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Science 24 September 1993:
Vol. 261. no. 5129, pp. 1736 - 1739
DOI: 10.1126/science.8378775
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Articles

Science, Vol 261, Issue 5129, 1736-1739
Copyright © 1993 by American Association for the Advancement of Science

articles

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

O Silvennoinen, C Schindler, J Schlessinger, and DE Levy

Department of Pharmacology, New York University School of Medicine, New York, 10016.

Interferons induce transcriptional activation through tyrosine phosphorylation of the latent, cytoplasmic transcription factor interferon-stimulated gene factor-3 (ISGF-3). Growth factors and cytokines were found to use a similar pathway: The 91-kilodalton subunit of ISGF-3 was activated and tyrosine phosphorylated in response to epidermal growth factor (EGF), platelet-derived growth factor, and colony stimulating factor-1. The tyrosine phosphorylated factor acquired DNA binding activity and accumulated in nuclei. Activation required the major sites for autophosphorylation on the EGF receptor that bind Src homology region 2 domain-containing proteins implicated in Ras activation. However, activation of this factor was independent of the normal functioning of Ras.


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Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor.
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Mapping of the Cytoplasmic Domain of the Human Growth Hormone Receptor Required for the Activation of Jak2 and Stat Proteins.
R. H. Hackett, Y.-D. Wang, and A. C. Larner (1995)
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Activation of the STAT Pathway by Angiotensin II in T3CHO/AT[IMAGE] Cells.
G. J. Bhat, T. J. Thekkumkara, W. G. Thomas, K. M. Conrad, and K. M. Baker (1995)
J. Biol. Chem. 270, 19059-19065
   Abstract »    Full Text »    PDF »
Transmembrane Signaling by the alpha Subunit of the Type I Interferon Receptor Is Essential for Activation of the Jak Kinases and the Transcriptional Factor ISGF3.
O. R. Colamonici, L. C. Platanias, P. Domanski, R. Handa, K. C. Gilmour, M. O. Diaz, N. Reich, and P. Pitha-Rowe (1995)
J. Biol. Chem. 270, 8188-8193
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Requirement of serine phosphorylation for formation of STAT-promoter complexes.
X Zhang, J Blenis, H. Li, C Schindler, and S Chen-Kiang (1995)
Science 267, 1990-1994
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Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone.
G. S. Campbell, D. J. Meyer, R. Raz, D. E. Levy, J. Schwartz, and C. Carter-Su (1995)
J. Biol. Chem. 270, 3974-3979
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Interferon-[IMAGE]-inducible Tryptophanyl-tRNA Synthetase Includes Alternative Splicing.
A. B. Tolstrup, A. Bejder, J. Fleckner, and J. Justesen (1995)
J. Biol. Chem. 270, 397-403
   Abstract »    Full Text »    PDF »
Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors..
R A Hipskind, D Buscher, A Nordheim, and M Baccarini (1994)
Genes & Dev. 8, 1803-1816
   Abstract »    PDF »
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
J. Darnell Jr, I. Kerr, and G. Stark (1994)
Science 264, 1415-1421
   Abstract »    PDF »
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
Z Zhong, Z Wen, and J. Darnell Jr (1994)
Science 264, 95-98
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Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus.
A Bonni, D. Frank, C Schindler, and M. Greenberg (1993)
Science 262, 1575-1579
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Trying on a new pair of SH2s.
M Montminy (1993)
Science 261, 1694-1695
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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.
T. Bowman, M. A. Broome, D. Sinibaldi, W. Wharton, W. J. Pledger, J. M. Sedivy, R. Irby, T. Yeatman, S. A. Courtneidge, and R. Jove (2001)
PNAS 98, 7319-7324
   Abstract »    Full Text »    PDF »


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