Science 7 January 1994: Vol. 263. no. 5143, pp. 92 - 95 DOI: 10.1126/science.8272873

Prev | Table of Contents | Next

Articles

Tyrosine Kinase 2 Plays Critical Roles in the Pathogenic CD4 T Cell Responses for the Development of Experimental Autoimmune Encephalomyelitis.

A. Oyamada, H. Ikebe, M. Itsumi, H. Saiwai, S. Okada, K. Shimoda, Y. Iwakura, K. I. Nakayama, Y. Iwamoto, Y. Yoshikai, et al. (2009)
J. Immunol. 183, 7539-7546
 |  Abstract »  |  Full Text »  |  PDF »

A Single Nucleotide Polymorphism in Tyk2 Controls Susceptibility to Experimental Allergic Encephalomyelitis.

K. M. Spach, R. Noubade, B. McElvany, W. F. Hickey, E. P. Blankenhorn, and C. Teuscher (2009)
J. Immunol. 182, 7776-7783
 |  Abstract »  |  Full Text »  |  PDF »

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.

R. Burger, S. Le Gouill, Y.-T. Tai, R. Shringarpure, P. Tassone, P. Neri, K. Podar, L. Catley, T. Hideshima, D. Chauhan, et al. (2009)
Mol. Cancer Ther. 8, 26-35
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia inhibitory factor as a regulator of steroidogenesis in human NCI-H295R adrenocortical cells.

I. V Mikhaylova, T. Jaaskelainen, J. Jaaskelainen, J. J Palvimo, and R. Voutilainen (2008)
J. Endocrinol. 199, 435-444
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor {alpha} Chain.

F. Rousseau, S. Chevalier, C. Guillet, E. Ravon, C. Diveu, J. Froger, F. Barbier, L. Grimaud, and H. Gascan (2008)
J. Biol. Chem. 283, 30341-30350
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor Regulates Trophoblast Giant Cell Differentiation via Janus Kinase 1-Signal Transducer and Activator of Transcription 3-Suppressor of Cytokine Signaling 3 Pathway.

Y. Takahashi, M. Takahashi, N. Carpino, S.-T. Jou, J.-R. Chao, S. Tanaka, Y. Shigeyoshi, E. Parganas, and J. N. Ihle (2008)
Mol. Endocrinol. 22, 1673-1681
 |  Abstract »  |  Full Text »  |  PDF »

Nucleocytoplasmic shuttling of persistently activated STAT3.

A. Herrmann, M. Vogt, M. Monnigmann, T. Clahsen, U. Sommer, S. Haan, V. Poli, P. C. Heinrich, and G. Muller-Newen (2007)
J. Cell Sci. 120, 3249-3261
 |  Abstract »  |  Full Text »  |  PDF »

Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells.

A. K. Pathak, M. Bhutani, A. S. Nair, K. S. Ahn, A. Chakraborty, H. Kadara, S. Guha, G. Sethi, and B. B. Aggarwal (2007)
Mol. Cancer Res. 5, 943-955
 |  Abstract »  |  Full Text »  |  PDF »

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.

T. Huyton, J.-G. Zhang, C. S. Luo, M.-Z. Lou, D. J. Hilton, N. A. Nicola, and T. P. J. Garrett (2007)
PNAS 104, 12737-12742
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-{gamma} production and the induction of Th1 cell differentiation.

N. Tokumasa, A. Suto, S.-i. Kagami, S. Furuta, K. Hirose, N. Watanabe, Y. Saito, K. Shimoda, I. Iwamoto, and H. Nakajima (2007)
Blood 110, 553-560
 |  Abstract »  |  Full Text »  |  PDF »

Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.

S. Finotto, T. Eigenbrod, R. Karwot, I. Boross, A. Doganci, H. Ito, N. Nishimoto, K. Yoshizaki, T. Kishimoto, S. Rose-John, et al. (2007)
Int. Immunol. 19, 685-693
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Cellular Alterations Induced by Sustained Expression of Ciliary Neurotrophic Factor in a Mouse Model of Retinitis Pigmentosa.

K. D. Rhee, A. Ruiz, J. L. Duncan, W. W. Hauswirth, M. M. LaVail, D. Bok, and X.-J. Yang (2007)
Invest. Ophthalmol. Vis. Sci. 48, 1389-1400
 |  Abstract »  |  Full Text »  |  PDF »

Mercury Abolishes Neurotrophic Factor-Stimulated Jak-STAT Signaling in Nerve Cells by Oxidative Stress.

R. K. Monroe and S. W. Halvorsen (2006)
Toxicol. Sci. 94, 129-138
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte 15-Lipoxygenase Expression Is Regulated by a Novel Cytosolic Signaling Complex with Protein Kinase C {delta} and Tyrosine-Phosphorylated Stat3.

A. Bhattacharjee, B. Xu, D. A. Frank, G. M. Feldman, and M. K. Cathcart (2006)
J. Immunol. 177, 3771-3781
 |  Abstract »  |  Full Text »  |  PDF »

Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway.

R. Rajgopal, M. Butcher, J. I. Weitz, and S. G. Shaughnessy (2006)
J. Biol. Chem. 281, 20780-20787
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Receptors and Jak-STAT Signaling.

C. Schindler (2006)
Sci. STKE 2006, tr7
 |  Abstract »  |  Full Text »  |  PDF »

The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling.

S. Wormald, J.-G. Zhang, D. L. Krebs, L. A. Mielke, J. Silver, W. S. Alexander, T. P. Speed, N. A. Nicola, and D. J. Hilton (2006)
J. Biol. Chem. 281, 11135-11143
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk among gp130 Cytokines in Adipocytes.

S. Zvonic, J. E. Baugh Jr., P. Arbour-Reily, R. L. Mynatt, and J. M. Stephens (2005)
J. Biol. Chem. 280, 33856-33863
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation: CONTRIBUTIONS OF Src- AND RECEPTOR-TYROSINE KINASES.

U. Sommer, C. Schmid, R. M. Sobota, U. Lehmann, N. J. Stevenson, J. A. Johnston, F. Schaper, P. C. Heinrich, and S. Haan (2005)
J. Biol. Chem. 280, 31478-31488
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor Blocks Expression of Crx and Nrl Transcription Factors to Inhibit Photoreceptor Differentiation.

D. R. Graham, P. A. Overbeek, and J. D. Ash (2005)
Invest. Ophthalmol. Vis. Sci. 46, 2601-2610
 |  Abstract »  |  Full Text »  |  PDF »

The LIM/Homeodomain Protein Islet1 Recruits Janus Tyrosine Kinases and Signal Transducer and Activator of Transcription 3 and Stimulates Their Activities.

A. Hao, V. Novotny-Diermayr, W. Bian, B. Lin, C. P. Lim, N. Jing, and X. Cao (2005)
Mol. Biol. Cell 16, 1569-1583
 |  Abstract »  |  Full Text »  |  PDF »

Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6.

J. Laflamme, A. Akoum, and P. Leclerc (2005)
Mol. Hum. Reprod. 11, 141-150
 |  Abstract »  |  Full Text »  |  PDF »

The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor {alpha} Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway.

M. A. Ozog, S. M. Bernier, D. C. Bates, B. Chatterjee, C. W. Lo, and C. C.G. Naus (2004)
Mol. Biol. Cell 15, 4761-4774
 |  Abstract »  |  Full Text »  |  PDF »

An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells.

S. Kamiya, T. Owaki, N. Morishima, F. Fukai, J. Mizuguchi, and T. Yoshimoto (2004)
J. Immunol. 173, 3871-3877
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation.

J. K. Mangan, S. G. Rane, A. D. Kang, A. Amanullah, B. C. Wong, and E. P. Reddy (2004)
Blood 103, 4093-4101
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 is enriched in nuclear bodies.

A. Herrmann, U. Sommer, A. L. Pranada, B. Giese, A. Kuster, S. Haan, W. Becker, P. C. Heinrich, and G. Muller-Newen (2004)
J. Cell Sci. 117, 339-349
 |  Abstract »  |  Full Text »  |  PDF »

Long Term Association of the Cytokine Receptor gp130 and the Janus Kinase Jak1 Revealed by FRAP Analysis.

B. Giese, C.-K. Au-Yeung, A. Herrmann, S. Diefenbach, C. Haan, A. Kuster, S. B. Wortmann, C. Roderburg, P. C. Heinrich, I. Behrmann, et al. (2003)
J. Biol. Chem. 278, 39205-39213
 |  Abstract »  |  Full Text »  |  PDF »

The WD Motif-Containing Protein RACK-1 Functions as a Scaffold Protein Within the Type I IFN Receptor-Signaling Complex.

A. Usacheva, X. Tian, R. Sandoval, D. Salvi, D. Levy, and O. R. Colamonici (2003)
J. Immunol. 171, 2989-2994
 |  Abstract »  |  Full Text »  |  PDF »

An Aminopeptidase, ARTS-1, Is Required for Interleukin-6 Receptor Shedding.

X. Cui, F. N. Rouhani, F. Hawari, and S. J. Levine (2003)
J. Biol. Chem. 278, 28677-28685
 |  Abstract »  |  Full Text »  |  PDF »

Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development.

S. Brown, N. Hu, and J. C.-G. Hombria (2003)
Development 130, 3077-3084
 |  Abstract »  |  Full Text »  |  PDF »

TNF-{alpha} Induces Tyrosine Phosphorylation and Recruitment of the Src Homology Protein-Tyrosine Phosphatase 2 to the gp130 Signal-Transducing Subunit of the IL-6 Receptor Complex.

J. G. Bode, J. Schweigart, J. Kehrmann, C. Ehlting, F. Schaper, P. C. Heinrich, and D. Haussinger (2003)
J. Immunol. 171, 257-266
 |  Abstract »  |  Full Text »  |  PDF »

Desensitization of Signaling by Oncostatin M in Human Vascular Cells Involves Cytoplasmic Tyr Residue 759 in gp130 but Is Not Mediated by Either Src Homology 2 Domain-containing Tyrosine Phosphatase 2 or Suppressor of Cytokine Signaling 3.

K. Mahboubi, N. C. Kirkiles-Smith, J. Karras, and J. S. Pober (2003)
J. Biol. Chem. 278, 25014-25023
 |  Abstract »  |  Full Text »  |  PDF »

A Fusion Protein of the gp130 and Interleukin-6Ralpha Ligand-binding Domains Acts as a Potent Interleukin-6 Inhibitor.

C. Ancey, A. Kuster, S. Haan, A. Herrmann, P. C. Heinrich, and G. Muller-Newen (2003)
J. Biol. Chem. 278, 16968-16972
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Airway Mucin Gene Expression by Interleukin (IL)-17 through IL-6 Paracrine/Autocrine Loop.

Y. Chen, P. Thai, Y.-H. Zhao, Y.-S. Ho, M. M. DeSouza, and R. Wu (2003)
J. Biol. Chem. 278, 17036-17043
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Suppression of Dopamine-beta -hydroxylase by Extracellular Signal-regulated Kinase-dependent and -independent Pathways.

S. Dziennis and B. A. Habecker (2003)
J. Biol. Chem. 278, 15897-15904
 |  Abstract »  |  Full Text »  |  PDF »

Transactivation of gp130 in Myeloma Cells.

J. D. French, D. K. Walters, and D. F. Jelinek (2003)
J. Immunol. 170, 3717-3723
 |  Abstract »  |  Full Text »  |  PDF »

Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3.

C. Niemand, A. Nimmesgern, S. Haan, P. Fischer, F. Schaper, R. Rossaint, P. C. Heinrich, and G. Muller-Newen (2003)
J. Immunol. 170, 3263-3272
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Th2 Cell-Mediated Allergic Inflammation in Tyk2-Deficient Mice.

Y. Seto, H. Nakajima, A. Suto, K. Shimoda, Y. Saito, K. I. Nakayama, and I. Iwamoto (2003)
J. Immunol. 170, 1077-1083
 |  Abstract »  |  Full Text »  |  PDF »

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130.

U. Lehmann, J. Schmitz, M. Weissenbach, R. M. Sobota, M. Hortner, K. Friederichs, I. Behrmann, W. Tsiaris, A. Sasaki, J. Schneider-Mergener, et al. (2003)
J. Biol. Chem. 278, 661-671
 |  Abstract »  |  Full Text »  |  PDF »

Negative Association of Melanoma Differentiation-associated Gene (mda-7) and Inducible Nitric Oxide Synthase (iNOS) in Human Melanoma: MDA-7 Regulates iNOS Expression in Melanoma Cells.

S. Ekmekcioglu, J. A. Ellerhorst, J. B. Mumm, M. Zheng, L. Broemeling, V. G. Prieto, A. L. Stewart, A. M. Mhashilkar, S. Chada, and E. A. Grimm (2003)
Mol. Cancer Ther. 2, 9-17
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C delta Associates with the Interleukin-6 Receptor Subunit Glycoprotein (gp) 130 via Stat3 and Enhances Stat3-gp130 Interaction.

V. Novotny-Diermayr, T. Zhang, L. Gu, and X. Cao (2002)
J. Biol. Chem. 277, 49134-49142
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation.

A. Usacheva, R. Sandoval, P. Domanski, S. V. Kotenko, K. Nelms, M. A. Goldsmith, and O. R. Colamonici (2002)
J. Biol. Chem. 277, 48220-48226
 |  Abstract »  |  Full Text »  |  PDF »

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway.

M. Chatterjee, D. Honemann, S. Lentzsch, K. Bommert, C. Sers, P. Herrmann, S. Mathas, B. Dorken, and R. C. Bargou (2002)
Blood 100, 3311-3318
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 Down-regulates the Expression of Cyclin D during Liver Development.

T. Matsui, T. Kinoshita, T. Hirano, T. Yokota, and A. Miyajima (2002)
J. Biol. Chem. 277, 36167-36173
 |  Abstract »  |  Full Text »  |  PDF »

Heparin acts synergistically with interleukin-11 to induce STAT3 activation and in vitro osteoclast formation.

K. J. Walton, J. M. Duncan, P. Deschamps, and S. G. Shaughnessy (2002)
Blood 100, 2530-2536
 |  Abstract »  |  Full Text »  |  PDF »

IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats.

B. Roy, A. Bhattacharjee, B. Xu, D. Ford, A. L. Maizel, and M. K. Cathcart (2002)
J. Leukoc. Biol. 72, 580-589
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration.

W. Li, X. Liang, C. Kellendonk, V. Poli, and R. Taub (2002)
J. Biol. Chem. 277, 28411-28417
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Domains Within the N-Terminal Region of Janus Kinase 1 Interact with Cytokine Receptors.

A. Usacheva, S. Kotenko, M. M. Witte, and O. R. Colamonici (2002)
J. Immunol. 169, 1302-1308
 |  Abstract »  |  Full Text »  |  PDF »

Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation.

S. Diehl, C.-W. Chow, L. Weiss, A. Palmetshofer, T. Twardzik, L. Rounds, E. Serfling, R. J. Davis, J. Anguita, and M. Rincon (2002)
J. Exp. Med. 196, 39-49
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Amino Acid Residues of gp130 Signal Transducer and gp80 {alpha} Receptor Subunit That Are Involved in Ligand Binding and Signaling by Human Herpesvirus 8-Encoded Interleukin-6.

H. Li and J. Nicholas (2002)
J. Virol. 76, 5627-5636
 |  Abstract »  |  Full Text »  |  PDF »

Interdomain Interaction of Stat3 Regulates Its Src Homology 2 Domain-mediated Receptor Binding Activity.

T. Zhang, K. T. Seow, C. T. Ong, and X. Cao (2002)
J. Biol. Chem. 277, 17556-17563
 |  Abstract »  |  Full Text »  |  PDF »

Interaction between STAT-3 and HNF-3 Leads to the Activation of Liver-Specific Hepatitis B Virus Enhancer 1 Function.

G. Waris and A. Siddiqui (2002)
J. Virol. 76, 2721-2729
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways.

T. Ueda, N. Bruchovsky, and M. D. Sadar (2002)
J. Biol. Chem. 277, 7076-7085
 |  Abstract »  |  Full Text »  |  PDF »

Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases.

M. Schaeffer, M. Schneiderbauer, S. Weidler, R. Tavares, M. Warmuth, G. de Vos, and M. Hallek (2001)
Mol. Cell. Biol. 21, 8068-8081
 |  Abstract »  |  Full Text »  |  PDF »

Autocrine Production of Interleukin 6 Causes Multidrug Resistance in Breast Cancer Cells.

D. Conze, L. Weiss, P. S. Regen, A. Bhushan, D. Weaver, P. Johnson, and M. Rincon (2001)
Cancer Res. 61, 8851-8858
 |  Abstract »  |  Full Text »  |  PDF »

The Stat1 Binding Motif of the Interferon-gamma Receptor Is Sufficient to Mediate Stat5 Activation and Its Repression by SOCS3.

I. Woldman, L. Varinou, K. Ramsauer, B. Rapp, and T. Decker (2001)
J. Biol. Chem. 276, 45722-45728
 |  Abstract »  |  Full Text »  |  PDF »

Soluble interleukin-6 receptor activates the human papillomavirus type 18 long control region in SW756 cervical carcinoma cells in a STAT3-dependent manner.

S. Smola-Hess, U. Sandaradura de Silva, D. Hadaschik, and H. J. Pfister (2001)
J. Gen. Virol. 82, 2335-2339
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Serine Protease Inhibitor 3 in Ocular Tissues in Endotoxin-Induced Uveitis in Rat.

A. Takamiya, M. Takeda, A. Yoshida, and H. Kiyama (2001)
Invest. Ophthalmol. Vis. Sci. 42, 2427-2433
 |  Abstract »  |  Full Text »  |  PDF »

The Inhibitory Effect of IL-1{beta} on IL-6-Induced {alpha}2-Macroglobulin Expression Is Due to Activation of NF-{kappa}B.

J. G. Bode, R. Fischer, D. Haussinger, L. Graeve, P. C. Heinrich, and F. Schaper (2001)
J. Immunol. 167, 1469-1481
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 is constitutively activated in Hodgkin cell lines.

D. Kube, U. Holtick, M. Vockerodt, T. Ahmadi, B. Haier, I. Behrmann, P. C. Heinrich, V. Diehl, and H. Tesch (2001)
Blood 98, 762-770
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver.

T. Alonzi, D. Maritano, B. Gorgoni, G. Rizzuto, C. Libert, and V. Poli (2001)
Mol. Cell. Biol. 21, 1621-1632
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 6 Inhibits Proliferation and, in Cooperation with an Epidermal Growth Factor Receptor Autocrine Loop, Increases Migration of T47D Breast Cancer Cells.

A. Badache and N. E. Hynes (2001)
Cancer Res. 61, 383-391
 |  Abstract »  |  Full Text »

Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma.

C. L. Campbell, Z. Jiang, D. M. F. Savarese, and T. M. Savarese (2001)
Am. J. Pathol. 158, 25-32
 |  Abstract »  |  Full Text »  |  PDF »

Two Different Epitopes of the Signal Transducer gp130 Sequentially Cooperate on IL-6-Induced Receptor Activation.

S. Pflanz, I. Kurth, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (2000)
J. Immunol. 165, 7042-7049
 |  Abstract »  |  Full Text »  |  PDF »

A Purine-Sensitive Pathway Regulates Multiple Genes Involved in Axon Regeneration in Goldfish Retinal Ganglion Cells.

B. Petrausch, R. Tabibiazar, T. Roser, Y. Jing, D. Goldman, C. A. O. Stuermer, N. Irwin, and L. I. Benowitz (2000)
J. Neurosci. 20, 8031-8041
 |  Abstract »  |  Full Text »  |  PDF »

The Coiled-Coil Domain of Stat3 Is Essential for Its SH2 Domain-Mediated Receptor Binding and Subsequent Activation Induced by Epidermal Growth Factor and Interleukin-6.

T. Zhang, W. H. Kee, K. T. Seow, W. Fung, and X. Cao (2000)
Mol. Cell. Biol. 20, 7132-7139
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation.

D. Anhuf, M. Weissenbach, J. Schmitz, R. Sobota, H. M. Hermanns, S. Radtke, S. Linnemann, I. Behrmann, P. C. Heinrich, and F. Schaper (2000)
J. Immunol. 165, 2535-2543
 |  Abstract »  |  Full Text »  |  PDF »

Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production.

S. Hess, H. Smola, U. Sandaradura de Silva, D. Hadaschik, D. Kube, S. E. Baldus, U. Flucke, and H. Pfister (2000)
J. Immunol. 165, 1939-1948
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 6 and liver regeneration.

K L STREETZ, T LUEDDE, M P MANNS, and C TRAUTWEIN (2000)
Gut 47, 309-312
 |  Full Text »  |  PDF »

Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function.

C. J. Auernhammer and S. Melmed (2000)
Endocr. Rev. 21, 313-345
 |  Abstract »  |  Full Text »

Ciliary Neurotrophic Factor and Stress Stimuli Activate the Jak-STAT Pathway in Retinal Neurons and Glia.

W. M. Peterson, Q. Wang, R. Tzekova, and S. J. Wiegand (2000)
J. Neurosci. 20, 4081-4090
 |  Abstract »  |  Full Text »  |  PDF »

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130.

J. Schmitz, M. Weissenbach, S. Haan, P. C. Heinrich, and F. Schaper (2000)
J. Biol. Chem. 275, 12848-12856
 |  Abstract »  |  Full Text »  |  PDF »

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis.

S. C. Manolagas (2000)
Endocr. Rev. 21, 115-137
 |  Abstract »  |  Full Text »

Characterization of Signaling Cascades Triggered by Human Interleukin-6 versus Kaposi's Sarcoma-associated Herpes Virus-encoded Viral Interleukin 6.

T. Hideshima, D. Chauhan, G. Teoh, N. Raje, S. P. Treon, Y.-T. Tai, Y. Shima, and K. C. Anderson (2000)
Clin. Cancer Res. 6, 1180-1189
 |  Abstract »  |  Full Text »

Identification of a gp130 Cytokine Receptor Critical Site Involved in Oncostatin M Response.

C. Olivier, P. Auguste, M. Chabbert, E. Lelievre, S. Chevalier, and H. Gascan (2000)
J. Biol. Chem. 275, 5648-5656
 |  Abstract »  |  Full Text »  |  PDF »

Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies.

G. Muller-Newen, A. Kuster, J. Wijdenes, F. Schaper, and P. C. Heinrich (2000)
J. Biol. Chem. 275, 4579-4586
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine-Induced Nuclear Factor Kappa B Activation Promotes the Survival of Developing Neurons.

G. Middleton, M. Hamanoue, Y. Enokido, S. Wyatt, D. Pennica, E. Jaffray, R. T. Hay, and A. M. Davies (2000)
J. Cell Biol. 148, 325-332
 |  Abstract »  |  Full Text »  |  PDF »

The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction.

J. Schmitz, H. Dahmen, C. Grimm, C. Gendo, G. Muller-Newen, P. C. Heinrich, and F. Schaper (2000)
J. Immunol. 164, 848-854
 |  Abstract »  |  Full Text »  |  PDF »

Granulocyte Colony-Stimulating Factor Is Present in Human Milk and Its Receptor Is Present in Human Fetal Intestine.

D. A. Calhoun, M. Lunoe, Y. Du, and R. D. Christensen (2000)
Pediatrics 105, e7
 |  Abstract »  |  Full Text »  |  PDF »

Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130.

H. M. Hermanns, S. Radtke, C. Haan, H. Schmitz-Van de Leur, J. Tavernier, P. C. Heinrich, and I. Behrmann (1999)
J. Immunol. 163, 6651-6658
 |  Abstract »  |  Full Text »  |  PDF »

A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells.

M. Dorsch, N. N. Danial, P. B. Rothman, and S. P. Goff (1999)
Blood 94, 2676-2685
 |  Abstract »  |  Full Text »  |  PDF »

The Expression of p53 Tumor Suppressor Gene in Breast Cancer Cells Is Down-Regulated by Cytokine Oncostatin M.

J. Liu, C. Li, T. E. Ahlborn, M. J. Spence, L. Meng, and L. M. Boxer (1999)
Cell Growth Differ. 10, 677-683
 |  Abstract »  |  Full Text »

Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family.

G. Senaldi, B. C. Varnum, U. Sarmiento, C. Starnes, J. Lile, S. Scully, J. Guo, G. Elliott, J. McNinch, C. L. Shaklee, et al. (1999)
PNAS 96, 11458-11463
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Physiology of STAT3: Where's the Cytoplasmic Monomer?.

M. I. Ndubuisi, G. G. Guo, V. A. Fried, J. D. Etlinger, and P. B. Sehgal (1999)
J. Biol. Chem. 274, 25499-25509
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C delta Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner.

N. Jain, T. Zhang, W. H. Kee, W. Li, and X. Cao (1999)
J. Biol. Chem. 274, 24392-24400
 |  Abstract »  |  Full Text »  |  PDF »

Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells.

H. Kim and H. Baumann (1999)
Mol. Cell. Biol. 19, 5326-5338
 |  Abstract »  |  Full Text »  |  PDF »

Mechanical Stretch Activates the JAK/STAT Pathway in Rat Cardiomyocytes.

J. Pan, K. Fukuda, M. Saito, J. Matsuzaki, H. Kodama, M. Sano, T. Takahashi, T. Kato, and S. Ogawa (1999)
Circ. Res. 84, 1127-1136
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Different Subtypes of Angiotensin II Receptors, AT1 and AT2 Receptors, Regulates STAT Activation by Negative Crosstalk.

M. Horiuchi, W. Hayashida, M. Akishita, K. Tamura, L. Daviet, J. Y. A. Lehtonen, and V. J. Dzau (1999)
Circ. Res. 84, 876-882
 |  Abstract »  |  Full Text »  |  PDF »

The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation. INVOLVEMENT OF STAT3.

M. Ernst, U. Novak, S. E. Nicholson, J. E. Layton, and A. R. Dunn (1999)
J. Biol. Chem. 274, 9729-9737
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a.

T. J. Pircher, H. Petersen, J.-A. Gustafsson, and L.-A. Haldosén (1999)
Mol. Endocrinol. 13, 555-565
 |  Abstract »  |  Full Text »

Induction of Low Density Lipoprotein Receptor (LDLR) Transcription by Oncostatin M Is Mediated by the Extracellular Signal-regulated Kinase Signaling Pathway and the Repeat 3 Element of the LDLR Promoter.

C. Li, F. B. Kraemer, T. E. Ahlborn, and J. Liu (1999)
J. Biol. Chem. 274, 6747-6753
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of the Functional Mouse Oncostatin M (OSM) Receptor: Molecular Cloning of the Mouse OSM Receptor beta  Subunit.

M. Tanaka, T. Hara, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and A. Miyajima (1999)
Blood 93, 804-815
 |  Abstract »  |  Full Text »  |  PDF »

The Designer Cytokine Hyper-Interleukin-6 Is a Potent Activator of STAT3-dependent Gene Transcription in Vivo and in Vitro.

T. Rakemann, M. Niehof, S. Kubicka, M. Fischer, M. P. Manns, S. Rose-John, and C. Trautwein (1999)
J. Biol. Chem. 274, 1257-1266
 |  Abstract »  |  Full Text »  |  PDF »

Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain.

S. Haan, U. Hemmann, U. Hassiepen, F. Schaper, J. Schneider-Mergener, A. Wollmer, P. C. Heinrich, and J. Grotzinger (1999)
J. Biol. Chem. 274, 1342-1348
 |  Abstract »  |  Full Text »  |  PDF »

Src-Related Protein Tyrosine Kinases in Hematopoiesis.

S. J. Corey and S. M. Anderson (1999)
Blood 93, 1-14
 |  Full Text »  |  PDF »

The Box-1 Region of the Leukemia Inhibitory Factor Receptor alpha -Chain Cytoplasmic Domain Is Sufficient for Hemopoietic Cell Proliferation and Differentiation.

Y. Zhang, T. Willson, D. Metcalf, D. Cary, D. J. Hilton, R. Clark, and N. A. Nicola (1998)
J. Biol. Chem. 273, 34370-34383
 |  Abstract »  |  Full Text »  |  PDF »

Chronic Interleukin-6 Alters NMDA Receptor-Mediated Membrane Responses and Enhances Neurotoxicity in Developing CNS Neurons.

Z. Qiu, D. D. Sweeney, J. G. Netzeband, and D. L. Gruol (1998)
J. Neurosci. 18, 10445-10456
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-{gamma} Production Following IL-12 Stimulation.

H.-J. Ahn, M. Tomura, W.-G. Yu, M. Iwasaki, W.-R. Park, T. Hamaoka, and H. Fujiwara (1998)
J. Immunol. 161, 5893-5900
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products