Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
DNA Star, Inc.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 2 July 1993:
Vol. 261. no. 5117, pp. 91 - 93
DOI: 10.1126/science.8316860
Prev | Table of Contents | Next

Articles

Science, Vol 261, Issue 5117, 91-93
Copyright © 1993 by American Association for the Advancement of Science

articles

Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus

E Mozes, LD Kohn, F Hakim, and DS Singer

Experimental Immunology Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892.

Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they did not develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transcriptional regulation of major histocompatibility complex class I gene by insulin and IGF-I in FRTL-5 thyroid cells..
C Giuliani, M Saji, I Bucci, G Fiore, M Liberatore, D S Singer, F Monaco, L D Kohn, and G Napolitano (2006)
J. Endocrinol. 189, 605-615
   Abstract »    Full Text »    PDF »
Thyrocytes Express a Functional Toll-Like Receptor 3: Overexpression Can Be Induced by Viral Infection and Reversed by Phenylmethimazole and Is Associated with Hashimoto's Autoimmune Thyroiditis.
N. Harii, C. J. Lewis, V. Vasko, K. McCall, U. Benavides-Peralta, X. Sun, M. D. Ringel, M. Saji, C. Giuliani, G. Napolitano, et al. (2005)
Mol. Endocrinol. 19, 1231-1250
   Abstract »    Full Text »    PDF »
MHC class I expression regulates susceptibility to spontaneous autoimmune disease in (NZBxNZW)F1 mice.
E Mozes, J Lovchik, H Zinger, and D S Singer (2005)
Lupus 14, 308-314
   Abstract »    PDF »
Mechanism of hypoalbuminemia in rodents.
M. Koltun, J. Nikolovski, K. Strong, D. Nikolic-Paterson, and W. D. Comper (2005)
Am J Physiol Heart Circ Physiol 288, H1604-H1610
   Abstract »    Full Text »    PDF »
A T Lymphocyte-Specific Transcription Complex Containing RUNX1 Activates MHC Class I Expression.
T. K. Howcroft, J. D. Weissman, A. Gegonne, and D. S. Singer (2005)
J. Immunol. 174, 2106-2115
   Abstract »    Full Text »    PDF »
Phenyl Methimazole Inhibits TNF-{alpha}-Induced VCAM-1 Expression in an IFN Regulatory Factor-1-Dependent Manner and Reduces Monocytic Cell Adhesion to Endothelial Cells.
N. M. Dagia, N. Harii, A. E. Meli, X. Sun, C. J. Lewis, L. D. Kohn, and D. J. Goetz (2004)
J. Immunol. 173, 2041-2049
   Abstract »    Full Text »    PDF »
Biochemical Characterization of Proline Racemases from the Human Protozoan Parasite Trypanosoma cruzi and Definition of Putative Protein Signatures.
N. Chamond, C. Gregoire, N. Coatnoan, C. Rougeot, L. H. Freitas-Junior, J. F. da Silveira, W. M. Degrave, and P. Minoprio (2003)
J. Biol. Chem. 278, 15484-15494
   Abstract »    Full Text »    PDF »
The Major Histocompatibility Complex-related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan.
C. Chaudhury, S. Mehnaz, J. M. Robinson, W. L. Hayton, D. K. Pearl, D. C. Roopenian, and C. L. Anderson (2003)
J. Exp. Med. 197, 315-322
   Abstract »    Full Text »    PDF »
Methimazole protects from experimental autoimmune uveitis (EAU) by inhibiting antigen presenting cell function and reducing antigen priming.
P. Wang, S.-H. Sun, P. B. Silver, C.-C. Chan, R. K. Agarwal, B. Wiggert, L. D. Kohn, G. A. Jamieson Jr, and R. R. Caspi (2003)
J. Leukoc. Biol. 73, 57-64
   Abstract »    Full Text »    PDF »
High Glucose Levels Increase Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells and Amplify Interferon-{gamma} Action.
G. Napolitano, I. Bucci, C. Giuliani, C. Massafra, C. Di Petta, E. Devangelio, D. S. Singer, F. Monaco, and L. D. Kohn (2002)
Endocrinology 143, 1008-1017
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-{beta}1 Down-Regulation of Major Histocompatibility Complex Class I in Thyrocytes: Coordinate Regulation Of Two Separate Elements by Thyroid-Specific as Well as Ubiquitous Transcription Factors.
G. Napolitano, V. Montani, C. Giuliani, S. Di Vincenzo, I. Bucci, V. Todisco, G. Laglia, A. Coppa, D. S. Singer, M. Nakazato, et al. (2000)
Mol. Endocrinol. 14, 486-505
   Abstract »    Full Text »
Major Histocompatibility Class I Gene Transcription in Thyrocytes: A Series of Interacting Regulatory DNA Sequence Elements Mediate Thyrotropin/Cyclic Adenosine 3',5'-Monophosphate Repression.
S. Kirshner, L. Palmer, J. Bodor, M. Saji, L. D. Kohn, and D. S. Singer (2000)
Mol. Endocrinol. 14, 82-98
   Abstract »    Full Text »
{beta}2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-{beta}1 Null Mouse.
S. Kobayashi, K. Yoshida, J. M. Ward, J. J. Letterio, G. Longenecker, L. Yaswen, B. Mittleman, E. Mozes, A. B. Roberts, S. Karlsson, et al. (1999)
J. Immunol. 163, 4013-4019
   Abstract »    Full Text »    PDF »
Analysis of MHC Class II Genes in the Susceptibility to Lupus in New Zealand Mice.
S. J. Rozzo, T. J. Vyse, C. S. David, E. Palmer, S. Izui, and B. L. Kotzin (1999)
J. Immunol. 162, 2623-2630
   Abstract »    Full Text »    PDF »
Thyrotropin Receptor Epitopes Recognized by Graves' Autoantibodies Developing under Immunosuppressive Therapy.
J. Wortsman, P. McConnachie, K. Tahara, and L. D. Kohn (1998)
J. Clin. Endocrinol. Metab. 83, 2302-2308
   Abstract »    Full Text »
Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines.
D. Zeng, M. Dick, L. Cheng, M. Amano, S. Dejbakhsh-Jones, P. Huie, R. Sibley, and S. Strober (1998)
J. Exp. Med. 187, 525-536
   Abstract »    Full Text »    PDF »
Iodide Suppression of Major Histocompatibility Class I Gene Expression in Thyroid Cells Involves Enhancer A and the Transcription Factor NF-{kappa}B.
S.-I. Taniguchi, M. Shong, C. Giuliani, G. Napolitano, M. Saji, V. Montani, K. Suzuki, D. S. Singer, and L. D. Kohn (1998)
Mol. Endocrinol. 12, 19-33
   Abstract »    Full Text »
Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells.
B.-n. Zhang, T. Yamamura, T. Kondo, M. Fujiwara, and T. Tabira (1997)
J. Exp. Med. 186, 1677-1687
   Abstract »    Full Text »    PDF »
beta 2-microglobulin-deficient Mice Are Resistant to Bullous Pemphigoid.
Z. Liu, D. C. Roopenian, X. Zhou, G. J. Christianson, L. A. Diaz, D. D. Sedmak, and C. L. Anderson (1997)
J. Exp. Med. 186, 777-783
   Abstract »    Full Text »    PDF »
Regulation of Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells. ROLE OF THE cAMP RESPONSE ELEMENT-LIKE SEQUENCE.
M. Saji, M. Shong, G. Napolitano, L. A. Palmer, S.-I. Taniguchi, M. Ohmori, M. Ohta, K. Suzuki, S. L. Kirshner, C. Giuliani, et al. (1997)
J. Biol. Chem. 272, 20096-20107
   Abstract »    Full Text »    PDF »
Active Repression of Major Histocompatibility Complex Class I Genes in a Human Neuroblastoma Cell Line.
C. Murphy, D. Nikodem, K. Howcroft, J. D. Weissman, and D. S. Singer (1996)
J. Biol. Chem. 271, 30992-30999
   Abstract »    Full Text »    PDF »
A subset of CD4+ thymocytes selected by MHC class I molecules.
A Bendelac, N Killeen, D. Littman, and R. Schwartz (1994)
Science 263, 1774-1778
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)