Science 10 December 1993: Vol. 262. no. 5140, pp. 1734 - 1737 DOI: 10.1126/science.8259519

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Articles

In Pursuit of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor-5 Regulation and Function in the Uterus.

X. Sun, L. Jackson, S. K. Dey, and T. Daikoku (2009)
Endocrinology 150, 5065-5073
 |  Abstract »  |  Full Text »  |  PDF »

Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva.

L. Abbas and T. T. Whitfield (2009)
Development 136, 2837-2848
 |  Abstract »  |  Full Text »  |  PDF »

Expression of E-Cadherin, {beta}-Catenin and APC protein in Canine Colorectal Tumours.

B. RESTUCCI, M. MARTANO, G. DE VICO, L. LO MUZIO, and P. MAIOLINO (2009)
Anticancer Res 29, 2919-2925
 |  Abstract »  |  Full Text »  |  PDF »

Wnt Signaling from Development to Disease: Insights from Model Systems.

K. M. Cadigan and M. Peifer (2009)
Cold Spring Harb Perspect Biol 1, a002881
 |  Abstract »  |  Full Text »  |  PDF »

Scribble Interacts with {beta}-Catenin to Localize Synaptic Vesicles to Synapses.

Y. Sun, M. Aiga, E. Yoshida, P. O. Humbert, and S. X. Bamji (2009)
Mol. Biol. Cell 20, 3390-3400
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation.

W.-C. Lee, K. Beebe, L. Sudmeier, and C. A. Micchelli (2009)
Development 136, 2255-2264
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Link between the SAMP Repeats of Adenomatous Polyposis Coli Tumor Suppressor and the Src Homology 3 Domain of DDEF.

C. Matsui, S. Kaieda, T. Ikegami, and Y. Mimori-Kiyosue (2008)
J. Biol. Chem. 283, 33006-33020
 |  Abstract »  |  Full Text »  |  PDF »

Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours.

E. M. Kohler, A. Derungs, G. Daum, J. Behrens, and J. Schneikert (2008)
Hum. Mol. Genet. 17, 1978-1987
 |  Abstract »  |  Full Text »  |  PDF »

Human Colon Cancer Stem Cells: A New Paradigm in Gastrointestinal Oncology.

B. M. Boman and E. Huang (2008)
J. Clin. Oncol. 26, 2828-2838
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Rare Nonsynonymous Variants in the Adenomatous Polyposis Coli Gene Predispose to Colorectal Adenomas.

D. Azzopardi, A. R. Dallosso, K. Eliason, B. C. Hendrickson, N. Jones, E. Rawstorne, J. Colley, V. Moskvina, C. Frye, J. R. Sampson, et al. (2008)
Cancer Res. 68, 358-363
 |  Abstract »  |  Full Text »  |  PDF »

The Intercalated Disc Protein, mXin{alpha}, Is Capable of Interacting with -Catenin and Bundling Actin Filaments.

S. Choi, E. A. Gustafson-Wagner, Q. Wang, S. M. Harlan, H. W. Sinn, J. L.-C. Lin, and J. J.-C. Lin (2007)
J. Biol. Chem. 282, 36024-36036
 |  Abstract »  |  Full Text »  |  PDF »

The genetics of hereditary colon cancer.

A. K. Rustgi (2007)
Genes & Dev. 21, 2525-2538
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.

K. Aoki and M. M. Taketo (2007)
J. Cell Sci. 120, 3327-3335
 |  Abstract »  |  Full Text »  |  PDF »

Axin Inhibits Extracellular Signal-regulated Kinase Pathway by Ras Degradation via beta-Catenin.

S. H. Jeon, J.-Y. Yoon, Y.-N. Park, W.-J. Jeong, S. Kim, E.-H. Jho, Y.-J. Surh, and K.-Y. Choi (2007)
J. Biol. Chem. 282, 14482-14492
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Binding of Adenomatous Polyposis Coli Protein to Actin.

J. B. Moseley, F. Bartolini, K. Okada, Y. Wen, G. G. Gundersen, and B. L. Goode (2007)
J. Biol. Chem. 282, 12661-12668
 |  Abstract »  |  Full Text »  |  PDF »

Cinderella no longer: {alpha}-catenin steps out of cadherin's shadow.

J. A. Scott and A. S. Yap (2006)
J. Cell Sci. 119, 4599-4605
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Pathologic Aspects of Endometrial Carcinogenesis.

J. L. Hecht and G. L. Mutter (2006)
J. Clin. Oncol. 24, 4783-4791
 |  Abstract »  |  Full Text »  |  PDF »

An interlocker concept of carcinogenesis..

L. W. Wattenberg (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 1425-1426
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous Polyposis Coli on Microtubule Plus Ends in Cell Extensions Can Promote Microtubule Net Growth with or without EB1.

K. Kita, T. Wittmann, I. S. Nathke, and C. M. Waterman-Storer (2006)
Mol. Biol. Cell 17, 2331-2345
 |  Abstract »  |  Full Text »  |  PDF »

Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention..

E. Krieghoff, J. Behrens, and B. Mayr (2006)
J. Cell Sci. 119, 1453-1463
 |  Abstract »  |  Full Text »  |  PDF »

Neurotensin receptor 1 gene activation by the Tcf/{beta}-catenin pathway is an early event in human colonic adenomas.

F. Souaze, V. Viardot-Foucault, N. Roullet, M. Toy-Miou-Leong, A. Gompel, E. Bruyneel, E. Comperat, M. C Faux, M. Mareel, W. Rostene, et al. (2006)
Carcinogenesis 27, 708-716
 |  Abstract »  |  Full Text »  |  PDF »

Emerging role of KLF4 in human gastrointestinal cancer.

D. Wei, M. Kanai, S. Huang, and K. Xie (2006)
Carcinogenesis 27, 23-31
 |  Abstract »  |  Full Text »  |  PDF »

MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3{beta}-Mediated Phosphorylation and Degradation of {beta}-Catenin.

L. Huang, D. Chen, D. Liu, L. Yin, S. Kharbanda, and D. Kufe (2005)
Cancer Res. 65, 10413-10422
 |  Abstract »  |  Full Text »  |  PDF »

Overexpressed {beta}-Catenin Blocks Nitric Oxide-Induced Apoptosis in Colonic Cancer Cells.

H. Wang and W. K. MacNaughton (2005)
Cancer Res. 65, 8604-8607
 |  Abstract »  |  Full Text »  |  PDF »

Crosstalk between NF-{kappa}B and {beta}-catenin pathways in bacterial-colonized intestinal epithelial cells.

J. Sun, M. E. Hobert, Y. Duan, A. S. Rao, T.-C. He, E. B. Chang, and J. L. Madara (2005)
Am J Physiol Gastrointest Liver Physiol 289, G129-G137
 |  Abstract »  |  Full Text »  |  PDF »

Self-Renewal and Cancer of the Gut: Two Sides of a Coin.

F. Radtke and H. Clevers (2005)
Science 307, 1904-1909
 |  Abstract »  |  Full Text »  |  PDF »

Systematic Peptide Array-based Delineation of the Differential {beta}-Catenin Interaction with Tcf4, E-Cadherin, and Adenomatous Polyposis Coli.

R. Gail, R. Frank, and A. Wittinghofer (2005)
J. Biol. Chem. 280, 7107-7117
 |  Abstract »  |  Full Text »  |  PDF »

Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end.

K. C. Slep, S. L. Rogers, S. L. Elliott, H. Ohkura, P. A. Kolodziej, and R. D. Vale (2005)
J. Cell Biol. 168, 587-598
 |  Abstract »  |  Full Text »  |  PDF »

The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro.

K. Steigerwald, G. K. Behbehani, K. A. Combs, M. C. Barton, and J. Groden (2005)
Mol. Cancer Res. 3, 78-89
 |  Abstract »  |  Full Text »  |  PDF »

Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4.

R. Gonzalez-Quevedo, M. Shoffer, L. Horng, and A. E. Oro (2005)
J. Cell Biol. 168, 453-463
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin.

J. Choi, S. Y. Park, F. Costantini, E.-h. Jho, and C.-K. Joo (2004)
J. Biol. Chem. 279, 49188-49198
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice.

J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. (2004)
Mol. Cell. Biol. 24, 7598-7611
 |  Abstract »  |  Full Text »  |  PDF »

APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study.

M. Luchtenborg, M. P. Weijenberg, G. M. J. M. Roemen, A. P. de Bruine, P. A. van den Brandt, M. H. F. M. Lentjes, M. Brink, M. van Engeland, R. A. Goldbohm, and A. F. P. M. de Goeij (2004)
Carcinogenesis 25, 1219-1226
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor, c-MET, {beta}-Catenin, and p53 Expression as Prognostic Indicators in Stage II Colon Cancer: A Tissue Microarray Study.

M. B. Resnick, J. Routhier, T. Konkin, E. Sabo, and V. E. Pricolo (2004)
Clin. Cancer Res. 10, 3069-3075
 |  Abstract »  |  Full Text »  |  PDF »

Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-{beta} Signaling, as a Target of the {beta}-Catenin Pathway in Colorectal Tumor Cells.

T. Sekiya, S. Adachi, K. Kohu, T. Yamada, O. Higuchi, Y. Furukawa, Y. Nakamura, T. Nakamura, K. Tashiro, S. Kuhara, et al. (2004)
J. Biol. Chem. 279, 6840-6846
 |  Abstract »  |  Full Text »  |  PDF »

Glucocorticoids Control {beta}-Catenin Protein Expression and Localization through Distinct Pathways that Can Be Uncoupled by Disruption of Signaling Events Required for Tight Junction Formation in Rat Mammary Epithelial Tumor Cells.

Y. Guan, N. M. Rubenstein, K. L. Failor, P. L. Woo, and G. L. Firestone (2004)
Mol. Endocrinol. 18, 214-227
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse.

N. F. Paoni, M. W. Feldman, L. S. Gutierrez, V. A. Ploplis, and F. J. Castellino (2003)
Physiol Genomics 15, 228-235
 |  Abstract »  |  Full Text »  |  PDF »

Eradication of pathogenic {beta}-catenin by Skp1/Cullin/F box ubiquitination machinery.

Y. Su, S. Ishikawa, M. Kojima, and B. Liu (2003)
PNAS 100, 12729-12734
 |  Abstract »  |  Full Text »  |  PDF »

Novel Candidate Targets of {beta}-Catenin/T-cell Factor Signaling Identified by Gene Expression Profiling of Ovarian Endometrioid Adenocarcinomas.

D. R. Schwartz, R. Wu, S. L. R. Kardia, A. M. Levin, C.-C. Huang, K. A. Shedden, R. Kuick, D. E. Misek, S. M. Hanash, J. M. G. Taylor, et al. (2003)
Cancer Res. 63, 2913-2922
 |  Abstract »  |  Full Text »  |  PDF »

The Human T-Cell Factor-4 Gene Splicing Isoforms, Wnt Signal Pathway, and Apoptosis in Renal Cell Carcinoma.

H. Shiina, M. Igawa, J. Breault, L. Ribeiro-Filho, D. Pookot, S. Urakami, M. Terashima, M. Deguchi, M. Yamanaka, M. Shirai, et al. (2003)
Clin. Cancer Res. 9, 2121-2132
 |  Abstract »  |  Full Text »  |  PDF »

Clinical, Cellular, and Molecular Aspects of Cancer Invasion.

M. Mareel and A. Leroy (2003)
Physiol Rev 83, 337-376
 |  Abstract »  |  Full Text »  |  PDF »

Small Interfering RNAs Directed against {beta}-Catenin Inhibit the in Vitro and in Vivo Growth of Colon Cancer Cells.

U. N. Verma, R. M. Surabhi, A. Schmaltieg, C. Becerra, and R. B. Gaynor (2003)
Clin. Cancer Res. 9, 1291-1300
 |  Abstract »  |  Full Text »  |  PDF »

Genetics - cellular basis: Advances in colorectal cancer.

A. Buda and M. Pignatelli (2002)
Br. Med. Bull. 64, 45-58
 |  Abstract »  |  Full Text »  |  PDF »

APC-dependent suppression of colon carcinogenesis by PPARgamma.

G. D. Girnun, W. M. Smith, S. Drori, P. Sarraf, E. Mueller, C. Eng, P. Nambiar, D. W. Rosenberg, R. T. Bronson, W. Edelmann, et al. (2002)
PNAS 99, 13771-13776
 |  Abstract »  |  Full Text »  |  PDF »

The Genetics of Colorectal Cancer.

P. M. Calvert and H. Frucht (2002)
Ann Intern Med 137, 603-612
 |  Abstract »  |  Full Text »  |  PDF »

A novel aberrant splice site mutation in the APC gene.

G S Charames, H Cheng, C A Gilpin, A G W Hunter, T Berk, and B Bapat (2002)
J. Med. Genet. 39, 754-757
 |  Full Text »  |  PDF »

PC-SPES Inhibits Colon Cancer Growth in Vitro and in Vivo.

S. Huerta, J. R. Arteaga, R. W. Irwin, T. Ikezoe, D. Heber, and H. P. Koeffler (2002)
Cancer Res. 62, 5204-5209
 |  Abstract »  |  Full Text »  |  PDF »

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta -catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.

T. Schwarz-Romond, C. Asbrand, J. Bakkers, M. Kuhl, H.-J. Schaeffer, J. Huelsken, J. Behrens, M. Hammerschmidt, and W. Birchmeier (2002)
Genes & Dev. 16, 2073-2084
 |  Abstract »  |  Full Text »  |  PDF »

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the {beta}-catenin signaling cascade.

C. Albuquerque, C. Breukel, R. van der Luijt, P. Fidalgo, P. Lage, F. J.M. Slors, C. N. Leitao, R. Fodde, and R. Smits (2002)
Hum. Mol. Genet. 11, 1549-1560
 |  Abstract »  |  Full Text »  |  PDF »

Targeted inactivation of CTNNB1 reveals unexpected effects of beta -catenin mutation.

T. A. Chan, Z. Wang, L. H. Dang, B. Vogelstein, and K. W. Kinzler (2002)
PNAS 99, 8265-8270
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable beta -Catenin Protein.

Z. Weng, M. Xin, L. Pablo, D. Grueneberg, M. Hagel, G. Bain, T. Muller, and J. Papkoff (2002)
J. Biol. Chem. 277, 18677-18686
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C delta Regulates Function of the DF3/MUC1 Carcinoma Antigen in beta -Catenin Signaling.

J. Ren, Y. Li, and D. Kufe (2002)
J. Biol. Chem. 277, 17616-17622
 |  Abstract »  |  Full Text »  |  PDF »

Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.

M. K. Homma, D. Li, E. G. Krebs, Y. Yuasa, and Y. Homma (2002)
PNAS 99, 5959-5964
 |  Abstract »  |  Full Text »  |  PDF »

Expression status of E-cadherin and {alpha}-, {beta}-, and {gamma}-catenins in thymoma.

I. Yoshino, S. Kase, T. Yano, K. Sugio, and K. Sugimachi (2002)
Ann. Thorac. Surg. 73, 933-937
 |  Abstract »  |  Full Text »  |  PDF »

1{alpha},25-(OH)2-D3 and Its Synthetic Analogue Decrease Tumor Load in the Apcmin Mouse.

S. Huerta, R. W. Irwin, D. Heber, V. L. W. Go, H. P. Koeffler, M. R. Uskokovic, and D. M. Harris (2002)
Cancer Res. 62, 741-746
 |  Abstract »  |  Full Text »  |  PDF »

Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein.

F. Zhang, R. L. White, and K. L. Neufeld (2001)
Mol. Cell. Biol. 21, 8143-8156
 |  Abstract »  |  Full Text »  |  PDF »

Tissue Microarray Analysis of {beta}-Catenin in Colorectal Cancer Shows Nuclear Phospho-{beta}-catenin Is Associated with a Better Prognosis.

G. G. Chung, E. Provost, E. P. Kielhorn, L. A. Charette, B. L. Smith, and D. L. Rimm (2001)
Clin. Cancer Res. 7, 4013-4020
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of beta -Catenin Function by the Ikappa B Kinases.

C. Lamberti, K.-M. Lin, Y. Yamamoto, U. Verma, I. M. Verma, S. Byers, and R. B. Gaynor (2001)
J. Biol. Chem. 276, 42276-42286
 |  Abstract »  |  Full Text »  |  PDF »

Genetics of Nonmelanoma Skin Cancer.

H. Tsao (2001)
Arch Dermatol 137, 1486-1492
 |  Abstract »  |  Full Text »  |  PDF »

Axin-dependent Phosphorylation of the Adenomatous Polyposis Coli Protein Mediated by Casein Kinase 1epsilon.

B. Rubinfeld, D. A. Tice, and P. Polakis (2001)
J. Biol. Chem. 276, 39037-39045
 |  Abstract »  |  Full Text »  |  PDF »

Alterations of {beta}- and {gamma}-Catenin in N-Butyl-N-(-4-hydroxybutyl)nitrosamine-induced Murine Bladder Cancer.

H. Shiina, M. Igawa, S. Urakami, K. Shigeno, T. Yoneda, M. Terashima, M. Deguchi, L. Ribeiro-Filho, and R. Dahiya (2001)
Cancer Res. 61, 7101-7109
 |  Abstract »  |  Full Text »  |  PDF »

Cyclooxygenase-independent actions of cyclooxygenase inhibitors.

I. TEGEDER, J. PFEILSCHIFTER, and G. GEISSLINGER (2001)
FASEB J 15, 2057-2072
 |  Abstract »  |  Full Text »  |  PDF »

Where is APC going?.

Y. Mimori-Kiyosue and S. Tsukita (2001)
J. Cell Biol. 154, 1105-1110
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of {beta}-Catenin Inhibits the Neoplastic Growth of APC-Mutant Colon Cancer Cells.

H. Roh, D. W. Green, C. B. Boswell, J. A. Pippin, and J. A. Drebin (2001)
Cancer Res. 61, 6563-6568
 |  Abstract »  |  Full Text »  |  PDF »

The Divergent Caenorhabditis elegans {beta}-Catenin Proteins BAR-1, WRM-1 and HMP-2 Make Distinct Protein Interactions but Retain Functional Redundancy in Vivo.

L. Natarajan, N. E. Witwer, and D. M. Eisenmann (2001)
Genetics 159, 159-172
 |  Abstract »  |  Full Text »  |  PDF »

What we could do now: molecular pathology of colorectal cancer.

R S Houlston (2001)
Mol. Pathol. 54, 206-214
 |  Abstract »  |  Full Text »  |  PDF »

Genetic alterations and growth pattern in biliary duct carcinomas: loss of heterozygosity at chromosome 5q bears a close relation with polypoid growth.

E Hidaka, A Yanagisawa, M Seki, T Setoguchi, and Y Kato (2001)
Gut 48, 656-659
 |  Abstract »  |  Full Text »  |  PDF »

The ABC of APC.

N. S. Fearnhead, M. P. Britton, and W. F. Bodmer (2001)
Hum. Mol. Genet. 10, 721-733
 |  Abstract »  |  Full Text »  |  PDF »

A distinct splice form of APC is highly expressed in neurones but not commonly mutated in neuroepithelial tumours.

K. STEIGERWALD, I. M SANTORO, J. J KORDICH, V. GISMONDI, C. TRZEPACZ, M. BADIALI, F GIANGASPERO, M G. BALKO, J. S GRAHAM, N. RATNER, et al. (2001)
J. Med. Genet. 38, 257-262
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Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells.

C. Decaens and D. Cassio (2001)
Am J Physiol Cell Physiol 280, C527-C539
 |  Abstract »  |  Full Text »  |  PDF »

Apical Membrane Localization of the Adenomatous Polyposis Coli Tumor Suppressor Protein and Subcellular Distribution of the {beta}-Catenin Destruction Complex in Polarized Epithelial Cells.

A. Reinacher-Schick and B. M. Gumbiner (2001)
J. Cell Biol. 152, 491-502
 |  Abstract »  |  Full Text »  |  PDF »

Gas6 Induces Growth, {beta}-Catenin Stabilization, and T-Cell Factor Transcriptional Activation in Contact-Inhibited C57 Mammary Cells.

S. Goruppi, C. Chiaruttini, M. E. Ruaro, B. Varnum, and C. Schneider (2001)
Mol. Cell. Biol. 21, 902-915
 |  Abstract »  |  Full Text »

WNT-1 Signaling Inhibits Apoptosis by Activating {beta}-Catenin/T Cell Factor-Mediated Transcription.

S. Chen, D. C. Guttridge, Z. You, Z. Zhang, A. Fribley, M. W. Mayo, J. Kitajewski, and C.-Y. Wang (2001)
J. Cell Biol. 152, 87-96
 |  Abstract »  |  Full Text »  |  PDF »

A Possible Role for the Wnt~1 Pathway in Oral Carcinogenesis.

L. Lo Muzio (2001)
Critical Reviews in Oral Biology & Medicine 12, 152-165
 |  Abstract »  |  Full Text »  |  PDF »

Mutant E-cadherin Breast Cancer Cells Do Not Display Constitutive Wnt Signaling.

M. van de Wetering, N. Barker, I. C. Harkes, M. van der Heyden, N. J. Dijk, A. Hollestelle, J. G. M. Klijn, H. Clevers, and M. Schutte (2001)
Cancer Res. 61, 278-284
 |  Abstract »  |  Full Text »

Expression of E-cadherin and {beta}-Catenin in Human Non-Small Cell Lung Cancer and the Clinical Significance.

S. Kase, K. Sugio, K. Yamazaki, T. Okamoto, T. Yano, and K. Sugimachi (2000)
Clin. Cancer Res. 6, 4789-4796
 |  Abstract »  |  Full Text »

{beta}-Catenin Mutations Are Associated with a Subset of Low-Stage Hepatocellular Carcinoma Negative for Hepatitis B Virus and with Favorable Prognosis.

H.-C. Hsu, Y.-M. Jeng, T.-L. Mao, J.-S. Chu, P.-L. Lai, and S.-Y. Peng (2000)
Am. J. Pathol. 157, 763-770
 |  Abstract »  |  Full Text »  |  PDF »

Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling.

Y. Kawasaki, T. Senda, T. Ishidate, R. Koyama, T. Morishita, Y. Iwayama, O. Higuchi, and T. Akiyama (2000)
Science 289, 1194-1197
 |  Abstract »  |  Full Text »

Molecular pathogenesis of oral squamous carcinoma.

H K Williams (2000)
Mol. Pathol. 53, 165-172
 |  Abstract »  |  Full Text »

Wnt signaling and cancer.

P. Polakis (2000)
Genes & Dev. 14, 1837-1851
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gamma -Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta -catenin.

F. T. Kolligs, B. Kolligs, K. M. Hajra, G. Hu, M. Tani, K. R. Cho, and E. R. Fearon (2000)
Genes & Dev. 14, 1319-1331
 |  Abstract »  |  Full Text »

Biology of the Adenomatous Polyposis Coli Tumor Suppressor.

K. H. Goss and J. Groden (2000)
J. Clin. Oncol. 18, 1967-1979
 |  Abstract »  |  Full Text »  |  PDF »

Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis.

N. N. Mahmoud, A. M. Carothers, D. Grunberger, R. T. Bilinski, M. R. Churchill, C. Martucci, H. L. Newmark, and M. M. Bertagnolli (2000)
Carcinogenesis 21, 921-927
 |  Abstract »  |  Full Text »  |  PDF »

E-Cadherin Expression in Melanoma Cells Restores Keratinocyte-Mediated Growth Control and Down-Regulates Expression of Invasion-Related Adhesion Receptors.

M.-Y. Hsu, F. E. Meier, M. Nesbit, J.-Y. Hsu, P. Van Belle, D. E. Elder, and M. Herlyn (2000)
Am. J. Pathol. 156, 1515-1525
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of beta -Catenin by the Colorectal Tumor Suppressor APC Requires Association with Axin and beta -Catenin.

K. Kawahara, T. Morishita, T. Nakamura, F. Hamada, K. Toyoshima, and T. Akiyama (2000)
J. Biol. Chem. 275, 8369-8374
 |  Abstract »  |  Full Text »  |  PDF »

The {beta}-Catenin Binding Domain of Adenomatous Polyposis Coli Is Sufficient for Tumor Suppression.

I.-M. Shih, J. Yu, T.-C. He, B. Vogelstein, and K. W. Kinzler (2000)
Cancer Res. 60, 1671-1676
 |  Abstract »  |  Full Text »

Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification.

G. H. Farr III, D. M. Ferkey, C. Yost, S. B. Pierce, C. Weaver, and D. Kimelman (2000)
J. Cell Biol. 148, 691-702
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells.

Y. Mimori-Kiyosue, N. Shiina, and S. Tsukita (2000)
J. Cell Biol. 148, 505-518
 |  Abstract »  |  Full Text »  |  PDF »

The Relationship Between Frequencies of Extracolonic Manifestations and the Position of APC Germline Mutation in Patients with Familial Adenomatous Polyposis.

M. Enomoto, M. Konishi, T. Iwama, J. Utsunomiya, K.-i. Sugihara, and M. Miyaki (2000)
Jpn. J. Clin. Oncol. 30, 82-88
 |  Abstract »  |  Full Text »  |  PDF »

Altered Expression of {beta}-Catenin in Renal Cell Cancer and Transitional Cell Cancer with the Absence of {beta}-catenin Gene Mutations.

V. Bilim, T. Kawasaki, A. Katagiri, S.-j. Wakatsuki, K. Takahashi, and Y. Tomita (2000)
Clin. Cancer Res. 6, 460-466
 |  Abstract »  |  Full Text »

Plakoglobin and beta-catenin: protein interactions, regulation and biological roles.

J Zhurinsky, M Shtutman, and A Ben-Ze'ev (2000)
J. Cell Sci. 113, 3127-3139
 |  Abstract »  |  PDF »

The p120 catenin family: complex roles in adhesion, signaling and cancer.

P. Anastasiadis and A. Reynolds (2000)
J. Cell Sci. 113, 1319-1334
 |  Abstract »  |  PDF »

Mitotic Checkpoints, Genetic Instability, and Cancer.

M. DOBLES and P.K. SORGER (2000)
Cold Spring Harb Symp Quant Biol 65, 361-368
 |  Abstract »  |  PDF »

APCL, a Central Nervous System-specific Homologue of Adenomatous Polyposis Coli Tumor Suppressor, Binds to p53-binding Protein 2 and Translocates it to the Perinucleus.

H. Nakagawa, K. Koyama, Y. Murata, M. Morito, T. Akiyama, and Y. Nakamura (2000)
Cancer Res. 60, 101-105
 |  Abstract »  |  Full Text »

Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation.

S. Roura, S. Miravet, J. Piedra, A. G. de Herreros, and M. Dunach (1999)
J. Biol. Chem. 274, 36734-36740
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Gene Expression in Human Bullous Keratopathy Corneas Containing Limiting Amounts of RNA.

K. S. Spirin, A. V. Ljubimov, R. Castellon, O. Wiedoeft, M. Marano, D. Sheppard, M. C. Kenney, and D. J. Brown (1999)
Invest. Ophthalmol. Vis. Sci. 40, 3108-3115
 |  Abstract »  |  Full Text »  |  PDF »

Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level.

L. C. Hsi, J. Angerman-Stewart, and T. E. Eling (1999)
Carcinogenesis 20, 2045-2049
 |  Abstract »  |  Full Text »  |  PDF »

Butyrate-induced Apoptotic Cascade in Colonic Carcinoma Cells: Modulation of the {beta}-Catenin-Tcf Pathway and Concordance with Effects of Sulindac and Trichostatin A but not Curcumin.

M. Bordonaro, J. M. Mariadason, F. Aslam, B. G. Heerdt, and L. H. Augenlicht (1999)
Cell Growth Differ. 10, 713-720
 |  Abstract »  |  Full Text »

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