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Science 29 October 1993:
Vol. 262. no. 5134, pp. 713 - 718
DOI: 10.1126/science.8235591

Articles

Science, Vol 262, Issue 5134, 713-718
Copyright © 1993 by American Association for the Advancement of Science


articles

Neural induction by the secreted polypeptide noggin

TM Lamb, AK Knecht, WC Smith, SE Stachel, AN Economides, N Stahl, GD Yancopolous, and RM Harland

Department of Molecular and Cell Biology, University of California, Berkeley 94720.

The Spermann organizer induces neural tissue from dorsal ectoderm and dorsalizes lateral and ventral mesoderm in Xenopus. The secreted factor noggin, which is expressed in the organizer, can mimic the dorsalizing signal of the organizer. Data are presented showing that noggin directly induces neural tissue, that it induces neural tissue in the absence of dorsal mesoderm, and that it acts at the appropriate stage to be an endogenous neural inducing signal. Noggin induces cement glands and anterior brain markers, but not hindbrain or spinal cord markers. Thus, noggin has the expression pattern and activity expected of an endogenous neural inducer.


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Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a.
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K. Nakata, T. Nagai, J. Aruga, and K. Mikoshiba (1997)
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