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Science 29 October 1993:
Vol. 262. no. 5134, pp. 744 - 747
DOI: 10.1126/science.8235595
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Articles

Science, Vol 262, Issue 5134, 744-747
Copyright © 1993 by American Association for the Advancement of Science

articles

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

R Rizzuto, M Brini, M Murgia, and T Pozzan

Department of Biomedical Sciences, University of Padova, Italy.

Microdomains of high intracellular calcium ion concentration, [Ca2+]i, have been hypothesized to occur in living cells exposed to stimuli that generate inositol 1,4,5-trisphosphate (IP3). Mitochondrially targeted recombinant aequorin was used to show that IP3-induced Ca2+ mobilization from intracellular stores caused increases of mitochondrial Ca2+ concentration, [Ca2+]m, the speed and amplitude of which are not accounted for by the relatively small increases in mean [Ca2+]i. A similar response was obtained by the addition of IP3 to permeabilized cells but not by perfusion of cells with Ca2+ at concentrations similar to those measured in intact cells. It is concluded that in vivo, domains of high [Ca2+]i are transiently generated close to IP3-gated channels and sensed by nearby mitochondria; this may provide an efficient mechanism for optimizing mitochondrial activity upon cell stimulation.


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Physiol Rev 79, 1127-1155
   Abstract »    Full Text »    PDF »
ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria.
E. L Holmuhamedov, L. Wang, and A. Terzic (1999)
J. Physiol. 519, 347-360
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ATP-Induced Ca2+ Release in Cochlear Outer Hair Cells: Localization of an Inositol Triphosphate-Gated Ca2+ Store to the Base of the Sensory Hair Bundle.
F. Mammano, G. I. Frolenkov, L. Lagostena, I. A. Belyantseva, M. Kurc, V. Dodane, A. Colavita, and B. Kachar (1999)
J. Neurosci. 19, 6918-6929
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ATP Regulation of Type 1 Inositol 1,4,5-Trisphosphate Receptor Channel Gating by Allosteric Tuning of Ca2+ Activation.
D.-O. D. Mak, S. McBride, and J. K. Foskett (1999)
J. Biol. Chem. 274, 22231-22237
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Uptake and Release of Ca2+ by the Endoplasmic Reticulum Contribute to the Oscillations of the Cytosolic Ca2+ Concentration Triggered by Ca2+ Influx in the Electrically Excitable Pancreatic B-cell.
P. Gilon, A. Arredouani, P. Gailly, J. Gromada, and J.-C. Henquin (1999)
J. Biol. Chem. 274, 20197-20205
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