Science 5 November 1993: Vol. 262. no. 5135, pp. 900 - 902 DOI: 10.1126/science.8235612

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Articles

Cancer-Associated Transforming Growth Factor {beta} Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype.

S. Bharathy, W. Xie, J. M. Yingling, and M. Reiss (2008)
Cancer Res. 68, 1656-1666
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From The Cover: Dysregulation of TGF-{beta}1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.

X. Wang, S. Inoue, J. Gu, E. Miyoshi, K. Noda, W. Li, Y. Mizuno-Horikawa, M. Nakano, M. Asahi, M. Takahashi, et al. (2005)
PNAS 102, 15791-15796
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Change of Plasma Transforming Growth Factor-{beta}1 Levels in Nasopharyngeal Carcinoma Patients Treated with Concurrent Chemo-radiotherapy.

H.-W. Chen, Y.-C. Chang, Y.-L. Lai, Y.-J. Chen, M.-J. Huang, Y.-S. Leu, Y.-K. Fu, L.-W. Wang, and J.-J. Hwang (2005)
Jpn. J. Clin. Oncol. 35, 427-432
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Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice.

C. Schramm, M. Protschka, H. H. Kohler, J. Podlech, M. J. Reddehase, P. Schirmacher, P. R. Galle, A. W. Lohse, and M. Blessing (2003)
Am J Physiol Gastrointest Liver Physiol 284, G525-G535
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TGF-{beta} Regulates Airway Responses Via T Cells.

C. Schramm, U. Herz, J. Podlech, M. Protschka, S. Finotto, M. J. Reddehase, H. Kohler, P. R. Galle, A. W. Lohse, and M. Blessing (2003)
J. Immunol. 170, 1313-1319
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Regulation of ALK-1 Signaling by the Nuclear Receptor LXRbeta.

J. Mo, S. J. Fang, W. Chen, and G. C. Blobe (2002)
J. Biol. Chem. 277, 50788-50794
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Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily.

H. Chang, C. W. Brown, and M. M. Matzuk (2002)
Endocr. Rev. 23, 787-823
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Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins.

Z. A. Quinn, C.-C. Yang, J. L. Wrana, and J. C. McDermott (2001)
Nucleic Acids Res. 29, 732-742
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The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo.

H Bauer, Z Lele, G. Rauch, R Geisler, and M Hammerschmidt (2001)
Development 128, 849-858
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Activin beta C and beta E Genes Are Not Essential for Mouse Liver Growth, Differentiation, and Regeneration.

A. L. Lau, T. R. Kumar, K. Nishimori, J. Bonadio, and M. M. Matzuk (2000)
Mol. Cell. Biol. 20, 6127-6137
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Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation.

K. Kitamura, S.-i. Aota, R. Sakamoto, S.-I. Yoshikawa, and K. Okazaki (2000)
Blood 95, 3371-3379
 |  Abstract »  |  Full Text »  |  PDF »

Activin A-Induced HepG2 Liver Cell Apoptosis: Involvement of Activin Receptors and Smad Proteins.

W. Chen, T. K. Woodruff, and K. E. Mayo (2000)
Endocrinology 141, 1263-1272
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Human Ovarian Cancer, Cell Lines, and Primary Ascites Cells Express the Human Mullerian Inhibiting Substance (MIS) Type II Receptor, Bind, and Are Responsive to MIS.

P. T. Masiakos, D. T. MacLaughlin, S. Maheswaran, J. Teixeira, A. F. Fuller Jr., P. C. Shah, D. J. Kehas, M. K. Kenneally, D. M. Dombkowski, T. U. Ha, et al. (1999)
Clin. Cancer Res. 5, 3488-3499
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Extracellular Domain of the Transforming Growth Factor-beta Receptor Negatively Regulates Ligand-independent Receptor Activation.

H.-J. Zhu and A. M. Sizeland (1999)
J. Biol. Chem. 274, 29220-29227
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Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters.

Q. Wang, Y. Wang, D. M Hyde, P. J Gotwals, V. E Koteliansky, S. T Ryan, and S. N Giri (1999)
Thorax 54, 805-812
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Activin and Inhibin Binding to the Soluble Extracellular Domain of Activin Receptor II.

C. J. Donaldson, J. M. Vaughan, A. Z. Corrigan, W. H. Fischer, and W. W. Vale (1999)
Endocrinology 140, 1760-1766
 |  Abstract »  |  Full Text »

Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-beta Family Receptors.

Y.-G. Chen and J. Massague (1999)
J. Biol. Chem. 274, 3672-3677
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Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-beta Superfamily.

N. P. Barbara, J. L. Wrana, and M. Letarte (1999)
J. Biol. Chem. 274, 584-594
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Control of digit formation by activin signalling.

R Merino, D Macias, Y Ganan, J Rodriguez-Leon, A. Economides, C Rodriguez-Esteban, J. Izpisua-Belmonte, and J. Hurle (1999)
Development 126, 2161-2170
 |  Abstract »  |  PDF »

Roles of Pathway-Specific and Inhibitory Smads in Activin Receptor Signaling.

J.-J. Lebrun, K. Takabe, Y. Chen, and W. Vale (1999)
Mol. Endocrinol. 13, 15-23
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Smad7 Is an Activin-inducible Inhibitor of Activin-induced Growth Arrest and Apoptosis in Mouse B Cells.

A. Ishisaki, K. Yamato, A. Nakao, K. Nonaka, M. Ohguchi, P. ten Dijke, and T. Nishihara (1998)
J. Biol. Chem. 273, 24293-24296
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The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse.

Z. Gu, M. Nomura, B. B. Simpson, H. Lei, A. Feijen, J. van den Eijnden-van Raaij, P. K. Donahoe, and E. Li (1998)
Genes & Dev. 12, 844-857
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Smad8 mediates the signaling of the receptor serine kinase.

Y. Chen, A. Bhushan, and W. Vale (1997)
PNAS 94, 12938-12943
 |  Abstract »  |  Full Text »  |  PDF »

Function of the Type V Transforming Growth Factor beta  Receptor in Transforming Growth Factor beta -induced Growth Inhibition of Mink Lung Epithelial Cells.

Q. Liu, S. S. Huang, and J. S. Huang (1997)
J. Biol. Chem. 272, 18891-18895
 |  Abstract »  |  Full Text »  |  PDF »

The Type II Transforming Growth Factor-beta Receptor Autophosphorylates Not Only on Serine and Threonine but Also on Tyrosine Residues.

S. Lawler, X.-H. Feng, R.-H. Chen, E. M. Maruoka, C. W. Turck, I. Griswold-Prenner, and R. Derynck (1997)
J. Biol. Chem. 272, 14850-14859
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Bovine Activin Receptor Type IIB Messenger Ribonucleic Acid Displays Alternative Splicing Involving a Sequence Homologous to Src-Homology 3 domain Binding Sites.

J.-F. Ethier, J. G. Lussier, and D. W. Silversides (1997)
Endocrinology 138, 2425-2434
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Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5.

H. Nishitoh, H. Ichijo, M. Kimura, T. Matsumoto, F. Makishima, A. Yamaguchi, H. Yamashita, S. Enomoto, and K. Miyazono (1996)
J. Biol. Chem. 271, 21345-21352
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Ligand-independent Activation of Transforming Growth Factor (TGF) beta Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-beta Receptors.

X.-H. Feng and R. Derynck (1996)
J. Biol. Chem. 271, 13123-13129
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-beta.

M. Saitoh, H. Nishitoh, T. Amagasa, K. Miyazono, M. Takagi, and H. Ichijo (1996)
J. Biol. Chem. 271, 2769-2775
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Interaction of the Transforming Growth Factor-beta Type I Receptor with Farnesyl-protein Transferase-alpha.

M. Kawabata, T. Imamura, K. Miyazono, M. E. Engel, and H. L. Moses (1995)
J. Biol. Chem. 270, 29628-29631
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Transforming Growth Factor-beta (TGF-beta)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-beta Receptor Complex.

X.-H. Feng, E. H. Filvaroff, and R. Derynck (1995)
J. Biol. Chem. 270, 24237-24245
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Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors.

T. Nohno, T. Ishikawa, T. Saito, K. Hosokawa, S. Noji, D. H. Wolsing, and J. S. Rosenbaum (1995)
J. Biol. Chem. 270, 22522-22526
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Demonstration That Mutation of the Type II Transforming Growth Factor beta Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells.

J. Wang, L. Sun, L. Myeroff, X. Wang, L. E. Gentry, J. Yang, J. Liang, E. Zborowska, S. Markowitz, J. K. V. Willson, et al. (1995)
J. Biol. Chem. 270, 22044-22049
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Cooperative Binding of Transforming Growth Factor (TGF)-[IMAGE]2 to the Types I and II TGF-[IMAGE] Receptors.

C. Rodriguez, F. Chen, R. A. Weinberg, and H. F. Lodish (1995)
J. Biol. Chem. 270, 15919-15922
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-[IMAGE] Receptors.

R.-H. Chen, H. L. Moses, E. M. Maruoka, R. Derynck, and M. Kawabata (1995)
J. Biol. Chem. 270, 12235-12241
 |  Abstract »  |  Full Text »  |  PDF »

Inactive Type II and Type I Receptors for TGFbeta Are Dominant Inhibitors of TGFbeta-dependent Transcription.

T. Brand and M. D. Schneider (1995)
J. Biol. Chem. 270, 8274-8284
 |  Abstract »  |  Full Text »  |  PDF »

Inhibin Antagonizes Inhibition of Liver Cell Growth by Activin by a Dominant-negative Mechanism.

J. Xu, K. McKeehan, K. Matsuzaki, and W. L. McKeehan (1995)
J. Biol. Chem. 270, 6308-6313
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of a Novel Type II Serine/Threonine Kinase Receptor through Interaction with the Type I Transforming Growth Factor-beta Receptor.

M. Kawabata, A. Chytil, and H. L. Moses (1995)
J. Biol. Chem. 270, 5625-5630
 |  Abstract »  |  Full Text »  |  PDF »

The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-beta Receptor.

H. Y. Lin, A. Moustakas, P. Knaus, R. G. Wells, Y. I. Henis, and H. F. Lodish (1995)
J. Biol. Chem. 270, 2747-2754
 |  Abstract »  |  Full Text »  |  PDF »

GH3 Pituitary Tumor Cells Contain Heteromeric Type I and Type II Receptor Complexes for Transforming Growth Factor beta and Activin-A.

A. Moustakas, T. Takumi, H. Y. Lin, and H. F. Lodish (1995)
J. Biol. Chem. 270, 765-769
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta} in Tissue Fibrosis.

W. A. Border and N. A. Noble (1994)
N. Engl. J. Med. 331, 1286-1292
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Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12.

T Wang, P. Donahoe, and A. Zervos (1994)
Science 265, 674-676
 |  Abstract »  |  PDF »

Characterization of type I receptors for transforming growth factor-beta and activin.

P ten Dijke, H Yamashita, H Ichijo, P Franzen, M Laiho, K Miyazono, and C. Heldin (1994)
Science 264, 101-104
 |  Abstract »  |  PDF »

The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-beta superfamily.

T Xie, A. Finelli, and R. Padgett (1994)
Science 263, 1756-1759
 |  Abstract »  |  PDF »

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms..

D M Kingsley (1994)
Genes & Dev. 8, 133-146
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Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins.

A Feijen, M. Goumans, and A. van den Eijnden-van Raaij (1994)
Development 120, 3621-3637
 |  Abstract »  |  PDF »

A transforming growth factor beta type I receptor that signals to activate gene expression.

C. Bassing, J. Yingling, D. Howe, T Wang, W. He, M. Gustafson, P Shah, P. Donahoe, and X. Wang (1994)
Science 263, 87-89
 |  Abstract »  |  PDF »

Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor.

E. Filvaroff, R Ebner, and R Derynck (1994)
Development 120, 1085-1095
 |  Abstract »  |  PDF »

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