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Science 17 December 1993:
Vol. 262. no. 5141, pp. 1889 - 1892
DOI: 10.1126/science.8266081
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Articles

Science, Vol 262, Issue 5141, 1889-1892
Copyright © 1993 by American Association for the Advancement of Science

articles

Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc

A Shrivastava, S Saleque, GV Kalpana, S Artandi, SP Goff, and K Calame

Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032.

Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.


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