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Science 23 July 1993:
Vol. 261. no. 5120, pp. 466 - 469
DOI: 10.1126/science.8101391
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Articles

Science, Vol 261, Issue 5120, 466-469
Copyright © 1993 by American Association for the Advancement of Science

articles

Direct association of adenosine deaminase with a T cell activation antigen, CD26

J Kameoka, T Tanaka, Y Nojima, SF Schlossman, and C Morimoto

Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.

CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA). ADA was coexpressed with CD26 on the Jurkat T cell lines, and an in vitro binding assay showed that the binding was through the extracellular domain of CD26. ADA deficiency causes severe combined immunodeficiency disease (SCID) in humans. Thus, ADA and CD26 (DPPIV) interact on the T cell surface, and this interaction may provide a clue to the pathophysiology of SCID caused by ADA deficiency.


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