Science 7 January 1994: Vol. 263. no. 5143, pp. 89 - 92 DOI: 10.1126/science.8272872

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Articles

Glucose ingestion during endurance training in men attenuates expression of myokine receptor.

T. C. A. Akerstrom, R. Krogh-Madsen, A. M. W. Petersen, and B. K. Pedersen (2009)
Exp Physiol 94, 1124-1131
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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation.

D. J. Gough, A. Corlett, K. Schlessinger, J. Wegrzyn, A. C. Larner, and D. E. Levy (2009)
Science 324, 1713-1716
 |  Abstract »  |  Full Text »  |  PDF »

ORF3 protein of hepatitis E virus interacts with the B{beta} chain of fibrinogen resulting in decreased fibrinogen secretion from HuH-7 cells.

R. Ratra, A. Kar-Roy, and S. K. Lal (2009)
J. Gen. Virol. 90, 1359-1370
 |  Abstract »  |  Full Text »  |  PDF »

Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency.

Y. Minegishi and H. Karasuyama (2009)
Int. Immunol. 21, 105-112
 |  Abstract »  |  Full Text »  |  PDF »

The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain.

T. Hou, S. Ray, C. Lee, and A. R. Brasier (2008)
J. Biol. Chem. 283, 30725-30734
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Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor {alpha} Chain.

F. Rousseau, S. Chevalier, C. Guillet, E. Ravon, C. Diveu, J. Froger, F. Barbier, L. Grimaud, and H. Gascan (2008)
J. Biol. Chem. 283, 30341-30350
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Blockade of Virus Infection by Human CD4+ T Cells via a Cytokine Relay Network.

A. M. Davis, K. A. Hagan, L. A. Matthews, G. Bajwa, M. A. Gill, M. Gale Jr., and J. D. Farrar (2008)
J. Immunol. 180, 6923-6932
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ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3.

Y.-S. Bong, H.-S. Lee, L. Carim-Todd, K. Mood, T. G. Nishanian, L. Tessarollo, and I. O. Daar (2007)
PNAS 104, 17305-17310
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer Therapy.

D. Germain and D. A. Frank (2007)
Clin. Cancer Res. 13, 5665-5669
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Suppressive Protein Gene Associated with Retinoid-Interferon-Induced Mortality (GRIM)-19 Inhibits src-Induced Oncogenic Transformation at Multiple Levels.

S. Kalakonda, S. C. Nallar, P. Gong, D. J. Lindner, S. E. Goldblum, S. P. Reddy, and D. V. Kalvakolanu (2007)
Am. J. Pathol. 171, 1352-1368
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Nucleocytoplasmic shuttling of persistently activated STAT3.

A. Herrmann, M. Vogt, M. Monnigmann, T. Clahsen, U. Sommer, S. Haan, V. Poli, P. C. Heinrich, and G. Muller-Newen (2007)
J. Cell Sci. 120, 3249-3261
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Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer.

D. Loffler, K. Brocke-Heidrich, G. Pfeifer, C. Stocsits, J. Hackermuller, A. K. Kretzschmar, R. Burger, M. Gramatzki, C. Blumert, K. Bauer, et al. (2007)
Blood 110, 1330-1333
 |  Abstract »  |  Full Text »  |  PDF »

Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.

S. Finotto, T. Eigenbrod, R. Karwot, I. Boross, A. Doganci, H. Ito, N. Nishimoto, K. Yoshizaki, T. Kishimoto, S. Rose-John, et al. (2007)
Int. Immunol. 19, 685-693
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An Essential Role for gp130 in Neointima Formation Following Arterial Injury.

D. Wang, Z. Liu, Q. Li, M. Karpurapu, V. Kundumani-Sridharan, H. Cao, N. Dronadula, F. Rizvi, A. K. Bajpai, C. Zhang, et al. (2007)
Circ. Res. 100, 807-816
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Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure.

B. G. Helwig, T. I. Musch, R. A. Craig, and M. J. Kenney (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1165-R1173
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte 15-Lipoxygenase Expression Is Regulated by a Novel Cytosolic Signaling Complex with Protein Kinase C {delta} and Tyrosine-Phosphorylated Stat3.

A. Bhattacharjee, B. Xu, D. A. Frank, G. M. Feldman, and M. K. Cathcart (2006)
J. Immunol. 177, 3771-3781
 |  Abstract »  |  Full Text »  |  PDF »

Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway.

R. Rajgopal, M. Butcher, J. I. Weitz, and S. G. Shaughnessy (2006)
J. Biol. Chem. 281, 20780-20787
 |  Abstract »  |  Full Text »  |  PDF »

The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling.

S. Wormald, J.-G. Zhang, D. L. Krebs, L. A. Mielke, J. Silver, W. S. Alexander, T. P. Speed, N. A. Nicola, and D. J. Hilton (2006)
J. Biol. Chem. 281, 11135-11143
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Cross-talk among gp130 Cytokines in Adipocytes.

S. Zvonic, J. E. Baugh Jr., P. Arbour-Reily, R. L. Mynatt, and J. M. Stephens (2005)
J. Biol. Chem. 280, 33856-33863
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Physical activity and modulation of systemic low-level inflammation.

H. Bruunsgaard (2005)
J. Leukoc. Biol. 78, 819-835
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Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation: CONTRIBUTIONS OF Src- AND RECEPTOR-TYROSINE KINASES.

U. Sommer, C. Schmid, R. M. Sobota, U. Lehmann, N. J. Stevenson, J. A. Johnston, F. Schaper, P. C. Heinrich, and S. Haan (2005)
J. Biol. Chem. 280, 31478-31488
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Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1.

J. Xu, S. Ji, D. Y Venable, J. L Franklin, and J. L Messina (2005)
J. Endocrinol. 184, 481-492
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Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6.

J. Laflamme, A. Akoum, and P. Leclerc (2005)
Mol. Hum. Reprod. 11, 141-150
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G-Quartet Oligonucleotides: A New Class of Signal Transducer and Activator of Transcription 3 Inhibitors That Suppresses Growth of Prostate and Breast Tumors through Induction of Apoptosis.

N. Jing, Y. Li, W. Xiong, W. Sha, L. Jing, and D. J. Tweardy (2004)
Cancer Res. 64, 6603-6609
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An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells.

S. Kamiya, T. Owaki, N. Morishima, F. Fukai, J. Mizuguchi, and T. Yoshimoto (2004)
J. Immunol. 173, 3871-3877
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Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor.

A. Dreuw, S. Radtke, S. Pflanz, B. E. Lippok, P. C. Heinrich, and H. M. Hermanns (2004)
J. Biol. Chem. 279, 36112-36120
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Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation.

J. K. Mangan, S. G. Rane, A. D. Kang, A. Amanullah, B. C. Wong, and E. P. Reddy (2004)
Blood 103, 4093-4101
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Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced Stat3 Activation.

C.-S. Shi and J. H. Kehrl (2004)
J. Biol. Chem. 279, 17224-17231
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Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo.

H.-J. Kim, T. Higashimori, S.-Y. Park, H. Choi, J. Dong, Y.-J. Kim, H.-L. Noh, Y.-R. Cho, G. Cline, Y.-B. Kim, et al. (2004)
Diabetes 53, 1060-1067
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STAT3 is enriched in nuclear bodies.

A. Herrmann, U. Sommer, A. L. Pranada, B. Giese, A. Kuster, S. Haan, W. Becker, P. C. Heinrich, and G. Muller-Newen (2004)
J. Cell Sci. 117, 339-349
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Nicotine Enhances Angiotensin II-Induced Mitogenic Response in Vascular Smooth Muscle Cells and Fibroblasts.

J.-M. Li, T.-X. Cui, T. Shiuchi, H.-W. Liu, L.-J. Min, M. Okumura, T. Jinno, L. Wu, M. Iwai, and M. Horiuchi (2004)
Arterioscler Thromb Vasc Biol 24, 80-84
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Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation.

K. Brocke-Heidrich, A. K. Kretzschmar, G. Pfeifer, C. Henze, D. Loffler, D. Koczan, H.-J. Thiesen, R. Burger, M. Gramatzki, and F. Horn (2004)
Blood 103, 242-251
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GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor.

C. Diveu, E. Lelievre, D. Perret, A.-H. L. Lak-Hal, J. Froger, C. Guillet, S. Chevalier, F. Rousseau, A. Wesa, L. Preisser, et al. (2003)
J. Biol. Chem. 278, 49850-49859
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Long Term Association of the Cytokine Receptor gp130 and the Janus Kinase Jak1 Revealed by FRAP Analysis.

B. Giese, C.-K. Au-Yeung, A. Herrmann, S. Diefenbach, C. Haan, A. Kuster, S. B. Wortmann, C. Roderburg, P. C. Heinrich, I. Behrmann, et al. (2003)
J. Biol. Chem. 278, 39205-39213
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Interleukin-11 and Interleukin-6 Protect Cultured Human Endothelial Cells from H2O2-Induced Cell Death.

A. B. Waxman, K. Mahboubi, R. G. Knickelbein, L. L. Mantell, N. Manzo, J. S. Pober, and J. A. Elias (2003)
Am. J. Respir. Cell Mol. Biol. 29, 513-522
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An Aminopeptidase, ARTS-1, Is Required for Interleukin-6 Receptor Shedding.

X. Cui, F. N. Rouhani, F. Hawari, and S. J. Levine (2003)
J. Biol. Chem. 278, 28677-28685
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TNF-{alpha} Induces Tyrosine Phosphorylation and Recruitment of the Src Homology Protein-Tyrosine Phosphatase 2 to the gp130 Signal-Transducing Subunit of the IL-6 Receptor Complex.

J. G. Bode, J. Schweigart, J. Kehrmann, C. Ehlting, F. Schaper, P. C. Heinrich, and D. Haussinger (2003)
J. Immunol. 171, 257-266
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A Fusion Protein of the gp130 and Interleukin-6Ralpha Ligand-binding Domains Acts as a Potent Interleukin-6 Inhibitor.

C. Ancey, A. Kuster, S. Haan, A. Herrmann, P. C. Heinrich, and G. Muller-Newen (2003)
J. Biol. Chem. 278, 16968-16972
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Constitutive Activation of Nuclear Factor {kappa}B p50/p65 and Fra-1 and JunD Is Essential for Deregulated Interleukin 6 Expression in Prostate Cancer.

L. F. Zerbini, Y. Wang, J.-Y. Cho, and T. A Libermann (2003)
Cancer Res. 63, 2206-2215
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Suppression of Dopamine-beta -hydroxylase by Extracellular Signal-regulated Kinase-dependent and -independent Pathways.

S. Dziennis and B. A. Habecker (2003)
J. Biol. Chem. 278, 15897-15904
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Phosphopeptide Motifs Specific for the Src Homology 2 Domains of Signal Transducer and Activator of Transcription 1 (STAT1) and STAT3.

M. Wiederkehr-Adam, P. Ernst, K. Muller, E. Bieck, F. O. Gombert, J. Ottl, P. Graff, F. Grossmuller, and M. H. Heim (2003)
J. Biol. Chem. 278, 16117-16128
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Transactivation of gp130 in Myeloma Cells.

J. D. French, D. K. Walters, and D. F. Jelinek (2003)
J. Immunol. 170, 3717-3723
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Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3.

C. Niemand, A. Nimmesgern, S. Haan, P. Fischer, F. Schaper, R. Rossaint, P. C. Heinrich, and G. Muller-Newen (2003)
J. Immunol. 170, 3263-3272
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SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130.

U. Lehmann, J. Schmitz, M. Weissenbach, R. M. Sobota, M. Hortner, K. Friederichs, I. Behrmann, W. Tsiaris, A. Sasaki, J. Schneider-Mergener, et al. (2003)
J. Biol. Chem. 278, 661-671
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Protein Kinase C delta Associates with the Interleukin-6 Receptor Subunit Glycoprotein (gp) 130 via Stat3 and Enhances Stat3-gp130 Interaction.

V. Novotny-Diermayr, T. Zhang, L. Gu, and X. Cao (2002)
J. Biol. Chem. 277, 49134-49142
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Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation.

A. Usacheva, R. Sandoval, P. Domanski, S. V. Kotenko, K. Nelms, M. A. Goldsmith, and O. R. Colamonici (2002)
J. Biol. Chem. 277, 48220-48226
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Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.

M. Hayashi, M.-C. Rho, A. Enomoto, A. Fukami, Y.-P. Kim, Y. Kikuchi, T. Sunazuka, T. Hirose, K. Komiyama, and S. Omura (2002)
PNAS 99, 14728-14733
 |  Abstract »  |  Full Text »  |  PDF »

Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20S,21-Epoxy-resibufogenin-3-formate.

M. Hayashi, M.-C. Rho, A. Fukami, A. Enomoto, S. Nonaka, Y. Sekiguchi, T. Yanagisawa, A. Yamashita, T. Nogawa, Y. Kamano, et al. (2002)
J. Pharmacol. Exp. Ther. 303, 104-109
 |  Abstract »  |  Full Text »  |  PDF »

Heparin acts synergistically with interleukin-11 to induce STAT3 activation and in vitro osteoclast formation.

K. J. Walton, J. M. Duncan, P. Deschamps, and S. G. Shaughnessy (2002)
Blood 100, 2530-2536
 |  Abstract »  |  Full Text »  |  PDF »

IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats.

B. Roy, A. Bhattacharjee, B. Xu, D. Ford, A. L. Maizel, and M. K. Cathcart (2002)
J. Leukoc. Biol. 72, 580-589
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Domains Within the N-Terminal Region of Janus Kinase 1 Interact with Cytokine Receptors.

A. Usacheva, S. Kotenko, M. M. Witte, and O. R. Colamonici (2002)
J. Immunol. 169, 1302-1308
 |  Abstract »  |  Full Text »  |  PDF »

Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation.

S. Diehl, C.-W. Chow, L. Weiss, A. Palmetshofer, T. Twardzik, L. Rounds, E. Serfling, R. J. Davis, J. Anguita, and M. Rincon (2002)
J. Exp. Med. 196, 39-49
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Interdomain Interaction of Stat3 Regulates Its Src Homology 2 Domain-mediated Receptor Binding Activity.

T. Zhang, K. T. Seow, C. T. Ong, and X. Cao (2002)
J. Biol. Chem. 277, 17556-17563
 |  Abstract »  |  Full Text »  |  PDF »

Interaction between STAT-3 and HNF-3 Leads to the Activation of Liver-Specific Hepatitis B Virus Enhancer 1 Function.

G. Waris and A. Siddiqui (2002)
J. Virol. 76, 2721-2729
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways.

T. Ueda, N. Bruchovsky, and M. D. Sadar (2002)
J. Biol. Chem. 277, 7076-7085
 |  Abstract »  |  Full Text »  |  PDF »

The Stat1 Binding Motif of the Interferon-gamma Receptor Is Sufficient to Mediate Stat5 Activation and Its Repression by SOCS3.

I. Woldman, L. Varinou, K. Ramsauer, B. Rapp, and T. Decker (2001)
J. Biol. Chem. 276, 45722-45728
 |  Abstract »  |  Full Text »  |  PDF »

Soluble interleukin-6 receptor activates the human papillomavirus type 18 long control region in SW756 cervical carcinoma cells in a STAT3-dependent manner.

S. Smola-Hess, U. Sandaradura de Silva, D. Hadaschik, and H. J. Pfister (2001)
J. Gen. Virol. 82, 2335-2339
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Serine Protease Inhibitor 3 in Ocular Tissues in Endotoxin-Induced Uveitis in Rat.

A. Takamiya, M. Takeda, A. Yoshida, and H. Kiyama (2001)
Invest. Ophthalmol. Vis. Sci. 42, 2427-2433
 |  Abstract »  |  Full Text »  |  PDF »

The Inhibitory Effect of IL-1{beta} on IL-6-Induced {alpha}2-Macroglobulin Expression Is Due to Activation of NF-{kappa}B.

J. G. Bode, R. Fischer, D. Haussinger, L. Graeve, P. C. Heinrich, and F. Schaper (2001)
J. Immunol. 167, 1469-1481
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 is constitutively activated in Hodgkin cell lines.

D. Kube, U. Holtick, M. Vockerodt, T. Ahmadi, B. Haier, I. Behrmann, P. C. Heinrich, V. Diehl, and H. Tesch (2001)
Blood 98, 762-770
 |  Abstract »  |  Full Text »  |  PDF »

The soluble interleukin 6 receptor: mechanisms of production and implications in disease.

S. A. JONES, S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G. M. FULLER (2001)
FASEB J 15, 43-58
 |  Abstract »  |  Full Text »  |  PDF »

Two Different Epitopes of the Signal Transducer gp130 Sequentially Cooperate on IL-6-Induced Receptor Activation.

S. Pflanz, I. Kurth, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (2000)
J. Immunol. 165, 7042-7049
 |  Abstract »  |  Full Text »  |  PDF »

The Coiled-Coil Domain of Stat3 Is Essential for Its SH2 Domain-Mediated Receptor Binding and Subsequent Activation Induced by Epidermal Growth Factor and Interleukin-6.

T. Zhang, W. H. Kee, K. T. Seow, W. Fung, and X. Cao (2000)
Mol. Cell. Biol. 20, 7132-7139
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation.

D. Anhuf, M. Weissenbach, J. Schmitz, R. Sobota, H. M. Hermanns, S. Radtke, S. Linnemann, I. Behrmann, P. C. Heinrich, and F. Schaper (2000)
J. Immunol. 165, 2535-2543
 |  Abstract »  |  Full Text »  |  PDF »

Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production.

S. Hess, H. Smola, U. Sandaradura de Silva, D. Hadaschik, D. Kube, S. E. Baldus, U. Flucke, and H. Pfister (2000)
J. Immunol. 165, 1939-1948
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 6 and liver regeneration.

K L STREETZ, T LUEDDE, M P MANNS, and C TRAUTWEIN (2000)
Gut 47, 309-312
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SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130.

J. Schmitz, M. Weissenbach, S. Haan, P. C. Heinrich, and F. Schaper (2000)
J. Biol. Chem. 275, 12848-12856
 |  Abstract »  |  Full Text »  |  PDF »

IL-11 Activates Human Endothelial Cells to Resist Immune-Mediated Injury.

K. Mahboubi, B. C. Biedermann, J. M. Carroll, and J. S. Pober (2000)
J. Immunol. 164, 3837-3846
 |  Abstract »  |  Full Text »  |  PDF »

Activation-Induced Inhibition of Interleukin 6-Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling.

T. K. Teague, B. C. Schaefer, D. Hildeman, J. Bender, T. Mitchell, J. W. Kappler, and P. Marrack (2000)
J. Exp. Med. 191, 915-926
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Signaling Cascades Triggered by Human Interleukin-6 versus Kaposi's Sarcoma-associated Herpes Virus-encoded Viral Interleukin 6.

T. Hideshima, D. Chauhan, G. Teoh, N. Raje, S. P. Treon, Y.-T. Tai, Y. Shima, and K. C. Anderson (2000)
Clin. Cancer Res. 6, 1180-1189
 |  Abstract »  |  Full Text »

Identification of a gp130 Cytokine Receptor Critical Site Involved in Oncostatin M Response.

C. Olivier, P. Auguste, M. Chabbert, E. Lelievre, S. Chevalier, and H. Gascan (2000)
J. Biol. Chem. 275, 5648-5656
 |  Abstract »  |  Full Text »  |  PDF »

Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies.

G. Muller-Newen, A. Kuster, J. Wijdenes, F. Schaper, and P. C. Heinrich (2000)
J. Biol. Chem. 275, 4579-4586
 |  Abstract »  |  Full Text »  |  PDF »

The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction.

J. Schmitz, H. Dahmen, C. Grimm, C. Gendo, G. Muller-Newen, P. C. Heinrich, and F. Schaper (2000)
J. Immunol. 164, 848-854
 |  Abstract »  |  Full Text »  |  PDF »

How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli.

S. Rivest, S. Lacroix, L. Vallières, S. Nadeau, J. Zhang, and N. Laflamme (2000)
Experimental Biology and Medicine 223, 22-38
 |  Abstract »  |  Full Text »

Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130.

H. M. Hermanns, S. Radtke, C. Haan, H. Schmitz-Van de Leur, J. Tavernier, P. C. Heinrich, and I. Behrmann (1999)
J. Immunol. 163, 6651-6658
 |  Abstract »  |  Full Text »  |  PDF »

The chemokine SDF-1{alpha} triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.

A. J. VILA-CORO, J. M. RODRÍGUEZ-FRADE, A. MARTÍN DE ANA, M. C. MORENO-ORTÍZ, C. MARTÍNEZ-A, and M. MELLADO (1999)
FASEB J 13, 1699-1710
 |  Abstract »  |  Full Text »

Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family.

G. Senaldi, B. C. Varnum, U. Sarmiento, C. Starnes, J. Lile, S. Scully, J. Guo, G. Elliott, J. McNinch, C. L. Shaklee, et al. (1999)
PNAS 96, 11458-11463
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Cellular Physiology of STAT3: Where's the Cytoplasmic Monomer?.

M. I. Ndubuisi, G. G. Guo, V. A. Fried, J. D. Etlinger, and P. B. Sehgal (1999)
J. Biol. Chem. 274, 25499-25509
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of {beta}2-microglobulin expression in different human cell lines by proinflammatory cytokines.

T. Vraetz, T. H. Ittel, M. G. van Mackelenbergh, P. C. Heinrich, H. G. Sieberth, and L. Graeve (1999)
Nephrol. Dial. Transplant. 14, 2137-2143
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C delta Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner.

N. Jain, T. Zhang, W. H. Kee, W. Li, and X. Cao (1999)
J. Biol. Chem. 274, 24392-24400
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Interleukin-6 Inhibits Transforming Growth Factor-beta -induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways.

R.-H. Chen, M.-C. Chang, Y.-H. Su, Y.-T. Tsai, and M.-L. Kuo (1999)
J. Biol. Chem. 274, 23013-23019
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Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells.

H. Kim and H. Baumann (1999)
Mol. Cell. Biol. 19, 5326-5338
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 Activation in Stromal/Osteoblastic Cells Is Required for Induction of the Receptor Activator of NF-kappa B Ligand and Stimulation of Osteoclastogenesis by gp130-utilizing Cytokines or Interleukin-1 but Not 1,25-Dihydroxyvitamin D3 or Parathyroid Hormone.

C. A. O'Brien, I. Gubrij, S.-C. Lin, R. L. Saylors, and S. C. Manolagas (1999)
J. Biol. Chem. 274, 19301-19308
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Stimulation of Different Subtypes of Angiotensin II Receptors, AT1 and AT2 Receptors, Regulates STAT Activation by Negative Crosstalk.

M. Horiuchi, W. Hayashida, M. Akishita, K. Tamura, L. Daviet, J. Y. A. Lehtonen, and V. J. Dzau (1999)
Circ. Res. 84, 876-882
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a.

T. J. Pircher, H. Petersen, J.-A. Gustafsson, and L.-A. Haldosén (1999)
Mol. Endocrinol. 13, 555-565
 |  Abstract »  |  Full Text »

Essential role of STAT3 for embryonic stem cell pluripotency.

R. Raz, C.-K. Lee, L. A. Cannizzaro, P. d'Eustachio, and D. E. Levy (1999)
PNAS 96, 2846-2851
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Both Stat3-Activation and Stat3-Independent BCL2 Downregulation Are Important for Interleukin-6-Induced Apoptosis of 1A9-M Cells.

K. Oritani, Y. Tomiyama, P. W. Kincade, K. Aoyama, T. Yokota, I. Matsumura, Y. Kanakura, K. Nakajima, T. Hirano, and Y. Matsuzawa (1999)
Blood 93, 1346-1354
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Signal Transducer Glycoprotein 130 by Both IL-6 and IL-11 Requires Two Distinct Binding Epitopes.

I. Kurth, U. Horsten, S. Pflanz, H. Dahmen, A. Kuster, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (1999)
J. Immunol. 162, 1480-1487
 |  Abstract »  |  Full Text »  |  PDF »

The Designer Cytokine Hyper-Interleukin-6 Is a Potent Activator of STAT3-dependent Gene Transcription in Vivo and in Vitro.

T. Rakemann, M. Niehof, S. Kubicka, M. Fischer, M. P. Manns, S. Rose-John, and C. Trautwein (1999)
J. Biol. Chem. 274, 1257-1266
 |  Abstract »  |  Full Text »  |  PDF »

Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain.

S. Haan, U. Hemmann, U. Hassiepen, F. Schaper, J. Schneider-Mergener, A. Wollmer, P. C. Heinrich, and J. Grotzinger (1999)
J. Biol. Chem. 274, 1342-1348
 |  Abstract »  |  Full Text »  |  PDF »

Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses.

G. Muller-Newen, A. Kuster, U. Hemmann, R. Keul, U. Horsten, A. Martens, L. Graeve, J. Wijdenes, and P. C. Heinrich (1998)
J. Immunol. 161, 6347-6355
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo and In Vitro Activities of the gp130-Stimulating Designer Cytokine Hyper-IL-6.

M. Peters, G. Blinn, F. Solem, M. Fischer, K.-H. M. zum Buschenfelde, and S. Rose-John (1998)
J. Immunol. 161, 3575-3581
 |  Abstract »  |  Full Text »  |  PDF »

HBx Protein of Hepatitis B Virus Activates Jak1-STAT Signaling.

Y.-H. Lee and Y. Yun (1998)
J. Biol. Chem. 273, 25510-25515
 |  Abstract »  |  Full Text »  |  PDF »

Specific Contribution of Tyk2 JH Regions to the Binding and the Expression of the Interferon alpha /beta Receptor Component IFNAR1.

M. F. Richter, G. Dumenil, G. Uze, M. Fellous, and S. Pellegrini (1998)
J. Biol. Chem. 273, 24723-24729
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway by Osmotic Shock.

P. Gatsios, L. Terstegen, F. Schliess, D. Haussinger, I. M. Kerr, P. C. Heinrich, and L. Graeve (1998)
J. Biol. Chem. 273, 22962-22968
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine-Like Factor-1, a Novel Soluble Protein, Shares Homology with Members of the Cytokine Type I Receptor Family.

G. C. A. Elson, P. Graber, C. Losberger, S. Herren, D. Gretener, L. N. Menoud, T. N. C. Wells, M. H. Kosco-Vilbois, and J.-F. Gauchat (1998)
J. Immunol. 161, 1371-1379
 |  Abstract »  |  Full Text »  |  PDF »

The Chemokine Monocyte Chemotactic Protein 1 Triggers Janus Kinase 2 Activation and Tyrosine Phosphorylation of the CCR2B Receptor.

M. Mellado, J. M. Rodriguez-Frade, A. Aragay, G. del Real, A. M. Martin, A. J. Vila-Coro, A. Serrano, F. Mayor Jr., and C. Martinez-A. (1998)
J. Immunol. 161, 805-813
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of {alpha}2-Macroglobulin Expression in Rat Sertoli Cells and Hepatocytes by Germ Cells In Vitro.

L. Braghiroli, B. Silvestrini, C. Sorrentino, J. Grima, D. Mruk, and C. Yan Cheng (1998)
Biol Reprod 59, 111-123
 |  Abstract »  |  Full Text »

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