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Science 16 July 1993:
Vol. 261. no. 5119, pp. 352 - 355
DOI: 10.1126/science.8392749
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Articles

Science, Vol 261, Issue 5119, 352-355
Copyright © 1993 by American Association for the Advancement of Science

articles

Calcium mobilization by dual receptors during fertilization of sea urchin eggs

HC Lee, R Aarhus, and TF Walseth

Department of Physiology, University of Minnesota, Minneapolis 55455.

Fertilization is accompanied by a transient increase in the concentration of intracellular Ca2+, which serves as a signal for initiating development. Some of the Ca2+ appears to be released from intracellular stores by the binding of inositol trisphosphate (IP3) to its receptor. However, in sea urchin eggs, other mechanisms appear to participate. Cyclic adenosine diphosphate--ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide, is as potent as IP3 in mobilizing Ca2+ in sea urchin eggs. Experiments with antagonists of the cADPR and IP3 receptors revealed that both Ca2+ mobilizing systems were activated during fertilization. Blockage of either of the systems alone was not sufficient to prevent the sperm-induced Ca2+ transient. This study provides direct evidence for a physiological role of cADPR in the Ca2+ signaling process.


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