Related Content
Search Google Scholar for:
|
|
Science 29 October 1993: Vol. 262. no. 5134, pp. 740 - 744 DOI: 10.1126/science.8235594
|
|
Articles
Science, Vol 262, Issue 5134, 740-744
Copyright © 1993 by American Association for the Advancement of Science
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle
H Cheng,
WJ Lederer,
and
MB Cannell
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201.
Spontaneous local increases in the concentration of intracellular calcium, called "calcium sparks," were detected in quiescent rat heart cells with a laser scanning confocal microscope and the fluorescent calcium indicator fluo-3. Estimates of calcium flux associated with the sparks suggest that calcium sparks result from spontaneous openings of single sarcoplasmic reticulum (SR) calcium-release channels, a finding supported by ryanodine-dependent changes of spark kinetics. At resting intracellular calcium concentrations, these SR calcium-release channels had a low rate of opening (approximately 0.0001 per second). An increase in the calcium content of the SR, however, was associated with a fourfold increase in opening rate and resulted in some sparks triggering propagating waves of increased intracellular calcium concentration. The calcium spark is the consequence of elementary events underlying excitation-contraction coupling and provides an explanation for both spontaneous and triggered changes in the intracellular calcium concentration in the mammalian heart.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure.
- C. M. Sag, D. P. Wadsack, S. Khabbazzadeh, M. Abesser, C. Grefe, K. Neumann, M.-K. Opiela, J. Backs, E. N. Olson, J. H. Brown, et al. (2009)
Circ Heart Fail
2, 664-675
| Abstract »
| Full Text »
| PDF »
- Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure.
- T. L. Domeier, L. A. Blatter, and A. V. Zima (2009)
J. Physiol.
587, 5197-5209
| Abstract »
| Full Text »
| PDF »
- {beta}-Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel.
- P. Zhou, Y.-T. Zhao, Y.-B. Guo, S.-M. Xu, S.-H. Bai, E. G. Lakatta, H. Cheng, X.-M. Hao, and S.-Q. Wang (2009)
PNAS
106, 18028-18033
| Abstract »
| Full Text »
| PDF »
- Calcium-Induced Calcium Release in Skeletal Muscle.
- M. Endo (2009)
Physiol Rev
89, 1153-1176
| Abstract »
| Full Text »
| PDF »
- Comparison of sarcoplasmic reticulum calcium content in atrial and ventricular myocytes of three fish species.
- J. Haverinen and M. Vornanen (2009)
Am J Physiol Regulatory Integrative Comp Physiol
297, R1180-R1187
| Abstract »
| Full Text »
| PDF »
- Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors.
- J. M. Dubach, S. Das, A. Rosenzweig, and H. A. Clark (2009)
PNAS
106, 16145-16150
| Abstract »
| Full Text »
| PDF »
- Protein Kinase C-{varepsilon} Regulates Local Calcium Signaling in Airway Smooth Muscle Cells.
- Q.-H. Liu, Y.-M. Zheng, A. S. Korde, X.-Q. Li, J. Ma, H. Takeshima, and Y.-X. Wang (2009)
Am. J. Respir. Cell Mol. Biol.
40, 663-671
| Abstract »
| Full Text »
| PDF »
- Loss of Intracellular and Intercellular Synchrony of Calcium Release in Systolic Heart Failure.
- J. I. Goldhaber and J. H.B. Bridge (2009)
Circ Heart Fail
2, 157-159
| Full Text »
| PDF »
- Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca2+ signalling in rat ventricular myocytes.
- C. Soeller, I. D. Jayasinghe, P. Li, A. V. Holden, and M. B. Cannell (2009)
Exp Physiol
94, 496-508
| Abstract »
| Full Text »
| PDF »
- The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches.
- C. H. Orchard, M. Pasek, and F. Brette (2009)
Exp Physiol
94, 509-519
| Abstract »
| Full Text »
| PDF »
- Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins.
- A. M. Gomez, A. Rueda, Y. Sainte-Marie, L. Pereira, S. Zissimopoulos, X. Zhu, R. Schaub, E. Perrier, R. Perrier, C. Latouche, et al. (2009)
Circulation
119, 2179-2187
| Abstract »
| Full Text »
| PDF »
- Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart.
- T. Hayashi, M. E. Martone, Z. Yu, A. Thor, M. Doi, M. J. Holst, M. H. Ellisman, and M. Hoshijima (2009)
J. Cell Sci.
122, 1005-1013
| Abstract »
| Full Text »
| PDF »
- Activation of (Na++K+)-ATPase Modulates Cardiac L-Type Ca2+ Channel Function.
- D. I. Lee, M. G. Klein, W. Zhu, R.-P. Xiao, V. Gerzanich, and K. Y. Xu (2009)
Mol. Pharmacol.
75, 774-781
| Abstract »
| Full Text »
| PDF »
- Inositol-1,4,5-trisphosphate receptor-mediated Ca2+ waves in pyramidal neuron dendrites propagate through hot spots and cold spots.
- J. S. Fitzpatrick, A. M. Hagenston, D. N. Hertle, K. E. Gipson, L. Bertetto-D'Angelo, and M. F. Yeckel (2009)
J. Physiol.
587, 1439-1459
| Abstract »
| Full Text »
| PDF »
- Pulling on the Heart Strings: A New Mechanism Within Starling's Law of the Heart?.
- M. B. Cannell (2009)
Circ. Res.
104, 715-716
| Full Text »
| PDF »
- Axial Stretch of Rat Single Ventricular Cardiomyocytes Causes an Acute and Transient Increase in Ca2+ Spark Rate.
- G. Iribe, C. W. Ward, P. Camelliti, C. Bollensdorff, F. Mason, R. A.B. Burton, A. Garny, M. K. Morphew, A. Hoenger, W. J. Lederer, et al. (2009)
Circ. Res.
104, 787-795
| Abstract »
| Full Text »
| PDF »
- Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model.
- E. A. Sobie and H. R. Ramay (2009)
J. Physiol.
587, 1293-1299
| Abstract »
| Full Text »
| PDF »
- Increased Ca2+ Sensitivity of the Ryanodine Receptor Mutant RyR2R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia.
- M. Fernandez-Velasco, A. Rueda, N. Rizzi, J.-P. Benitah, B. Colombi, C. Napolitano, S. G. Priori, S. Richard, and A. M. Gomez (2009)
Circ. Res.
104, 201-209
| Abstract »
| Full Text »
| PDF »
- Local is as local does: the unitary nature of SR Ca2+ release in cardiac ventricular myocytes.
- M. R. Fowler (2009)
J. Physiol.
587, 301-302
| Full Text »
| PDF »
- Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes.
- K. A. Sheehan, Y. Ke, B. M. Wolska, and R. J. Solaro (2009)
Am J Physiol Cell Physiol
296, C47-C58
| Abstract »
| Full Text »
| PDF »
- Modulation of the Local SR Ca2+ Release by Intracellular Mg2+ in Cardiac Myocytes.
- K. Gusev and E. Niggli (2008)
J. Gen. Physiol.
132, 721-730
| Abstract »
| Full Text »
| PDF »
- Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes.
- A. V. Zima, J. Qin, M. Fill, and L. A. Blatter (2008)
Am J Physiol Heart Circ Physiol
295, H2008-H2016
| Abstract »
| Full Text »
| PDF »
- Termination of Cardiac Ca2+ Sparks: Role of Intra-SR [Ca2+], Release Flux, and Intra-SR Ca2+ Diffusion.
- A. V. Zima, E. Picht, D. M. Bers, and L. A. Blatter (2008)
Circ. Res.
103, e105-e115
| Abstract »
| Full Text »
| PDF »
- Calcium Sparks.
- H. Cheng and W. J. Lederer (2008)
Physiol Rev
88, 1491-1545
| Abstract »
| Full Text »
| PDF »
- New insights into the structure and function of couplons.
- J. H. B. Bridge, N. S. Torres, and E. A. Sobie (2008)
J. Physiol.
586, 3735
| Full Text »
| PDF »
- Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes.
- E. Polakova, A. Zahradnikova Jr, J. Pavelkova, I. Zahradnik, and A. Zahradnikova (2008)
J. Physiol.
586, 3839-3854
| Abstract »
| Full Text »
| PDF »
- A Close Association of RyRs with Highly Dense Clusters of Ca2+-activated Cl- Channels Underlies the Activation of STICs by Ca2+ Sparks in Mouse Airway Smooth Muscle.
- R. Bao, L. M. Lifshitz, R. A. Tuft, K. Bellve, K. E. Fogarty, and R. ZhuGe (2008)
J. Gen. Physiol.
132, 145-160
| Abstract »
| Full Text »
| PDF »
- Mathematical model of the neonatal mouse ventricular action potential.
- L. J. Wang and E. A. Sobie (2008)
Am J Physiol Heart Circ Physiol
294, H2565-H2575
| Abstract »
| Full Text »
| PDF »
- Calmodulin in adult mammalian skeletal muscle: localization and effect on sarcoplasmic reticulum Ca2+ release.
- G. G. Rodney (2008)
Am J Physiol Cell Physiol
294, C1288-C1297
| Abstract »
| Full Text »
| PDF »
- Calcium signalling in early embryos.
- M. Whitaker (2008)
Phil Trans R Soc B
363, 1401-1418
| Abstract »
| Full Text »
| PDF »
- Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca2+ signal integrators.
- M. Colella, F. Grisan, V. Robert, J. D. Turner, A. P. Thomas, and T. Pozzan (2008)
PNAS
105, 2859-2864
| Abstract »
| Full Text »
| PDF »
- S100A1 Binds to the Calmodulin-binding Site of Ryanodine Receptor and Modulates Skeletal Muscle Excitation-Contraction Coupling.
- B. L. Prosser, N. T. Wright, E. O. Hernandez-Ochoa, K. M. Varney, Y. Liu, R. O. Olojo, D. B. Zimmer, D. J. Weber, and M. F. Schneider (2008)
J. Biol. Chem.
283, 5046-5057
| Abstract »
| Full Text »
| PDF »
- AKAP150 Is Required for Stuttering Persistent Ca2+ Sparklets and Angiotensin II-Induced Hypertension.
- M. F. Navedo, M. Nieves-Cintron, G. C. Amberg, C. Yuan, V. S. Votaw, W. J. Lederer, G. S. McKnight, and L. F. Santana (2008)
Circ. Res.
102, e1-e11
| Abstract »
| Full Text »
| PDF »
- Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function.
- V. A. Maltsev and E. G. Lakatta (2008)
Cardiovasc Res
| Abstract »
| Full Text »
| PDF »
- Does a lack of RyR3 make mammalian skeletal muscle EC coupling a 'spark-less' affair?.
- C. W. Ward and G. G. Rodney (2008)
J. Physiol.
586, 313-314
| Full Text »
| PDF »
- Spontaneous and voltage-activated Ca2+ release in adult mouse skeletal muscle fibres expressing the type 3 ryanodine receptor.
- C. Legrand, E. Giacomello, C. Berthier, B. Allard, V. Sorrentino, and V. Jacquemond (2008)
J. Physiol.
586, 441-457
| Abstract »
| Full Text »
| PDF »
- t-tubules and sarcoplasmic reticulum function in cardiac ventricular myocytes.
- C. Orchard and F. Brette (2008)
Cardiovasc Res
77, 237-244
| Abstract »
| Full Text »
| PDF »
- Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?.
- C. H. George (2008)
Cardiovasc Res
77, 302-314
| Abstract »
| Full Text »
| PDF »
- Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes.
- Y. Yan, J. Liu, C. Wei, K. Li, W. Xie, Y. Wang, and H. Cheng (2008)
Cardiovasc Res
77, 432-441
| Abstract »
| Full Text »
| PDF »
- The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle.
- S. Chalmers and J. G. McCarron (2008)
J. Cell Sci.
121, 75-85
| Abstract »
| Full Text »
| PDF »
- Reactive oxygen species contribute to Ca2+ signals produced by osmotic stress in mouse skeletal muscle fibres.
- A. S. Martins, V. M. Shkryl, M. C. Nowycky, and N. Shirokova (2008)
J. Physiol.
586, 197-210
| Abstract »
| Full Text »
| PDF »
- Inherited Arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop Consensus Report About the Diagnosis, Phenotyping, Molecular Mechanisms, and Therapeutic Approaches for Primary Cardiomyopathies of Gene Mutations Affecting Ion Channel Function.
- S. E. Lehnart, M. J. Ackerman, D. W. Benson Jr, R. Brugada, C. E. Clancy, J. K. Donahue, A. L. George Jr, A. O. Grant, S. C. Groft, C. T. January, et al. (2007)
Circulation
116, 2325-2345
| Abstract »
| Full Text »
| PDF »
- Intact {beta}-Adrenergic Response and Unmodified Progression Toward Heart Failure in Mice With Genetic Ablation of a Major Protein Kinase A Phosphorylation Site in the Cardiac Ryanodine Receptor.
- N. A. Benkusky, C. S. Weber, J. A. Scherman, E. F. Farrell, T. A. Hacker, M. C. John, P. A. Powers, and H. H. Valdivia (2007)
Circ. Res.
101, 819-829
| Abstract »
| Full Text »
| PDF »
- Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells.
- K. Essin, A. Welling, F. Hofmann, F. C. Luft, M. Gollasch, and S. Moosmang (2007)
J. Physiol.
584, 205-219
| Abstract »
| Full Text »
| PDF »
- Calcium sparks activate calcium-dependent Cl current in rat corpus cavernosum smooth muscle cells.
- B. A. Williams and S. M. Sims (2007)
Am J Physiol Cell Physiol
293, C1239-C1251
| Abstract »
| Full Text »
| PDF »
- Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks.
- L. Balasubramanian, A. Ahmed, C.-M. Lo, J. S. K. Sham, and K.-P. Yip (2007)
Am J Physiol Regulatory Integrative Comp Physiol
293, R1586-R1594
| Abstract »
| Full Text »
| PDF »
- Analysis of ryanodine receptor clusters in rat and human cardiac myocytes.
- C. Soeller, D. Crossman, R. Gilbert, and M. B. Cannell (2007)
PNAS
104, 14958-14963
| Abstract »
| Full Text »
| PDF »
- Voltage Dependence of Cardiac Excitation Contraction Coupling: Unitary Ca2+ Current Amplitude and Open Channel Probability.
- J. Altamirano and D. M. Bers (2007)
Circ. Res.
101, 590-597
| Abstract »
| Full Text »
| PDF »
- The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes.
- L. Pereira, M. Metrich, M. Fernandez-Velasco, A. Lucas, J. Leroy, R. Perrier, E. Morel, R. Fischmeister, S. Richard, J.-P. Benitah, et al. (2007)
J. Physiol.
583, 685-694
| Abstract »
| Full Text »
| PDF »
- SparkMaster: automated calcium spark analysis with ImageJ.
- E. Picht, A. V. Zima, L. A. Blatter, and D. M. Bers (2007)
Am J Physiol Cell Physiol
293, C1073-C1081
| Abstract »
| Full Text »
| PDF »
- Hypersensitivity of BKCa to Ca2+ Sparks Underlies Hyporeactivity of Arterial Smooth Muscle in Shock.
- G. Zhao, Y. Zhao, B. Pan, J. Liu, X. Huang, X. Zhang, C. Cao, N. Hou, C. Wu, K.-s. Zhao, et al. (2007)
Circ. Res.
101, 493-502
| Abstract »
| Full Text »
| PDF »
- Functional groups of ryanodine receptors in rat ventricular cells.
- V. Lukyanenko, A. Ziman, A. Lukyanenko, V. Salnikov, and W. J. Lederer (2007)
J. Physiol.
583, 251-269
| Abstract »
| Full Text »
| PDF »
- Insights into the uterus.
- S. Wray (2007)
Exp Physiol
92, 621-631
| Abstract »
| Full Text »
| PDF »
- Sarcoplasmic reticulum Ca2+ release channel complex and automatism: A matter of fine tuning.
- J. W.M. Bassani and R. A. Bassani (2007)
Cardiovasc Res
75, 7-9
| Full Text »
| PDF »
- Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart.
- M. Reppel, B. K. Fleischmann, H. Reuter, P. Sasse, H. Schunkert, and J. Hescheler (2007)
Cardiovasc Res
75, 99-108
| Abstract »
| Full Text »
| PDF »
- Generation of Functional Cardiomyocytes From Adult Mouse Spermatogonial Stem Cells.
- K. Guan, S. Wagner, B. Unsold, L. S. Maier, D. Kaiser, B. Hemmerlein, K. Nayernia, W. Engel, and G. Hasenfuss (2007)
Circ. Res.
100, 1615-1625
| Abstract »
| Full Text »
| PDF »
- Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes.
- J. A. Copello, A. V. Zima, P. L. Diaz-Sylvester, M. Fill, and L. A. Blatter (2007)
Am J Physiol Cell Physiol
292, C2129-C2140
| Abstract »
| Full Text »
| PDF »
- Altered Ca2+ handling by ryanodine receptor and Na+-Ca2+ exchange in the heart from ovariectomized rats: role of protein kinase A.
- G. M. Kravtsov, K. W. L. Kam, J. Liu, S. Wu, and T. M. Wong (2007)
Am J Physiol Cell Physiol
292, C1625-C1635
| Abstract »
| Full Text »
| PDF »
- Calcium and Arrhythmogenesis.
- H. E. D. J. ter Keurs and P. A. Boyden (2007)
Physiol Rev
87, 457-506
| Abstract »
| Full Text »
| PDF »
- The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves.
- E. Hernandez, M. F. Leite, M. T. Guerra, E. A. Kruglov, O. Bruna-Romero, M. A. Rodrigues, D. A. Gomes, F. J. Giordano, J. A. Dranoff, and M. H. Nathanson (2007)
J. Biol. Chem.
282, 10057-10067
| Abstract »
| Full Text »
| PDF »
- Ca2+ sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle.
- S. Pouvreau, L. Royer, J. Yi, G. Brum, G. Meissner, E. Rios, and J. Zhou (2007)
PNAS
104, 5235-5240
| Abstract »
| Full Text »
| PDF »
- Ca2+ sparks and T tubule reorganization in dedifferentiating adult mouse skeletal muscle fibers.
- L. D. Brown, G. G. Rodney, E. Hernandez-Ochoa, C. W. Ward, and M. F. Schneider (2007)
Am J Physiol Cell Physiol
292, C1156-C1166
| Abstract »
| Full Text »
| PDF »
- Ca2+/Calmodulin Kinase II-Dependent Phosphorylation of Ryanodine Receptors Suppresses Ca2+ Sparks and Ca2+ Waves in Cardiac Myocytes.
- D. Yang, W.-Z. Zhu, B. Xiao, D. X.P. Brochet, S.R. W. Chen, E. G. Lakatta, R.-P. Xiao, and H. Cheng (2007)
Circ. Res.
100, 399-407
| Abstract »
| Full Text »
| PDF »
- Kinetics of calcium spikes in rat cardiac myocytes.
- A. Zahradnikova Jr, E. Polakova, I. Zahradnik, and A. Zahradnikova (2007)
J. Physiol.
578, 677-691
| Abstract »
| Full Text »
| PDF »
- The Cardiac Sarcoplasmic Reticulum: Filled With Ca2+ and Surprises.
- E. Niggli (2007)
Circ. Res.
100, 5-6
| Full Text »
| PDF »
- Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes.
- A. V. Zima, J. Kockskamper, and L. A. Blatter (2006)
J. Physiol.
577, 281-293
| Abstract »
| Full Text »
| PDF »
- Integrin Ligands Mobilize Ca2+ from Ryanodine Receptor-gated Stores and Lysosome-related Acidic Organelles in Pulmonary Arterial Smooth Muscle Cells.
- A. Umesh, M. A. Thompson, E. N. Chini, K.-P. Yip, and J. S. K. Sham (2006)
J. Biol. Chem.
281, 34312-34323
| Abstract »
| Full Text »
| PDF »
- Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.
- L. Hove-Madsen, C. Prat-Vidal, A. Llach, F. Ciruela, V. Casado, C. Lluis, A. Bayes-Genis, J. Cinca, and R. Franco (2006)
Cardiovasc Res
72, 292-302
| Abstract »
| Full Text »
| PDF »
- Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes..
- M. D. Bootman, D. R. Higazi, S. Coombes, and H. L. Roderick (2006)
J. Cell Sci.
119, 3915-3925
| Abstract »
| Full Text »
| PDF »
- The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function.
- J. Altamirano, Y. Li, J. DeSantiago, V. Piacentino 3rd, S. R. Houser, and D. M. Bers (2006)
J. Physiol.
575, 845-854
| Abstract »
| Full Text »
| PDF »
- The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions.
- R. M. Luik, M. M. Wu, J. Buchanan, and R. S. Lewis (2006)
J. Cell Biol.
174, 815-825
| Abstract »
| Full Text »
| PDF »
- KCa channel insensitivity to Ca2+ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells.
- A. Li, A. Adebiyi, C. W. Leffler, and J. H. Jaggar (2006)
Am J Physiol Heart Circ Physiol
291, H1118-H1125
| Abstract »
| Full Text »
| PDF »
- Thyroid hormone downregulates the expression and function of sarcoplasmic reticulum-associated CaM kinase II in the rabbit heart.
- M. Jiang, A. Xu, and N. Narayanan (2006)
Am J Physiol Heart Circ Physiol
291, H1384-H1394
| Abstract »
| Full Text »
| PDF »
- Remodeling of the Cardiac Pacemaker L-Type Calcium Current and Its {beta}-Adrenergic Responsiveness in Hypertension After Neuronal NO Synthase Gene Transfer.
- D. A. Heaton, M. Lei, D. Li, S. Golding, T. A. Dawson, R. M. Mohan, and D. J. Paterson (2006)
Hypertension
48, 443-452
| Abstract »
| Full Text »
| PDF »
- Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.
- N. Weisleder, M. Brotto, S. Komazaki, Z. Pan, X. Zhao, T. Nosek, J. Parness, H. Takeshima, and J. Ma (2006)
J. Cell Biol.
174, 639-645
| Abstract »
| Full Text »
| PDF »
- Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation of Ryanodine Receptor Does Affect Calcium Sparks in Mouse Ventricular Myocytes.
- T. Guo, T. Zhang, R. Mestril, and D. M. Bers (2006)
Circ. Res.
99, 398-406
| Abstract »
| Full Text »
| PDF »
- Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes.
- A. Proven, H. L. Roderick, S. J. Conway, M. J. Berridge, J. K. Horton, S. J. Capper, and M. D. Bootman (2006)
J. Cell Sci.
119, 3363-3375
| Abstract »
| Full Text »
| PDF »
- Life, Sudden Death, and Intracellular Calcium.
- D.A. Eisner, L.A. Venetucci, and A.W. Trafford (2006)
Circ. Res.
99, 223-224
| Full Text »
| PDF »
- Mini-dystrophin Expression Down-regulates IP3-mediated Calcium Release Events in Resting Dystrophin-deficient Muscle Cells.
- H. Balghi, S. Sebille, L. Mondin, A. Cantereau, B. Constantin, G. Raymond, and C. Cognard (2006)
J. Gen. Physiol.
128, 219-230
| Abstract »
| Full Text »
| PDF »
- Redox regulation of cardiac calcium channels and transporters.
- A. V. Zima and L. A. Blatter (2006)
Cardiovasc Res
71, 310-321
| Abstract »
| Full Text »
| PDF »
- Plasmalemmal Ca2+ Signaling in Arterial Smooth Muscle: It's Elementary!.
- I. Parker (2006)
J. Gen. Physiol.
127, 605-609
| Full Text »
| PDF »
- Is the Ryanodine Receptor a Target for Antiarrhythmic Therapy?.
- C. Pott and J. I. Goldhaber (2006)
Circ. Res.
98, 1232-1233
| Full Text »
| PDF »
- Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes.
- K. A. Sheehan, A. V. Zima, and L. A. Blatter (2006)
J. Physiol.
572, 799-809
| Abstract »
| Full Text »
| PDF »
- Calcium spark properties in ventricular myocytes are altered in aged mice.
- S. E. Howlett, S. A. Grandy, and G. R. Ferrier (2006)
Am J Physiol Heart Circ Physiol
290, H1566-H1574
| Abstract »
| Full Text »
| PDF »
- Orphaned ryanodine receptors in the failing heart..
- L.-S. Song, E. A. Sobie, S. McCulle, W. J. Lederer, C. W. Balke, and H. Cheng (2006)
PNAS
103, 4305-4310
| Abstract »
| Full Text »
| PDF »
- Mechanisms of [Ca2+]i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice.
- L. Pereira, J. Matthes, I. Schuster, H. H. Valdivia, S. Herzig, S. Richard, and A. M. Gomez (2006)
Diabetes
55, 608-615
| Abstract »
| Full Text »
| PDF »
- On the Loose: Uncaging Ca2+-induced Ca2+ Release in Smooth Muscle.
- G. C. Amberg, M. F. Navedo, and L. F. Santana (2006)
J. Gen. Physiol.
127, 221-223
| Full Text »
| PDF »
- Effects of Tetracaine on Voltage-activated Calcium Sparks in Frog Intact Skeletal Muscle Fibers.
- S. Hollingworth, W. K. Chandler, and S. M. Baylor (2006)
J. Gen. Physiol.
127, 291-307
| Abstract »
| Full Text »
| PDF »
- Depletion "skraps" and dynamic buffering inside the cellular calcium store.
- B. S. Launikonis, J. Zhou, L. Royer, T. R. Shannon, G. Brum, and E. Rios (2006)
PNAS
103, 2982-2987
| Abstract »
| Full Text »
| PDF »
- "Ryanogate": Who Leaked the Calcium?.
- S. E. Litwin (2006)
Circ. Res.
98, 165-168
| Full Text »
| PDF »
- Calcium-Activated Potassium Channels and the Regulation of Vascular Tone.
- J. Ledoux, M. E. Werner, J. E. Brayden, and M. T. Nelson (2006)
Physiology
21, 69-78
| Abstract »
| Full Text »
| PDF »
- A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle.
- J. Zhou, J. Yi, L. Royer, B. S. Launikonis, A. Gonzalez, J. Garcia, and E. Rios (2006)
Am J Physiol Cell Physiol
290, C539-C553
| Abstract »
| Full Text »
| PDF »
- Calcium at Fertilization and in Early Development.
- M. Whitaker (2006)
Physiol Rev
86, 25-88
| Abstract »
| Full Text »
| PDF »
- Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences.
- R. Rizzuto and T. Pozzan (2006)
Physiol Rev
86, 369-408
| Abstract »
| Full Text »
| PDF »
- Calcium events in smooth muscles and their interstitial cells; physiological roles of sparks.
- T. B. Bolton (2006)
J. Physiol.
570, 5-11
| Abstract »
| Full Text »
| PDF »
|
|