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Science 11 June 1993:
Vol. 260. no. 5114, pp. 1661 - 1664
DOI: 10.1126/science.8389057
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Articles

Science, Vol 260, Issue 5114, 1661-1664
Copyright © 1993 by American Association for the Advancement of Science

articles

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

U Frey, YY Huang, and ER Kandel

Center for Neurobiology and Behavior, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism for the establishment of certain forms of explicit memory in the mammalian brain. As is the case with behavioral memory, LTP in the CA1 region has stages: a short-term early potentiation lasting 1 to 3 hours, which is independent of protein synthesis, precedes a later, longer lasting stage (L-LTP), which requires protein synthesis. Inhibitors of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) blocked L-LTP, and analogs of cAMP induced a potentiation that blocked naturally induced L-LTP. The action of the cAMP analog was blocked by inhibitors of protein synthesis. Thus, activation of PKA may be a component of the mechanism that generates L-LTP.


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Mitogen-Activated Protein Kinase Regulates Early Phosphorylation and Delayed Expression of Ca2+/Calmodulin-Dependent Protein Kinase II in Long-Term Potentiation.
M. G. Giovannini, R. D. Blitzer, T. Wong, K. Asoma, P. Tsokas, J. H. Morrison, R. Iyengar, and E. M. Landau (2001)
J. Neurosci. 21, 7053-7062
   Abstract »    Full Text »    PDF »
A High-Efficiency Protein Transduction System Demonstrating the Role of PKA in Long-Lasting Long-Term Potentiation.
M. Matsushita, K. Tomizawa, A. Moriwaki, S.-T. Li, H. Terada, and H. Matsui (2001)
J. Neurosci. 21, 6000-6007
   Abstract »    Full Text »    PDF »
Reinforcement of Early Long-Term Potentiation (Early-LTP) in Dentate Gyrus by Stimulation of the Basolateral Amygdala: Heterosynaptic Induction Mechanisms of Late-LTP.
S. Frey, J. Bergado-Rosado, T. Seidenbecher, H.-C. Pape, and J. U. Frey (2001)
J. Neurosci. 21, 3697-3703
   Abstract »    Full Text »    PDF »
Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons.
C.-C. Huang, S.-W. Lo, and K.-S. Hsu (2001)
J. Physiol. 532, 731-748
   Abstract »    Full Text »    PDF »
Evidence for Involvement of Central 5-HT4 Receptors in Cholinergic Function Associated with Cognitive Processes: Behavioral, Electrophysiological, and Neurochemical Studies.
M. Matsumoto, H. Togashi, K. Mori, K.-i. Ueno, S. Ohashi, T. Kojima, and M. Yoshioka (2001)
J. Pharmacol. Exp. Ther. 296, 676-682
   Abstract »    Full Text »
Fornix-Dependent Induction of Hippocampal CCAAT Enhancer-Binding Protein {beta} and {delta} Co-Localizes with Phosphorylated cAMP Response Element-Binding Protein and Accompanies Long-Term Memory Consolidation.
S. M. Taubenfeld, K. A. Wiig, B. Monti, B. Dolan, G. Pollonini, and C. M. Alberini (2001)
J. Neurosci. 21, 84-91
   Abstract »    Full Text »    PDF »


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