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Science 21 May 1993:
Vol. 260. no. 5111, pp. 1121 - 1124
DOI: 10.1126/science.8493555
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Articles

Science, Vol 260, Issue 5111, 1121-1124
Copyright © 1993 by American Association for the Advancement of Science

articles

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C

M Colonna, EG Brooks, M Falco, GB Ferrara, and JL Strominger

Laboratory of Immunogenetics, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

The cytotoxicity of human natural killer (NK) cells is modulated by the major histocompatibility complex human leukocyte antigen (HLA)-C molecules on the surface of the target cell. Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were homozygous for HLA-C with asparagine at residue 77 and lysine at residue 80 [HLA-C(Asn77,Lys80)] by stimulation with target cells that were homozygous for HLA-C(Ser77,Asn80); the reciprocal stimulation yielded NK cells specific for the NK-2 alloantigen. However, neither homozygous target cell stimulated the generation of alloreactive NK cells from heterozygous individuals. Thus, these data reveal an unanticipated difference between human NK alloreactivity defined by this system and murine "hybrid resistance."


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