Science 14 January 1994: Vol. 263. no. 5144, pp. 227 - 230 DOI: 10.1126/science.8284673

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Articles

Fast-growing, non-infectious and intracellularly surviving drug-resistant Mycobacterium aurum: a model for high-throughput antituberculosis drug screening.

A. Gupta, S. Bhakta, S. Kundu, M. Gupta, B. S. Srivastava, and R. Srivastava (2009)
J. Antimicrob. Chemother. 64, 774-781
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis Isolates.

Y. M. Ho, Y.-J. Sun, S.-Y. Wong, and A. S. G. Lee (2009)
Antimicrob. Agents Chemother. 53, 4010-4012
 |  Abstract »  |  Full Text »  |  PDF »

Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages.

R. Reich-Slotky, C. A. Kabbash, P. Della-Latta, J. S. Blanchard, S. J. Feinmark, S. Freeman, G. Kaplan, H. A. Shuman, and S. C. Silverstein (2009)
J. Bacteriol. 191, 5262-5271
 |  Abstract »  |  Full Text »  |  PDF »

The Mycobacterium tuberculosis {beta}-Ketoacyl-Acyl Carrier Protein Synthase III Activity Is Inhibited by Phosphorylation on a Single Threonine Residue.

R. Veyron-Churlet, V. Molle, R. C. Taylor, A. K. Brown, G. S. Besra, I. Zanella-Cleon, K. Futterer, and L. Kremer (2009)
J. Biol. Chem. 284, 6414-6424
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking pathways of mycolic acids: structures, origin, mechanism of formation, and storage form of mycobacteric acids.

E. Rafidinarivo, M.-A. Laneelle, H. Montrozier, P. Valero-Guillen, J. Astola, M. Luquin, J.-C. Prome, and M. Daffe (2009)
J. Lipid Res. 50, 477-490
 |  Abstract »  |  Full Text »  |  PDF »

Susceptibility of Mycobacterium bovis BCG Vaccine Strains to Antituberculous Antibiotics.

N. Ritz, M. Tebruegge, T. G. Connell, A. Sievers, R. Robins-Browne, and N. Curtis (2009)
Antimicrob. Agents Chemother. 53, 316-318
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Interaction Linking the FAS-II and Phthiocerol Dimycocerosate (PDIM) Biosynthetic Pathways.

N. A. Kruh, J. G. Borgaro, B. P. Ruzsicska, H. Xu, and P. J. Tonge (2008)
J. Biol. Chem. 283, 31719-31725
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Inhibition of the fungal fatty acid synthase type I multienzyme complex.

P. Johansson, B. Wiltschi, P. Kumari, B. Kessler, C. Vonrhein, J. Vonck, D. Oesterhelt, and M. Grininger (2008)
PNAS 105, 12803-12808
 |  Abstract »  |  Full Text »  |  PDF »

Function of Heterologous Mycobacterium tuberculosis InhA, a Type 2 Fatty Acid Synthase Enzyme Involved in Extending C20 Fatty Acids to C60-to-C90 Mycolic Acids, during De Novo Lipoic Acid Synthesis in Saccharomyces cerevisiae.

A. Gurvitz, J. K. Hiltunen, and A. J. Kastaniotis (2008)
Appl. Envir. Microbiol. 74, 5078-5085
 |  Abstract »  |  Full Text »  |  PDF »

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.

V. Bhowruth, A. K. Brown, and G. S. Besra (2008)
Microbiology 154, 1866-1875
 |  Abstract »  |  Full Text »  |  PDF »

Biological and Molecular Characteristics of Mycobacterium tuberculosis Clinical Isolates with Low-Level Resistance to Isoniazid in Japan.

C. Abe, I. Kobayashi, S. Mitarai, M. Wada, Y. Kawabe, T. Takashima, K. Suzuki, L.-H. Sng, S. Wang, H. H. Htay, et al. (2008)
J. Clin. Microbiol. 46, 2263-2268
 |  Abstract »  |  Full Text »  |  PDF »

Bacterial Growth and Cell Division: a Mycobacterial Perspective.

E. C. Hett and E. J. Rubin (2008)
Microbiol. Mol. Biol. Rev. 72, 126-156
 |  Abstract »  |  Full Text »  |  PDF »

Antimycobacterial Activity and Mechanism of Action of NAS-91.

P. Gratraud, N. Surolia, G. S. Besra, A. Surolia, and L. Kremer (2008)
Antimicrob. Agents Chemother. 52, 1162-1166
 |  Abstract »  |  Full Text »  |  PDF »

Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis.

P. C. Karakousis, E. P. Williams, and W. R. Bishai (2008)
J. Antimicrob. Chemother. 61, 323-331
 |  Abstract »  |  Full Text »  |  PDF »

Investigating the Function of the Putative Mycolic Acid Methyltransferase UmaA: DIVERGENCE BETWEEN THE MYCOBACTERIUM SMEGMATIS AND MYCOBACTERIUM TUBERCULOSIS PROTEINS.

F. Laval, R. Haites, F. Movahedzadeh, A. Lemassu, C. Y. Wong, N. Stoker, H. Billman-Jacobe, and M. Daffe (2008)
J. Biol. Chem. 283, 1419-1427
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.

A. K. Brown, A. Bhatt, A. Singh, E. Saparia, A. F. Evans, and G. S. Besra (2007)
Microbiology 153, 4166-4173
 |  Abstract »  |  Full Text »  |  PDF »

Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

A. K. Brown, A. Papaemmanouil, V. Bhowruth, A. Bhatt, L. G. Dover, and G. S. Besra (2007)
Microbiology 153, 3314-3322
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity InhA Inhibitors.

M. E. Boyne, T. J. Sullivan, C. W. amEnde, H. Lu, V. Gruppo, D. Heaslip, A. G. Amin, D. Chatterjee, A. Lenaerts, P. J. Tonge, et al. (2007)
Antimicrob. Agents Chemother. 51, 3562-3567
 |  Abstract »  |  Full Text »  |  PDF »

X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy.

J. S. Freundlich, F. Wang, H.-C. Tsai, M. Kuo, H.-M. Shieh, J. W. Anderson, L. J. Nkrumah, J.-C. Valderramos, M. Yu, T. R. S. Kumar, et al. (2007)
J. Biol. Chem. 282, 25436-25444
 |  Abstract »  |  Full Text »  |  PDF »

Comparative genomic analysis of mycobacteriophage Tweety: evolutionary insights and construction of compatible site-specific integration vectors for mycobacteria.

T. T. Pham, D. Jacobs-Sera, M. L. Pedulla, R. W. Hendrix, and G. F. Hatfull (2007)
Microbiology 153, 2711-2723
 |  Abstract »  |  Full Text »  |  PDF »

Isoniazid Induces Its Own Resistance in Nonreplicating Mycobacterium tuberculosis.

S. Siddiqi, P. Takhar, C. Baldeviano, W. Glover, and Y. Zhang (2007)
Antimicrob. Agents Chemother. 51, 2100-2104
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

M. Seidel, L. J. Alderwick, H. L. Birch, H. Sahm, L. Eggeling, and G. S. Besra (2007)
J. Biol. Chem. 282, 14729-14740
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

J. Wang, S. Kodali, S. H. Lee, A. Galgoci, R. Painter, K. Dorso, F. Racine, M. Motyl, L. Hernandez, E. Tinney, et al. (2007)
PNAS 104, 7612-7616
 |  Abstract »  |  Full Text »  |  PDF »

EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets.

L. G. Dover, A. Alahari, P. Gratraud, J. M. Gomes, V. Bhowruth, R. C. Reynolds, G. S. Besra, and L. Kremer (2007)
Antimicrob. Agents Chemother. 51, 1055-1063
 |  Abstract »  |  Full Text »  |  PDF »

AccD6, a Member of the Fas II Locus, Is a Functional Carboxyltransferase Subunit of the Acyl-Coenzyme A Carboxylase in Mycobacterium tuberculosis.

J. Daniel, T.-J. Oh, C.-M. Lee, and P. E. Kolattukudy (2007)
J. Bacteriol. 189, 911-917
 |  Abstract »  |  Full Text »  |  PDF »

Aspirin Antagonism in Isoniazid Treatment of Tuberculosis in Mice.

S. T. Byrne, S. M. Denkin, and Y. Zhang (2007)
Antimicrob. Agents Chemother. 51, 794-795
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of thioamide drug action against tuberculosis and leprosy.

F. Wang, R. Langley, G. Gulten, L. G. Dover, G. S. Besra, W. R. Jacobs Jr., and J. C. Sacchettini (2007)
J. Exp. Med. 204, 73-78
 |  Abstract »  |  Full Text »  |  PDF »

Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli.

S. Rafi, P. Novichenok, S. Kolappan, X. Zhang, C. F. Stratton, R. Rawat, C. Kisker, C. Simmerling, and P. J. Tonge (2006)
J. Biol. Chem. 281, 39285-39293
 |  Abstract »  |  Full Text »  |  PDF »

Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA..

H. Guo, Q. Seet, S. Denkin, L. Parsons, and Y. Zhang (2006)
J. Med. Microbiol. 55, 1527-1531
 |  Abstract »  |  Full Text »  |  PDF »

Performance of the Genotype MTBDR Line Probe Assay for Detection of Resistance to Rifampin and Isoniazid in Strains of Mycobacterium tuberculosis with Low- and High-Level Resistance..

F. Brossier, N. Veziris, C. Truffot-Pernot, V. Jarlier, and W. Sougakoff (2006)
J. Clin. Microbiol. 44, 3659-3664
 |  Abstract »  |  Full Text »  |  PDF »

Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis..

M. H. Hazbon, M. Brimacombe, M. Bobadilla del Valle, M. Cavatore, M. I. Guerrero, M. Varma-Basil, H. Billman-Jacobe, C. Lavender, J. Fyfe, L. Garcia-Garcia, et al. (2006)
Antimicrob. Agents Chemother. 50, 2640-2649
 |  Abstract »  |  Full Text »  |  PDF »

Use of Genotype MTBDR Assay for Molecular Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Clinical Strains Isolated in Italy..

P. Miotto, F. Piana, V. Penati, F. Canducci, G. B. Migliori, and D. M. Cirillo (2006)
J. Clin. Microbiol. 44, 2485-2491
 |  Abstract »  |  Full Text »  |  PDF »

Rapid Genotypic Detection of Rifampin- and Isoniazid-Resistant Mycobacterium tuberculosis Directly in Clinical Specimens..

D. Bang, A. Bengard Andersen, and V. O. Thomsen (2006)
J. Clin. Microbiol. 44, 2605-2608
 |  Abstract »  |  Full Text »  |  PDF »

Inhibiting Bacterial Fatty Acid Synthesis.

Y.-M. Zhang, S. W. White, and C. O. Rock (2006)
J. Biol. Chem. 281, 17541-17544
 |  Abstract »  |  Full Text »  |  PDF »

The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria.

C. Chalut, L. Botella, C. de Sousa-D'Auria, C. Houssin, and C. Guilhot (2006)
PNAS 103, 8511-8516
 |  Abstract »  |  Full Text »  |  PDF »

Rapid detection of specific gene mutations associated with isoniazid or rifampicin resistance in Mycobacterium tuberculosis clinical isolates using non-fluorescent low-density DNA microarrays.

L. M. Aragon, F. Navarro, V. Heiser, M. Garrigo, M. Espanol, and P. Coll (2006)
J. Antimicrob. Chemother. 57, 825-831
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of Isoniazid Resistance in Mycobacterium tuberculosis: Identification of a Novel Mutation in inhA.

E. T. Y. Leung, P. L. Ho, K. Y. Yuen, W. L. Woo, T. H. Lam, R. Y. Kao, W. H. Seto, and W. C. Yam (2006)
Antimicrob. Agents Chemother. 50, 1075-1078
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of FabH/FabF Inhibitors from Natural Products.

K. Young, H. Jayasuriya, J. G. Ondeyka, K. Herath, C. Zhang, S. Kodali, A. Galgoci, R. Painter, V. Brown-Driver, R. Yamamoto, et al. (2006)
Antimicrob. Agents Chemother. 50, 519-526
 |  Abstract »  |  Full Text »  |  PDF »

Mutational and expression analysis of tbnat and its response to isoniazid.

C. Sholto-Douglas-Vernon, J. Sandy, T. C Victor, E. Sim, and P. D. Helden (2005)
J. Med. Microbiol. 54, 1189-1197
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Depletion of KasA, a Key Enzyme of Mycolic Acid Biosynthesis, Leads to Mycobacterial Cell Lysis.

A. Bhatt, L. Kremer, A. Z. Dai, J. C. Sacchettini, and W. R. Jacobs Jr (2005)
J. Bacteriol. 187, 7596-7606
 |  Abstract »  |  Full Text »  |  PDF »

mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatis.

M. R. Pasca, P. Guglierame, E. De Rossi, F. Zara, and G. Riccardi (2005)
Antimicrob. Agents Chemother. 49, 4775-4777
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of Isoniazid-Resistant Mycobacterium tuberculosis Isolates Collected in Australia.

C. Lavender, M. Globan, A. Sievers, H. Billman-Jacobe, and J. Fyfe (2005)
Antimicrob. Agents Chemother. 49, 4068-4074
 |  Abstract »  |  Full Text »  |  PDF »

Mass spectrometry of the M. smegmatis proteome: Protein expression levels correlate with function, operons, and codon bias.

R. Wang, J. T. Prince, and E. M. Marcotte (2005)
Genome Res. 15, 1118-1126
 |  Abstract »  |  Full Text »  |  PDF »

Drug Resistance Evolution of a Mycobacterium tuberculosis Strain from a Noncompliant Patient.

F. Meacci, G. Orru, E. Iona, F. Giannoni, C. Piersimoni, G. Pozzi, L. Fattorini, and M. R. Oggioni (2005)
J. Clin. Microbiol. 43, 3114-3120
 |  Abstract »  |  Full Text »  |  PDF »

New Small-Molecule Synthetic Antimycobacterials.

L. Ballell, R. A. Field, K. Duncan, and R. J. Young (2005)
Antimicrob. Agents Chemother. 49, 2153-2163
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Responses of Mycobacterium tuberculosis to Growth in the Mouse Lung.

E. Dubnau, J. Chan, V. P. Mohan, and I. Smith (2005)
Infect. Immun. 73, 3754-3757
 |  Abstract »  |  Full Text »  |  PDF »

Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.

A. Burguiere, P. G. Hitchen, L. G. Dover, A. Dell, and G. S. Besra (2005)
Microbiology 151, 2087-2095
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Analysis of Isoniazid-Resistant Mycobacterium tuberculosis Isolates from England and Wales Reveals the Phylogenetic Significance of the ahpC -46A Polymorphism.

L. V. Baker, T. J. Brown, O. Maxwell, A. L. Gibson, Z. Fang, M. D. Yates, and F. A. Drobniewski (2005)
Antimicrob. Agents Chemother. 49, 1455-1464
 |  Abstract »  |  Full Text »  |  PDF »

The Acyl-AMP Ligase FadD32 and AccD4-containing Acyl-CoA Carboxylase Are Required for the Synthesis of Mycolic Acids and Essential for Mycobacterial Growth: IDENTIFICATION OF THE CARBOXYLATION PRODUCT AND DETERMINATION OF THE ACYL-CoA CARBOXYLASE COMPONENTS.

D. Portevin, C. de Sousa-D'Auria, H. Montrozier, C. Houssin, A. Stella, M.-A. Laneelle, F. Bardou, C. Guilhot, and M. Daffe (2005)
J. Biol. Chem. 280, 8862-8874
 |  Abstract »  |  Full Text »  |  PDF »

Altered NADH/NAD+ Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria.

C. Vilcheze, T. R. Weisbrod, B. Chen, L. Kremer, M. H. Hazbon, F. Wang, D. Alland, J. C. Sacchettini, and W. R. Jacobs Jr. (2005)
Antimicrob. Agents Chemother. 49, 708-720
 |  Abstract »  |  Full Text »  |  PDF »

Determination of Selectivity and Efficacy of Fatty Acid Synthesis Inhibitors.

S. Kodali, A. Galgoci, K. Young, R. Painter, L. L. Silver, K. B. Herath, S. B. Singh, D. Cully, J. F. Barrett, D. Schmatz, et al. (2005)
J. Biol. Chem. 280, 1669-1677
 |  Abstract »  |  Full Text »  |  PDF »

Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis.

K. Takayama, C. Wang, and G. S. Besra (2005)
Clin. Microbiol. Rev. 18, 81-101
 |  Abstract »  |  Full Text »  |  PDF »

New Multiplex PCR for Rapid Detection of Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates.

L. Herrera-Leon, T. Molina, P. Saiz, J. A. Saez-Nieto, and M. S. Jimenez (2005)
Antimicrob. Agents Chemother. 49, 144-147
 |  Abstract »  |  Full Text »  |  PDF »

Screening and Characterization of Mutations in Isoniazid-Resistant Mycobacterium tuberculosis Isolates Obtained in Brazil.

R. F. Cardoso, R. C. Cooksey, G. P. Morlock, P. Barco, L. Cecon, F. Forestiero, C. Q. F. Leite, D. N. Sato, M. d. L. Shikama, E. M. Mamizuka, et al. (2004)
Antimicrob. Agents Chemother. 48, 3373-3381
 |  Abstract »  |  Full Text »  |  PDF »

Requirements for Nitric Oxide Generation from Isoniazid Activation In Vitro and Inhibition of Mycobacterial Respiration In Vivo.

G. S. Timmins, S. Master, F. Rusnak, and V. Deretic (2004)
J. Bacteriol. 186, 5427-5431
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis.

G. S. Timmins, S. Master, F. Rusnak, and V. Deretic (2004)
Antimicrob. Agents Chemother. 48, 3006-3009
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of Epigallocatechin Gallate and Related Plant Polyphenols as Inhibitors of the FabG and FabI Reductases of Bacterial Type II Fatty-acid Synthase.

Y.-M. Zhang and C. O. Rock (2004)
J. Biol. Chem. 279, 30994-31001
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Mycobacterium smegmatis Expressing the Mycobacterium tuberculosis Fatty Acid Synthase I (fas1) Gene.

O. Zimhony, C. Vilcheze, and W. R. Jacobs Jr. (2004)
J. Bacteriol. 186, 4051-4055
 |  Abstract »  |  Full Text »  |  PDF »

Direct Detection of Rifampin- and Isoniazid-Resistant Mycobacterium tuberculosis in Auramine-Rhodamine-Positive Sputum Specimens by Real-Time PCR.

M. Ruiz, M. J. Torres, A. C. Llanos, A. Arroyo, J. C. Palomares, and J. Aznar (2004)
J. Clin. Microbiol. 42, 1585-1589
 |  Abstract »  |  Full Text »  |  PDF »

The Prodrug Activator EtaA from Mycobacterium tuberculosis Is a Baeyer-Villiger Monooxygenase.

M. W. Fraaije, N. M. Kamerbeek, A. J. Heidekamp, R. Fortin, and D. B. Janssen (2004)
J. Biol. Chem. 279, 3354-3360
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Inhibition of the Mycobacterium tuberculosis {beta}-Ketoacyl-Acyl Carrier Protein Reductase MabA by Isoniazid.

S. Ducasse-Cabanot, M. Cohen-Gonsaud, H. Marrakchi, M. Nguyen, D. Zerbib, J. Bernadou, M. Daffe, G. Labesse, and A. Quemard (2004)
Antimicrob. Agents Chemother. 48, 242-249
 |  Abstract »  |  Full Text »  |  PDF »

ethA, inhA, and katG Loci of Ethionamide-Resistant Clinical Mycobacterium tuberculosis Isolates.

G. P. Morlock, B. Metchock, D. Sikes, J. T. Crawford, and R. C. Cooksey (2003)
Antimicrob. Agents Chemother. 47, 3799-3805
 |  Abstract »  |  Full Text »  |  PDF »

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance.

R. Rawat, A. Whitty, and P. J. Tonge (2003)
PNAS 100, 13881-13886
 |  Abstract »  |  Full Text »  |  PDF »

Detection of a Point Mutation Associated with High-Level Isoniazid Resistance in Mycobacterium tuberculosis by Using Real-Time PCR Technology with 3'-Minor Groove Binder-DNA Probes.

H. R. van Doorn, E. C. J. Claas, K. E. Templeton, A. G. M. van der Zanden, A. te Koppele Vije, M. D. de Jong, J. Dankert, and E. J. Kuijper (2003)
J. Clin. Microbiol. 41, 4630-4635
 |  Abstract »  |  Full Text »  |  PDF »

Signature Gene Expression Profiles Discriminate between Isoniazid-, Thiolactomycin-, and Triclosan-Treated Mycobacterium tuberculosis.

J. C. Betts, A. McLaren, M. G. Lennon, F. M. Kelly, P. T. Lukey, S. J. Blakemore, and K. Duncan (2003)
Antimicrob. Agents Chemother. 47, 2903-2913
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in katG, inhA, and ahpC Genes of Brazilian Isoniazid-Resistant Isolates of Mycobacterium tuberculosis.

M. S. N. Silva, S. G. Senna, M. O. Ribeiro, A. R. M. Valim, M. A. Telles, A. Kritski, G. P. Morlock, R. C. Cooksey, A. Zaha, and M. L. R. Rossetti (2003)
J. Clin. Microbiol. 41, 4471-4474
 |  Abstract »  |  Full Text »  |  PDF »

The 1.3-Angstrom-Resolution Crystal Structure of {beta}-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.

A. C. Price, C. O. Rock, and S. W. White (2003)
J. Bacteriol. 185, 4136-4143
 |  Abstract »  |  Full Text »  |  PDF »

Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence.

I. Smith (2003)
Clin. Microbiol. Rev. 16, 463-496
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates in Lithuania.

D. Bakonyte, A. Baranauskaite, J. Cicenaite, A. Sosnovskaja, and P. Stakenas (2003)
Antimicrob. Agents Chemother. 47, 2009-2011
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria.

L. Kremer, L. G. Dover, H. R. Morbidoni, C. Vilcheze, W. N. Maughan, A. Baulard, S.-C. Tu, N. Honore, V. Deretic, J. C. Sacchettini, et al. (2003)
J. Biol. Chem. 278, 20547-20554
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase: COMPOUND ACTIVITY AND STRUCTURAL DATA.

M. R. Kuo, H. R. Morbidoni, D. Alland, S. F. Sneddon, B. B. Gourlie, M. M. Staveski, M. Leonard, J. S. Gregory, A. D. Janjigian, C. Yee, et al. (2003)
J. Biol. Chem. 278, 20851-20859
 |  Abstract »  |  Full Text »  |  PDF »

Single Nucleotide Polymorphisms in Genes Associated with Isoniazid Resistance in Mycobacterium tuberculosis.

S. V. Ramaswamy, R. Reich, S.-J. Dou, L. Jasperse, X. Pan, A. Wanger, T. Quitugua, and E. A. Graviss (2003)
Antimicrob. Agents Chemother. 47, 1241-1250
 |  Abstract »  |  Full Text »  |  PDF »

Tracking the Putative Biosynthetic Precursors of Oxygenated Mycolates of Mycobacterium tuberculosis. STRUCTURAL ANALYSIS OF FATTY ACIDS OF A MUTANT STRAIN DEVOID OF METHOXY- AND KETOMYCOLATES.

P. Dinadayala, F. Laval, C. Raynaud, A. Lemassu, M.-A. Laneelle, G. Laneelle, and M. Daffe (2003)
J. Biol. Chem. 278, 7310-7319
 |  Abstract »  |  Full Text »  |  PDF »

Isoniazid Activation Defects in Recombinant Mycobacterium tuberculosis Catalase-Peroxidase (KatG) Mutants Evident in InhA Inhibitor Production.

C.-J. Wei, B. Lei, J. M. Musser, and S.-C. Tu (2003)
Antimicrob. Agents Chemother. 47, 670-675
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Exploring the Structure and Function of the Mycobacterial KatG Protein Using trans-Dominant Mutants.

J. A. DeVito and S. Morris (2003)
Antimicrob. Agents Chemother. 47, 188-195
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Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid.

V. M. Bulatovic, N. L. Wengenack, J. R. Uhl, L. Hall, G. D. Roberts, F. R. Cockerill III, and F. Rusnak (2002)
Antimicrob. Agents Chemother. 46, 2765-2771
 |  Abstract »  |  Full Text »  |  PDF »

Isoniazid-Induced Transient High-Level Resistance in Mycobacterium tuberculosis.

M. Viveiros, I. Portugal, R. Bettencourt, T. C. Victor, A. M. Jordaan, C. Leandro, D. Ordway, and L. Amaral (2002)
Antimicrob. Agents Chemother. 46, 2804-2810
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Mn(III) Pyrophosphate as an Efficient Tool for Studying the Mode of Action of Isoniazid on the InhA Protein of Mycobacterium tuberculosis.

M. Nguyen, A. Quemard, S. Broussy, J. Bernadou, and B. Meunier (2002)
Antimicrob. Agents Chemother. 46, 2137-2144
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Mycobacterium tuberculosis Genes Induced during Infection of Human Macrophages.

E. Dubnau, P. Fontan, R. Manganelli, S. Soares-Appel, and I. Smith (2002)
Infect. Immun. 70, 2787-2795
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The Antituberculosis Drug Ethionamide Is Activated by a Flavoprotein Monooxygenase.

T. A. Vannelli, A. Dykman, and P. R. Ortiz de Montellano (2002)
J. Biol. Chem. 277, 12824-12829
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MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II.

H. Marrakchi, S. Ducasse, G. Labesse, H. Montrozier, E. Margeat, L. Emorine, X. Charpentier, M. Daffe, and A. Quemard (2002)
Microbiology 148, 951-960
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In Vitro Antimycobacterial Activities of 2'-Monosubstituted Isonicotinohydrazides and Their Cyanoborane Adducts.

R. Maccari, R. Ottana, F. Monforte, and M. G. Vigorita (2002)
Antimicrob. Agents Chemother. 46, 294-299
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Rapid Detection of Pyrazinamide-Resistant Mycobacterium tuberculosis by a PCR-Based In Vitro System.

Y. Suzuki, A. Suzuki, A. Tamaru, C. Katsukawa, and H. Oda (2002)
J. Clin. Microbiol. 40, 501-507
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Purification and Biochemical Characterization of the Mycobacterium tuberculosisbeta -Ketoacyl-acyl Carrier Protein Synthases KasA and KasB.

M. L. Schaeffer, G. Agnihotri, C. Volker, H. Kallender, P. J. Brennan, and J. T. Lonsdale (2001)
J. Biol. Chem. 276, 47029-47037
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Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein.

S. Peters, M. Munoz, S. Yerly, V. Sanchez-Merino, C. Lopez-Galindez, L. Perrin, B. Larder, D. Cmarko, S. Fakan, P. Meylan, et al. (2001)
J. Virol. 75, 9644-9653
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Activity of a Novel Antimycobacterial Compound, N-Octanesulfonylacetamide, and Its Effects on Lipid and Mycolic Acid Synthesis.

N. M. Parrish, T. Houston, P. B. Jones, C. Townsend, and J. D. Dick (2001)
Antimicrob. Agents Chemother. 45, 1143-1150
 |  Abstract »  |  Full Text »

The Susceptibility of Mycobacterium tuberculosis to Isoniazid and the Arg{right-arrow}Leu Mutation at Codon 463 of katG Are Not Associated.

H. R. van Doorn, E. J. Kuijper, A. van der Ende, A. G. A. Welten, D. van Soolingen, P. E. W. de Haas, and J. Dankert (2001)
J. Clin. Microbiol. 39, 1591-1594
 |  Abstract »  |  Full Text »

Differential expression of mycobacterial proteins following phagocytosis by macrophages.

I. M. Monahan, J. Betts, D. K. Banerjee, and P. D. Butcher (2001)
Microbiology 147, 459-471
 |  Abstract »  |  Full Text »

Use of Real-Time PCR and Fluorimetry for Rapid Detection of Rifampin and Isoniazid Resistance-Associated Mutations in Mycobacterium tuberculosis.

M. J. Torres, A. Criado, J. C. Palomares, and J. Aznar (2000)
J. Clin. Microbiol. 38, 3194-3199
 |  Abstract »  |  Full Text »

Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis.

A. E. DeBarber, K. Mdluli, M. Bosman, L.-G. Bekker, and C. E. Barry 3rd (2000)
PNAS 97, 9677-9682
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium smegmatis.

C. Vilchèze, H. R. Morbidoni, T. R. Weisbrod, H. Iwamoto, M. Kuo, J. C. Sacchettini, and W. R. Jacobs Jr. (2000)
J. Bacteriol. 182, 4059-4067
 |  Abstract »  |  Full Text »

Characterization of the Mycobacterium tuberculosis iniBAC Promoter, a Promoter That Responds to Cell Wall Biosynthesis Inhibition.

D. Alland, A. J. Steyn, T. Weisbrod, K. Aldrich, and W. R. Jacobs Jr. (2000)
J. Bacteriol. 182, 1802-1811
 |  Abstract »  |  Full Text »

Inhibition of the Staphylococcus aureus NADPH-dependent Enoyl-Acyl Carrier Protein Reductase by Triclosan and Hexachlorophene.

R. J. Heath, J. Li, G. E. Roland, and C. O. Rock (2000)
J. Biol. Chem. 275, 4654-4659
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of the Genes Encoding Antigen 85A and Antigen 85B of Mycobacterium tuberculosis H37Rv: Effect on Growth in Culture and in Macrophages.

L. Y. Armitige, C. Jagannath, A. R. Wanger, and S. J. Norris (2000)
Infect. Immun. 68, 767-778
 |  Abstract »  |  Full Text »  |  PDF »

InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II.

H. Marrakchi, G. Lanéelle, and A. Quémard (2000)
Microbiology 146, 289-296
 |  Abstract »  |  Full Text »

Action Mechanism of Antitubercular Isoniazid. ACTIVATION BY MYCOBACTERIUM TUBERCULOSIS KatG, ISOLATION, AND CHARACTERIZATION OF InhA INHIBITOR.

B. Lei, C.-J. Wei, and S.-C. Tu (2000)
J. Biol. Chem. 275, 2520-2526
 |  Abstract »  |  Full Text »  |  PDF »

High-Dose Isoniazid Therapy for Isoniazid-Resistant Murine Mycobacterium tuberculosis Infection.

M. H. Cynamon, Y. Zhang, T. Harpster, S. Cheng, and M. S. DeStefano (1999)
Antimicrob. Agents Chemother. 43, 2922-2924
 |  Abstract »  |  Full Text »

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