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Science 18 March 1994:
Vol. 263. no. 5153, pp. 1600 - 1603
DOI: 10.1126/science.8128245
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Articles

Science, Vol 263, Issue 5153, 1600-1603
Copyright © 1994 by American Association for the Advancement of Science

articles

Biodegradable long-circulating polymeric nanospheres

R Gref, Y Minamitake, MT Peracchia, V Trubetskoy, V Torchilin, and R Langer

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.

Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these limitations, monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks. The nanospheres exhibited dramatically increased blood circulation times and reduced liver accumulation in mice. Furthermore, they entrapped up to 45 percent by weight of the drug in the dense core in a one-step procedure and could be freeze-dried and easily redispersed without additives in aqueous solutions.


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