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Science 2 July 1993:
Vol. 261. no. 5117, pp. 91 - 93
DOI: 10.1126/science.8316860
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Articles

Science, Vol 261, Issue 5117, 91-93
Copyright © 1993 by American Association for the Advancement of Science

articles

Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus

E Mozes, LD Kohn, F Hakim, and DS Singer

Experimental Immunology Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892.

Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they did not develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.


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