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Science 25 March 1994:
Vol. 263. no. 5154, pp. 1756 - 1759
DOI: 10.1126/science.8134837
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Articles

Science, Vol 263, Issue 5154, 1756-1759
Copyright © 1994 by American Association for the Advancement of Science

articles

The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-beta superfamily

T Xie, AL Finelli, and RW Padgett

Waksman Institute, Rutgers University, Piscataway, NJ 08855-0759.

The Drosophila decapentaplegic (dpp) gene encodes a transforming growth factor-beta (TGF-beta)-like protein that plays a key role in several aspects of development. Transduction of the DPP signal was investigated by cloning of serine-threonine kinase transmembrane receptors from Drosophila because this type of receptor is specific for the TGF-beta-like ligands. Here evidence is provided demonstrating that the Drosophila saxophone (sax) gene, a previously identified female sterile locus, encodes a TGF-beta-like type I receptor. Embryos from sax mothers and dpp embryos exhibit similar mutant phenotypes during early gastrulation, and these two loci exhibit genetic interactions, which suggest that they are utilized in the same pathway. These data suggest that sax encodes a receptor for dpp.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional Analysis of saxophone, the Drosophila Gene Encoding the BMP Type I Receptor Ortholog of Human ALK1/ACVRL1 and ACVR1/ALK2.
V. Twombly, E. Bangi, V. Le, B. Malnic, M. A. Singer, and K. A. Wharton (2009)
Genetics 183, 563-579
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Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina.
J. B. Cordero, D. E. Larson, C. R. Craig, R. Hays, and R. Cagan (2007)
Development 134, 1861-1871
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Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis.
E. Kawase, M. D. Wong, B. C. Ding, and T. Xie (2004)
Development 131, 1365-1375
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Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo.
O. Shimmi and M. B. O'Connor (2003)
Development 130, 4673-4682
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Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region.
R Dorfman and B. Shilo (2001)
Development 128, 965-972
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mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins.
Y Funakoshi, M Minami, and T Tabata (2001)
Development 128, 67-74
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Genetic Analysis of the Bone Morphogenetic Protein-Related Gene, gbb, Identifies Multiple Requirements During Drosophila Development.
K. A. Wharton, J. M. Cook, S. Torres-Schumann, K. de Castro, E. Borod, and D. A. Phillips (1999)
Genetics 152, 629-640
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Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-beta Family Receptors.
Y.-G. Chen and J. Massague (1999)
J. Biol. Chem. 274, 3672-3677
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Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
S Krishna, L. Maduzia, and R. Padgett (1999)
Development 126, 251-260
   Abstract »    PDF »
Interplay of Signal Mediators of Decapentaplegic (Dpp): Molecular Characterization of Mothers against dpp, Medea, and Daughters against dpp.
H. Inoue, T. Imamura, Y. Ishidou, M. Takase, Y. Udagawa, Y. Oka, K. Tsuneizumi, T. Tabata, K. Miyazono, and M. Kawabata (1998)
Mol. Biol. Cell 9, 2145-2156
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Identification of Chromosomal Regions Involved in decapentaplegic Function in Drosophila.
R. E. Nicholls and W. M. Gelbart (1998)
Genetics 149, 203-215
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Interaction of Drosophila Inhibitors of Apoptosis with Thick Veins, a Type I Serine/Threonine Kinase Receptor for Decapentaplegic.
E. Oeda, Y. Oka, K. Miyazono, and M. Kawabata (1998)
J. Biol. Chem. 273, 9353-9356
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Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila.
T. Haerry, O Khalsa, M. O'Connor, and K. Wharton (1998)
Development 125, 3977-3987
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decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc.
D. Hazelett, M Bourouis, U Walldorf, and J. Treisman (1998)
Development 125, 3741-3751
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TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing.
O Khalsa, J. Yoon, S Torres-Schumann, and K. Wharton (1998)
Development 125, 2723-2734
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A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A.
Y Chen, M. Riese, M. Killinger, and F. Hoffmann (1998)
Development 125, 1759-1768
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The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.
J. Hudson, S. Podos, K Keith, S. Simpson, and E. Ferguson (1998)
Development 125, 1407-1420
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The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling.
P Das, L. Maduzia, H Wang, A. Finelli, S. Cho, M. Smith, and R. Padgett (1998)
Development 125, 1519-1528
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The Type II Transforming Growth Factor-beta Receptor Autophosphorylates Not Only on Serine and Threonine but Also on Tyrosine Residues.
S. Lawler, X.-H. Feng, R.-H. Chen, E. M. Maruoka, C. W. Turck, I. Griswold-Prenner, and R. Derynck (1997)
J. Biol. Chem. 272, 14850-14859
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Biosynthesis of the Type I and Type II TGF-beta Receptors. IMPLICATIONS FOR COMPLEX FORMATION.
R. G. Wells, H. Yankelev, H. Y. Lin, and H. F. Lodish (1997)
J. Biol. Chem. 272, 11444-11451
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Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade.
S. Newfeld, A Mehra, M. Singer, J. Wrana, L Attisano, and W. Gelbart (1997)
Development 124, 3167-3176
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Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing.
J. de Celis (1997)
Development 124, 1007-1018
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Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing.
M. Singer, A Penton, V Twombly, F. Hoffmann, and W. Gelbart (1997)
Development 124, 79-89
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Regulation of a dpp target gene in the Drosophila embryo.
J Rusch and M Levine (1997)
Development 124, 303-311
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Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina.
F Chanut and U Heberlein (1997)
Development 124, 559-567
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Transcriptional Regulation by Transforming Growth Factorbeta of the Expression of Retinoic Acid and Retinoid X Receptor Genes in Osteoblastic Cells Is Mediated through AP-1.
Y. Chen, A. Takeshita, K. Ozaki, S. Kitano, and S. Hanazawa (1996)
J. Biol. Chem. 271, 31602-31606
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Purification, Characterization, and cDNA Cloning of a Novel Growth Factor from the Conditioned Medium of NIH-Sape-4, an Embryonic Cell Line of Sarcophaga peregrina (Flesh Fly).
K.-i. Homma, T. Matsushita, and S. Natori (1996)
J. Biol. Chem. 271, 13770-13775
   Abstract »    Full Text »    PDF »
Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells.
S. Newfeld, E. Chartoff, J. Graff, D. Melton, and W. Gelbart (1996)
Development 122, 2099-2108
   Abstract »    PDF »
Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis..
Y Mishina, A Suzuki, N Ueno, and R R Behringer (1995)
Genes & Dev. 9, 3027-3037
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GH3 Pituitary Tumor Cells Contain Heteromeric Type I and Type II Receptor Complexes for Transforming Growth Factor beta and Activin-A.
A. Moustakas, T. Takumi, H. Y. Lin, and H. F. Lodish (1995)
J. Biol. Chem. 270, 765-769
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A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.
K Staehling-Hampton, A. Laughon, and F. Hoffmann (1995)
Development 121, 3393-3403
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Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene.
J. Treisman, Z. Lai, and G. Rubin (1995)
Development 121, 2835-2845
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Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene..
V Francois, M Solloway, J W O'Neill, J Emery, and E Bier (1994)
Genes & Dev. 8, 2602-2616
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