiomyocytes were observed as long as 2 months after implantation, the latest date assayed. Intracardiac graft formation did not induce overtly negative effects on the host myocardium and was not associated with chronic immune rejection. Electron microscopy revealed the presence of nascent intercalated disks connecting the engrafted fetal cardiomyocytes and the host myocardium. These results suggest that intracardiac grafting might provide a useful approach for myocardial repair, provided that the grafted cells can contribute to myocardial function.


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