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Science 18 March 1994:
Vol. 263. no. 5153, pp. 1603 - 1606
DOI: 10.1126/science.8128246
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Articles

Science, Vol 263, Issue 5153, 1603-1606
Copyright © 1994 by American Association for the Advancement of Science

articles

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless

A Sehgal, JL Price, B Man, and MW Young

Howard Hughes Medical Institute, National Science Foundation Science and Technology Center for Biological Timing, Rockefeller University, New York, NY 10021.

Eclosion, or emergence of adult flies from the pupa, and locomotor activity of adults occur rhythmically in Drosophila melanogaster, with a circadian period of about 24 hours. Here, a clock mutation, timeless (tim), is described that produces arrhythmia for both behaviors. The effects of tim on behavioral rhythms are likely to involve products of the X chromosome-linked clock gene period (per), because tim alters circadian oscillations of per RNA. Genetic mapping places tim on the left arm of the second chromosome between dumpy (dp) and decapentaplegic (dpp).


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J Biol Rhythms 12, 157-172
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J. Neurosci. 17, 676-696
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C. B. Green and J. C. Besharse (1996)
PNAS 93, 14884-14888
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Molecular Anatomy of a Light-sensitive Circadian Pacemaker in Drosophila.
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Cold Spring Harb Symp Quant Biol 61, 295-302
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Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless.
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J. Biol. Chem. 275, 37078-37085
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Oscillation and Light Induction of timeless mRNA in the Mammalian Circadian Clock.
S. A. Tischkau, J. A. Barnes, F.-J. Lin, E. M. Myers, J. W. Soucy, E. L. Meyer-Bernstein, W. J. Hurst, P. W. Burgoon, D. Chen, A. Sehgal, et al. (1999)
J. Neurosci. 19, RC15
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