Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 29 October 1993:
Vol. 262. no. 5134, pp. 740 - 744
DOI: 10.1126/science.8235594

Articles

Science, Vol 262, Issue 5134, 740-744
Copyright © 1993 by American Association for the Advancement of Science


articles

Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle

H Cheng, WJ Lederer, and MB Cannell

Department of Physiology, University of Maryland School of Medicine, Baltimore 21201.

Spontaneous local increases in the concentration of intracellular calcium, called "calcium sparks," were detected in quiescent rat heart cells with a laser scanning confocal microscope and the fluorescent calcium indicator fluo-3. Estimates of calcium flux associated with the sparks suggest that calcium sparks result from spontaneous openings of single sarcoplasmic reticulum (SR) calcium-release channels, a finding supported by ryanodine-dependent changes of spark kinetics. At resting intracellular calcium concentrations, these SR calcium-release channels had a low rate of opening (approximately 0.0001 per second). An increase in the calcium content of the SR, however, was associated with a fourfold increase in opening rate and resulted in some sparks triggering propagating waves of increased intracellular calcium concentration. The calcium spark is the consequence of elementary events underlying excitation-contraction coupling and provides an explanation for both spontaneous and triggered changes in the intracellular calcium concentration in the mammalian heart.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure.
C. M. Sag, D. P. Wadsack, S. Khabbazzadeh, M. Abesser, C. Grefe, K. Neumann, M.-K. Opiela, J. Backs, E. N. Olson, J. H. Brown, et al. (2009)
Circ Heart Fail 2, 664-675
   Abstract »    Full Text »    PDF »
Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure.
T. L. Domeier, L. A. Blatter, and A. V. Zima (2009)
J. Physiol. 587, 5197-5209
   Abstract »    Full Text »    PDF »
{beta}-Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel.
P. Zhou, Y.-T. Zhao, Y.-B. Guo, S.-M. Xu, S.-H. Bai, E. G. Lakatta, H. Cheng, X.-M. Hao, and S.-Q. Wang (2009)
PNAS 106, 18028-18033
   Abstract »    Full Text »    PDF »
Calcium-Induced Calcium Release in Skeletal Muscle.
M. Endo (2009)
Physiol Rev 89, 1153-1176
   Abstract »    Full Text »    PDF »
Comparison of sarcoplasmic reticulum calcium content in atrial and ventricular myocytes of three fish species.
J. Haverinen and M. Vornanen (2009)
Am J Physiol Regulatory Integrative Comp Physiol 297, R1180-R1187
   Abstract »    Full Text »    PDF »
Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors.
J. M. Dubach, S. Das, A. Rosenzweig, and H. A. Clark (2009)
PNAS 106, 16145-16150
   Abstract »    Full Text »    PDF »
Protein Kinase C-{varepsilon} Regulates Local Calcium Signaling in Airway Smooth Muscle Cells.
Q.-H. Liu, Y.-M. Zheng, A. S. Korde, X.-Q. Li, J. Ma, H. Takeshima, and Y.-X. Wang (2009)
Am. J. Respir. Cell Mol. Biol. 40, 663-671
   Abstract »    Full Text »    PDF »
Loss of Intracellular and Intercellular Synchrony of Calcium Release in Systolic Heart Failure.
J. I. Goldhaber and J. H.B. Bridge (2009)
Circ Heart Fail 2, 157-159
   Full Text »    PDF »
Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca2+ signalling in rat ventricular myocytes.
C. Soeller, I. D. Jayasinghe, P. Li, A. V. Holden, and M. B. Cannell (2009)
Exp Physiol 94, 496-508
   Abstract »    Full Text »    PDF »
The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches.
C. H. Orchard, M. Pasek, and F. Brette (2009)
Exp Physiol 94, 509-519
   Abstract »    Full Text »    PDF »
Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins.
A. M. Gomez, A. Rueda, Y. Sainte-Marie, L. Pereira, S. Zissimopoulos, X. Zhu, R. Schaub, E. Perrier, R. Perrier, C. Latouche, et al. (2009)
Circulation 119, 2179-2187
   Abstract »    Full Text »    PDF »
Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart.
T. Hayashi, M. E. Martone, Z. Yu, A. Thor, M. Doi, M. J. Holst, M. H. Ellisman, and M. Hoshijima (2009)
J. Cell Sci. 122, 1005-1013
   Abstract »    Full Text »    PDF »
Activation of (Na++K+)-ATPase Modulates Cardiac L-Type Ca2+ Channel Function.
D. I. Lee, M. G. Klein, W. Zhu, R.-P. Xiao, V. Gerzanich, and K. Y. Xu (2009)
Mol. Pharmacol. 75, 774-781
   Abstract »    Full Text »    PDF »
Inositol-1,4,5-trisphosphate receptor-mediated Ca2+ waves in pyramidal neuron dendrites propagate through hot spots and cold spots.
J. S. Fitzpatrick, A. M. Hagenston, D. N. Hertle, K. E. Gipson, L. Bertetto-D'Angelo, and M. F. Yeckel (2009)
J. Physiol. 587, 1439-1459
   Abstract »    Full Text »    PDF »
Pulling on the Heart Strings: A New Mechanism Within Starling's Law of the Heart?.
M. B. Cannell (2009)
Circ. Res. 104, 715-716
   Full Text »    PDF »
Axial Stretch of Rat Single Ventricular Cardiomyocytes Causes an Acute and Transient Increase in Ca2+ Spark Rate.
G. Iribe, C. W. Ward, P. Camelliti, C. Bollensdorff, F. Mason, R. A.B. Burton, A. Garny, M. K. Morphew, A. Hoenger, W. J. Lederer, et al. (2009)
Circ. Res. 104, 787-795
   Abstract »    Full Text »    PDF »
Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model.
E. A. Sobie and H. R. Ramay (2009)
J. Physiol. 587, 1293-1299
   Abstract »    Full Text »    PDF »
Increased Ca2+ Sensitivity of the Ryanodine Receptor Mutant RyR2R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia.
M. Fernandez-Velasco, A. Rueda, N. Rizzi, J.-P. Benitah, B. Colombi, C. Napolitano, S. G. Priori, S. Richard, and A. M. Gomez (2009)
Circ. Res. 104, 201-209
   Abstract »    Full Text »    PDF »
Local is as local does: the unitary nature of SR Ca2+ release in cardiac ventricular myocytes.
M. R. Fowler (2009)
J. Physiol. 587, 301-302
   Full Text »    PDF »
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes.
K. A. Sheehan, Y. Ke, B. M. Wolska, and R. J. Solaro (2009)
Am J Physiol Cell Physiol 296, C47-C58
   Abstract »    Full Text »    PDF »
Modulation of the Local SR Ca2+ Release by Intracellular Mg2+ in Cardiac Myocytes.
K. Gusev and E. Niggli (2008)
J. Gen. Physiol. 132, 721-730
   Abstract »    Full Text »    PDF »
Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes.
A. V. Zima, J. Qin, M. Fill, and L. A. Blatter (2008)
Am J Physiol Heart Circ Physiol 295, H2008-H2016
   Abstract »    Full Text »    PDF »
Termination of Cardiac Ca2+ Sparks: Role of Intra-SR [Ca2+], Release Flux, and Intra-SR Ca2+ Diffusion.
A. V. Zima, E. Picht, D. M. Bers, and L. A. Blatter (2008)
Circ. Res. 103, e105-e115
   Abstract »    Full Text »    PDF »
Calcium Sparks.
H. Cheng and W. J. Lederer (2008)
Physiol Rev 88, 1491-1545
   Abstract »    Full Text »    PDF »
New insights into the structure and function of couplons.
J. H. B. Bridge, N. S. Torres, and E. A. Sobie (2008)
J. Physiol. 586, 3735
   Full Text »    PDF »
Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes.
E. Polakova, A. Zahradnikova Jr, J. Pavelkova, I. Zahradnik, and A. Zahradnikova (2008)
J. Physiol. 586, 3839-3854
   Abstract »    Full Text »    PDF »
A Close Association of RyRs with Highly Dense Clusters of Ca2+-activated Cl- Channels Underlies the Activation of STICs by Ca2+ Sparks in Mouse Airway Smooth Muscle.
R. Bao, L. M. Lifshitz, R. A. Tuft, K. Bellve, K. E. Fogarty, and R. ZhuGe (2008)
J. Gen. Physiol. 132, 145-160
   Abstract »    Full Text »    PDF »
Mathematical model of the neonatal mouse ventricular action potential.
L. J. Wang and E. A. Sobie (2008)
Am J Physiol Heart Circ Physiol 294, H2565-H2575
   Abstract »    Full Text »    PDF »
Calmodulin in adult mammalian skeletal muscle: localization and effect on sarcoplasmic reticulum Ca2+ release.
G. G. Rodney (2008)
Am J Physiol Cell Physiol 294, C1288-C1297
   Abstract »    Full Text »    PDF »
Calcium signalling in early embryos.
M. Whitaker (2008)
Phil Trans R Soc B 363, 1401-1418
   Abstract »    Full Text »    PDF »
Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca2+ signal integrators.
M. Colella, F. Grisan, V. Robert, J. D. Turner, A. P. Thomas, and T. Pozzan (2008)
PNAS 105, 2859-2864
   Abstract »    Full Text »    PDF »
S100A1 Binds to the Calmodulin-binding Site of Ryanodine Receptor and Modulates Skeletal Muscle Excitation-Contraction Coupling.
B. L. Prosser, N. T. Wright, E. O. Hernandez-Ochoa, K. M. Varney, Y. Liu, R. O. Olojo, D. B. Zimmer, D. J. Weber, and M. F. Schneider (2008)
J. Biol. Chem. 283, 5046-5057
   Abstract »    Full Text »    PDF »
AKAP150 Is Required for Stuttering Persistent Ca2+ Sparklets and Angiotensin II-Induced Hypertension.
M. F. Navedo, M. Nieves-Cintron, G. C. Amberg, C. Yuan, V. S. Votaw, W. J. Lederer, G. S. McKnight, and L. F. Santana (2008)
Circ. Res. 102, e1-e11
   Abstract »    Full Text »    PDF »
Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function.
V. A. Maltsev and E. G. Lakatta (2008)
Cardiovasc Res
   Abstract »    Full Text »    PDF »
Does a lack of RyR3 make mammalian skeletal muscle EC coupling a 'spark-less' affair?.
C. W. Ward and G. G. Rodney (2008)
J. Physiol. 586, 313-314
   Full Text »    PDF »
Spontaneous and voltage-activated Ca2+ release in adult mouse skeletal muscle fibres expressing the type 3 ryanodine receptor.
C. Legrand, E. Giacomello, C. Berthier, B. Allard, V. Sorrentino, and V. Jacquemond (2008)
J. Physiol. 586, 441-457
   Abstract »    Full Text »    PDF »
t-tubules and sarcoplasmic reticulum function in cardiac ventricular myocytes.
C. Orchard and F. Brette (2008)
Cardiovasc Res 77, 237-244
   Abstract »    Full Text »    PDF »
Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?.
C. H. George (2008)
Cardiovasc Res 77, 302-314
   Abstract »    Full Text »    PDF »
Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes.
Y. Yan, J. Liu, C. Wei, K. Li, W. Xie, Y. Wang, and H. Cheng (2008)
Cardiovasc Res 77, 432-441
   Abstract »    Full Text »    PDF »
The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle.
S. Chalmers and J. G. McCarron (2008)
J. Cell Sci. 121, 75-85
   Abstract »    Full Text »    PDF »
Reactive oxygen species contribute to Ca2+ signals produced by osmotic stress in mouse skeletal muscle fibres.
A. S. Martins, V. M. Shkryl, M. C. Nowycky, and N. Shirokova (2008)
J. Physiol. 586, 197-210
   Abstract »    Full Text »    PDF »
Inherited Arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop Consensus Report About the Diagnosis, Phenotyping, Molecular Mechanisms, and Therapeutic Approaches for Primary Cardiomyopathies of Gene Mutations Affecting Ion Channel Function.
S. E. Lehnart, M. J. Ackerman, D. W. Benson Jr, R. Brugada, C. E. Clancy, J. K. Donahue, A. L. George Jr, A. O. Grant, S. C. Groft, C. T. January, et al. (2007)
Circulation 116, 2325-2345
   Abstract »    Full Text »    PDF »
Intact {beta}-Adrenergic Response and Unmodified Progression Toward Heart Failure in Mice With Genetic Ablation of a Major Protein Kinase A Phosphorylation Site in the Cardiac Ryanodine Receptor.
N. A. Benkusky, C. S. Weber, J. A. Scherman, E. F. Farrell, T. A. Hacker, M. C. John, P. A. Powers, and H. H. Valdivia (2007)
Circ. Res. 101, 819-829
   Abstract »    Full Text »    PDF »
Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells.
K. Essin, A. Welling, F. Hofmann, F. C. Luft, M. Gollasch, and S. Moosmang (2007)
J. Physiol. 584, 205-219
   Abstract »    Full Text »    PDF »
Calcium sparks activate calcium-dependent Cl current in rat corpus cavernosum smooth muscle cells.
B. A. Williams and S. M. Sims (2007)
Am J Physiol Cell Physiol 293, C1239-C1251
   Abstract »    Full Text »    PDF »
Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks.
L. Balasubramanian, A. Ahmed, C.-M. Lo, J. S. K. Sham, and K.-P. Yip (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R1586-R1594
   Abstract »    Full Text »    PDF »
Analysis of ryanodine receptor clusters in rat and human cardiac myocytes.
C. Soeller, D. Crossman, R. Gilbert, and M. B. Cannell (2007)
PNAS 104, 14958-14963
   Abstract »    Full Text »    PDF »
Voltage Dependence of Cardiac Excitation Contraction Coupling: Unitary Ca2+ Current Amplitude and Open Channel Probability.
J. Altamirano and D. M. Bers (2007)
Circ. Res. 101, 590-597
   Abstract »    Full Text »    PDF »
The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes.
L. Pereira, M. Metrich, M. Fernandez-Velasco, A. Lucas, J. Leroy, R. Perrier, E. Morel, R. Fischmeister, S. Richard, J.-P. Benitah, et al. (2007)
J. Physiol. 583, 685-694
   Abstract »    Full Text »    PDF »
SparkMaster: automated calcium spark analysis with ImageJ.
E. Picht, A. V. Zima, L. A. Blatter, and D. M. Bers (2007)
Am J Physiol Cell Physiol 293, C1073-C1081
   Abstract »    Full Text »    PDF »
Hypersensitivity of BKCa to Ca2+ Sparks Underlies Hyporeactivity of Arterial Smooth Muscle in Shock.
G. Zhao, Y. Zhao, B. Pan, J. Liu, X. Huang, X. Zhang, C. Cao, N. Hou, C. Wu, K.-s. Zhao, et al. (2007)
Circ. Res. 101, 493-502
   Abstract »    Full Text »    PDF »
Functional groups of ryanodine receptors in rat ventricular cells.
V. Lukyanenko, A. Ziman, A. Lukyanenko, V. Salnikov, and W. J. Lederer (2007)
J. Physiol. 583, 251-269
   Abstract »    Full Text »    PDF »
Insights into the uterus.
S. Wray (2007)
Exp Physiol 92, 621-631
   Abstract »    Full Text »    PDF »
Sarcoplasmic reticulum Ca2+ release channel complex and automatism: A matter of fine tuning.
J. W.M. Bassani and R. A. Bassani (2007)
Cardiovasc Res 75, 7-9
   Full Text »    PDF »
Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart.
M. Reppel, B. K. Fleischmann, H. Reuter, P. Sasse, H. Schunkert, and J. Hescheler (2007)
Cardiovasc Res 75, 99-108
   Abstract »    Full Text »    PDF »
Generation of Functional Cardiomyocytes From Adult Mouse Spermatogonial Stem Cells.
K. Guan, S. Wagner, B. Unsold, L. S. Maier, D. Kaiser, B. Hemmerlein, K. Nayernia, W. Engel, and G. Hasenfuss (2007)
Circ. Res. 100, 1615-1625
   Abstract »    Full Text »    PDF »
Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes.
J. A. Copello, A. V. Zima, P. L. Diaz-Sylvester, M. Fill, and L. A. Blatter (2007)
Am J Physiol Cell Physiol 292, C2129-C2140
   Abstract »    Full Text »    PDF »
Altered Ca2+ handling by ryanodine receptor and Na+-Ca2+ exchange in the heart from ovariectomized rats: role of protein kinase A.
G. M. Kravtsov, K. W. L. Kam, J. Liu, S. Wu, and T. M. Wong (2007)
Am J Physiol Cell Physiol 292, C1625-C1635
   Abstract »    Full Text »    PDF »
Calcium and Arrhythmogenesis.
H. E. D. J. ter Keurs and P. A. Boyden (2007)
Physiol Rev 87, 457-506
   Abstract »    Full Text »    PDF »
The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves.
E. Hernandez, M. F. Leite, M. T. Guerra, E. A. Kruglov, O. Bruna-Romero, M. A. Rodrigues, D. A. Gomes, F. J. Giordano, J. A. Dranoff, and M. H. Nathanson (2007)
J. Biol. Chem. 282, 10057-10067
   Abstract »    Full Text »    PDF »
Ca2+ sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle.
S. Pouvreau, L. Royer, J. Yi, G. Brum, G. Meissner, E. Rios, and J. Zhou (2007)
PNAS 104, 5235-5240
   Abstract »    Full Text »    PDF »
Ca2+ sparks and T tubule reorganization in dedifferentiating adult mouse skeletal muscle fibers.
L. D. Brown, G. G. Rodney, E. Hernandez-Ochoa, C. W. Ward, and M. F. Schneider (2007)
Am J Physiol Cell Physiol 292, C1156-C1166
   Abstract »    Full Text »    PDF »
Ca2+/Calmodulin Kinase II-Dependent Phosphorylation of Ryanodine Receptors Suppresses Ca2+ Sparks and Ca2+ Waves in Cardiac Myocytes.
D. Yang, W.-Z. Zhu, B. Xiao, D. X.P. Brochet, S.R. W. Chen, E. G. Lakatta, R.-P. Xiao, and H. Cheng (2007)
Circ. Res. 100, 399-407
   Abstract »    Full Text »    PDF »
Kinetics of calcium spikes in rat cardiac myocytes.
A. Zahradnikova Jr, E. Polakova, I. Zahradnik, and A. Zahradnikova (2007)
J. Physiol. 578, 677-691
   Abstract »    Full Text »    PDF »
The Cardiac Sarcoplasmic Reticulum: Filled With Ca2+ and Surprises.
E. Niggli (2007)
Circ. Res. 100, 5-6
   Full Text »    PDF »
Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes.
A. V. Zima, J. Kockskamper, and L. A. Blatter (2006)
J. Physiol. 577, 281-293
   Abstract »    Full Text »    PDF »
Integrin Ligands Mobilize Ca2+ from Ryanodine Receptor-gated Stores and Lysosome-related Acidic Organelles in Pulmonary Arterial Smooth Muscle Cells.
A. Umesh, M. A. Thompson, E. N. Chini, K.-P. Yip, and J. S. K. Sham (2006)
J. Biol. Chem. 281, 34312-34323
   Abstract »    Full Text »    PDF »
Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.
L. Hove-Madsen, C. Prat-Vidal, A. Llach, F. Ciruela, V. Casado, C. Lluis, A. Bayes-Genis, J. Cinca, and R. Franco (2006)
Cardiovasc Res 72, 292-302
   Abstract »    Full Text »    PDF »
Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes..
M. D. Bootman, D. R. Higazi, S. Coombes, and H. L. Roderick (2006)
J. Cell Sci. 119, 3915-3925
   Abstract »    Full Text »    PDF »
The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function.
J. Altamirano, Y. Li, J. DeSantiago, V. Piacentino 3rd, S. R. Houser, and D. M. Bers (2006)
J. Physiol. 575, 845-854
   Abstract »    Full Text »    PDF »
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions.
R. M. Luik, M. M. Wu, J. Buchanan, and R. S. Lewis (2006)
J. Cell Biol. 174, 815-825
   Abstract »    Full Text »    PDF »
KCa channel insensitivity to Ca2+ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells.
A. Li, A. Adebiyi, C. W. Leffler, and J. H. Jaggar (2006)
Am J Physiol Heart Circ Physiol 291, H1118-H1125
   Abstract »    Full Text »    PDF »
Thyroid hormone downregulates the expression and function of sarcoplasmic reticulum-associated CaM kinase II in the rabbit heart.
M. Jiang, A. Xu, and N. Narayanan (2006)
Am J Physiol Heart Circ Physiol 291, H1384-H1394
   Abstract »    Full Text »    PDF »
Remodeling of the Cardiac Pacemaker L-Type Calcium Current and Its {beta}-Adrenergic Responsiveness in Hypertension After Neuronal NO Synthase Gene Transfer.
D. A. Heaton, M. Lei, D. Li, S. Golding, T. A. Dawson, R. M. Mohan, and D. J. Paterson (2006)
Hypertension 48, 443-452
   Abstract »    Full Text »    PDF »
Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.
N. Weisleder, M. Brotto, S. Komazaki, Z. Pan, X. Zhao, T. Nosek, J. Parness, H. Takeshima, and J. Ma (2006)
J. Cell Biol. 174, 639-645
   Abstract »    Full Text »    PDF »
Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation of Ryanodine Receptor Does Affect Calcium Sparks in Mouse Ventricular Myocytes.
T. Guo, T. Zhang, R. Mestril, and D. M. Bers (2006)
Circ. Res. 99, 398-406
   Abstract »    Full Text »    PDF »
Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes.
A. Proven, H. L. Roderick, S. J. Conway, M. J. Berridge, J. K. Horton, S. J. Capper, and M. D. Bootman (2006)
J. Cell Sci. 119, 3363-3375
   Abstract »    Full Text »    PDF »
Life, Sudden Death, and Intracellular Calcium.
D.A. Eisner, L.A. Venetucci, and A.W. Trafford (2006)
Circ. Res. 99, 223-224
   Full Text »    PDF »
Mini-dystrophin Expression Down-regulates IP3-mediated Calcium Release Events in Resting Dystrophin-deficient Muscle Cells.
H. Balghi, S. Sebille, L. Mondin, A. Cantereau, B. Constantin, G. Raymond, and C. Cognard (2006)
J. Gen. Physiol. 128, 219-230
   Abstract »    Full Text »    PDF »
Redox regulation of cardiac calcium channels and transporters.
A. V. Zima and L. A. Blatter (2006)
Cardiovasc Res 71, 310-321
   Abstract »    Full Text »    PDF »
Plasmalemmal Ca2+ Signaling in Arterial Smooth Muscle: It's Elementary!.
I. Parker (2006)
J. Gen. Physiol. 127, 605-609
   Full Text »    PDF »
Is the Ryanodine Receptor a Target for Antiarrhythmic Therapy?.
C. Pott and J. I. Goldhaber (2006)
Circ. Res. 98, 1232-1233
   Full Text »    PDF »
Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes.
K. A. Sheehan, A. V. Zima, and L. A. Blatter (2006)
J. Physiol. 572, 799-809
   Abstract »    Full Text »    PDF »
Calcium spark properties in ventricular myocytes are altered in aged mice.
S. E. Howlett, S. A. Grandy, and G. R. Ferrier (2006)
Am J Physiol Heart Circ Physiol 290, H1566-H1574
   Abstract »    Full Text »    PDF »
Orphaned ryanodine receptors in the failing heart..
L.-S. Song, E. A. Sobie, S. McCulle, W. J. Lederer, C. W. Balke, and H. Cheng (2006)
PNAS 103, 4305-4310
   Abstract »    Full Text »    PDF »
Mechanisms of [Ca2+]i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice.
L. Pereira, J. Matthes, I. Schuster, H. H. Valdivia, S. Herzig, S. Richard, and A. M. Gomez (2006)
Diabetes 55, 608-615
   Abstract »    Full Text »    PDF »
On the Loose: Uncaging Ca2+-induced Ca2+ Release in Smooth Muscle.
G. C. Amberg, M. F. Navedo, and L. F. Santana (2006)
J. Gen. Physiol. 127, 221-223
   Full Text »    PDF »
Effects of Tetracaine on Voltage-activated Calcium Sparks in Frog Intact Skeletal Muscle Fibers.
S. Hollingworth, W. K. Chandler, and S. M. Baylor (2006)
J. Gen. Physiol. 127, 291-307
   Abstract »    Full Text »    PDF »
Depletion "skraps" and dynamic buffering inside the cellular calcium store.
B. S. Launikonis, J. Zhou, L. Royer, T. R. Shannon, G. Brum, and E. Rios (2006)
PNAS 103, 2982-2987
   Abstract »    Full Text »    PDF »
"Ryanogate": Who Leaked the Calcium?.
S. E. Litwin (2006)
Circ. Res. 98, 165-168
   Full Text »    PDF »
Calcium-Activated Potassium Channels and the Regulation of Vascular Tone.
J. Ledoux, M. E. Werner, J. E. Brayden, and M. T. Nelson (2006)
Physiology 21, 69-78
   Abstract »    Full Text »    PDF »
A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle.
J. Zhou, J. Yi, L. Royer, B. S. Launikonis, A. Gonzalez, J. Garcia, and E. Rios (2006)
Am J Physiol Cell Physiol 290, C539-C553
   Abstract »    Full Text »    PDF »
Calcium at Fertilization and in Early Development.
M. Whitaker (2006)
Physiol Rev 86, 25-88
   Abstract »    Full Text »    PDF »
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences.
R. Rizzuto and T. Pozzan (2006)
Physiol Rev 86, 369-408
   Abstract »    Full Text »    PDF »
Calcium events in smooth muscles and their interstitial cells; physiological roles of sparks.
T. B. Bolton (2006)
J. Physiol. 570, 5-11
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)