Science 17 September 1993: Vol. 261. no. 5128, pp. 1584 - 1588 DOI: 10.1126/science.8372353

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Islet {beta}-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli.

E. M. Carrington, M. D. McKenzie, E. Jansen, M. Myers, S. Fynch, C. Kos, A. Strasser, T. W. Kay, C. L. Scott, and J. Allison (2009)
Diabetes 58, 2316-2323
 |  Abstract »  |  Full Text »  |  PDF »

Critical Roles of Translationally Controlled Tumor Protein in the Homeostasis and TCR-Mediated Proliferation of Peripheral T Cells.

P.-S. Wu, C.-Y. Yang, J. J.-Y. Yen, C.-H. Chou, S. H. Chen, C.-K. L. Wang, Y.-G. Lai, N.-S. Liao, and H.-F. Yang-Yen (2009)
J. Immunol. 183, 2373-2381
 |  Abstract »  |  Full Text »  |  PDF »

Promoter Knock-In Mutations Reveal a Role of Mcl-1 in Thymocyte-Positive Selection and Tissue or Cell Lineage-Specific Regulation of Mcl-1 Expression.

C.-Y. Yang, N.-H. Lin, J.-M. Lee, C.-Y. Huang, H.-J. Min, J. J.-Y. Yen, N.-S. Liao, and H.-F. Yang-Yen (2009)
J. Immunol. 182, 2959-2968
 |  Abstract »  |  Full Text »  |  PDF »

The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages.

I. Dzhagalov, A. Dunkle, and Y.-W. He (2008)
J. Immunol. 181, 521-528
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse..

M. Shirane, M. Ogawa, J. Motoyama, and K. I. Nakayama (2008)
Genes Cells 13, 635-651
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Expression of Bcl-xL or Bcl-2 by Murine B Cells Enhances the In Vivo Antipolysaccharide, but Not Antiprotein, Response to Intact Streptococcus pneumoniae.

G. Chattopadhyay, A. Q. Khan, G. Sen, J. Colino, W. duBois, A. Rubtsov, R. M. Torres, M. Potter, and C. M. Snapper (2007)
J. Immunol. 179, 7523-7534
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Proteomics Analysis of Interleukin (IL)-7-induced Signaling Effectors Shows Selective Changes in IL-7R{alpha}449F Knock-in T Cell Progenitors.

K. A. Duthie, L. C. Osborne, L. J. Foster, and N. Abraham (2007)
Mol. Cell. Proteomics 6, 1700-1710
 |  Abstract »  |  Full Text »  |  PDF »

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.

S. Wojciechowski, P. Tripathi, T. Bourdeau, L. Acero, H. L. Grimes, J. D. Katz, F. D. Finkelman, and D. A. Hildeman (2007)
J. Exp. Med. 204, 1665-1675
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous bcl-2 is not required for the development of E{micro}-myc induced B-cell lymphoma.

P. N. Kelly, H. Puthalakath, J. M. Adams, and A. Strasser (2007)
Blood 109, 4907-4913
 |  Abstract »  |  Full Text »  |  PDF »

Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R{alpha} mutant mice.

L. C. Osborne, S. Dhanji, J. W. Snow, J. J. Priatel, M. C. Ma, M. J. Miners, H.-S. Teh, M. A. Goldsmith, and N. Abraham (2007)
J. Exp. Med. 204, 619-631
 |  Abstract »  |  Full Text »  |  PDF »

Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4+CD8+ immature thymocyte line.

H. Oda, H. Suzuki, K. Sakai, S. Kitahara, M. S. Patrick, Y. Azuma, K. Sugi, T. Kitamura, J. Kaye, and M. Shirai (2007)
J. Leukoc. Biol. 81, 500-508
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 family members and apoptosis, taken to heart.

A. B. Gustafsson and R. A. Gottlieb (2007)
Am J Physiol Cell Physiol 292, C45-C51
 |  Abstract »  |  Full Text »  |  PDF »

Early Embryonic Death in Mice Lacking the {beta}-Catenin-Binding Protein Duplin.

M. Nishiyama, K. Nakayama, R. Tsunematsu, T. Tsukiyama, A. Kikuchi, and K. I. Nakayama (2004)
Mol. Cell. Biol. 24, 8386-8394
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced In Vitro Midbrain Dopamine Neuron Differentiation, Dopaminergic Function, Neurite Outgrowth, and 1-Methyl-4-Phenylpyridium Resistance in Mouse Embryonic Stem Cells Overexpressing Bcl-XL.

J.-W. Shim, H.-C. Koh, M.-Y. Chang, E. Roh, C.-Y. Choi, Y. J. Oh, H. Son, Y.-S. Lee, L. Studer, and S.-H. Lee (2004)
J. Neurosci. 24, 843-852
 |  Abstract »  |  Full Text »  |  PDF »

Control of Bcl-2 expression by reactive oxygen species.

D. A. Hildeman, T. Mitchell, B. Aronow, S. Wojciechowski, J. Kappler, and P. Marrack (2003)
PNAS 100, 15035-15040
 |  Abstract »  |  Full Text »  |  PDF »

Plasma Cell Survival Is Mediated by Synergistic Effects of Cytokines and Adhesion-Dependent Signals.

G. Cassese, S. Arce, A. E. Hauser, K. Lehnert, B. Moewes, M. Mostarac, G. Muehlinghaus, M. Szyska, A. Radbruch, and R. A. Manz (2003)
J. Immunol. 171, 1684-1690
 |  Abstract »  |  Full Text »  |  PDF »

Sonic Hedgehog Signaling Modulates Activation of and Cytokine Production by Human Peripheral CD4+ T Cells.

G. A. Stewart, J. A. Lowrey, S. J. Wakelin, P. M. Fitch, S. Lindey, M. J. Dallman, J. R. Lamb, and S. E. M. Howie (2002)
J. Immunol. 169, 5451-5457
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 Determines Susceptibility to Induction of Lung Cancer by Oncogenic CRaf.

L. M. Fedorov, O. Yu. Tyrsin, T. Papadopoulos, G. Camarero, R. Gotz, and U. R. Rapp (2002)
Cancer Res. 62, 6297-6303
 |  Abstract »  |  Full Text »  |  PDF »

Sonic Hedgehog Promotes Cell Cycle Progression in Activated Peripheral CD4+ T Lymphocytes.

J. A. Lowrey, G. A. Stewart, S. Lindey, G. F. Hoyne, M. J. Dallman, S. E. M. Howie, and J. R. Lamb (2002)
J. Immunol. 169, 1869-1875
 |  Abstract »  |  Full Text »  |  PDF »

Linking Hematopoiesis to Endochondral Skeletogenesis through Analysis of Mice Transgenic for Collagen X.

O. Jacenko, D. W. Roberts, M. R. Campbell, P. M. McManus, C. J. Gress, and Z. Tao (2002)
Am. J. Pathol. 160, 2019-2034
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive nuclear factor-kappa B activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2 family proteins.

F. Bureau, A. Vanderplasschen, F. Jaspar, F. Minner, P.-P. Pastoret, M.-P. Merville, V. Bours, and P. Lekeux (2002)
Blood 99, 3683-3691
 |  Abstract »  |  Full Text »  |  PDF »

Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1.

P. I. Chuang, S. Morefield, C.-Y. Liu, S. Chen, J. M. Harlan, and D. M. Willerford (2002)
Blood 99, 3350-3359
 |  Abstract »  |  Full Text »  |  PDF »

Myeloid cell factor-1 is a critical survival factor for multiple myeloma.

B. Zhang, I. Gojo, and R. G. Fenton (2002)
Blood 99, 1885-1893
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency of phospholipase C-{gamma}1 impairs renal development and hematopoiesis.

M. Shirane, H. Sawa, Y. Kobayashi, T. Nakano, K. Kitajima, Y. Shinkai, K. Nagashima, and I. Negishi (2001)
Development 128, 5173-5180
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the PU.1 gene by distal elements.

Y. Li, Y. Okuno, P. Zhang, H. S. Radomska, H.-m. Chen, H. Iwasaki, K. Akashi, M. J. Klemsz, S. R. McKercher, R. A. Maki, et al. (2001)
Blood 98, 2958-2965
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis in sepsis: a new target for therapeutic exploration.

C. OBERHOLZER, A. OBERHOLZER, M. CLARE-SALZLER, and L. L. MOLDAWER (2001)
FASEB J 15, 879-892
 |  Abstract »  |  Full Text »  |  PDF »

MHC Recognition in Thymic Development: Distinct, Parallel Pathways for Survival and Lineage Commitment.

D. Chang, P. Valdez, T. Ho, and E. Robey (2000)
J. Immunol. 165, 6710-6715
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of Apoptosis Underlies B Lymphocyte Stimulator Enhancement of Humoral Immune Response.

R. K.G. Do, E. Hatada, H. Lee, M. R. Tourigny, D. Hilbert, and S. Chen-Kiang (2000)
J. Exp. Med. 192, 953-964
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with Bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia.

L. Karawajew, V. Ruppert, C. Wuchter, A. Kosser, M. Schrappe, B. Dorken, and W.-D. Ludwig (2000)
Blood 96, 297-306
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice.

H. Takai, K. Tominaga, N. Motoyama, Y. A. Minamishima, H. Nagahama, T. Tsukiyama, K. Ikeda, K. Nakayama, M. Nakanishi, and K.-i. Nakayama (2000)
Genes & Dev. 14, 1439-1447
 |  Abstract »  |  Full Text »

Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors.

K. L. Medina, A. Strasser, and P. W. Kincade (2000)
Blood 95, 2059-2067
 |  Abstract »  |  Full Text »  |  PDF »

Lessons From Genetically Engineered Animal Models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice.

A. J. M. Watson and D. M. Pritchard (2000)
Am J Physiol Gastrointest Liver Physiol 278, G1-G5
 |  Abstract »  |  Full Text »  |  PDF »

Spontaneous Apoptosis in Lymphocytes From Patients With Wiskott-Aldrich Syndrome: Correlation of Accelerated Cell Death and Attenuated Bcl-2 Expression.

S. L. Rawlings, G. M. Crooks, D. Bockstoce, L. W. Barsky, R. Parkman, and K. I. Weinberg (1999)
Blood 94, 3872-3882
 |  Abstract »  |  Full Text »  |  PDF »

Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-xL Transgenic Mice.

Y. Takahashi, D. M. Cerasoli, J. M. Dal Porto, M. Shimoda, R. Freund, W. Fang, D. G. Telander, E.-N. Malvey, D. L. Mueller, T. W. Behrens, et al. (1999)
J. Exp. Med. 190, 399-410
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 inhibits ischemia-reperfusion-induced apoptosis in the intestinal epithelium of transgenic mice.

C. M. Coopersmith, D. O'Donnell, and J. I. Gordon (1999)
Am J Physiol Gastrointest Liver Physiol 276, G677-G686
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of IL-2 and IL-15 on the Death and Survival of Activated TCR{gamma}{delta}+ Intestinal Intraepithelial Lymphocytes.

C.-L. Chu, S.-S. Chen, T.-S. Wu, S.-C. Kuo, and N.-S. Liao (1999)
J. Immunol. 162, 1896-1903
 |  Abstract »  |  Full Text »  |  PDF »

BCL-2 Blocks Perforin-induced Nuclear Translocation of Granzymes Concomitant with Protection against the Nuclear Events of Apoptosis.

D. A. Jans, V. R. Sutton, P. Jans, C. J. Froelich, and J. A. Trapani (1999)
J. Biol. Chem. 274, 3953-3961
 |  Abstract »  |  Full Text »  |  PDF »

Increased Susceptibility of Thymocytes to Apoptosis in Mice Lacking AIM, a Novel Murine Macrophage-derived Soluble Factor Belonging to the Scavenger Receptor Cysteine-rich Domain Superfamily.

T. Miyazaki, Y. Hirokami, N. Matsuhashi, H. Takatsuka, and M. Naito (1999)
J. Exp. Med. 189, 413-422
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.

T. Naka, T. Matsumoto, M. Narazaki, M. Fujimoto, Y. Morita, Y. Ohsawa, H. Saito, T. Nagasawa, Y. Uchiyama, and T. Kishimoto (1998)
PNAS 95, 15577-15582
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2-related A1 Gene.

A. Hamasaki, F. Sendo, K. Nakayama, N. Ishida, I. Negishi, K.-i. Nakayama, and S. Hatakeyama (1998)
J. Exp. Med. 188, 1985-1992
 |  Abstract »  |  Full Text »  |  PDF »

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice.

K. Takeda, T. Kaisho, N. Yoshida, J. Takeda, T. Kishimoto, and S. Akira (1998)
J. Immunol. 161, 4652-4660
 |  Abstract »  |  Full Text »  |  PDF »

Supraoptimal Peptide-Major Histocompatibility Complex Causes a Decrease in Bcl-2 Levels and Allows Tumor Necrosis Factor {alpha} Receptor II-mediated Apoptosis of Cytotoxic T Lymphocytes.

M. A. Alexander-Miller, M. A. Derby, A. Sarin, P. A. Henkart, and J. A. Berzofsky (1998)
J. Exp. Med. 188, 1391-1399
 |  Abstract »  |  Full Text »  |  PDF »

mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response.

J.-R. Chao, J.-M. Wang, S.-F. Lee, H.-W. Peng, Y.-H. Lin, C.-H. Chou, J.-C. Li, H.-M. Huang, C.-K. Chou, M.-L. Kuo, et al. (1998)
Mol. Cell. Biol. 18, 4883-4898
 |  Abstract »  |  Full Text »

Down-Modulation of a Novel Bax-Associated Protein During Apoptosis in Normal Mature B Lymphocytes.

H. He, P. A. Hershberger, and S. A. McCarthy (1998)
J. Immunol. 161, 1176-1182
 |  Abstract »  |  Full Text »  |  PDF »

IL-4-Producing NK1.1+ T Cells Are Resistant to Glucocorticoid-Induced Apoptosis: Implications for the Th1/Th2 Balance.

K. Tamada, M. Harada, K. Abe, T. Li, and K. Nomoto (1998)
J. Immunol. 161, 1239-1247
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease.

A. Haunstetter and S. Izumo (1998)
Circ. Res. 82, 1111-1129
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Bcl-2 Accelerates the Maturation of Early Sensory Neurons.

G. Middleton, L. G. P. Pinon, S. Wyatt, and A. M. Davies (1998)
J. Neurosci. 18, 3344-3350
 |  Abstract »  |  Full Text »  |  PDF »

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off.

L. V. Parijs and A. K. Abbas (1998)
Science 280, 243-248
 |  Abstract »  |  Full Text »

IGF-I alters lymphocyte survival and regeneration in thymus and spleen after dexamethasone treatment.

P. S. Hinton, C. A. Peterson, E. M. Dahly, and D. M. Ney (1998)
Am J Physiol Regulatory Integrative Comp Physiol 274, R912-R920
 |  Abstract »  |  Full Text »  |  PDF »

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation.

J. Domen, K. L. Gandy, and I. L. Weissman (1998)
Blood 91, 2272-2282
 |  Abstract »  |  Full Text »  |  PDF »

Long-Lived B Cells Are Distinguished by Elevated Expression of A1.

M. M. Tomayko and M. P. Cancro (1998)
J. Immunol. 160, 107-111
 |  Abstract »  |  Full Text »  |  PDF »

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex-Encoded Molecules.

J. Kirberg, A. Berns, and H. v. Boehmer (1997)
J. Exp. Med. 186, 1269-1275
 |  Abstract »  |  Full Text »  |  PDF »

The bcl-2 Gene Product Prevents Programmed Cell Death of Ventricular Myocytes.

L. A. Kirshenbaum and D. de Moissac (1997)
Circulation 96, 1580-1585
 |  Abstract »  |  Full Text »

Defining Apoptosis: Players and Systems.

G. F. Erickson (1997)
Reproductive Sciences 4, 219-228
 |  Abstract »  |  PDF »

The antisense bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides.

S. Morelli, D. Delia, S. Capaccioli, A. Quattrone, N. Schiavone, A. Bevilacqua, S. Tomasini, and A. Nicolin (1997)
PNAS 94, 8150-8155
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Cell Death in Yeast by the Bcl-2 Family of Proteins.

W. Tao, C. Kurschner, and J. I. Morgan (1997)
J. Biol. Chem. 272, 15547-15552
 |  Abstract »  |  Full Text »  |  PDF »

bax Deficiency Prevents the Increased Cell Death of Immature Neurons in bcl-x-Deficient Mice.

K. S. Shindler, C. B. Latham, and K. A. Roth (1997)
J. Neurosci. 17, 3112-3119
 |  Abstract »  |  Full Text »  |  PDF »

Role of bcl-2 in the Development of Lymphoid Cells From the Hematopoietic Stem Cell.

Y. Matsuzaki, K.-i. Nakayama, K. Nakayama, T. Tomita, M. Isoda, D. Y. Loh, and H. Nakauchi (1997)
Blood 89, 853-862
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 Lies Downstream of Parathyroid Hormone-related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development.

M. Amling, L. Neff, S. Tanaka, D. Inoue, K. Kuida, E. Weir, W. M. Philbrick, A. E. Broadus, and R. Baron (1997)
J. Cell Biol. 136, 205-213
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development.

L. Pinon, G Middleton, and A. Davies (1997)
Development 124, 4173-4178
 |  Abstract »  |  PDF »

Bax promotes neuronal cell death and is downregulated during the development of the nervous system.

K Vekrellis, M. McCarthy, A Watson, J Whitfield, L. Rubin, and J Ham (1997)
Development 124, 1239-1249
 |  Abstract »  |  PDF »

DNA-dependent Protein Kinase Is a Target for a CPP32-like Apoptotic Protease.

Z. Han, N. Malik, T. Carter, W. H. Reeves, J. H. Wyche, and E. A. Hendrickson (1996)
J. Biol. Chem. 271, 25035-25040
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-x(S) Antagonizes the Protective Effects of Bcl-x(L).

A. J. Minn, L. H. Boise, and C. B. Thompson (1996)
J. Biol. Chem. 271, 6306-6312
 |  Abstract »  |  Full Text »  |  PDF »

Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors.

G Middleton, G Nunez, and A. Davies (1996)
Development 122, 695-701
 |  Abstract »  |  PDF »

Life, death, and the pursuit of apoptosis..

E White (1996)
Genes & Dev. 10, 1-15
 |  PDF »

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death.

C. M. Knudson, K. S. K. Tung, W. G. Tourtellotte, G. A. J. Brown, and S. J. Korsmeyer (1995)
Science 270, 96-99
 |  Abstract »  |  PDF »

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.

K Kuida, J. Lippke, G Ku, M. Harding, D. Livingston, M. Su, and R. Flavell (1995)
Science 267, 2000-2003
 |  Abstract »  |  PDF »

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice.

N Motoyama, F Wang, K. Roth, H Sawa, K Nakayama, K Nakayama, I Negishi, S Senju, Q Zhang, S Fujii, et al. (1995)
Science 267, 1506-1510
 |  Abstract »  |  PDF »

Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.

K Nakayama, K Nakayama, I Negishi, K Kuida, M. Louie, O Kanagawa, H Nakauchi, and D. Loh (1994)
Science 263, 1131-1133
 |  Abstract »  |  PDF »

bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria.

M Gonzalez-Garcia, R Perez-Ballestero, L Ding, L Duan, L. Boise, C. Thompson, and G Nunez (1994)
Development 120, 3033-3042
 |  Abstract »  |  PDF »

Bcl-2 Gene Family and the Regulation of Programmed Cell Death.

X.-M. Yin, Z.N. Oltvai, D.J. Veis-Novack, G.P. Linette, and S.J. Korsmeyer (1994)
Cold Spring Harb Symp Quant Biol 59, 387-393
 |  Abstract »  |  PDF »

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