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Science 3 December 1993:
Vol. 262. no. 5139, pp. 1575 - 1579
DOI: 10.1126/science.7504325
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Articles

Science, Vol 262, Issue 5139, 1575-1579
Copyright © 1993 by American Association for the Advancement of Science

articles

Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus

A Bonni, DA Frank, C Schindler, and ME Greenberg

Program in Neuroscience, Harvard Medical School, Boston, MA 02115.

Components of a signaling pathway that couples the ciliary neurotrophic factor (CNTF) receptor to induction of transcription were identified. CNTF stimulated the tyrosine phosphorylation of p91, a protein implicated in interferon signaling pathways, and of two proteins that are distinct but related to p91. Tyrosine-phosphorylated p91 translocated to the nucleus, where p91 and p91-related proteins bound to a DNA sequence found in promoters of genes responsive to CNTF. This DNA sequence, when inserted upstream of a reporter gene, conferred a transcriptional response to CNTF. A pathway that transduces interferon signals may therefore have a more general function in the propagation of responses to certain neurotrophic factors.


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