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Science 8 October 1993:
Vol. 262. no. 5131, pp. 250 - 253
DOI: 10.1126/science.8211145
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Articles

Science, Vol 262, Issue 5131, 250-253
Copyright © 1993 by American Association for the Advancement of Science

articles

An antiviral soluble form of the LDL receptor induced by interferon

DG Fischer, N Tal, D Novick, S Barak, and M Rubinstein

Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel.

Interferons, which induce several intracellular antiviral proteins, also induce an extracellular soluble protein that inhibits vesicular stomatitis virus (VSV) infection. This 28-kilodalton soluble protein was purified to homogeneity and identified by protein sequencing as the ligand-binding domain of the human 160-kilodalton low density lipoprotein receptor (LDLR). The existence of an antiviral soluble LDLR was confirmed by immunoaffinity chromatography with monoclonal antibody to LDLR. This soluble receptor mediates most of the interferon-triggered antiviral activity against VSV, apparently by interfering with virus assembly or budding, and not by inhibiting virus attachment to cells.


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