Science 3 December 1993: Vol. 262. no. 5139, pp. 1557 - 1560 DOI: 10.1126/science.8248803

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Multiple Levels of Redundant Processes Inhibit Caenorhabditis elegans Vulval Cell Fates.

E. C. Andersen, A. M. Saffer, and H. R. Horvitz (2008)
Genetics 179, 2001-2012
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Human TFDP3, a Novel DP Protein, Inhibits DNA Binding and Transactivation by E2F.

H. Qiao, L. Di Stefano, C. Tian, Y.-Y. Li, Y.-H. Yin, X.-P. Qian, X.-W. Pang, Y. Li, M. A. McNutt, K. Helin, et al. (2007)
J. Biol. Chem. 282, 454-466
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Lamina-associated polypeptide 2{alpha} regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway..

D. Dorner, S. Vlcek, N. Foeger, A. Gajewski, C. Makolm, J. Gotzmann, C. J. Hutchison, and R. Foisner (2006)
J. Cell Biol. 173, 83-93
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Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway.

S.-i. Matsuzawa, M. Cuddy, T. Fukushima, and J. C. Reed (2005)
PNAS 102, 14982-14987
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Identification and Characterization of Novel Isoforms of Human DP-1: DP-1{alpha} REGULATES THE TRANSCRIPTIONAL ACTIVITY OF E2F1 AS WELL AS CELL CYCLE PROGRESSION IN A DOMINANT-NEGATIVE MANNER.

H. Ishida, Y. Masuhiro, A. Fukushima, J. G. M. Argueta, N. Yamaguchi, S. Shiota, and S. Hanazawa (2005)
J. Biol. Chem. 280, 24642-24648
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The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II.

A. Yart, M. Gstaiger, C. Wirbelauer, M. Pecnik, D. Anastasiou, D. Hess, and W. Krek (2005)
Mol. Cell. Biol. 25, 5052-5060
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E2F-Dependent Repression of Topoisomerase II Regulates Heterochromatin Formation and Apoptosis in Cells with Melanoma-Prone Mutation.

W. Jiao, H.-M. Lin, J. Timmons, A. K. Nagaich, S.-W. Ng, T. Misteli, and S. G. Rane (2005)
Cancer Res. 65, 4067-4077
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ORF73 of Herpesvirus Saimiri, a Viral Homolog of Kaposi's Sarcoma-Associated Herpesvirus, Modulates the Two Cellular Tumor Suppressor Proteins p53 and pRb.

S. Borah, S. C. Verma, and E. S. Robertson (2004)
J. Virol. 78, 10336-10347
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Cul7/p185/p193 Binding to Simian Virus 40 Large T Antigen Has a Role in Cellular Transformation.

S. H. Ali, J. S. Kasper, T. Arai, and J. A. DeCaprio (2004)
J. Virol. 78, 2749-2757
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Transforming Growth Factor {beta}-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element.

J. P. Frederick, N. T. Liberati, D. S. Waddell, Y. Shi, and X.-F. Wang (2004)
Mol. Cell. Biol. 24, 2546-2559
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Extracellular Matrix Enhances Heregulin-Dependent BRCA1 Phosphorylation and Suppresses BRCA1 Expression through Its C Terminus.

T. Miralem and H. K. Avraham (2003)
Mol. Cell. Biol. 23, 579-593
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Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.

C. Lee, J. H. Chang, H. S. Lee, and Y. Cho (2002)
Genes & Dev. 16, 3199-3212
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Retinoblastoma Function Is a Better Indicator of Cellular Phenotype in Cultured Breast Adenocarcinoma Cells than Retinoblastoma Expression.

J. Botos, R. Smith III, and D. T. Kochevar (2002)
Experimental Biology and Medicine 227, 354-362
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Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo.

J. E. Cloud, C. Rogers, T. L. Reza, U. Ziebold, J. R. Stone, M. H. Picard, A. M. Caron, R. T. Bronson, and J. A. Lees (2002)
Mol. Cell. Biol. 22, 2663-2672
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Nuclear membrane protein LAP2{beta} mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less).

E. Nili, G. S. Cojocaru, Y. Kalma, D. Ginsberg, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, R. Berger, S. Shaklai, N. Amariglio, et al. (2002)
J. Cell Sci. 114, 3297-3307
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Nucleocytoplasmic Shuttling of p130/RBL2: Novel Regulatory Mechanism.

A. Chestukhin, L. Litovchick, K. Rudich, and J. A. DeCaprio (2002)
Mol. Cell. Biol. 22, 453-468
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Unbound E2F modulates TGF-{beta}1-induced apoptosis in HuH-7 cells.

G. Fan, X. Ma, B. T. Kren, and C. J. Steer (2002)
J. Cell Sci. 115, 3181-3191
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Ras Induces Elevation of E2F-1 mRNA Levels.

E. Berkovich and D. Ginsberg (2001)
J. Biol. Chem. 276, 42851-42856
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E-cadherin regulates cell growth by modulating proliferation-dependent {beta}-catenin transcriptional activity.

A. Stockinger, A. Eger, J. Wolf, H. Beug, and R. Foisner (2001)
J. Cell Biol. 154, 1185-1196
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UCN-01 Suppresses E2F-1 Mediated by Ubiquitin-proteasome-dependent Degradation.

C.-T. Hsueh, Y.-C. Wu, and G. K. Schwartz (2001)
Clin. Cancer Res. 7, 669-674
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E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner.

S. Gaubatz, J. A. Lees, G. J. Lindeman, and D. M. Livingston (2001)
Mol. Cell. Biol. 21, 1384-1392
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Loss of p19ARF Eliminates the Requirement for the pRB-Binding Motif in Simian Virus 40 Large T Antigen-Mediated Transformation.

H. H. A. Chao, A. M. Buchmann, and J. A. DeCaprio (2000)
Mol. Cell. Biol. 20, 7624-7633
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Deregulated E2F-1 blocks terminal differentiation and loss of leukemogenicity of M1 myeloblastic leukemia cells without abrogating induction of p15INK4B and p16INK4A.

A. Amanullah, B. Hoffman, and D. A. Liebermann (2000)
Blood 96, 475-482
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Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb.

M. FANCIULLI, T. BRUNO, M. DI PADOVA, R. DE ANGELIS, S. IEZZI, C. IACOBINI, A. FLORIDI, and C. PASSANANTI (2000)
FASEB J 14, 904-912
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Distinct Cellular Factors Regulate the c-myb Promoter through Its E2F Element.

M. R. Campanero, M. Armstrong, and E. Flemington (1999)
Mol. Cell. Biol. 19, 8442-8450
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Characterization of CELO Virus Proteins That Modulate the pRb/E2F Pathway.

H. Lehrmann and M. Cotten (1999)
J. Virol. 73, 6517-6525
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Transcriptional Activation of E2F1 Gene Expression by 17{beta}-Estradiol in MCF-7 Cells Is Regulated by NF-Y-Sp1/Estrogen Receptor Interactions.

W. Wang, L. Dong, B. Saville, and S. Safe (1999)
Mol. Endocrinol. 13, 1373-1387
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Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity.

V. D. Brown, R. A. Phillips, and B. L. Gallie (1999)
Mol. Cell. Biol. 19, 3246-3256
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Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.

N. Zheng, E. Fraenkel, C. O. Pabo, and N. P. Pavletich (1999)
Genes & Dev. 13, 666-674
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E2F-1 Has Properties of a Radiosensitizer and Its Regulation by Cyclin A Kinase Is Required for Cell Survival of Fibrosarcoma Cells Lacking p53.

M. Pruschy, C. Wirbelauer, C. Glanzmann, S. Bodis, and W. Krek (1999)
Cell Growth Differ. 10, 141-146
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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.

O. Iliopoulos, M. Ohh, and W. G. Kaelin Jr. (1998)
PNAS 95, 11661-11666
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Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16INK4A-negative T-cell Line.

I. Lemasson, S. Thebault, C. Sardet, C. Devaux, and J.-M. Mesnard (1998)
J. Biol. Chem. 273, 23598-23604
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Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.

S. Gaubatz, J. G. Wood, and D. M. Livingston (1998)
PNAS 95, 9190-9195
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The regulation of E2F by pRB-family proteins.

N. Dyson (1998)
Genes & Dev. 12, 2245-2262
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E2F-6, a member of the E2F family that can behave as a transcriptional repressor.

J. M. Trimarchi, B. Fairchild, R. Verona, K. Moberg, N. Andon, and J. A. Lees (1998)
PNAS 95, 2850-2855
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The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins.

J. Zalvide, H. Stubdal, and J. A. DeCaprio (1998)
Mol. Cell. Biol. 18, 1408-1415
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Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes.

A. S. Lundberg and R. A. Weinberg (1998)
Mol. Cell. Biol. 18, 753-761
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Mutations of the Drosophila dDP, dE2F, and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G1-S Transition.

R. J. Duronio, P. C. Bonnette, and P. H. O'Farrell (1998)
Mol. Cell. Biol. 18, 141-151
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Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth.

W. R. Sellers, B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. B. Lassar, and W. G. Kaelin Jr. (1998)
Genes & Dev. 12, 95-106
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Constitutive Protection of E2F Recognition Sequences in the Human Thymidine Kinase Promoter during Cell Cycle Progression.

S. Tommasi and G. P. Pfeifer (1997)
J. Biol. Chem. 272, 30483-30490
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PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.

S. Altiok, M. Xu, and B. M. Spiegelman (1997)
Genes & Dev. 11, 1987-1998
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The subcellular localization of E2F-4 is cell-cycle dependent.

G. J. Lindeman, S. Gaubatz, D. M. Livingston, and D. Ginsberg (1997)
PNAS 94, 5095-5100
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein.

M. R. Campanero and E. K. Flemington (1997)
PNAS 94, 2221-2226
 |  Abstract »  |  Full Text »  |  PDF »

Accumulation of E2F-4·DP-1 DNA Binding Complexes Correlates with Induction of dhfr Gene Expression during the G1 to S Phase Transition.

J. M. Wells, S. Illenye, J. Magae, C.-L. Wu, and N. H. Heintz (1997)
J. Biol. Chem. 272, 4483-4492
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Identification, Cloning, and Characterization of Cystatin M, a Novel Cysteine Proteinase Inhibitor, Down-regulated in Breast Cancer.

G. Sotiropoulou, A. Anisowicz, and R. Sager (1997)
J. Biol. Chem. 272, 903-910
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Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit..

F Hofmann and D M Livingston (1996)
Genes & Dev. 10, 851-861
 |  Abstract »  |  PDF »

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal.

S de la Luna, M. Burden, C. Lee, and N. La Thangue (1996)
J. Cell Sci. 109, 2443-2452
 |  Abstract »  |  PDF »

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.

J Magae, C. Wu, S Illenye, E Harlow, and N. Heintz (1996)
J. Cell Sci. 109, 1717-1726
 |  Abstract »  |  PDF »

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes..

R L Beijersbergen, L Carlee, R M Kerkhoven, and R Bernards (1995)
Genes & Dev. 9, 1340-1353
 |  Abstract »  |  PDF »

An Inverted Repeat Motif Stabilizes Binding of E2F and Enhances Transcription of the Dihydrofolate Reductase Gene.

M. Wade, M. C. Blake, R. C. Jambou, K. Helin, E. Harlow, and J. C. Azizkhan (1995)
J. Biol. Chem. 270, 9783-9791
 |  Abstract »  |  Full Text »  |  PDF »

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members..

G Vairo, D M Livingston, and D Ginsberg (1995)
Genes & Dev. 9, 869-881
 |  Abstract »  |  PDF »

NF1-L Is the DNA-binding Component of the Protein Complex at the Peripherin Negative Regulatory Element.

A. D. Adams, D. M. Choate, and M. A. Thompson (1995)
J. Biol. Chem. 270, 6975-6983
 |  Abstract »  |  Full Text »  |  PDF »

E2F-4, a new member of the E2F transcription factor family, interacts with p107..

D Ginsberg, G Vairo, T Chittenden, Z X Xiao, G Xu, K L Wydner, J A DeCaprio, J B Lawrence, and D M Livingston (1994)
Genes & Dev. 8, 2665-2679
 |  Abstract »  |  PDF »

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo..

R L Beijersbergen, R M Kerkhoven, L Zhu, L Carlee, P M Voorhoeve, and R Bernards (1994)
Genes & Dev. 8, 2680-2690
 |  Abstract »  |  PDF »

Differential regulation of E2F transactivation by cyclin/cdk2 complexes..

B D Dynlacht, O Flores, J A Lees, and E Harlow (1994)
Genes & Dev. 8, 1772-1786
 |  Abstract »  |  PDF »

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression..

D G Johnson, K Ohtani, and J R Nevins (1994)
Genes & Dev. 8, 1514-1525
 |  Abstract »  |  PDF »

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter..

K M Hsiao, S L McMahon, and P J Farnham (1994)
Genes & Dev. 8, 1526-1537
 |  Abstract »  |  PDF »

DcE2F, a Functional Plant E2F-like Transcriptional Activator from Daucus carota.

D. Albani, L. Mariconti, S. Ricagno, L. Pitto, C. Moroni, K. Helin, and R. Cella (2000)
J. Biol. Chem. 275, 19258-19267
 |  Abstract »  |  Full Text »  |  PDF »

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.

J. M. Trimarchi, B. Fairchild, J. Wen, and J. A. Lees (2001)
PNAS 98, 1519-1524
 |  Abstract »  |  Full Text »  |  PDF »

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