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Science 17 September 1993:
Vol. 261. no. 5128, pp. 1588 - 1591
DOI: 10.1126/science.7690497
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Articles

Science, Vol 261, Issue 5128, 1588-1591
Copyright © 1993 by American Association for the Advancement of Science

articles

Immunoglobulin VH3 gene products: natural ligands for HIV gp120

L Berberian, L Goodglick, TJ Kipps, and J Braun

Department of Pathology and Laboratory Medicine, University of California, Los Angeles 90024.

Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing CD4 and B cells expressing immunoglobulin (Ig) VH3 gene products. A subpopulation of normal B cells from non-HIV-infected individuals was shown to bind to HIV gp120 by means of membrane Ig; most of these B cells expressed VH3 family Ig. Serum VH3 IgM from uninfected individuals also avidly bound gp120. Finally, gp120 selectively induced Ig secretion by VH3 B cells, indicating that the binding of gp120 functionally activated these cells. These results indicate that naturally occurring VH3 Ig is a second ligand for gp120 and a candidate superantigen for VH3 B cells.


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