Science 24 December 1993: Vol. 262. no. 5142, pp. 2050 - 2054 DOI: 10.1126/science.8266103

Prev | Table of Contents | Next

Articles

Cullin 1 Functions as a Centrosomal Suppressor of Centriole Multiplication by Regulating Polo-like Kinase 4 Protein Levels.

N. Korzeniewski, L. Zheng, R. Cuevas, J. Parry, P. Chatterjee, B. Anderton, A. Duensing, K. Munger, and S. Duensing (2009)
Cancer Res. 69, 6668-6675
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.

J. J. Molenaar, M. E. Ebus, D. Geerts, J. Koster, F. Lamers, L. J. Valentijn, E. M. Westerhout, R. Versteeg, and H. N. Caron (2009)
PNAS 106, 12968-12973
 |  Abstract »  |  Full Text »  |  PDF »

Bub1 regulates chromosome segregation in a kinetochore-independent manner.

C. Klebig, D. Korinth, and P. Meraldi (2009)
J. Cell Biol. 185, 841-858
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation by Cyclin C/Cyclin-Dependent Kinase 2 following Mitogenic Stimulation of Murine Fibroblasts Inhibits Transcriptional Activity of LSF during G1 Progression.

U. H. Saxena, C. M. H. Powell, J. K. Fecko, R. Cacioppo, H. S. Chou, G. M. Cooper, and U. Hansen (2009)
Mol. Cell. Biol. 29, 2335-2345
 |  Abstract »  |  Full Text »  |  PDF »

The oral multitarget tumour growth inhibitor, ZK 304709, inhibits growth of pancreatic neuroendocrine tumours in an orthotopic mouse model.

A Scholz, K Wagner, M Welzel, F Remlinger, B Wiedenmann, G Siemeister, S Rosewicz, and K M Detjen (2009)
Gut 58, 261-270
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase-3-Mediated c-Jun Phosphorylation at Ser63 and Ser73 Enhances Cell Transformation.

Y.-Y. Cho, F. Tang, K. Yao, C. Lu, F. Zhu, D. Zheng, A. Pugliese, A. M. Bode, and Z. Dong (2009)
Cancer Res. 69, 272-281
 |  Abstract »  |  Full Text »  |  PDF »

Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells.

A. G. Atanasov, D. Leiser, C. Roesselet, M. Noti, N. Corazza, K. Schoonjans, and T. Brunner (2008)
FASEB J 22, 4117-4125
 |  Abstract »  |  Full Text »  |  PDF »

cAMP-mediated Induction of Cyclin E Sensitizes Growth-arrested Adipose Stem Cells to DNA Damage-induced Apoptosis.

H. Ugland, A. C. Boquest, S. Naderi, P. Collas, and H. K. Blomhoff (2008)
Mol. Biol. Cell 19, 5082-5092
 |  Abstract »  |  Full Text »  |  PDF »

A Dietary Anthocyanidin Delphinidin Induces Apoptosis of Human Prostate Cancer PC3 Cells In vitro and In vivo: Involvement of Nuclear Factor-{kappa}B Signaling.

B. B. Hafeez, I. A. Siddiqui, M. Asim, A. Malik, F. Afaq, V. M. Adhami, M. Saleem, M. Din, and H. Mukhtar (2008)
Cancer Res. 68, 8564-8572
 |  Abstract »  |  Full Text »  |  PDF »

Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells.

S. Hebbar, M. T. Mesngon, A. M. Guillotte, B. Desai, R. Ayala, and D. S. Smith (2008)
J. Cell Biol. 182, 1063-1071
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase 3-Mediated Activating Transcription Factor 1 Phosphorylation Enhances Cell Transformation.

D. Zheng, Y.-Y. Cho, A. T.Y. Lau, J. Zhang, W.-Y. Ma, A. M. Bode, and Z. Dong (2008)
Cancer Res. 68, 7650-7660
 |  Abstract »  |  Full Text »  |  PDF »

CDK2 Activation in Mouse Epidermis Induces Keratinocyte Proliferation but Does Not Affect Skin Tumor Development.

E. Macias, P. L. Miliani de Marval, A. De Siervi, C. J. Conti, A. M. Senderowicz, and M. L. Rodriguez-Puebla (2008)
Am. J. Pathol. 173, 526-535
 |  Abstract »  |  Full Text »  |  PDF »

Cytoplasmic initiation of cisplatin cytotoxicity.

F. Yu, J. Megyesi, and P. M. Price (2008)
Am J Physiol Renal Physiol 295, F44-F52
 |  Abstract »  |  Full Text »  |  PDF »

TLS-ERG Leukemia Fusion Protein Deregulates Cyclin-Dependent Kinase 1 and Blocks Terminal Differentiation of Myeloid Progenitor Cells.

J. Pan, J. Zou, D. Y. Wu, R. S. Roberson, L. J. Hennings, X. Ma, M. Yared, M. L. Blackburn, H. A. Chansky, and L. Yang (2008)
Mol. Cancer Res. 6, 862-872
 |  Abstract »  |  Full Text »  |  PDF »

The Nonsteroidal Anti-Inflammatory Drug NS398 Reactivates SPARC Expression via Promoter Demethylation to Attenuate Invasiveness of Lung Cancer Cells.

M.-R. Pan, H.-C. Chang, L.-Y. Chuang, and W.-C. Hung (2008)
Experimental Biology and Medicine 233, 456-462
 |  Abstract »  |  Full Text »  |  PDF »

Ku is involved in cell growth, DNA replication and G1-S transition.

E. Rampakakis, D. Di Paola, and M. Zannis-Hadjopoulos (2008)
J. Cell Sci. 121, 590-600
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase Inhibitors Block Leukocyte Adhesion and Migration.

L. Liu, B. Schwartz, Y. Tsubota, E. Raines, H. Kiyokawa, K. Yonekawa, J. M. Harlan, and L. M. Schnapp (2008)
J. Immunol. 180, 1808-1817
 |  Abstract »  |  Full Text »  |  PDF »

Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone.

B. Jablonska, A. Aguirre, R. Vandenbosch, S. Belachew, C. Berthet, P. Kaldis, and V. Gallo (2007)
J. Cell Biol. 179, 1231-1245
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.

P. Aggarwal, M. D. Lessie, D. I. Lin, L. Pontano, A. B. Gladden, B. Nuskey, A. Goradia, M. A. Wasik, A. J.P. Klein-Szanto, A. K. Rustgi, et al. (2007)
Genes & Dev. 21, 2908-2922
 |  Abstract »  |  Full Text »  |  PDF »

Cdk2 Deficiency Decreases ras/CDK4-Dependent Malignant Progression, but Not myc-Induced Tumorigenesis.

E. Macias, Y. Kim, P. L. Miliani de Marval, A. Klein-Szanto, and M. L. Rodriguez-Puebla (2007)
Cancer Res. 67, 9713-9720
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition.

E. Susaki, K. Nakayama, and K. I. Nakayama (2007)
Mol. Cell. Biol. 27, 4626-4640
 |  Abstract »  |  Full Text »  |  PDF »

CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16INK4a-Independent Mechanisms.

M. Ruas, F. Gregory, R. Jones, R. Poolman, M. Starborg, J. Rowe, S. Brookes, and G. Peters (2007)
Mol. Cell. Biol. 27, 4273-4282
 |  Abstract »  |  Full Text »  |  PDF »

Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy.

L. A. Gomez, A. de las Pozas, T. Reiner, K. Burnstein, and C. Perez-Stable (2007)
Mol. Cancer Ther. 6, 1534-1543
 |  Abstract »  |  Full Text »  |  PDF »

Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2.

Y. Gui, H. Yin, J.-Y. He, S.-H. Yang, M. P. Walsh, and X.-L. Zheng (2007)
Am J Physiol Heart Circ Physiol 292, H1313-H1320
 |  Abstract »  |  Full Text »  |  PDF »

ATM mediates oxidative stress-induced dephosphorylation of DNA ligase III{alpha}.

Z. Dong and A. E. Tomkinson (2006)
Nucleic Acids Res. 34, 5721-5279
 |  Abstract »  |  Full Text »  |  PDF »

The Transcriptional ETS2 Repressor Factor Associates with Active and Inactive Erks through Distinct FXF Motifs.

S. Polychronopoulos, M. Verykokakis, M. N. Yazicioglu, M. Sakarellos-Daitsiotis, M. H. Cobb, and G. Mavrothalassitis (2006)
J. Biol. Chem. 281, 25601-25611
 |  Abstract »  |  Full Text »  |  PDF »

Dependence of Cisplatin-Induced Cell Death In Vitro and In Vivo on Cyclin-Dependent Kinase 2.

P. M. Price, F. Yu, P. Kaldis, E. Aleem, G. Nowak, R. L. Safirstein, and J. Megyesi (2006)
J. Am. Soc. Nephrol. 17, 2434-2442
 |  Abstract »  |  Full Text »  |  PDF »

Endothelin is a dose-dependent trophic factor and a mitogen in small arteries in vivo.

H. H. Dao, C. Bouvet, S. Moreau, P. Beaucage, R. Lariviere, M. J. Servant, J. de Champlain, and P. Moreau (2006)
Cardiovasc Res 71, 61-68
 |  Abstract »  |  Full Text »  |  PDF »

Discovery and Evaluation of Dual CDK1 and CDK2 Inhibitors..

M. Payton, G. Chung, P. Yakowec, A. Wong, D. Powers, L. Xiong, N. Zhang, J. Leal, T. L. Bush, V. Santora, et al. (2006)
Cancer Res. 66, 4299-4308
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment.

G. I. Shapiro (2006)
J. Clin. Oncol. 24, 1770-1783
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of the Cyclin-Dependent Kinase Inhibitor p21Cip1 on Serine 130 Is Essential for Viral Cyclin-Mediated Bypass of a p21Cip1-Imposed G1 Arrest..

A. Jarviluoma, E. S. Child, G. Sarek, P. Sirimongkolkasem, G. Peters, P. M. Ojala, and D. J. Mann (2006)
Mol. Cell. Biol. 26, 2430-2440
 |  Abstract »  |  Full Text »  |  PDF »

AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9.

D. Cai, K. F. Byth, and G. I. Shapiro (2006)
Cancer Res. 66, 435-444
 |  Abstract »  |  Full Text »  |  PDF »

KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.

M. Cannon, E. Cesarman, and C. Boshoff (2006)
Blood 107, 277-284
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Microfilament Organization by Kaposi Sarcoma-associated Herpes Virus-cyclin{middle dot}CDK6 Phosphorylation of Caldesmon.

M. E. Cuomo, A. Knebel, G. Platt, N. Morrice, P. Cohen, and S. Mittnacht (2005)
J. Biol. Chem. 280, 35844-35858
 |  Abstract »  |  Full Text »  |  PDF »

The Scatter Factor/Hepatocyte Growth Factor: c-Met Pathway in Human Embryonal Central Nervous System Tumor Malignancy.

Y. Li, B. Lal, S. Kwon, X. Fan, U. Saldanha, T. E. Reznik, E. B. Kuchner, C. Eberhart, J. Laterra, and R. Abounader (2005)
Cancer Res. 65, 9355-9362
 |  Abstract »  |  Full Text »  |  PDF »

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

J. Rashidian, G. Iyirhiaro, H. Aleyasin, M. Rios, I. Vincent, S. Callaghan, R. J. Bland, R. S. Slack, M. J. During, and D. S. Park (2005)
PNAS 102, 14080-14085
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of CDP/Cux p110 by Cyclin A/Cdk2 and Cyclin A/Cdk1.

M. Santaguida and A. Nepveu (2005)
J. Biol. Chem. 280, 32712-32721
 |  Abstract »  |  Full Text »  |  PDF »

Schlafen-1 Causes a Cell Cycle Arrest by Inhibiting Induction of Cyclin D1.

G. Brady, L. Boggan, A. Bowie, and L. A. J. O'Neill (2005)
J. Biol. Chem. 280, 30723-30734
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the functional domain of p21WAF1/CIP1 that protects cells from cisplatin cytotoxicity.

F. Yu, J. Megyesi, R. L. Safirstein, and P. M. Price (2005)
Am J Physiol Renal Physiol 289, F514-F520
 |  Abstract »  |  Full Text »  |  PDF »

Cdk2-dependent Inhibition of p21 Stability via a C-terminal Cyclin-binding Motif.

H. Zhu, L. Nie, and C. G. Maki (2005)
J. Biol. Chem. 280, 29282-29288
 |  Abstract »  |  Full Text »  |  PDF »

Acute Reduction of an Origin Recognition Complex (ORC) Subunit in Human Cells Reveals a Requirement of ORC for Cdk2 Activation.

Y. J. Machida, J. K. Teer, and A. Dutta (2005)
J. Biol. Chem. 280, 27624-27630
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Dissection of the Interaction between p27 and Kip1 Ubiquitylation-promoting Complex, the Ubiquitin Ligase That Regulates Proteolysis of p27 in G1 Phase.

S. Kotoshiba, T. Kamura, T. Hara, N. Ishida, and K. I. Nakayama (2005)
J. Biol. Chem. 280, 17694-17700
 |  Abstract »  |  Full Text »  |  PDF »

Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways.

P.-F. Hung, B.-T. Wu, H.-C. Chen, Y.-H. Chen, C.-L. Chen, M.-H. Wu, H.-C. Liu, M.-J. Lee, and Y.-H. Kao (2005)
Am J Physiol Cell Physiol 288, C1094-C1108
 |  Abstract »  |  Full Text »  |  PDF »

The N-terminal Peptide of the Kaposi's Sarcoma-associated Herpesvirus (KSHV)-cyclin Determines Substrate Specificity.

P. Kaldis (2005)
J. Biol. Chem. 280, 11165-11174
 |  Abstract »  |  Full Text »  |  PDF »

Chromatin decondensation in S-phase involves recruitment of Cdk2 by Cdc45 and histone H1 phosphorylation.

M. G. Alexandrow and J. L. Hamlin (2005)
J. Cell Biol. 168, 875-886
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Cell-Cycle Arrest by all-trans Retinoic Acid in Mouse Embryonic Palatal Mesenchymal (MEPM) Cells.

Z. Yu, J. Lin, Y. Xiao, J. Han, X. Zhang, H. Jia, Y. Tang, and Y. Li (2005)
Toxicol. Sci. 83, 349-354
 |  Abstract »  |  Full Text »  |  PDF »

Living with or without cyclins and cyclin-dependent kinases.

C. J. Sherr and J. M. Roberts (2004)
Genes & Dev. 18, 2699-2711
 |  Abstract »  |  Full Text »  |  PDF »

Construction of a Cyclin D1-Cdk2 Fusion Protein to Model the Biological Functions of Cyclin D1-Cdk2 Complexes.

A. Chytil, M. Waltner-Law, R. West, D. Friedman, M. Aakre, D. Barker, and B. Law (2004)
J. Biol. Chem. 279, 47688-47698
 |  Abstract »  |  Full Text »  |  PDF »

The Putative Zinc Finger of the Human Cytomegalovirus IE2 86-Kilodalton Protein Is Dispensable for DNA Binding and Autorepression, Thereby Demarcating a Concise Core Domain in the C Terminus of the Protein.

J. Asmar, L. Wiebusch, M. Truss, and C. Hagemeier (2004)
J. Virol. 78, 11853-11864
 |  Abstract »  |  Full Text »  |  PDF »

A Centrosomal Localization Signal in Cyclin E Required for Cdk2-Independent S Phase Entry.

Y. Matsumoto and J. L. Maller (2004)
Science 306, 885-888
 |  Abstract »  |  Full Text »  |  PDF »

Repression of G0/G1 Traverse in Human Fibroblasts Exposed to Low Levels of Ionizing Radiation.

W. Wharton (2004)
J. Biol. Chem. 279, 43667-43674
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Sp1 by Cyclin-dependent Kinase 2 Modulates the Role of Sp1 in CTP:Phosphocholine Cytidylyltransferase {alpha} Regulation during the S Phase of the Cell Cycle.

C. Banchio, L. M. Schang, and D. E. Vance (2004)
J. Biol. Chem. 279, 40220-40226
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Activation-induced Fas (CD95/Apo-1) Ligand Expression in T Cells by the Cyclin B1/Cdk1 Complex.

R. Torgler, S. Jakob, E. Ontsouka, U. Nachbur, C. Mueller, D. R. Green, and T. Brunner (2004)
J. Biol. Chem. 279, 37334-37342
 |  Abstract »  |  Full Text »  |  PDF »

Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis.

M. A. T. M. van Vugt, B. C. M. van de Weerdt, G. Vader, H. Janssen, J. Calafat, R. Klompmaker, R. M. F. Wolthuis, and R. H. Medema (2004)
J. Biol. Chem. 279, 36841-36854
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Interaction Partners and Substrates of the Cyclin A1-CDK2 Complex.

S. Diederichs, N. Baumer, P. Ji, S. K. Metzelder, G. E. Idos, T. Cauvet, W. Wang, M. Moller, S. Pierschalski, J. Gromoll, et al. (2004)
J. Biol. Chem. 279, 33727-33741
 |  Abstract »  |  Full Text »  |  PDF »

Intra-S-Phase Checkpoint Activation by Direct CDK2 Inhibition.

Y. Zhu, C. Alvarez, R. Doll, H. Kurata, X. M. Schebye, D. Parry, and E. Lees (2004)
Mol. Cell. Biol. 24, 6268-6277
 |  Abstract »  |  Full Text »  |  PDF »

A Phase II Clinical and Pharmacodynamic Study of E7070 in Patients with Metastatic, Recurrent, or Refractory Squamous Cell Carcinoma of the Head and Neck: Modulation of Retinoblastoma Protein Phosphorylation by a Novel Chloroindolyl Sulfonamide Cell Cycle Inhibitor.

R. I. Haddad, L. J. Weinstein, T. J. Wieczorek, N. Bhattacharya, H. Raftopoulos, M. W. Oster, X. Zhang, V. M. Latham Jr., R. Costello, J. Faucher, et al. (2004)
Clin. Cancer Res. 10, 4680-4687
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-dependent Kinase 5 Associated with p39 Promotes Munc18-1 Phosphorylation and Ca2+-dependent Exocytosis.

L. Lilja, J. U. Johansson, J. Gromada, S. A. Mandic, G. Fried, P.-O. Berggren, and C. Bark (2004)
J. Biol. Chem. 279, 29534-29541
 |  Abstract »  |  Full Text »  |  PDF »

A Dominant Negative Mutant of Cyclin-Dependent Kinase A Reduces Endoreduplication but Not Cell Size or Gene Expression in Maize Endosperm.

J. T. Leiva-Neto, G. Grafi, P. A. Sabelli, R. A. Dante, Y.-m. Woo, S. Maddock, W. J. Gordon-Kamm, and B. A. Larkins (2004)
PLANT CELL 16, 1854-1869
 |  Abstract »  |  Full Text »  |  PDF »

Glucose-Induced Expression of the Cyclin-Dependent Protein Kinase 5 Activator p35 Involved in Alzheimer's Disease Regulates Insulin Gene Transcription in Pancreatic {beta}-Cells.

M. Ubeda, D. M. Kemp, and J. F. Habener (2004)
Endocrinology 145, 3023-3031
 |  Abstract »  |  Full Text »  |  PDF »

Failure To Proliferate and Mitotic Arrest of CDK11p110/p58-Null Mutant Mice at the Blastocyst Stage of Embryonic Cell Development.

T. Li, A. Inoue, J. M. Lahti, and V. J. Kidd (2004)
Mol. Cell. Biol. 24, 3188-3197
 |  Abstract »  |  Full Text »  |  PDF »

B1-Type Cyclin-Dependent Kinases Are Essential for the Formation of Stomatal Complexes in Arabidopsis thaliana.

V. Boudolf, R. Barroco, J. d. A. Engler, A. Verkest, T. Beeckman, M. Naudts, D. Inze, and L. De Veylder (2004)
PLANT CELL 16, 945-955
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107.

T. Chibazakura, S. G. McGrew, J. A. Cooper, H. Yoshikawa, and J. M. Roberts (2004)
PNAS 101, 4465-4470
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer Cells.

R. M. Harwell, B. B. Mull, D. C. Porter, and K. Keyomarsi (2004)
J. Biol. Chem. 279, 12695-12705
 |  Abstract »  |  Full Text »  |  PDF »

Promiscuity Rules? The Dispensability of Cyclin E and Cdk2.

T. T. Su and J. Stumpff (2004)
Sci. STKE 2004, pe11
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope.

J.-L. Perfettini, T. Roumier, M. Castedo, N. Larochette, P. Boya, B. Raynal, V. Lazar, F. Ciccosanti, R. Nardacci, J. Penninger, et al. (2004)
J. Exp. Med. 199, 629-640
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Cyclin E Renders Cyclin D-CDK4 Dispensable for Inactivation of the Retinoblastoma Tumor Suppressor Protein, Activation of E2F, and G1-S Phase Progression.

S. M. Keenan, N. H. Lents, and J. J. Baldassare (2004)
J. Biol. Chem. 279, 5387-5396
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase 6 Inhibits Proliferation of Human Mammary Epithelial Cells.

J. J. Lucas, J. Domenico, and E. W. Gelfand (2004)
Mol. Cancer Res. 2, 105-114
 |  Abstract »  |  Full Text »  |  PDF »

The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway.

S. R. Whittaker, M. I. Walton, M. D. Garrett, and P. Workman (2004)
Cancer Res. 64, 262-272
 |  Abstract »  |  Full Text »  |  PDF »

Mullerian Inhibiting Substance Promotes Interferon {gamma}-induced Gene Expression and Apoptosis in Breast Cancer Cells.

Y. Hoshiya, V. Gupta, H. Kawakubo, E. Brachtel, J. L. Carey, L. Sasur, A. Scott, P. K. Donahoe, and S. Maheswaran (2003)
J. Biol. Chem. 278, 51703-51712
 |  Abstract »  |  Full Text »  |  PDF »

p73 Is Regulated by Phosphorylation at the G2/M Transition.

M. Fulco, A. Costanzo, P. Merlo, R. Mangiacasale, S. Strano, G. Blandino, C. Balsano, P. Lavia, and M. Levrero (2003)
J. Biol. Chem. 278, 49196-49202
 |  Abstract »  |  Full Text »  |  PDF »

Identification of protein kinases responsible for phosphorylation of Epstein-Barr virus nuclear antigen leader protein at serine-35, which regulates its coactivator function.

K. Kato, A. Yokoyama, Y. Tohya, H. Akashi, Y. Nishiyama, and Y. Kawaguchi (2003)
J. Gen. Virol. 84, 3381-3392
 |  Abstract »  |  Full Text »  |  PDF »

DNA replication of mitotic chromatin in Xenopus egg extracts.

T. A. Prokhorova, K. Mowrer, C. H. Gilbert, and J. C. Walter (2003)
PNAS 100, 13241-13246
 |  Abstract »  |  Full Text »  |  PDF »

Cdk2-dependent Phosphorylation of the NF-Y Transcription Factor and Its Involvement in the p53-p21 Signaling Pathway.

J. Yun, H.-D. Chae, T.-S. Choi, E.-H. Kim, Y.-J. Bang, J. Chung, K.-S. Choi, R. Mantovani, and D. Y. Shin (2003)
J. Biol. Chem. 278, 36966-36972
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cdc25A Half-life in Interphase by Cyclin-dependent Kinase 2 Activity.

A. P. Ducruet and J. S. Lazo (2003)
J. Biol. Chem. 278, 31838-31842
 |  Abstract »  |  Full Text »  |  PDF »

pRb Inactivation in Senescent Cells Leads to an E2F-Dependent Apoptosis Requiring p73.

K. Alexander, H.-S. Yang, and P. W. Hinds (2003)
Mol. Cancer Res. 1, 716-728
 |  Abstract »  |  Full Text »  |  PDF »

Human Spy1 Promotes Survival of Mammalian Cells following DNA Damage.

E. A. Barnes, L. A. Porter, J.-L. Lenormand, R. W. Dellinger, and D. J. Donoghue (2003)
Cancer Res. 63, 3701-3707
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Cyclin-Dependent Kinase 6, but not Cyclin-Dependent Kinase 4, Alters Morphology of Cultured Mouse Astrocytes.

K. K. Ericson, D. Krull, P. Slomiany, and M. J. Grossel (2003)
Mol. Cancer Res. 1, 654-664
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}v{beta}3 integrin expression up-regulates cdc2, which modulates cell migration.

T. Manes, D.-Q. Zheng, S. Tognin, A. S. Woodard, P. C. Marchisio, and L. R. Languino (2003)
J. Cell Biol. 161, 817-826
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Models in Applied Physiology: Invited Review: Effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest.

R. M. Douglas and G. G. Haddad (2003)
J Appl Physiol 94, 2068-2083
 |  Abstract »  |  Full Text »  |  PDF »

Herpes simplex virus 1 activates cdc2 to recruit topoisomerase IIalpha for post-DNA synthesis expression of late genes.

S. J. Advani, R. R. Weichselbaum, and B. Roizman (2003)
PNAS 100, 4825-4830
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Cdk4 Activity Enhances Translation of p27kip1 in Quiescent Rb-negative Cells.

T. Gonzalez, M. Seoane, P. Caamano, J. Vinuela, F. Dominguez, and J. Zalvide (2003)
J. Biol. Chem. 278, 12688-12695
 |  Abstract »  |  Full Text »  |  PDF »

The E2F-Cdc2 Cell-Cycle Pathway Specifically Mediates Activity Deprivation-Induced Apoptosis of Postmitotic Neurons.

Y. Konishi and A. Bonni (2003)
J. Neurosci. 23, 1649-1658
 |  Abstract »  |  Full Text »  |  PDF »

Casein Kinase 2 Interacts with Cyclin-dependent Kinase 11 (CDK11) in Vivo and Phosphorylates Both the RNA Polymerase II Carboxyl-terminal Domain and CDK11 in Vitro.

J. H. Trembley, D. Hu, C. A. Slaughter, J. M. Lahti, and V. J. Kidd (2003)
J. Biol. Chem. 278, 2265-2270
 |  Abstract »  |  Full Text »  |  PDF »

Structure-based Design of p18INK4c Proteins with Increased Thermodynamic Stability and Cell Cycle Inhibitory Activity.

R. N. Venkataramani, T. K. MacLachlan, X. Chai, W. S. El-Deiry, and R. Marmorstein (2002)
J. Biol. Chem. 277, 48827-48833
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Tea on Preneoplastic Lesions and Cell Cycle Regulators in Rat Liver.

X. Jia, C. Han, and J. Chen (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 1663-1667
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-dependent kinases as cellular targets for antiviral drugs.

L. M. Schang (2002)
J. Antimicrob. Chemother. 50, 779-792
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D.

M. Schmidt, S. Fernandez de Mattos, A. van der Horst, R. Klompmaker, G. J. P. L Kops, E. W.-F. Lam, B. M. T. Burgering, and R. H. Medema (2002)
Mol. Cell. Biol. 22, 7842-7852
 |  Abstract »  |  Full Text »  |  PDF »

Coupling of DNA Synthesis and Histone Synthesis in S Phase Independent of Cyclin/cdk2 Activity.

D. M. Nelson, X. Ye, C. Hall, H. Santos, T. Ma, G. D. Kao, T. J. Yen, J. W. Harper, and P. D. Adams (2002)
Mol. Cell. Biol. 22, 7459-7472
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Hypoxia-Induced Apoptosis by Modulation of Retinoblastoma Protein-Dependent Signaling in Cardiomyocytes.

L. Hauck, G. Hansmann, R. Dietz, and R. von Harsdorf (2002)
Circ. Res. 91, 782-789
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase-2 Controls Oligodendrocyte Progenitor Cell Cycle Progression and Is Downregulated in Adult Oligodendrocyte Progenitors.

S. Belachew, A. A. Aguirre, H. Wang, F. Vautier, X. Yuan, S. Anderson, M. Kirby, and V. Gallo (2002)
J. Neurosci. 22, 8553-8562
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of the c-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage.

M. H. Ghahremani, E. Keramaris, T. Shree, Z. Xia, R. J. Davis, R. Flavell, R. S. Slack, and D. S. Park (2002)
J. Biol. Chem. 277, 35586-35596
 |  Abstract »  |  Full Text »  |  PDF »

Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells.

L Khare, A Astrinidis, W Senapedis, P D Adams, and E P. Henske (2002)
J. Med. Genet. 39, 676-680
 |  Full Text »  |  PDF »

Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes.

C. Tarn, L. Zou, R. L. Hullinger, and O. M. Andrisani (2002)
J. Virol. 76, 9763-9772
 |  Abstract »  |  Full Text »  |  PDF »

The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles.

T. Mayor, U. Hacker, Y.-D. Stierhof, and E. A. Nigg (2002)
J. Cell Sci. 115, 3275-3284
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation.

J.-B. Lazaro, P. J. Bailey, and A. B. Lassar (2002)
Genes & Dev. 16, 1792-1805
 |  Abstract »  |  Full Text »  |  PDF »

Flavopiridol and Trastuzumab Synergistically Inhibit Proliferation of Breast Cancer Cells: Association with Selective Cooperative Inhibition of Cyclin D1-dependent Kinase and Akt Signaling Pathways.

K. Wu, C. Wang, M. D'Amico, R. J. Lee, C. Albanese, R. G. Pestell, and S. Mani (2002)
Mol. Cancer Ther. 1, 695-706
 |  Abstract »  |  Full Text »  |  PDF »

Explant-Induced Reactivation of Herpes Simplex Virus Occurs in Neurons Expressing Nuclear cdk2 and cdk4.

L. M. Schang, A. Bantly, and P. A. Schaffer (2002)
J. Virol. 76, 7724-7735
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products