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Science 10 September 1993:
Vol. 261. no. 5127, pp. 1442 - 1445
DOI: 10.1126/science.8367725
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Articles

Science, Vol 261, Issue 5127, 1442-1445
Copyright © 1993 by American Association for the Advancement of Science

articles

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

Y Devary, C Rosette, JA DiDonato, and M Karin

Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla 92093.

Exposure of mammalian cells to radiation triggers the ultraviolet (UV) response, which includes activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B). This was postulated to occur by induction of a nuclear signaling cascade by damaged DNA. Recently, induction of AP-1 by UV was shown to be mediated by a pathway involving Src tyrosine kinases and the Ha-Ras small guanosine triphosphate-binding protein, proteins located at the plasma membrane. It is demonstrated here that the same pathway mediates induction of NF-kappa B by UV. Because inactive NF-kappa B is stored in the cytosol, analysis of its activation directly tests the involvement of a nuclear-initiated signaling cascade. Enucleated cells are fully responsive to UV both in NF-kappa B induction and in activation of another key signaling event. Therefore, the UV response does not require a signal generated in the nucleus and is likely to be initiated at or near the plasma membrane.


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Oncogenic Ras Sensitizes Cells to Apoptosis by Par-4.
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N. Chen, W.-y. Ma, C. Huang, and Z. Dong (1999)
J. Biol. Chem. 274, 15389-15394
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Radiation-induced mutations in unirradiated DNA.
A. J. Grosovsky (1999)
PNAS 96, 5346-5347
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Transcriptional Cross Talk between NF-kappa B and p53.
G. A. Webster and N. D. Perkins (1999)
Mol. Cell. Biol. 19, 3485-3495
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S. Montaner, R. Perona, L. Saniger, and J. C. Lacal (1999)
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P. Pandey, S. Avraham, A. Place, V. Kumar, P. K. Majumder, K. Cheng, A. Nakazawa, S. Saxena, and S. Kharbanda (1999)
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L. Wang, D. Xu, W. Dai, and L. Lu (1999)
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L. Zhuang, B. Wang, G. A. Shinder, G. M. Shivji, T. W. Mak, and D. N. Sauder (1999)
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Activation of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway by Osmotic Shock.
P. Gatsios, L. Terstegen, F. Schliess, D. Haussinger, I. M. Kerr, P. C. Heinrich, and L. Graeve (1998)
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UV Irradiation Induces the Murine Urokinase-Type Plasminogen Activator Gene via the c-Jun N-Terminal Kinase Signaling Pathway: Requirement of an AP1 Enhancer Element.
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Mol. Cell. Biol. 18, 4537-4547
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Ultraviolet Radiation Triggers the Ribotoxic Stress Response in Mammalian Cells.
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J. Biol. Chem. 273, 15794-15803
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Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor kappa B by the Rho Family of GTPases.
S. Montaner, R. Perona, L. Saniger, and J. C. Lacal (1998)
J. Biol. Chem. 273, 12779-12785
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A Chemical and Genetic Approach Together Define the Biological Consequences of 3-Methyladenine Lesions in the Mammalian Genome.
B. P. Engelward, J. M. Allan, A. J. Dreslin, J. D. Kelly, M. M. Wu, B. Gold, and L. D. Samson (1998)
J. Biol. Chem. 273, 5412-5418
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Amino Acid Analogs Activate NF-kappa B through Redox-dependent Ikappa B-alpha Degradation by the Proteasome without Apparent Ikappa B-alpha Phosphorylation. CONSEQUENCE ON HIV-1 LONG TERMINAL REPEAT ACTIVATION.
C. Kretz-Remy, E. E. M. Bates, and A.-P. Arrigo (1998)
J. Biol. Chem. 273, 3180-3191
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A Role for Nuclear Factor kappa B in the Antiapoptotic Function of Insulin.
F. Bertrand, A. Atfi, A. Cadoret, G. L'Allemain, H. Robin, O. Lascols, J. Capeau, and G. Cherqui (1998)
J. Biol. Chem. 273, 2931-2938
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Differential Regulation of Urokinase-type Plasminogen Activator Expression by Basic Fibroblast Growth Factor and Serum in Myogenesis. REQUIREMENT OF A COMMON MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY.
F. Miralles, D. Ron, M. Baiget, J. Felez, and P. Munoz-Canoves (1998)
J. Biol. Chem. 273, 2052-2058
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UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins.
D. Tobin, M. van Hogerlinden, and R. Toftgard (1998)
PNAS 95, 565-569
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Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L.
Y. Aragane, D. Kulms, D. Metze, G. Wilkes, B. Poppelmann, T. A. Luger, and T. Schwarz (1998)
J. Cell Biol. 140, 171-182
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   Abstract »    Full Text »    PDF »
Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva.
Y. Galley, G. Hagens, I. Glaser, W. Davis, M. Eichhorn, and D. Dobbelaere (1997)
PNAS 94, 5119-5124
   Abstract »    Full Text »    PDF »
c-Jun NH2-terminal Kinase Regulation of the Apoptotic Response of Small Cell Lung Cancer Cells to Ultraviolet Radiation.
L. Butterfield, B. Storey, L. Maas, and L. E. Heasley (1997)
J. Biol. Chem. 272, 10110-10116
   Abstract »    Full Text »    PDF »
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins..
R Perona, S Montaner, L Saniger, I Sanchez-Perez, R Bravo, and J C Lacal (1997)
Genes & Dev. 11, 463-475
   Abstract »    PDF »
Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae.
Y. Ho, S. Mason, R. Kobayashi, M. Hoekstra, and B. Andrews (1997)
PNAS 94, 581-586
   Abstract »    Full Text »    PDF »
Ultraviolet B-induced Activated Protein-1 Activation Does Not Require Epidermal Growth Factor Receptor but Is Blocked by a Dominant Negative PKClambda /iota.
C. Huang, W.-y. Ma, G. T. Bowden, and Z. Dong (1996)
J. Biol. Chem. 271, 31262-31268
   Abstract »    Full Text »    PDF »
Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase.
S. Kumar, M. J. Orsini, J. C. Lee, P. C. McDonnell, C. Debouck, and PeterR. Young (1996)
J. Biol. Chem. 271, 30864-30869
   Abstract »    Full Text »    PDF »
Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation.
J. M. Kyriakis and J. Avruch (1996)
J. Biol. Chem. 271, 24313-24316
   Full Text »    PDF »
Fluid Flow Inhibits Endothelial Adhesiveness: Nitric Oxide and Transcriptional Regulation of VCAM-1.
P. S. Tsao, R. Buitrago, J. R. Chan, and J. P. Cooke (1996)
Circulation 94, 1682-1689
   Abstract »    Full Text »
Activation of p38 Mitogen-activated Protein Kinase by c-Abl-dependent and -independent Mechanisms.
P. Pandey, J. Raingeaud, M. Kaneki, R. Weichselbaum, R. J. Davis, D. Kufe, and S. Kharbanda (1996)
J. Biol. Chem. 271, 23775-23779
   Abstract »    Full Text »    PDF »
MEK Kinase Is Involved in Tumor Necrosis Factor alpha -Induced NF-kappa B Activation and Degradation of Ikappa B-alpha.
M. Hirano, S.-i. Osada, T. Aoki, S.-i. Hirai, M. Hosaka, J.-i. Inoue, and S. Ohno (1996)
J. Biol. Chem. 271, 13234-13238
   Abstract »    Full Text »    PDF »
Oxidative Stress Increases Production of beta-Amyloid Precursor Protein and beta-Amyloid (Abeta) in Mammalian Lenses, and Abeta Has Toxic Effects on Lens Epithelial Cells.
P. H. Frederikse, D. Garland, J. S. Zigler Jr., and J. Piatigorsky (1996)
J. Biol. Chem. 271, 10169-10174
   Abstract »    Full Text »    PDF »
Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in [IMAGE] Radiation-induced Apoptosis.
Y.-R. Chen, C. F. Meyer, and T.-H. Tan (1996)
J. Biol. Chem. 271, 631-634
   Abstract »    Full Text »    PDF »
UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways.
V. Adler, A.às Schaffer, J. Kim, L. Dolan, and Z.'e. Ronai (1995)
J. Biol. Chem. 270, 26071-26077
   Abstract »    Full Text »    PDF »
Activation of Transcription Factor NF-kappaB Is Suppressed by Curcumin (Diferuloylmethane).
S. Singh and B. B. Aggarwal (1995)
J. Biol. Chem. 270, 24995-25000
   Abstract »    Full Text »    PDF »
Insulin Activates Nuclear Factor kappaB in Mammalian Cells through a Raf-1-mediated Pathway.
F. Bertrand, C. Philippe, P. J. Antoine, L. Baud, A. Groyer, J. Capeau, and G.èl. Cherqui (1995)
J. Biol. Chem. 270, 24435-24441
   Abstract »    Full Text »    PDF »
Salicylate Triggers Heat Shock Factor Differently than Heat.
D. A. Jurivich, C. Pachetti, L. Qiu, and J. F. Welk (1995)
J. Biol. Chem. 270, 24489-24495
   Abstract »    Full Text »    PDF »
Immunosuppression by Glucocorticoids: Inhibition of NF-kappaB Activity Through Induction of IkappaB Sy nthesis.
N. Auphan, J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin (1995)
Science 270, 286-290
   Abstract »    PDF »
p21[IMAGE] as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress.
H. M. Lander, J. S. Ogiste, K. K. Teng, and A. Novogrodsky (1995)
J. Biol. Chem. 270, 21195-21198
   Abstract »    Full Text »    PDF »
c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes.
Y.-P. Hsueh and M.-Z. Lai (1995)
J. Biol. Chem. 270, 18094-18098
   Abstract »    Full Text »    PDF »


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