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Science 29 October 1993:
Vol. 262. no. 5134, pp. 747 - 750
DOI: 10.1126/science.8235596

Articles

Science, Vol 262, Issue 5134, 747-750
Copyright © 1993 by American Association for the Advancement of Science


articles

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

BH Ye, F Lista, F Lo Coco, DM Knowles, K Offit, RS Chaganti, and R Dalla-Favera

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.


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RP58 Associates with Condensed Chromatin and Mediates a Sequence-specific Transcriptional Repression.
K. Aoki, G. Meng, K. Suzuki, T. Takashi, Y. Kameoka, K. Nakahara, R. Ishida, and M. Kasai (1998)
J. Biol. Chem. 273, 26698-26704
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Expression Status of BCL-6 and Syndecan-1 Identifies Distinct Histogenetic Subtypes of Hodgkin's Disease.
A. Carbone, A. Gloghini, G. Gaidano, S. Franceschi, D. Capello, H. G. Drexler, B. Falini, and R. Dalla-Favera (1998)
Blood 92, 2220-2228
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BCL-6 Gene Mutations in Posttransplantation Lymphoproliferative Disorders Predict Response to Therapy and Clinical Outcome.
E. Cesarman, A. Chadburn, Y.-F. Liu, A. Migliazza, R. Dalla-Favera, and D. M. Knowles (1998)
Blood 92, 2294-2302
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BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci.
L. Pasqualucci, A. Migliazza, N. Fracchiolla, C. William, A. Neri, L. Baldini, R. S. K. Chaganti, U. Klein, R. Kuppers, K. Rajewsky, et al. (1998)
PNAS 95, 11816-11821
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The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis.
R. Shaknovich, P. L. Yeyati, S. Ivins, A. Melnick, C. Lempert, S. Waxman, A. Zelent, and J. D. Licht (1998)
Mol. Cell. Biol. 18