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Science 10 September 1993:
Vol. 261. no. 5127, pp. 1451 - 1454
DOI: 10.1126/science.7690157
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Articles

Science, Vol 261, Issue 5127, 1451-1454
Copyright © 1993 by American Association for the Advancement of Science

articles

MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination

J Zhang, R Medaer, P Stinissen, D Hafler, and J Raus

Multiple Sclerosis Research Unit, Dr. L. Willems Instituut, Diepenbeek, Belgium.

Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell vaccination). In the present study, patients with multiple sclerosis were inoculated with irradiated myelin basic protein (MBP)-reactive T cells. T cell responses to the inoculates were induced to deplete circulating MBP-reactive T cells in the recipients. Regulatory T cell lines isolated from the recipients inhibited T cells used for vaccination. The cytotoxicity of the CD8+ T cell lines was restricted by major histocompatibility antigens. Thus, clonotypic interactions regulating autoreactive T cells in humans can be induced by T cell vaccination.


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