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Science 12 November 1993:
Vol. 262. no. 5136, pp. 1061 - 1065
DOI: 10.1126/science.8235626
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Articles

Science, Vol 262, Issue 5136, 1061-1065
Copyright © 1993 by American Association for the Advancement of Science

articles

A Ca-dependent early step in the release of catecholamines from adrenal chromaffin cells

L von Ruden and E Neher

Department of Membrane Biophysics, Max-Planck-Institut fur biophysikalische Chemie, Gottingen, Germany.

Intense stimuli, such as trains of depolarizing pulses or the caffeine-induced release of calcium from intracellular stores, readily depress the secretory response in neuroendocrine cells. Secretory responses are restored by rest periods of minutes in duration. This recovery was accelerated when the concentration of cytosolic calcium was moderately increased and probably resulted from calcium-dependent replenishment of a pool of release-ready granules. Continuously increased concentrations of calcium led the over-filling of such a pool. Subsequently, secretory responses to stronger calcium stimuli were augmented. Hormone-induced calcium transients with a plateau phase of increased concentration of calcium may enhance the secretory response in this way.


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   Abstract »    PDF »
Correlation of Real-time Catecholamine Release and Cytosolic Ca[IMAGE] at Single Bovine Chromaffin Cells.
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   Abstract »    Full Text »    PDF »
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The Biochemistry of Neurotransmitter Secretion.
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Late ATP-dependent and Ca++-activated Steps of Dense Core Granule Exocytosis.
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Cold Spring Harb Symp Quant Biol 60, 197-204
   Abstract »    PDF »
The Last Seconds in the Life of a Secretory Vesicle.
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Cold Spring Harb Symp Quant Biol 60, 389-396
   Abstract »    PDF »
Targeting of Membrane Proteins to the Regulated Secretory Pathway in Anterior Pituitary Endocrine Cells.
R. El Meskini, G. J. Galano, R. Marx, R. E. Mains, and B. A. Eipper (2001)
J. Biol. Chem. 276, 3384-3393
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Signal Transduction in Eclosion Hormone-induced Secretion of Ecdysis-triggering Hormone.
T. G. Kingan, R. A. Cardullo, and M. E. Adams (2001)
J. Biol. Chem. 276, 25136-25142
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Calcium Regulation of Exocytosis in PC12 Cells.
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J. Biol. Chem. 276, 26680-26687
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