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Science 10 September 1993:
Vol. 261. no. 5127, pp. 1448 - 1451
DOI: 10.1126/science.8367726
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Articles

Science, Vol 261, Issue 5127, 1448-1451
Copyright © 1993 by American Association for the Advancement of Science

articles

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

RM Locksley, SL Reiner, F Hatam, DR Littman, and N Killeen

Department of Medicine, University of California, San Francisco 94143-0654.

Expression of either the CD4 or CD8 glycoproteins discriminates two functionally distinct lineages of T lymphocytes. A null mutation in the gene encoding CD4 impairs the development of the helper cell lineage that is normally defined by CD4 expression. Infection of CD4-null mice with Leishmania has revealed a population of functional helper T cells that develops despite the absence of CD4. These CD8- alpha beta T cell receptor+ T cells are major histocompatibility complex class II-restricted and produce interferon-gamma when challenged with parasite antigens. These results indicate that T lymphocyte lineage commitment and peripheral function need not depend on the function of CD4.


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   Abstract »    Full Text »    PDF »
Expression cloning of a protective Leishmania antigen.
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Science 268, 563-566
   Abstract »    PDF »
A subset of CD4+ thymocytes selected by MHC class I molecules.
A Bendelac, N Killeen, D. Littman, and R. Schwartz (1994)
Science 263, 1774-1778
   Abstract »    PDF »
Impaired survival of T helper cells in the absence of CD4.
J. Strong, Q. Wang, and N. Killeen (2001)
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   Abstract »    Full Text »    PDF »


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