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Science 15 October 1993:
Vol. 262. no. 5132, pp. 422 - 424
DOI: 10.1126/science.8211163
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Articles

Science, Vol 262, Issue 5132, 422-424
Copyright © 1993 by American Association for the Advancement of Science

articles

Expression of two T cell receptor alpha chains: dual receptor T cells

E Padovan, G Casorati, P Dellabona, S Meyer, M Brockhaus, and A Lanzavecchia

Basel Institute for Immunology, Switzerland.

Although many T cells carry two in-frame V alpha rearrangements, the products of both V alpha rearrangements have never been shown simultaneously on the surface of normal cells. With the use of monoclonal antibodies to V alpha 2, V alpha 12, and V alpha 24, up to one-third of mature T cells expressed two V alpha chains as part of two functional and independent T cell receptors (TCRs). Thus, the "one cell, one receptor" rule does not apply to a large subset of alpha beta T cells. Cells that belong to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor, which may be important for autoimmunity and alloreactivity.


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J. Immunol. 164, 5466-5473
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J. Immunol. 164, 5499-5507
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J. Hernandez, P. P. Lee, M. M. Davis, and L. A. Sherman (2000)
J. Immunol. 164, 596-602
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Frequency and Characterization of Phenotypic Ig Heavy Chain Allelically Included IgM-Expressing B Cells in Mice.
V. Barreto and A. Cumano (2000)
J. Immunol. 164, 893-899
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Deriving Quantitative Constraints on T Cell Selection from Data on the Mature T Cell Repertoire.
V. Detours, R. Mehr, and A. S. Perelson (2000)
J. Immunol. 164, 121-128
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Characterization of CD8+ T Lymphocytes That Persist After Peripheral Tolerance to a Self Antigen Expressed in the Pancreas.
C. T. Nugent, D. J. Morgan, J. A. Biggs, A. Ko, I. M. Pilip, E. G. Pamer, and L. A. Sherman (2000)
J. Immunol. 164, 191-200
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Amino Acids Specifying MHC Class Preference in TCR V{alpha}2 Regions.
M. Correia-Neves, C. Waltzinger, J.-M. Wurtz, C. Benoist, and D. Mathis (1999)
J. Immunol. 163, 5471-5477
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Selective Expansion of Cross-reactive CD8+ Memory T Cells by Viral Variants.
J. B.A.G. Haanen, M. C. Wolkers, A. M. Kruisbeek, and T. N.M. Schumacher (1999)
J. Exp. Med. 190, 1319-1328
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A Direct Estimate of the Human T Cell Receptor Diversity.
T. P. Arstila, A. Casrouge, V. Baron, J. Even, J. Kanellopoulos, and P. Kourilsky (1999)
Science 286, 958-961
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Triggering a Second T Cell Receptor on Diabetogenic T Cells Can Prevent Induction of Diabetes.
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J. Exp. Med. 190, 577-584
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Models for Antigen Receptor Gene Rearrangement. II. Multiple Rearrangement in the TCR: Allelic Exclusion or Inclusion?.
H. Piper, S. Litwin, and R. Mehr (1999)
J. Immunol. 163, 1799-1808
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Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR.
A. Saparov, L. A. Kraus, Y. Cong, J. Marwill, X.-Y. Xu, C. O. Elson, and C. T. Weaver (1999)
Int. Immunol. 11, 1253-1264
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Human Vascular Endothelial Cells Favor Clonal Expansion of Unusual Alloreactive CTL.
B. C. Biedermann and J. S. Pober (1999)
J. Immunol. 162, 7022-7030
   Abstract »    Full Text »    PDF »
Diverse Fine Specificity and Receptor Repertoire of T Cells Reactive to the Major VP1 Epitope (VP1230-250) of Theiler's Virus: V{beta} Restriction Correlates with T Cell Recognition of the C-Terminal Residue.
B. S. Kim, Y. Y. Bahk, H.-K. Kang, R. L. Yauch, J.-A. Kang, M.-J. Park, and N. M. Ponzio (1999)
J. Immunol. 162, 7049-7057
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Limiting TCR Expression Leads to Quantitative But Not Qualitative Changes in Thymic Selection.
V. P. Dave, D. Allman, D. L. Wiest, and D. J. Kappes (1999)
J. Immunol. 162, 5764-5774
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H. Gudmundsdottir, A. D. Wells, and L. A. Turka (1999)
J. Immunol. 162, 5212-5223
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An enlarged subpopulation of T lymphocytes bearing two distinct {gamma}{delta} TCR in an HIV-positive patient.
J.-L. Taupin, F. Halary, J. Dechanet, M.-A. Peyrat, J.-M. Ragnaud, M. Bonneville, and J.-F. Moreau (1999)
Int. Immunol. 11, 545-552
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A Conserved Sequence Block in the Murine and Human TCR J{alpha} Region: Assessment of Regulatory Function In Vivo.
P. Riegert and S. Gilfillan (1999)
J. Immunol. 162, 3471-3480
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Qualitative and Quantitative Requirements for CD4+ T Cell-Mediated Antiviral Protection.
K. J. Maloy, C. Burkhart, G. Freer, T. Rulicke, H. Pircher, D. H. Kono, A. N. Theofilopoulos, B. Ludewig, U. Hoffmann-Rohrer, R. M. Zinkernagel, et al. (1999)
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Development and function of autospecific dual TCR+ T lymphocytes.
R. K. Paterson, H. Bluethmann, P.-o. Tseng, A. Dunlap, and T. H. Finkel (1999)
Int. Immunol. 11, 113-119
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Persistent Expression of Experimental Autoimmune Encephalomyelitis (EAE)-Specific V{beta}8.2 TCR Spectratype in the Central Nervous System of Rats with Chronic Relapsing EAE.
G. Kim, K. Kohyama, N. Tanuma, H. Arimito, and Y. Matsumoto (1998)
J. Immunol. 161, 6993-6998
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Tolerant CD8 T Cells Induced by Multiple Injections of Peptide Antigen Show Impaired TCR Signaling and Altered Proliferative Responses In Vitro and In Vivo.
P. M. Dubois, M. Pihlgren, M. Tomkowiak, M. Van Mechelen, and J. Marvel (1998)
J. Immunol. 161, 5260-5267
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Self-Restricted Dual Receptor Memory T Cells.
W. T. Lee, V. Shiledar-Baxi, G. M. Winslow, D. Mix, and D. B. Murphy (1998)
J. Immunol. 161, 4513-4519
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Structural Aspects of the Interaction Between Heterogeneic Human Papillomavirus Type 1 E4-Specific T Cell Receptors and the Same Peptide/HLA-DQ8 Complex.
J. C. Steele, S. P. Young, J. C. Goodall, and P. H. Gallimore (1998)
J. Immunol. 161, 4745-4752
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Assembly of Productive T Cell Receptor delta  Variable Region Genes Exhibits Allelic Inclusion.
B. P. Sleckman, B. Khor, R. Monroe, and F. W. Alt (1998)
J. Exp. Med. 188, 1465-1471
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Receptor-Specific Allelic Exclusion of TCRV{alpha}-Chains During Development.
R. Boyd, I. Kozieradzki, A. Chidgey, H.-W. Mittrucker, D. Bouchard, E. Timms, K. Kishihara, C. J. Ong, D. Chui, J. D. Marth, et al. (1998)
J. Immunol. 161, 1718-1727
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TCR Transgenic Mice in Which Usage of Transgenic {alpha}- and {beta}-Chains Is Highly Dependent on the Level of Selecting Ligand.
G. J. Kersh, D. L. Donermeyer, K. E. Frederick, J. M. White, B. L. Hsu, and P. M. Allen (1998)
J. Immunol. 161, 585-593
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In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines.
A. Cerwenka, L. L. Carter, J. B. Reome, S. L. Swain, and R. W. Dutton (1998)
J. Immunol. 161, 97-105
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On defining the rules for interactions between the T cell receptor and its ligand: A critical role for a specific amino acid residue of the T cell receptor beta  chain.
F. Wang, T. Ono, A. M. Kalergis, W. Zhang, T. P. DiLorenzo, K. Lim, and S. G. Nathenson (1998)
PNAS 95, 5217-5222
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Posttranslational Regulation of TCR V{alpha} Allelic Exclusion During T Cell Differentiation.
S. M. Alam and N. R. J. Gascoigne (1998)
J. Immunol. 160, 3883-3890
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Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes.
L. Van Parijs, A. Biuckians, and A. K. Abbas (1998)
J. Immunol. 160, 2065-2071
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Biochemical and Functional Analyses of Chromatin Changes at the TCR-{beta} Gene Locus During CD4-CD8- to CD4+CD8+ Thymocyte Differentiation.
S. Chattopadhyay, C. E. Whitehurst, F. Schwenk, and J. Chen (1998)
J. Immunol. 160, 1256-1267
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Normal Responsiveness of CTLA-4-Deficient Anti-Viral Cytotoxic T Cells.
M. F. Bachmann, P. Waterhouse, D. E. Speiser, K. McKall-Faienza, T. W. Mak, and P. S. Ohashi (1998)
J. Immunol. 160, 95-100
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Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex-Encoded Molecules.
J. Kirberg, A. Berns, and H. v. Boehmer (1997)
J. Exp. Med. 186, 1269-1275
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A. Krotkova, H. v. Boehmer, and H. J. Fehling (1997)
J. Exp. Med. 186, 767-775
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Requirements for CD1d Recognition by Human Invariant Valpha 24+ CD4-CD8- T Cells.
M. Exley, J. Garcia, S. P. Balk, and S. Porcelli (1997)
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Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia.
L. Z. Rassenti and T. J. Kipps (1997)
J. Exp. Med. 185, 1435-1446
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Functional differentiation of T cells in the intestine of T cell receptor transgenic mice.
S. D. Hurst, S. M. Sitterding, S. Ji, and T. A. Barrett (1997)
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   Abstract »    Full Text »    PDF »
Bystander Activation of Cytotoxic T Cells: Studies on the Mechanism and Evaluation of In Vivo Significance in a Transgenic Mouse Model.
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Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of All