Science 17 December 1993: Vol. 262. no. 5141, pp. 1880 - 1883 DOI: 10.1126/science.8266078

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Articles

An Atopy-Associated Polymorphism in the Ectodomain of the IL-4R{alpha} Chain (V50) Regulates the Persistence of STAT6 Phosphorylation.

A. Q. Ford, N. M. Heller, L. Stephenson, M. R. Boothby, and A. D. Keegan (2009)
J. Immunol. 183, 1607-1616
 |  Abstract »  |  Full Text »  |  PDF »

Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.

S. R. White, L. D. Martin, M. K. Abe, B. A. Marroquin, R. Stern, and X. Fu (2009)
Am J Physiol Lung Cell Mol Physiol 297, L164-L173
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Proteomics Reveals GIMAP Family Proteins 1 and 4 to Be Differentially Regulated during Human T Helper Cell Differentiation.

J.-J. Filen, S. Filen, R. Moulder, S. Tuomela, H. Ahlfors, A. West, P. Kouvonen, S. Kantola, M. Bjorkman, M. Katajamaa, et al. (2009)
Mol. Cell. Proteomics 8, 32-44
 |  Abstract »  |  Full Text »  |  PDF »

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways.

M. Wills-Karp and F. D. Finkelman (2008)
Science Signaling 1, pe55
 |  Abstract »  |  Full Text »  |  PDF »

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages.

N. M. Heller, X. Qi, I. S. Junttila, K. A. Shirey, S. N. Vogel, W. E. Paul, and A. D. Keegan (2008)
Science Signaling 1, ra17
 |  Abstract »  |  Full Text »  |  PDF »

The "Bubble Boy" Paradox: An Answer That Led to a Question.

L. J. Berg (2008)
J. Immunol. 181, 5815-5816
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Kaempferol Inhibits IL-4-Induced STAT6 Activation by Specifically Targeting JAK3.

J. R. Cortes, M. Perez-G, M. D. Rivas, and J. Zamorano (2007)
J. Immunol. 179, 3881-3887
 |  Abstract »  |  Full Text »  |  PDF »

IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo.

A. Frohlich, B. J. Marsland, I. Sonderegger, M. Kurrer, M. R. Hodge, N. L. Harris, and M. Kopf (2007)
Blood 109, 2023-2031
 |  Abstract »  |  Full Text »  |  PDF »

Immunostimulatory Effects of the Anionic Alkali Mineral Complex BARODON on Equine Lymphocytes.

H. Koo, S.-H. Ryu, H. J. Ahn, W. K. Jung, Y. K. Park, N. H. Kwon, S. H. Kim, J. M. Kim, B. W. Yoo, S. I. Choi, et al. (2006)
Clin. Vaccine Immunol. 13, 1255-1266
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activation of STAT5 Supersedes the Requirement for Cytokine and TCR Engagement of CD4+ T Cells in Steady-State Homeostasis.

D. K. Taylor, P. T. Walsh, D. F. LaRosa, J. Zhang, M. A. Burchill, M. A. Farrar, and L. A. Turka (2006)
J. Immunol. 177, 2216-2223
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Receptor {alpha} Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets..

A.-L. Andrews, J. W. Holloway, S. T. Holgate, and D. E. Davies (2006)
J. Immunol. 176, 7456-7461
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-13-regulated M2 Macrophages in Combination with Myeloid Suppressor Cells Block Immune Surveillance against Metastasis.

P. Sinha, V. K. Clements, and S. Ostrand-Rosenberg (2005)
Cancer Res. 65, 11743-11751
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Uteroglobin-Related Protein 2 (Ugrp2) Gene Expression by the Th2 Cytokines IL-4 and IL-13.

A. Yamada, F. Sheikh, T. Niimi, F. J. DeMayo, A. D. Keegan, R. P. Donnelly, and S. Kimura (2005)
J. Immunol. 175, 5708-5715
 |  Abstract »  |  Full Text »  |  PDF »

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chainnull mice.

F. Ishikawa, M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe, K. Akashi, L. D. Shultz, and M. Harada (2005)
Blood 106, 1565-1573
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic Regulation of Activated STAT6 by Calpains.

J. Zamorano, M. D. Rivas, F. Setien, and M. Perez-G (2005)
J. Immunol. 174, 2843-2848
 |  Abstract »  |  Full Text »  |  PDF »

IFN-{gamma} Suppresses STAT6 Phosphorylation by Inhibiting Its Recruitment to the IL-4 Receptor.

Z. Huang, J. Xin, J. Coleman, and H. Huang (2005)
J. Immunol. 174, 1332-1337
 |  Abstract »  |  Full Text »  |  PDF »

Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

J. L. Roberts, A. Lengi, S. M. Brown, M. Chen, Y.-J. Zhou, J. J. O'Shea, and R. H. Buckley (2004)
Blood 103, 2009-2018
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency.

M. P. McCormack and T. H. Rabbitts (2004)
N. Engl. J. Med. 350, 913-922
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Identification of the Interleukin 4 Receptor {alpha} Gene as a Direct Target for p73.

Y. Sasaki, H. Mita, M. Toyota, S. Ishida, I. Morimoto, T. Yamashita, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino (2003)
Cancer Res. 63, 8145-8152
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Inactivation of the IL-4 Receptor {alpha} Chain I4R Motif Promotes Allergic Airway Inflammation.

F. Blaeser, P. J. Bryce, N. Ho, V. Raman, F. Dedeoglu, D. D. Donaldson, R. S. Geha, H. C. Oettgen, and T. A. Chatila (2003)
J. Exp. Med. 198, 1189-1200
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylcholine-Specific Phospholipase C Activity Is Necessary for the Activation of STAT6.

J. Zamorano, M. D. Rivas, A. Garcia-Trinidad, C.-K. Qu, and A. D. Keegan (2003)
J. Immunol. 171, 4203-4209
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis.

S.-K. Lee, J. F. Kalinowski, S. L. Jastrzebski, L. Puddington, and J. A. Lorenzo (2003)
Endocrinology 144, 3524-3531
 |  Abstract »  |  Full Text »  |  PDF »

Regulation and Function of the Interleukin 13 Receptor {alpha} 2 During a T Helper Cell Type 2-dominant Immune Response.

M. G. Chiaramonte, M. Mentink-Kane, B. A. Jacobson, A. W. Cheever, M. J. Whitters, M. E.P. Goad, A. Wong, M. Collins, D. D. Donaldson, M. J. Grusby, et al. (2003)
J. Exp. Med. 197, 687-701
 |  Abstract »  |  Full Text »  |  PDF »

Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential.

J. H. Von der Thusen, J. Kuiper, T. J. C. Van Berkel, and E. A. L. Biessen (2003)
Pharmacol. Rev. 55, 133-166
 |  Abstract »  |  Full Text »  |  PDF »

Kinetic Analysis of the Interleukin-13 Receptor Complex.

A.-L. Andrews, J. W. Holloway, S. M. Puddicombe, S. T. Holgate, and D. E. Davies (2002)
J. Biol. Chem. 277, 46073-46078
 |  Abstract »  |  Full Text »  |  PDF »

Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
 |  Abstract »  |  Full Text »  |  PDF »

Structural Basis for Binding Multiple Ligands by the Common Cytokine Receptor gamma -Chain.

F. Olosz and T. R. Malek (2002)
J. Biol. Chem. 277, 12047-12052
 |  Abstract »  |  Full Text »  |  PDF »

Aspirin and Salicylates Inhibit the IL-4- and IL-13-Induced Activation of STAT6.

M. Perez-G., M. Melo, A. D. Keegan, and J. Zamorano (2002)
J. Immunol. 168, 1428-1434
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT.

E. Kelly, A. Won, Y. Refaeli, and L. V. Parijs (2002)
J. Immunol. 168, 597-603
 |  Abstract »  |  Full Text »  |  PDF »

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.

S. M. Stepkowski, R. A. Erwin-Cohen, F. Behbod, M.-E. Wang, X. Qu, N. Tejpal, Z. S. Nagy, B. D. Kahan, and R. A. Kirken (2002)
Blood 99, 680-689
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Interleukin-4 Receptor Complex in Human Corneal Fibroblasts.

K. Fukuda, Y. Fujitsu, N. Kumagai, and T. Nishida (2002)
Invest. Ophthalmol. Vis. Sci. 43, 183-188
 |  Abstract »  |  Full Text »  |  PDF »

Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays.

H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman (2002)
Blood 99, 282-289
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Receptor-Stat6 Signaling in Murine Infections with a Tissue-Dwelling Nematode Parasite.

L. Spencer, L. Shultz, and T. V. Rajan (2001)
Infect. Immun. 69, 7743-7752
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B activation plays an important role in the IL-4-induced protection from apoptosis.

J. Zamorano, A. L. Mora, M. Boothby, and A. D. Keegan (2001)
Int. Immunol. 13, 1479-1487
 |  Abstract »  |  Full Text »  |  PDF »

Immunoreceptor Tyrosine-Based Inhibitory Motif of the IL-4 Receptor Associates with SH2-Containing Phosphatases and Regulates IL-4-Induced Proliferation.

M. Kashiwada, C. C. Giallourakis, P.-Y. Pan, and P. B. Rothman (2001)
J. Immunol. 167, 6382-6387
 |  Abstract »  |  Full Text »  |  PDF »

The interleukin-13 receptor {alpha}2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway.

K. Kawakami, J. Taguchi, T. Murata, and R. K. Puri (2001)
Blood 97, 2673-2679
 |  Abstract »  |  Full Text »  |  PDF »

Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts.

F. Behbod, R. A. Erwin-Cohen, M.-E. Wang, B. W. Trawick, X. Qu, R. Verani, B. D. Kahan, S. M. Stepkowski, and R. A. Kirken (2001)
J. Immunol. 166, 3724-3732
 |  Abstract »  |  Full Text »  |  PDF »

A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1{beta}2.

N. L. Monson, T. J. Fenske, S. Wei, A. J. Okragly, J. L.O. de Jong, M. Haak-Frendscho, J. O’Shea, J. Djeu, and P. M. Sondel (2001)
J. Leukoc. Biol. 69, 419-425
 |  Abstract »  |  Full Text »

NF-{{kappa}}B/Rel Participation in the Lymphokine-Dependent Proliferation of T Lymphoid Cells.

A. L. Mora, J. Youn, A. D. Keegan, and M. Boothby (2001)
J. Immunol. 166, 2218-2227
 |  Abstract »  |  Full Text »  |  PDF »

IFN-{gamma} and IFN-{alpha} Posttranscriptionally Down-Regulate the IL-4-Induced IL-4 Receptor Gene Expression.

E.-Y. So, H.-H. Park, and C.-E. Lee (2000)
J. Immunol. 165, 5472-5479
 |  Abstract »  |  Full Text »  |  PDF »

Primary Immunodeficiency Diseases Due to Defects in Lymphocytes.

R. H. Buckley (2000)
N. Engl. J. Med. 343, 1313-1324
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Memory-Type CD8+ T Cells Protect IL-2 Receptor {alpha}-Deficient Mice from Systemic Infection with Herpes Simplex Virus Type 2.

H. Tsunobuchi, H. Nishimura, F. Goshima, T. Daikoku, Y. Nishiyama, and Y. Yoshikai (2000)
J. Immunol. 165, 4552-4560
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-3 Expression Promotes Cell Survival following Interleukin-4 Deprivation and Is Controlled by AP1 and AP1-Like Transcription Factors.

A. Rebollo, L. Dumoutier, J.-C. Renauld, A. Zaballos, V. Ayllón, and C. Martínez-A. (2000)
Mol. Cell. Biol. 20, 3407-3416
 |  Abstract »  |  Full Text »

Regulation of Lymphoid Homeostasis by IL-2 Receptor Signals In Vivo.

D. T. M. Leung, S. Morefield, and D. M. Willerford (2000)
J. Immunol. 164, 3527-3534
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Interleukin 7 Receptor Signaling by Antigen Receptor Assembly.

F. M. Smart and A. R. Venkitaraman (2000)
J. Exp. Med. 191, 737-742
 |  Abstract »  |  Full Text »  |  PDF »

Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor {alpha}-Chain.

H. Huang and W. E. Paul (2000)
J. Immunol. 164, 1211-1215
 |  Abstract »  |  Full Text »  |  PDF »

Soluble IL-4 Receptor Inhibits Airway Inflammation Following Allergen Challenge in a Mouse Model of Asthma.

W. R. Henderson Jr., E. Y. Chi, and C. R. Maliszewski (2000)
J. Immunol. 164, 1086-1095
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6.

M. Pesu, K. Takaluoma, S. Aittomaki, A. Lagerstedt, K. Saksela, P. E. Kovanen, and O. Silvennoinen (2000)
Blood 95, 494-502
 |  Abstract »  |  Full Text »  |  PDF »

FUNCTIONAL INTERLEUKIN 4 RECEPTOR AND INTERLEUKIN 2 RECEPTOR COMMON {gamma}-CHAIN ON HUMAN NON-SMALL CELL LUNG CANCERS: NOVEL TARGETS FOR IMMUNE THERAPY.

R. Essner, Y. Huynh, T. Nguyen, D. L. Morton, and D. S. B. Hoon (2000)
J. Thorac. Cardiovasc. Surg. 119, 10-20
 |  Abstract »  |  Full Text »  |  PDF »

Homologous Human and Murine Antisense Oligonucleotides Targeting Stat6 . Functional Effects on Germline Cepsilon Transcript.

S. Hill, E. Herlaar, A. Le Cardinal, G. van Heeke, and P. Nicklin (1999)
Am. J. Respir. Cell Mol. Biol. 21, 728-737
 |  Abstract »  |  Full Text »

Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach.

M. Lo, M. L. Bloom, K. Imada, M. Berg, J. M. Bollenbacher, E. T. Bloom, B. L. Kelsall, and W. J. Leonard (1999)
Blood 94, 3027-3036
 |  Abstract »  |  Full Text »  |  PDF »

Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

H. L. Dickensheets, C. Venkataraman, U. Schindler, and R. P. Donnelly (1999)
PNAS 96, 10800-10805
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines in asthma.

K F Chung and P J Barnes (1999)
Thorax 54, 825-857
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Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.

K. Friedrich, W. Kammer, I. Erhardt, S. Brandlein, W. Sebald, and R. Moriggl (1999)
Int. Immunol. 11, 1283-1294
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Cytoplasmic Domain of Interleukin-13 Receptor-alpha.

P. L. Orchansky, R. Kwan, F. Lee, and J. W. Schrader (1999)
J. Biol. Chem. 274, 20818-20825
 |  Abstract »  |  Full Text »  |  PDF »

No Association between Atopy/Asthma and the Ile50val Polymorphism of IL-4 Receptor.

E. NOGUCHI, M. SHIBASAKI, T. ARINAMI, K. TAKEDA, Y. YOKOUCHI, K. KOBAYASHI, N. IMOTO, S. NAKAHARA, A. MATSUI, and H. HAMAGUCHI (1999)
Am. J. Respir. Crit. Care Med. 160, 342-345
 |  Abstract »  |  Full Text »

Differences Between IL-4- and IL-4 Receptor {alpha}-Deficient Mice in Chronic Leishmaniasis Reveal a Protective Role for IL-13 Receptor Signaling.

M. Mohrs, B. Ledermann, G. Kohler, A. Dorfmuller, A. Gessner, and F. Brombacher (1999)
J. Immunol. 162, 7302-7308
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacology of the Eosinophil.

M. A. Giembycz and M. A. Lindsay (1999)
Pharmacol. Rev. 51, 213-340
 |  Abstract »  |  Full Text »  |  PDF »

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains.

N. Noben-Trauth, W. E. Paul, and D. L. Sacks (1999)
J. Immunol. 162, 6132-6140
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor alpha  Gene to Transcription Factors.

C. Rusterholz, P. C. Henrioud, and M. Nabholz (1999)
Mol. Cell. Biol. 19, 2681-2689
 |  Abstract »  |  Full Text »  |  PDF »

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response.

L. H. Wang, R. A. Kirken, R. A. Erwin, C.-R. Yu, and W. L. Farrar (1999)
J. Immunol. 162, 3897-3904
 |  Abstract »  |  Full Text »  |  PDF »

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency.

S. Kumaki, N. Ishii, M. Minegishi, S. Tsuchiya, D. Cosman, K. Sugamura, and T. Konno (1999)
Blood 93, 607-612
 |  Abstract »  |  Full Text »  |  PDF »

Induction of 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Type 1 Gene Transcription in Human Breast Cancer Cell Lines and in Normal Mammary Epithelial Cells by Interleukin-4 and Interleukin-13.

S. Gingras, R. Moriggl, B. Groner, and J. Simard (1999)
Mol. Endocrinol. 13, 66-81
 |  Abstract »  |  Full Text »

Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus.

W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN (1999)
Cold Spring Harb Symp Quant Biol 64, 417-424
 |  Abstract »  |  PDF »

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins: Development of a Recombinant Interleukin-4-Pseudomonas Exotoxin for Therapy of Glioblastoma.

R. K. Puri (1999)
Toxicol Pathol 27, 53-57
 |  Abstract »  |  PDF »

Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction.

S. J. Haque, P. Harbor, M. Tabrizi, T. Yi, and B. R. G. Williams (1998)
J. Biol. Chem. 273, 33893-33896
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Mediators of Asthma: An Update.

P. J. Barnes, K. F. Chung, and C. P. Page (1998)
Pharmacol. Rev. 50, 515-596
 |  Abstract »  |  Full Text »  |  PDF »

The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common gamma -Chain.

A. Lischke, R. Moriggl, S. Brandlein, S. Berchtold, W. Kammer, W. Sebald, B. Groner, X. Liu, L. Hennighausen, and K. Friedrich (1998)
J. Biol. Chem. 273, 31222-31229
 |  Abstract »  |  Full Text »  |  PDF »

Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation.

A. Cerezo, C. Martínez-A, D. Lanzarot, S. Fischer, T. F. Franke, and A. Rebollo (1998)
Mol. Biol. Cell 9, 3107-3118
 |  Abstract »  |  Full Text »

Interaction affinity between cytokine receptor components on the cell surface.

A. Whitty, N. Raskin, D. L. Olson, C. W. Borysenko, C. M. Ambrose, C. D. Benjamin, and L. C. Burkly (1998)
PNAS 95, 13165-13170
 |  Abstract »  |  Full Text »  |  PDF »

Human Eosinophils Constitutively Express a Functional Interleukin-4 Receptor: Interleukin-4 -Induced Priming of Chemotactic Responses and Induction of PI-3 Kinase Activity.

G. R. Dubois, R. C. Schweizer, C. Versluis, C. A. F. M. Bruijnzeel-Koomen, and P. L. B. Bruijnzeel (1998)
Am. J. Respir. Cell Mol. Biol. 19, 691-699
 |  Abstract »  |  Full Text »

Molecular Mapping with Functional Antibodies Localizes Critical Sites on the Human IL Receptor Common {gamma} ({gamma}c) Chain.

N. Raskin, A. Jakubowski, I. Sizing, D. L. Olson, S. L. Kalled, C. A. Hession, C. D. Benjamin, D. P. Baker, and L. C. Burkly (1998)
J. Immunol. 161, 3474-3483
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis of the Common Cytokine Receptor gamma c Chain. IDENTIFICATION OF SEQUENCES INVOLVED IN INTERNALIZATION AND DEGRADATION.

E. Morelon and A. Dautry-Varsat (1998)
J. Biol. Chem. 273, 22044-22051
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Mobile Stat6 Activation Motif in the Human IL-4 Receptor.

J. J. Ryan, L. J. McReynolds, H. Huang, K. Nelms, and W. E. Paul (1998)
J. Immunol. 161, 1811-1821
 |  Abstract »  |  Full Text »  |  PDF »

An immune cell-selective interleukin 4 agonist.

A. B. Shanafelt, C. P. Forte, J. J. Kasper, L. Sanchez-Pescador, M. Wetzel, R. Gundel, and J. M. Greve (1998)
PNAS 95, 9454-9458
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Apoptosis by Tyrosine-Containing Domains of IL-4R{alpha}: Y497 and Y713, But Not the STAT6-Docking Tyrosines, Signal Protection from Apoptosis.

J. Zamorano and A. D. Keegan (1998)
J. Immunol. 161, 859-867
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-13 Receptor alpha ' But Not alpha  Chain: A Functional Component of Interleukin-4 Receptors.

T. Murata, J. Taguchi, and R. K. Puri (1998)
Blood 91, 3884-3891
 |  Abstract »  |  Full Text »  |  PDF »

Delineation of the Regions of Interleukin-2 (IL-2) Receptor beta  Chain Important for Association of Jak1 and Jak3. Jak1-INDEPENDENT FUNCTIONAL RECRUITMENT OF Jak3 TO IL-2Rbeta.

M.-h. Zhu, J. A. Berry, S. M. Russell, and W. J. Leonard (1998)
J. Biol. Chem. 273, 10719-10725
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells.

H. Huang and W. E. Paul (1998)
J. Exp. Med. 187, 1305-1313
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes.

H. Ogata, D. Ford, N. Kouttab, T. C. King, N. Vita, A. Minty, J. Stoeckler, D. Morgan, C. Girasole, J. W. Morgan, et al. (1998)
J. Biol. Chem. 273, 9864-9871
 |  Abstract »  |  Full Text »  |  PDF »

A Role for the Insulin-Interleukin (IL)-4 Receptor Motif of the IL-4 Receptor alpha -Chain in Regulating Activation of the Insulin Receptor Substrate 2 and Signal Transducer and Activator of Transcription 6 Pathways. ANALYSIS BY MUTAGENESIS.

H. Y. Wang, J. Zamorano, and A. D. Keegan (1998)
J. Biol. Chem. 273, 9898-9905
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Involvement of the IL-2 Receptor {gamma}-Chain ({gamma}c) in the Control by IL-4 of Human Monocyte and Macrophage Proinflammatory Mediator Production.

C. S. Bonder, H. L. Dickensheets, J. J. Finlay-Jones, R. P. Donnelly, and P. H. Hart (1998)
J. Immunol. 160, 4048-4056
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Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production.

K. Siemasko, A. S-F. Chong, H.-M. Jack, H. Gong, J. W. Williams, and A. Finnegan (1998)
J. Immunol. 160, 1581-1588
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The Association of Atopy with a Gain-of-Function Mutation in the {alpha} Subunit of the Interleukin-4 Receptor.

G. K. K. Hershey, M. F. Friedrich, L. A. Esswein, M. L. Thomas, and T. A. Chatila (1997)
N. Engl. J. Med. 337, 1720-1725
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Full Immunologic Reconstitution Following Nonconditioned Bone Marrow Transplantation for Canine X-Linked Severe Combined Immunodeficiency.

P. J. Felsburg, R. L. Somberg, B. J. Hartnett, S. F. Suter, P. S. Henthorn, P. F. Moore, K. I. Weinberg, and H. D. Ochs (1997)
Blood 90, 3214-3221
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Functional cleavage of the common cytokine receptor gamma  chain (gamma c) by calpain.

M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard (1997)
PNAS 94, 11534-11539
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HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor.

D. Wang, J. Zamorano, A. D. Keegan, and M. Boothby (1997)
J. Biol. Chem. 272, 25083-25090
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An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

N. Noben-Trauth, L. D. Shultz, F. Brombacher, J. F. Urban Jr., H. Gu, and W. E. Paul (1997)
PNAS 94, 10838-10843
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An Interleukin (IL)-13 Receptor Lacking the Cytoplasmic Domain Fails to Transduce IL-13-Induced Signals and Inhibits Responses to IL-4.

P. L. Orchansky, S. D. Ayres, D. J. Hilton, and J. W. Schrader (1997)
J. Biol. Chem. 272, 22940-22947
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Modulation of Interleukin (IL)-13 Binding and Signaling by the gamma c Chain of the IL-2 Receptor.

N. I. Obiri, T. Murata, W. Debinski, and R. K. Puri (1997)
J. Biol. Chem. 272, 20251-20258
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Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.

S. J. Haque, Q. Wu, W. Kammer, K. Friedrich, J. M. Smith, I. M. Kerr, G. R. Stark, and B. R. G. Williams (1997)
PNAS 94, 8563-8568
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Interleukin-15 Triggers Activation and Growth of the CD8 T-Cell Pool in Extravascular Tissues of Patients With Acquired Immunodeficiency Syndrome.

C. Agostini, L. Trentin, R. Sancetta, M. Facco, C. Tassinari, A. Cerutti, M. Bortolin, A. Milani, M. Siviero, R. Zambello, et al. (1997)
Blood 90, 1115-1123
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Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4.

A. Vella, T. K. Teague, J. Ihle, J. Kappler, and P. Marrack (1997)
J. Exp. Med. 186, 325-330
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Two Discrete Regions of Interleukin-2 (IL2) Receptor beta  Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase.

R. A. Kirken, M. G. Malabarba, J. Xu, L. DaSilva, R. A. Erwin, X. Liu, L. Hennighausen, H. Rui, and W. L. Farrar (1997)
J. Biol. Chem. 272, 15459-15465
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Clonal Proliferation and Cytokine Requirement of Murine Progenitors for Natural Killer Cells.

Y. Aiba, F. Hirayama, and M. Ogawa (1997)
Blood 89, 4005-4012
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Activation of Phosphatidylinositol 3-Kinase by Interleukin-13. AN INHIBITORY SIGNAL FOR INDUCIBLE NITRIC-OXIDE SYNTHASE EXPRESSION IN EPITHELIAL CELL LINE HT-29.

K. Wright, S. G. Ward, G. Kolios, and J. Westwick (1997)
J. Biol. Chem. 272, 12626-12633
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Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway.

A. Gonzalez-Garcia, I. Merida, C. Martinez-A, and A. C. Carrera (1997)
J. Biol. Chem. 272, 10220-10226
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Interleukin-4 Signaling in B Lymphocytes from Patients with X-linked Severe Combined Immunodeficiency.

N. Taylor, F. Candotti, S. Smith, S. A. Oakes, T. Jahn, J. Isakov, J. M. Puck, J. J. O'Shea, K. Weinberg, and J. A. Johnston (1997)
J. Biol. Chem. 272, 7314-7319
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A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha  chain.

Y. Wang, B.-J. Shen, and W. Sebald (1997)
PNAS 94, 1657-1662
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