Science 26 November 1993: Vol. 262. no. 5138, pp. 1441 - 1444 DOI: 10.1126/science.8248782

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Articles

Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo.

D. K. Coletta, B. Balas, A. O. Chavez, M. Baig, M. Abdul-Ghani, S. R. Kashyap, F. Folli, D. Tripathy, L. J. Mandarino, J. E. Cornell, et al. (2008)
Am J Physiol Endocrinol Metab 294, E910-E917
 |  Abstract »  |  Full Text »  |  PDF »

Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.

L. Yang, H. Li, T. Yu, H. Zhao, M. G. Cherian, L. Cai, and Y. Liu (2008)
Am J Physiol Endocrinol Metab 294, E987-E992
 |  Abstract »  |  Full Text »  |  PDF »

Rad GTPase Deficiency Leads to Cardiac Hypertrophy.

L. Chang, J. Zhang, Y.-H. Tseng, C.-Q. Xie, J. Ilany, J. C. Bruning, Z. Sun, X. Zhu, T. Cui, K. A. Youker, et al. (2007)
Circulation 116, 2976-2983
 |  Abstract »  |  Full Text »  |  PDF »

Plasma Membrane Targeting Is Essential for Rem-mediated Ca2+ Channel Inhibition.

R. N. Correll, C. Pang, B. S. Finlin, A. M. Dailey, J. Satin, and D. A. Andres (2007)
J. Biol. Chem. 282, 28431-28440
 |  Abstract »  |  Full Text »  |  PDF »

Dominant Negative Suppression of Rad Leads to QT Prolongation and Causes Ventricular Arrhythmias via Modulation of L-type Ca2+ Channels in the Heart.

H. Yada, M. Murata, K. Shimoda, S. Yuasa, H. Kawaguchi, M. Ieda, T. Adachi, M. Murata, S. Ogawa, and K. Fukuda (2007)
Circ. Res. 101, 69-77
 |  Abstract »  |  Full Text »  |  PDF »

RGK Small GTP-binding Proteins Interact with the Nucleotide Kinase Domain of Ca2+-channel beta-Subunits via an Uncommon Effector Binding Domain.

P. Beguin, Y. J. A. Ng, C. Krause, R. N. Mahalakshmi, M. Y. Ng, and W. Hunziker (2007)
J. Biol. Chem. 282, 11509-11520
 |  Abstract »  |  Full Text »  |  PDF »

Methylation and Gene Silencing of the Ras-Related GTPase Gene in Lung and Breast Cancers.

M. Suzuki, H. Shigematsu, D. S. Shames, N. Sunaga, T. Takahashi, N. Shivapurkar, T. Iizasa, J. D. Minna, T. Fujisawa, and A. F. Gazdar (2007)
Ann. Surg. Oncol. 14, 1397-1404
 |  Abstract »  |  Full Text »  |  PDF »

Gem Associates with Ezrin and Acts via the Rho-GAP Protein Gmip to Down-Regulate the Rho Pathway.

A. Hatzoglou, I. Ader, A. Splingard, J. Flanders, E. Saade, I. Leroy, S. Traver, S. Aresta, and J. de Gunzburg (2007)
Mol. Biol. Cell 18, 1242-1252
 |  Abstract »  |  Full Text »  |  PDF »

Nonalcoholic Fatty Liver Disease and Obesity.

S. Saadeh (2007)
Nutr Clin Pract 22, 1-10
 |  Abstract »  |  Full Text »  |  PDF »

Dose-dependent and Isoform-specific Modulation of Ca2+ Channels by RGK GTPases.

L. Seu and G. S. Pitt (2006)
J. Gen. Physiol. 128, 605-613
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the Complex between Ca2+ Channel beta-Subunit and the Rem GTPase.

B. S. Finlin, R. N. Correll, C. Pang, S. M. Crump, J. Satin, and D. A. Andres (2006)
J. Biol. Chem. 281, 23557-23566
 |  Abstract »  |  Full Text »  |  PDF »

Crystal structure of human Rad GTPase of the RGK-family..

A. Yanuar, S. Sakurai, K. Kitano, and T. Hakoshima (2006)
Genes Cells 11, 961-968
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.

J. Ilany, P. J. Bilan, S. Kapur, J. S. Caldwell, M.-E. Patti, A. Marette, and C. R. Kahn (2006)
PNAS 103, 4481-4486
 |  Abstract »  |  Full Text »  |  PDF »

Rad is temporally regulated within myogenic progenitor cells during skeletal muscle regeneration.

T. J. Hawke, S. B. Kanatous, C. M. Martin, S. C. Goetsch, and D. J. Garry (2006)
Am J Physiol Cell Physiol 290, C379-C387
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of Novel Methylation Biomarkers in Cervical Carcinoma by Global Demethylation and Microarray Analysis.

P. Sova, Q. Feng, G. Geiss, T. Wood, R. Strauss, V. Rudolf, A. Lieber, and N. Kiviat (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 114-123
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by the Rem2 GTPase.

B. S. Finlin, A. L. Mosley, S. M. Crump, R. N. Correll, S. Ozcan, J. Satin, and D. A. Andres (2005)
J. Biol. Chem. 280, 41864-41871
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Rem2, an RGK Family Small GTPase, Reduces N-Type Calcium Current without Affecting Channel Surface Density.

H. Chen, H. L. Puhl III, S.-L. Niu, D. C. Mitchell, and S. R. Ikeda (2005)
J. Neurosci. 25, 9762-9772
 |  Abstract »  |  Full Text »  |  PDF »

The Ala54Thr polymorphism of the fatty acid-binding protein 2 gene is associated with a change in insulin sensitivity after a change in the type of dietary fat.

C. Marin, F. Perez-Jimenez, P. Gomez, J. Delgado, J. A. Paniagua, A. Lozano, B. Cortes, Y. Jimenez-Gomez, M. J. Gomez, and J. Lopez-Miranda (2005)
Am. J. Clinical Nutrition 82, 196-200
 |  Abstract »  |  Full Text »  |  PDF »

Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy.

J. A. Timmons, O. Larsson, E. Jansson, H. Fischer, T. Gustafsson, P. L. Greenhaff, J. Ridden, J. Rachman, M. Peyrard-Janvid, C. Wahlestedt, et al. (2005)
FASEB J 19, 750-760
 |  Abstract »  |  Full Text »  |  PDF »

14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity.

P. Beguin, R. N. Mahalakshmi, K. Nagashima, D. H. K. Cher, A. Takahashi, Y. Yamada, Y. Seino, and W. Hunziker (2005)
J. Cell Sci. 118, 1923-1934
 |  Abstract »  |  Full Text »  |  PDF »

The -514 C/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population.

P. Gomez, F. Perez-Jimenez, C. Marin, J. A. Moreno, M. J. Gomez, C. Bellido, P. Perez-Martinez, F. Fuentes, J. A. Paniagua, and J. Lopez-Miranda (2005)
J. Mol. Endocrinol. 34, 331-338
 |  Abstract »  |  Full Text »  |  PDF »

Direct Inhibition of the Interaction between {alpha}-Interaction Domain and {beta}-Interaction Domain of Voltage-dependent Ca2+ Channels by Gem.

T. Sasaki, T. Shibasaki, P. Beguin, K. Nagashima, M. Miyazaki, and S. Seino (2005)
J. Biol. Chem. 280, 9308-9312
 |  Abstract »  |  Full Text »  |  PDF »

Rad GTPase Attenuates Vascular Lesion Formation by Inhibition of Vascular Smooth Muscle Cell Migration.

M. Fu, J. Zhang, Y.-H. Tseng, T. Cui, X. Zhu, Y. Xiao, Y. Mou, H. De Leon, M. M.J. Chang, Y. Hamamori, et al. (2005)
Circulation 111, 1071-1077
 |  Abstract »  |  Full Text »  |  PDF »

Alterations in Mitogen-Activated Protein Kinase Kinase and Extracellular Regulated Kinase Signaling in Theca Cells Contribute to Excessive Androgen Production in Polycystic Ovary Syndrome.

V. L. Nelson-Degrave, J. K. Wickenheisser, K. L. Hendricks, T. Asano, M. Fujishiro, R. S. Legro, S. R. Kimball, J. F. Strauss III, and J. M. McAllister (2005)
Mol. Endocrinol. 19, 379-390
 |  Abstract »  |  Full Text »  |  PDF »

Human RAS Superfamily Proteins and Related GTPases.

J. Colicelli (2004)
Sci. STKE 2004, re13
 |  Abstract »  |  Full Text »  |  PDF »

Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis.

J. Medina, L. I. Fernandez-Salazar, L. Garcia-Buey, and R. Moreno-Otero (2004)
Diabetes Care 27, 2057-2066
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Critical Serine Residues in Gem Separates Cytoskeletal Reorganization from Down-Regulation of Calcium Channel Activity.

Y. Ward, B. Spinelli, M. J. Quon, H. Chen, S. R. Ikeda, and K. Kelly (2004)
Mol. Cell. Biol. 24, 651-661
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.

B. S. Finlin, S. M. Crump, J. Satin, and D. A. Andres (2003)
PNAS 100, 14469-14474
 |  Abstract »  |  Full Text »  |  PDF »

Genome-Wide and Fine-Mapping Linkage Studies of Type 2 Diabetes and Glucose Traits in the Old Order Amish: Evidence for a New Diabetes Locus on Chromosome 14q11 and Confirmation of a Locus on Chromosome 1q21-q24.

W.-C. Hsueh, P. L. St. Jean, B. D. Mitchell, T. I. Pollin, W. C. Knowler, M. G. Ehm, C. J. Bell, H. Sakul, M. J. Wagner, D. K. Burns, et al. (2003)
Diabetes 52, 550-557
 |  Abstract »  |  Full Text »  |  PDF »

High Glucose Stimulates Synthesis of Fibronectin via a Novel Protein Kinase C, Rap1b, and B-Raf Signaling Pathway.

S. Lin, A. Sahai, S. S. Chugh, X. Pan, E. I. Wallner, F. R. Danesh, J. W. Lomasney, and Y. S. Kanwar (2002)
J. Biol. Chem. 277, 41725-41735
 |  Abstract »  |  Full Text »  |  PDF »

Menin, the Multiple Endocrine Neoplasia Type 1 Gene Product, Exhibits GTP-hydrolyzing Activity in the Presence of the Tumor Metastasis Suppressor nm23.

H. Yaguchi, N. Ohkura, T. Tsukada, and K. Yamaguchi (2002)
J. Biol. Chem. 277, 38197-38204
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Variants at the Resistin Locus and Risk of Type 2 Diabetes in Caucasians.

X. Ma, J. H. Warram, V. Trischitta, and A. Doria (2002)
J. Clin. Endocrinol. Metab. 87, 4407-4410
 |  Abstract »  |  Full Text »  |  PDF »

The gene expression fingerprint of human heart failure.

F.-L. Tan, C. S. Moravec, J. Li, C. Apperson-Hansen, P. M. McCarthy, J. B. Young, and M. Bond (2002)
PNAS 99, 11387-11392
 |  Abstract »  |  Full Text »  |  PDF »

Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene.

S. T. Mathews, G. P. Singh, M. Ranalletta, V. J. Cintron, X. Qiang, A. S. Goustin, K.-L. C. Jen, M. J. Charron, W. Jahnen-Dechent, and G. Grunberger (2002)
Diabetes 51, 2450-2458
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment.

R. Sreekumar, P. Halvatsiotis, J. C. Schimke, and K. S. Nair (2002)
Diabetes 51, 1913-1920
 |  Abstract »  |  Full Text »  |  PDF »

Nonalcoholic Fatty Liver Disease.

P. Angulo (2002)
N. Engl. J. Med. 346, 1221-1231
 |  Full Text »  |  PDF »

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.

Y. Ward, S.-F. Yap, V. Ravichandran, F. Matsumura, M. Ito, B. Spinelli, and K. Kelly (2002)
J. Cell Biol. 157, 291-302
 |  Abstract »  |  Full Text »  |  PDF »

COMMENT: Genetic Variability in Insulin Action Inhibitor Ikk{beta} (IKBKB) Does Not Play a Major Role in the Development of Type 2 Diabetes.

C. Menzaghi, N. Plengvidhya, X. Ma, J. H. Warram, S. E. Shoelson, and A. Doria (2002)
J. Clin. Endocrinol. Metab. 87, 1894-1897
 |  Abstract »  |  Full Text »  |  PDF »

The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function.

X. Li, X. Bu, B. Lu, H. Avraham, R. A. Flavell, and B. Lim (2002)
Mol. Cell. Biol. 22, 1158-1171
 |  Abstract »  |  Full Text »  |  PDF »

Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.

C. Reynet and C. R. Kahn (2001)
PNAS 98, 3422-3427
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Growth and Tumorigenicity of Breast Cancer Cells by the Low Molecular Weight GTPase Rad and Nm23.

Y.-H. Tseng, D. Vicent, J. Zhu, Y. Niu, A. Adeyinka, J. S. Moyers, P. H. Watson, and C. R. Kahn (2001)
Cancer Res. 61, 2071-2079
 |  Abstract »  |  Full Text »

Small GTP-Binding Proteins.

Y. Takai, T. Sasaki, and T. Matozaki (2001)
Physiol Rev 81, 153-208
 |  Abstract »  |  Full Text »  |  PDF »

Ges, A Human GTPase of the Rad/Gem/Kir Family, Promotes Endothelial Cell Sprouting and Cytoskeleton Reorganization.

J. Y. Pan, W. E. Fieles, A. M. White, M. M. Egerton, and D. S. Silberstein (2000)
J. Cell Biol. 149, 1107-1116
 |  Abstract »  |  Full Text »  |  PDF »

The Saccharomyces cerevisiae Rheb G-protein Is Involved in Regulating Canavanine Resistance and Arginine Uptake.

J. Urano, A. P. Tabancay, W. Yang, and F. Tamanoi (2000)
J. Biol. Chem. 275, 11198-11206
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Expression Analysis of Genes Regulated by Both Obesity and Leptin Reveals a Regulatory Loop between Leptin and Pituitary-derived ACTH.

M. Renz, E. Tomlinson, B. Hultgren, N. Levin, Q. Gu, R. A. Shimkets, D. A. Lewin, and T. A. Stewart (2000)
J. Biol. Chem. 275, 10429-10436
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Interaction of the Ras-related protein associated with diabetes Rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.

J. Zhu, Y.-H. Tseng, J. D. Kantor, C. J. Rhodes, B. R. Zetter, J. S. Moyers, and C. R. Kahn (1999)
PNAS 96, 14911-14918
 |  Abstract »  |  Full Text »  |  PDF »

Glucose Transporters and Insulin Action -- Implications for Insulin Resistance and Diabetes Mellitus.

P. R. Shepherd and B. B. Kahn (1999)
N. Engl. J. Med. 341, 248-257
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Rho3 of Saccharomyces cerevisiae, Which Regulates the Actin Cytoskeleton and Exocytosis, Is a GTPase Which Interacts with Myo2 and Exo70.

N. G. G. Robinson, L. Guo, J. Imai, A. Toh-e, Y. Matsui, and F. Tamanoi (1999)
Mol. Cell. Biol. 19, 3580-3587
 |  Abstract »  |  Full Text »  |  PDF »

Association of Rab25 and Rab11a with the Apical Recycling System of Polarized Madin-Darby Canine Kidney Cells.

J. E. Casanova, X. Wang, R. Kumar, S. G. Bhartur, J. Navarre, J. E. Woodrum, Y. Altschuler, G. S. Ray, and J. R. Goldenring (1999)
Mol. Biol. Cell 10, 47-61
 |  Abstract »  |  Full Text »

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration.

R. M. Guasch, P. Scambler, G. E. Jones, and A. J. Ridley (1998)
Mol. Cell. Biol. 18, 4761-4771
 |  Abstract »  |  Full Text »

Genetic Exclusion of 14 Candidate Genes in Lipoatropic Diabetes Using Linkage Analysis in 10 Consanguineous Families.

C. Vigouroux, E. Khallouf, C. Bourut, J.-J. Robert, M. de Kerdanet, N. Tubiana-Rufi, S. Faure, J. Weissenbach, J. Capeau, and J. Magre (1997)
J. Clin. Endocrinol. Metab. 82, 3438-3444
 |  Abstract »  |  Full Text »  |  PDF »

Rem Is a New Member of the Rad- and Gem/Kir Ras-related GTP-binding Protein Family Repressed by Lipopolysaccharide Stimulation.

B. S. Finlin and D. A. Andres (1997)
J. Biol. Chem. 272, 21982-21988
 |  Abstract »  |  Full Text »  |  PDF »

Rad and Rad-related GTPases Interact with Calmodulin and Calmodulin-dependent Protein Kinase II.

J. S. Moyers, P. J. Bilan, J. Zhu, and C. R. Kahn (1997)
J. Biol. Chem. 272, 11832-11839
 |  Abstract »  |  Full Text »  |  PDF »

The Dominant Negative Effects of H-Ras Harboring a Gly to Ala Mutation at Position 60.

Y.-J. Sung, M.-C. C. Hwang, and Y.-W. Hwang (1996)
J. Biol. Chem. 271, 30537-30543
 |  Abstract »  |  Full Text »  |  PDF »

Rin, a Neuron-Specific and Calmodulin-Binding Small G-Protein, and Rit Define a Novel Subfamily of Ras Proteins.

C.-H. J. Lee, N. G. Della, C. E. Chew, and D. J. Zack (1996)
J. Neurosci. 16, 6784-6794
 |  Abstract »  |  Full Text »  |  PDF »

Gq-coupled Receptors Transmit the Signal for GLUT4 Translocation via an Insulin-independent Pathway.

K. Kishi, H. Hayashi, L. Wang, S. Kamohara, K. Tamaoka, T. Shimizu, F. Ushikubi, S. Narumiya, and Y. Ebina (1996)
J. Biol. Chem. 271, 26561-26568
 |  Abstract »  |  Full Text »  |  PDF »

Calmodulin Binds to and Inhibits GTP Binding of the Ras-like GTPase Kir/Gem.

R. Fischer, Y. Wei, J. Anagli, and M. W. Berchtold (1996)
J. Biol. Chem. 271, 25067-25070
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Rad Inhibits Glucose Uptake in Cultured Muscle and Fat Cells.

J. S. Moyers, P. J. Bilan, C. Reynet, and C. R. Kahn (1996)
J. Biol. Chem. 271, 23111-23116
 |  Abstract »  |  Full Text »  |  PDF »

The Differential Effects of the Gly-60 to Ala Mutation on the Interaction of H-Ras p21 with Different Downstream Targets.

M.-C. C. Hwang, Y.-J. Sung, and Y.-W. Hwang (1996)
J. Biol. Chem. 271, 8196-8202
 |  Abstract »  |  Full Text »  |  PDF »

Rad, a Novel Ras-related GTPase, Interacts with Skeletal Muscle beta-Tropomyosin.

J. Zhu, P. J. Bilan, J. S. Moyers, D. A. Antonetti, and C. R. Kahn (1996)
J. Biol. Chem. 271, 768-773
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Rad, a New Member of Ras/GTPase Superfamily, and Its Regulation by a Unique GTPase-activating protein (GAP)-like Activity.

J. Zhu, C. Reynet, J. S. Caldwell, and C. R. Kahn (1995)
J. Biol. Chem. 270, 4805-4812
 |  Abstract »  |  Full Text »  |  PDF »

Gem: an induced, immediate early protein belonging to the Ras family.

J Maguire, T Santoro, P Jensen, U Siebenlist, J Yewdell, and K Kelly (1994)
Science 265, 241-244
 |  Abstract »  |  PDF »

Molecular Biology of Thermoregulation: Selected Contribution: Effect of acute heat shock on gene expression by human peripheral blood mononuclear cells.

L. A. Sonna, S. L. Gaffin, R. E. Pratt, M. L. Cullivan, K. C. Angel, and C. M. Lilly (2002)
J Appl Physiol 92, 2208-2220
 |  Abstract »  |  Full Text »  |  PDF »

EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis.

J. Svaren, T. Ehrig, S. A. Abdulkadir, M. U. Ehrengruber, M. A. Watson, and J. Milbrandt (2000)
J. Biol. Chem. 275, 38524-38531
 |  Abstract »  |  Full Text »  |  PDF »

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.

Y. Ward, S.-F. Yap, V. Ravichandran, F. Matsumura, M. Ito, B. Spinelli, and K. Kelly (2002)
J. Cell Biol. 157, 291-302
 |  Abstract »  |  Full Text »  |  PDF »

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