Science 7 May 1993: Vol. 260. no. 5109, pp. 816 - 819 DOI: 10.1126/science.8484122

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Articles

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology.

S. M. Woerner, Y. P. Yuan, A. Benner, S. Korff, M. von Knebel Doeberitz, and P. Bork (2009)
Nucleic Acids Res.
 |  Abstract »  |  Full Text »  |  PDF »

Associations between Smoking, Alcohol Consumption, and Colorectal Cancer, Overall and by Tumor Microsatellite Instability Status.

J. N. Poynter, R. W. Haile, K. D. Siegmund, P. T. Campbell, J. C. Figueiredo, P. Limburg, J. Young, L. Le Marchand, J. D. Potter, M. Cotterchio, et al. (2009)
Cancer Epidemiol. Biomarkers Prev. 18, 2745-2750
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Down-regulation of Epidermal Growth Factor Receptor by Selective Expansion of a 5'-End Regulatory Dinucleotide Repeat in Colon Cancer with Microsatellite Instability.

S. Baranovskaya, Y. Martin, S. Alonso, K. L. Pisarchuk, M. Falchetti, Y. Dai, S. Khaldoyanidi, S. Krajewski, I. Novikova, Y. S. Sidorenko, et al. (2009)
Clin. Cancer Res. 15, 4531-4537
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ATR Mutations in Endometrial Cancer: A Window Into the Role of Mismatch Repair Defects.

N. D. Kauff (2009)
J. Clin. Oncol. 27, 3077-3078
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Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): A gene-dependent effect on the cell surface glycan profile.

G. Patsos, S. Andre, N. Roeckel, R. Gromes, J. Gebert, J. Kopitz, and H.-J. Gabius (2009)
Glycobiology 19, 726-734
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Implications of Familial Colorectal Cancer Risk Profiles and Microsatellite Instability Status.

S. J. Lubbe, E. L. Webb, I. P. Chandler, and R. S. Houlston (2009)
J. Clin. Oncol. 27, 2238-2244
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Deficient DNA Mismatch Repair Is Common in Lynch Syndrome-Associated Colorectal Adenomas.

M. S. Pino, M. Mino-Kenudson, B. M. Wildemore, A. Ganguly, J. Batten, I. Sperduti, A. J. Iafrate, and D. C. Chung (2009)
J. Mol. Diagn. 11, 238-247
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Microsatellite Instability Predicts Improved Response to Adjuvant Therapy With Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B Protocol 89803.

M. M. Bertagnolli, D. Niedzwiecki, C. C. Compton, H. P. Hahn, M. Hall, B. Damas, S. D. Jewell, R. J. Mayer, R. M. Goldberg, L. B. Saltz, et al. (2009)
J. Clin. Oncol. 27, 1814-1821
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Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B.

S.-i. Asaka, Y. Arai, Y. Nishimura, K. Yamaguchi, T. Ishikubo, T. Yatsuoka, Y. Tanaka, and K. Akagi (2009)
Carcinogenesis 30, 494-499
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Human Postmeiotic Segregation 2 Exhibits Biased Repair at Tetranucleotide Microsatellite Sequences.

S. N. Shah and K. A. Eckert (2009)
Cancer Res. 69, 1143-1149
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High Frequency of LMAN1 Abnormalities in Colorectal Tumors with Microsatellite Instability.

N. Roeckel, S. M. Woerner, M. Kloor, Y.-P. Yuan, G. Patsos, R. Gromes, J. Kopitz, and J. Gebert (2009)
Cancer Res. 69, 292-299
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Smoking and Colorectal Cancer: A Meta-analysis.

E. Botteri, S. Iodice, V. Bagnardi, S. Raimondi, A. B. Lowenfels, and P. Maisonneuve (2008)
JAMA 300, 2765-2778
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Molecular Characterization of MSI-H Colorectal Cancer by MLHI Promoter Methylation, Immunohistochemistry, and Mismatch Repair Germline Mutation Screening.

J. N. Poynter, K. D. Siegmund, D. J. Weisenberger, T. I. Long, S. N. Thibodeau, N. Lindor, J. Young, M. A. Jenkins, J. L. Hopper, J. A. Baron, et al. (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 3208-3215
 |  Abstract »  |  Full Text »  |  PDF »

Systematic Review and Meta-analysis of Ovarian Cancers: Estimation of Microsatellite-High Frequency and Characterization of Mismatch Repair Deficient Tumor Histology.

T. Pal, J. Permuth-Wey, A. Kumar, and T. A. Sellers (2008)
Clin. Cancer Res. 14, 6847-6854
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Prognostic Impact of Bim, Puma, and Noxa Expression in Human Colon Carcinomas.

F. A. Sinicrope, R. L. Rego, K. Okumura, N. R. Foster, M. J. O'Connell, D. J. Sargent, and H. E. Windschitl (2008)
Clin. Cancer Res. 14, 5810-5818
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Immunohistochemistry versus Microsatellite Instability Testing for Screening Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome: Part II. The Utility of Microsatellite Instability Testing.

L. Zhang (2008)
J. Mol. Diagn. 10, 301-307
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Proapoptotic Bad and Bid Protein Expression Predict Survival in Stages II and III Colon Cancers.

F. A. Sinicrope, R. L. Rego, N. R. Foster, S. N. Thibodeau, S. R. Alberts, H. E. Windschitl, and D. J. Sargent (2008)
Clin. Cancer Res. 14, 4128-4133
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer.

A. J. French, D. J. Sargent, L. J. Burgart, N. R. Foster, B. F. Kabat, R. Goldberg, L. Shepherd, H. E. Windschitl, and S. N. Thibodeau (2008)
Clin. Cancer Res. 14, 3408-3415
 |  Abstract »  |  Full Text »  |  PDF »

Differential Wnt Pathway Gene Expression and E-Cadherin Truncation in Sporadic Colorectal Cancers with and without Microsatellite Instability.

P. Ortega, A. Moran, C. de Juan, C. Frias, S. Hernandez, J.-A. Lopez-Asenjo, A. Sanchez-Pernaute, A. Torres, P. Iniesta, and M. Benito (2008)
Clin. Cancer Res. 14, 995-1001
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Molecular Classification and Correlates in Colorectal Cancer.

S. Ogino and A. Goel (2008)
J. Mol. Diagn. 10, 13-27
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Frequency of Defective DNA Mismatch Repair in Colorectal Cancer among the Alaska Native People.

L. A. Boardman, A. P. Lanier, A. J. French, K. V. Schowalter, L. J. Burgart, K. R. Koller, S. K. McDonnell, D. J. Schaid, and S. N. Thibodeau (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 2344-2350
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Cecal Adenocarcinoma With Prominent Rhabdoid Feature: Report of a Case With Immunohistochemical, Ultrastructural, and Molecular Analyses.

T. Kono, Y. Imai, J. Imura, Y. Ono, S. Hagiwara, K. Taira, M. Fujita, M. Tsubaki, M. Sunagawa, and T. Fujimori (2007)
International Journal of Surgical Pathology 15, 414-420
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Functional Characterization of Pathogenic Human MSH2 Missense Mutations in Saccharomyces cerevisiae.

A. E. Gammie, N. Erdeniz, J. Beaver, B. Devlin, A. Nanji, and M. D. Rose (2007)
Genetics 177, 707-721
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Specific Clinical and Biological Features Characterize Inflammatory Bowel Disease Associated Colorectal Cancers Showing Microsatellite Instability.

M. Svrcek, J. El-Bchiri, A. Chalastanis, E. Capel, S. Dumont, O. Buhard, C. Oliveira, R. Seruca, C. Bossard, J.-F. Mosnier, et al. (2007)
J. Clin. Oncol. 25, 4231-4238
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Mismatch Repair Genes hMLH1 and hMSH2 May Not Play an Essential Role in Breast Carcinogenesis.

N. Khilko, P. Bourne, Qi Yang, and Ping Tang (2007)
International Journal of Surgical Pathology 15, 233-241
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Mutator pathways unleashed by epigenetic silencing in human cancer.

F. V. Jacinto and M. Esteller (2007)
Mutagenesis 22, 247-253
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Microsatellite Instability and Epigenetic Inactivation of MLH1 and Outcome of Patients With Endometrial Carcinomas of the Endometrioid Type.

I. Zighelboim, P. J. Goodfellow, F. Gao, R. K. Gibb, M. A. Powell, J. S. Rader, and D. G. Mutch (2007)
J. Clin. Oncol. 25, 2042-2048
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IMEx: Imperfect Microsatellite Extractor.

S. B. Mudunuri and H. A. Nagarajaram (2007)
Bioinformatics 23, 1181-1187
 |  Abstract »  |  Full Text »  |  PDF »

Higher Frequency of Diploidy in Young-Onset Microsatellite-Stable Colorectal Cancer.

L. A. Boardman, R. A. Johnson, G. M. Petersen, A. L. Oberg, B. F. Kabat, J. P. Slusser, L. Wang, B. W. Morlan, A. J. French, T. C. Smyrk, et al. (2007)
Clin. Cancer Res. 13, 2323-2328
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Prognostic and Predictive Roles of High-Degree Microsatellite Instability in Colon Cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study.

G. P. Kim, L. H. Colangelo, H. S. Wieand, S. Paik, I. R. Kirsch, N. Wolmark, and C. J. Allegra (2007)
J. Clin. Oncol. 25, 767-772
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Clinical Uses of Microsatellite Instability Testing in Colorectal Cancer: An Ongoing Challenge.

C. R. Boland (2007)
J. Clin. Oncol. 25, 754-756
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Performance of Different Microsatellite Marker Panels for Detection of Mismatch Repair-Deficient Colorectal Tumors.

R. M. Xicola, X. Llor, E. Pons, A. Castells, C. Alenda, V. Pinol, M. Andreu, S. Castellvi-Bel, A. Paya, R. Jover, et al. (2007)
J Natl Cancer Inst 99, 244-252
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APC Mutations and Other Genetic and Epigenetic Changes in Colon Cancer.

W. S. Samowitz, M. L. Slattery, C. Sweeney, J. Herrick, R. K. Wolff, and H. Albertsen (2007)
Mol. Cancer Res. 5, 165-170
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Establishment of Human Colon Cancer Cell Lines from Fresh Tumors versus Xenografts: Comparison of Success Rate and Cell Line Features.

V. Dangles-Marie, M. Pocard, S. Richon, L.-B. Weiswald, F. Assayag, P. Saulnier, J.-G. Judde, J.-L. Janneau, N. Auger, P. Validire, et al. (2007)
Cancer Res. 67, 398-407
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Explaining the Familial Colorectal Cancer Risk Associated with Mismatch Repair (MMR)-Deficient and MMR-Stable Tumors.

L. Aaltonen, L. Johns, H. Jarvinen, J.-P. Mecklin, and R. Houlston (2007)
Clin. Cancer Res. 13, 356-361
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The Malignant Potential of Freshly Developed Colorectal Polyps According to Age.

Y. Yamaji, T. Mitsushima, H. Yoshida, H. Watabe, M. Okamoto, R. Wada, H. Ikuma, T. Kawabe, and M. Omata (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 2418-2421
 |  Abstract »  |  Full Text »  |  PDF »

Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer.

R C Niessen, M J W Berends, Y Wu, R H Sijmons, H Hollema, M J L Ligtenberg, H E K de Walle, E G E de Vries, A Karrenbeld, C H C M Buys, et al. (2006)
Gut 55, 1781-1788
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ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer.

G. Y. Locker, S. Hamilton, J. Harris, J. M. Jessup, N. Kemeny, J. S. Macdonald, M. R. Somerfield, D. F. Hayes, and R. C. Bast Jr (2006)
J. Clin. Oncol. 24, 5313-5327
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Simplified detection of microsatellite instability in colorectal cancer without the need for corresponding germline DNA analysis..

M Ebinger, K Sotlar, A Weber, C T Bock, B D Bultmann, and R Kandolf (2006)
J. Clin. Pathol. 59, 1114-1115
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Associations of Ki-ras Proto-oncogene Mutation and p53 Gene Overexpression in Sporadic Colorectal Adenomas with Demographic and Clinicopathologic Characteristics..

J. G. Einspahr, M. E. Martinez, R. Jiang, C.-H. Hsu, A. K. Bhattacharrya, D. J. Ahnen, E. T. Jacobs, P. S. Houlihan, C. R. Webb, D. S. Alberts, et al. (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 1443-1450
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of the Microsatellite Instability Analysis System and the Bethesda Panel for the Determination of Microsatellite Instability in Colorectal Cancers.

K. M. Murphy, S. Zhang, T. Geiger, M. J. Hafez, J. Bacher, K. D. Berg, and J. R. Eshleman (2006)
J. Mol. Diagn. 8, 305-311
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Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians.

Y. M.C. Hendriks, A. E. de Jong, H. Morreau, C. M.J. Tops, H. F. Vasen, J. Th. Wijnen, M. H. Breuning, and A. H.J.T. Brocker-Vriends (2006)
CA Cancer J Clin 56, 213-225
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Risk of Microsatellite-Unstable Colorectal Cancer Is Associated Jointly with Smoking and Nonsteroidal Anti-inflammatory Drug Use..

V. M. Chia, P. A. Newcomb, J. Bigler, L. M. Morimoto, S. N. Thibodeau, and J. D. Potter (2006)
Cancer Res. 66, 6877-6883
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Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer.

R Jover, P Zapater, A Castells, X Llor, M Andreu, J Cubiella, V Pinol, R M Xicola, L Bujanda, J M Rene, et al. (2006)
Gut 55, 848-855
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Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer.

L. Luo, G.-Q. Shen, K. A. Stiffler, Q. K. Wang, T. G. Pretlow, and T. P. Pretlow (2006)
Carcinogenesis 27, 1153-1159
 |  Abstract »  |  Full Text »  |  PDF »

Immunohistochemical Test for MLH1 and MSH2 Expression Predicts Clinical Outcome in Stage II and III Colorectal Cancer Patients.

G. Lanza, R. Gafa, A. Santini, I. Maestri, L. Guerzoni, and L. Cavazzini (2006)
J. Clin. Oncol. 24, 2359-2367
 |  Abstract »  |  Full Text »  |  PDF »

Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas.

K Ishiguro, T Yoshida, H Yagishita, Y Numata, and T Okayasu (2006)
Gut 55, 695-702
 |  Abstract »  |  Full Text »  |  PDF »

Detection of microsatellite instability in endometrial cancer: advantages of a panel of five mononucleotide repeats over the National Cancer Institute panel of markers.

Y. F. Wong, T. H. Cheung, K. W. K. Lo, S. F. Yim, L. K. Y. Chan, O. Buhard, A. Duval, T. K. H. Chung, and R. Hamelin (2006)
Carcinogenesis 27, 951-955
 |  Abstract »  |  Full Text »  |  PDF »

Thymidylate synthase expression in colon carcinomas with microsatellite instability..

F. A. Sinicrope, R. L. Rego, K. C. Halling, N. R. Foster, D. J. Sargent, B. La Plant, A. J. French, C. J. Allegra, J. A. Laurie, R. M. Goldberg, et al. (2006)
Clin. Cancer Res. 12, 2738-2744
 |  Abstract »  |  Full Text »  |  PDF »

Clinicopathologic Significance of Defective DNA Mismatch Repair in Endometrial Carcinoma.

D. Black, R. A. Soslow, D. A. Levine, C. Tornos, S. C. Chen, A. J. Hummer, F. Bogomolniy, N. Olvera, R. R. Barakat, and J. Boyd (2006)
J. Clin. Oncol. 24, 1745-1753
 |  Abstract »  |  Full Text »  |  PDF »

Short fuzzy tandem repeats in genomic sequences, identification, and possible role in regulation of gene expression.

V. Boeva, M. Regnier, D. Papatsenko, and V. Makeev (2006)
Bioinformatics 22, 676-684
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Coalescent Trees With Two Mutation Rates and Their Application to Genomic Instability.

M. Emily and O. Francois (2006)
Genetics 172, 1809-1820
 |  Abstract »  |  Full Text »  |  PDF »

Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.

E. C. Chao and S. M. Lipkin (2006)
Nucleic Acids Res. 34, 840-852
 |  Abstract »  |  Full Text »  |  PDF »

Mutually Exclusive Promoter Hypermethylation Patterns of hMLH1 and O6-Methylguanine DNA Methyltransferase in Colorectal Cancer.

E. J. Fox, D. T. Leahy, R. Geraghty, H. E. Mulcahy, D. Fennelly, J. M. Hyland, D. P. O'Donoghue, and K. Sheahan (2006)
J. Mol. Diagn. 8, 68-75
 |  Abstract »  |  Full Text »  |  PDF »

Multipopulation Analysis of Polymorphisms in Five Mononucleotide Repeats Used to Determine the Microsatellite Instability Status of Human Tumors.

O. Buhard, F. Cattaneo, Y. F. Wong, S. F. Yim, E. Friedman, J.-F. Flejou, A. Duval, and R. Hamelin (2006)
J. Clin. Oncol. 24, 241-251
 |  Abstract »  |  Full Text »  |  PDF »

The Relationship between Global Methylation Level, Loss of Heterozygosity, and Microsatellite Instability in Sporadic Colorectal Cancer.

K. Matsuzaki, G. Deng, H. Tanaka, S. Kakar, S. Miura, and Y. S. Kim (2005)
Clin. Cancer Res. 11, 8564-8569
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite Instability and Alterations of Mismatch Repair Protein Expression in Choroidal Melanomas.

M. R. Hussein, A. K. Haemel, D. M. Albert, and G. S. Wood (2005)
Arch Ophthalmol 123, 1705-1711
 |  Abstract »  |  Full Text »  |  PDF »

Postreplicative Joining of DNA Double-Strand Breaks Causes Genomic Instability in DNA-PKcs-Deficient Mouse Embryonic Fibroblasts.

M. Martin, A. Genesca, L. Latre, I. Jaco, G. E. Taccioli, J. Egozcue, M. A. Blasco, G. Iliakis, and L. Tusell (2005)
Cancer Res. 65, 10223-10232
 |  Abstract »  |  Full Text »  |  PDF »

Increased Negative Superhelical Density in Vivo Enhances the Genetic Instability of Triplet Repeat Sequences.

M. Napierala, A. Bacolla, and R. D. Wells (2005)
J. Biol. Chem. 280, 37366-37376
 |  Abstract »  |  Full Text »  |  PDF »

Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma.

C. Tzao, H.-S. Hsu, G.-H. Sun, H.-L. Lai, Y.-C. Wang, H.-J. Tung, C.-P. Yu, Y.-L. Cheng, and S.-C. Lee (2005)
J. Thorac. Cardiovasc. Surg. 130, 1371
 |  Abstract »  |  Full Text »  |  PDF »

Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway.

X. Llor, E. Pons, R. M. Xicola, A. Castells, C. Alenda, V. Pinol, M. Andreu, S. Castellvi-Bel, A. Paya, R. Jover, et al. (2005)
Clin. Cancer Res. 11, 7304-7310
 |  Abstract »  |  Full Text »  |  PDF »

Isolated Loss of PMS2 Expression in Colorectal Cancers: Frequency, Patient Age, and Familial Aggregation.

S. Gill, N. M. Lindor, L. J. Burgart, R. Smalley, O. Leontovich, A. J. French, R. M. Goldberg, D. J. Sargent, J. R. Jass, J. L. Hopper, et al. (2005)
Clin. Cancer Res. 11, 6466-6471
 |  Abstract »  |  Full Text »  |  PDF »

Determination of TP53 Mutation Is More Relevant Than Microsatellite Instability Status for the Prediction of Disease-Free Survival in Adjuvant-Treated Stage III Colon Cancer Patients.

J. L. Westra, M. Schaapveld, H. Hollema, J. P. de Boer, M. M.J. Kraak, D. de Jong, A. ter Elst, N. H. Mulder, C. H.C.M. Buys, R. M.W. Hofstra, et al. (2005)
J. Clin. Oncol. 23, 5635-5643
 |  Abstract »  |  Full Text »  |  PDF »

Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers.

J. El-Bchiri, O. Buhard, V. Penard-Lacronique, G. Thomas, R. Hamelin, and A. Duval (2005)
Hum. Mol. Genet. 14, 2435-2442
 |  Abstract »  |  Full Text »  |  PDF »

Fruits, Vegetables, and hMLH1 Protein-Deficient and -Proficient Colon Cancer: The Netherlands Cohort Study.

P. A. Wark, M. P. Weijenberg, P. van 't Veer, G. van Wijhe, M. Luchtenborg, G. N.P. van Muijen, A. F.P.M. de Goeij, R. A. Goldbohm, and P. A. van den Brandt (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1619-1625
 |  Abstract »  |  Full Text »  |  PDF »

Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard.

S. Chen, P. Watson, and G. Parmigiani (2005)
Biostat. 6, 450-464
 |  Abstract »  |  Full Text »  |  PDF »

Association between family history and mismatch repair in colorectal cancer.

R P Coggins, L Cawkwell, S M Bell, G P Crockford, P Quirke, P J Finan, and D T Bishop (2005)
Gut 54, 636-642
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite Analysis of Hereditary Nonpolyposis Colorectal Cancer-Associated Colorectal Adenomas by Laser-Assisted Microdissection: Correlation with Mismatch Repair Protein Expression Provides New Insights in Early Steps of Tumorigenesis.

G. Giuffre, A. Muller, T. Brodegger, T. Bocker-Edmonston, J. Gebert, M. Kloor, W. Dietmaier, F. Kullmann, R. Buttner, G. Tuccari, et al. (2005)
J. Mol. Diagn. 7, 160-170
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of Stromelysin-1 Transcriptional Activity by Promoter Mutations in High Microsatellite Instability Colorectal Tumors.

A. Moran, P. Iniesta, C. de Juan, C. Garcia-Aranda, A. Diaz-Lopez, and M. Benito (2005)
Cancer Res. 65, 3811-3814
 |  Abstract »  |  Full Text »  |  PDF »

Progress in Genetic Testing, Classification, and Identification of Lynch Syndrome.

H. F. A. Vasen and C. R. Boland (2005)
JAMA 293, 2028-2030
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Low Microsatellite Instability Is Associated With Poor Prognosis in Stage C Colon Cancer.

M. R.J. Kohonen-Corish, J. J. Daniel, C. Chan, B. P.C. Lin, S. Y. Kwun, O. F. Dent, V. S. Dhillon, R. J.A. Trent, P. H. Chapuis, and E. L. Bokey (2005)
J. Clin. Oncol. 23, 2318-2324
 |  Abstract »  |  Full Text »  |  PDF »

A Lack of DNA Mismatch Repair on an Athymic Murine Background Predisposes to Hematologic Malignancy.

M. R. Campbell, P. N. Nation, and S. E. Andrew (2005)
Cancer Res. 65, 2626-2635
 |  Abstract »  |  Full Text »  |  PDF »

Self-Renewal and Cancer of the Gut: Two Sides of a Coin.

F. Radtke and H. Clevers (2005)
Science 307, 1904-1909
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Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.

S. Oda, Y. Maehara, Y. Ikeda, E. Oki, A. Egashira, Y. Okamura, I. Takahashi, Y. Kakeji, Y. Sumiyoshi, K. Miyashita, et al. (2005)
Nucleic Acids Res. 33, 1628-1636
 |  Abstract »  |  Full Text »  |  PDF »

Mutants with Temperature-Sensitive Defects in the Escherichia coli Mismatch Repair System: Sensitivity to Mispairs Generated In Vivo.

E. S. Hong, A. Yeung, P. Funchain, M. M. Slupska, and J. H. Miller (2005)
J. Bacteriol. 187, 840-846
 |  Abstract »  |  Full Text »  |  PDF »

Diet, Lifestyle, and Genomic Instability in the North Carolina Colon Cancer Study.

J. A. Satia, T. Keku, J. A. Galanko, C. Martin, R. T. Doctolero, A. Tajima, R. S. Sandler, and J. M. Carethers (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 429-436
 |  Abstract »  |  Full Text »  |  PDF »

Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis.

S. Popat, R. Hubner, and R.S. Houlston (2005)
J. Clin. Oncol. 23, 609-618
 |  Abstract »  |  Full Text »  |  PDF »

Hereditary Cancer Predisposition Syndromes.

J. E. Garber and K. Offit (2005)
J. Clin. Oncol. 23, 276-292
 |  Abstract »  |  Full Text »  |  PDF »

Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma.

C M Wright, O F Dent, R C Newland, M Barker, P H Chapuis, E L Bokey, J P Young, B A Leggett, J R Jass, and G A Macdonald (2005)
Gut 54, 103-108
 |  Abstract »  |  Full Text »  |  PDF »

Fecal DNA versus Fecal Occult Blood for Colorectal-Cancer Screening in an Average-Risk Population.

T. F. Imperiale, D. F. Ransohoff, S. H. Itzkowitz, B. A. Turnbull, M. E. Ross, and the Colorectal Cancer Study Group (2004)
N. Engl. J. Med. 351, 2704-2714
 |  Abstract »  |  Full Text »  |  PDF »

DNA polymerase {delta}, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae.

S. E. Corrette-Bennett, C. Borgeson, D. Sommer, P. M. J. Burgers, and R. S. Lahue (2004)
Nucleic Acids Res. 32, 6268-6275
 |  Abstract »  |  Full Text »  |  PDF »

Lower Incidence of Colorectal Cancer and Later Age of Disease Onset in 27 Families With Pathogenic MSH6 Germline Mutations Compared With Families With MLH1 or MSH2 Mutations: The German Hereditary Nonpolyposis Colorectal Cancer Consortium.

J. Plaschke, C. Engel, S. Kruger, E. Holinski-Feder, C. Pagenstecher, E. Mangold, G. Moeslein, K. Schulmann, J. Gebert, M. von Knebel Doeberitz, et al. (2004)
J. Clin. Oncol. 22, 4486-4494
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite Instability and MLH1 Promoter Methylation in Human Retinoblastoma.

K. W. Choy, C. P. Pang, D. S. P. Fan, T. C. Lee, J. H. Wang, D. H. Abramson, K. W. Lo, K. F. To, C. B. O. Yu, K. L. Beaverson, et al. (2004)
Invest. Ophthalmol. Vis. Sci. 45, 3404-3409
 |  Abstract »  |  Full Text »  |  PDF »

CT Colonography with Computer-aided Detection: Automated Recognition of Ileocecal Valve to Reduce Number of False-Positive Detections.

R. M. Summers, J. Yao, and C. D. Johnson (2004)
Radiology 233, 266-272
 |  Abstract »  |  Full Text »  |  PDF »

DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma.

M. R. Velangi, E. C. Matheson, G. J. Morgan, G. H. Jackson, P. R. Taylor, A. G. Hall, and J. A.E. Irving (2004)
Carcinogenesis 25, 1795-1803
 |  Abstract »  |  Full Text »  |  PDF »

BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.

E Domingo, P Laiho, M Ollikainen, M Pinto, L Wang, A J French, J Westra, T Frebourg, E Espin, M Armengol, et al. (2004)
J. Med. Genet. 41, 664-668
 |  Abstract »  |  Full Text »  |  PDF »

Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation.

J. Offman, G. Opelz, B. Doehler, D. Cummins, O. Halil, N. R. Banner, M. M. Burke, D. Sullivan, P. Macpherson, and P. Karran (2004)
Blood 104, 822-828
 |  Abstract »  |  Full Text »  |  PDF »

Colorectal cancer without high microsatellite instability and chromosomal instability--an alternative genetic pathway to human colorectal cancer.

R. Tang, C. R. Changchien, M.-C. Wu, C.-W. Fan, K.-W. Liu, J.-S. Chen, H.-T. Chien, and L.-L. Hsieh (2004)
Carcinogenesis 25, 841-846
 |  Abstract »  |  Full Text »  |  PDF »

The mutator pathway is a feature of immunodeficiency-related lymphomas.

A. Duval, M. Raphael, C. Brennetot, H. Poirel, O. Buhard, A. Aubry, A. Martin, A. Krimi, V. Leblond, J. Gabarre, et al. (2004)
PNAS 101, 5002-5007
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite instability mutator phenotype in hepatocellular carcinoma in non-alcoholic and non-virally infected normal livers.

F. Chiappini, M. Gross-Goupil, R. Saffroy, D. Azoulay, J.-F. Emile, L.-A. Veillhan, V. Delvart, S. Chevalier, H. Bismuth, B. Debuire, et al. (2004)
Carcinogenesis 25, 541-547
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic significance of microsatellite instability determined by immunohistochemical staining of MSH2 and MLH1 in sporadic T3N0M0 colon cancer.

Y Parc, S Gueroult, N Mourra, L Serfaty, J-F Flejou, E Tiret, and R Parc (2004)
Gut 53, 371-375
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Pathogenic Human MSH2 Missense Mutations Using Yeast as a Model System: A Laboratory Course in Molecular Biology.

A. E. Gammie and N. Erdeniz (2004)
CBE Life Sci Educ 3, 31-48
 |  Abstract »  |  Full Text »  |  PDF »

A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability.

Y. Ionov, S.-I. Matsui, and J. K. Cowell (2004)
PNAS 101, 1273-1278
 |  Abstract »  |  Full Text »  |  PDF »

Loss of MSH3 Protein Expression Is Frequent in MLH1-Deficient Colorectal Cancer and Is Associated with Disease Progression1.

J. Plaschke, S. Kruger, B. Jeske, F. Theissig, F. R. Kreuz, S. Pistorius, H. D. Saeger, I. Iaccarino, G. Marra, and H. K. Schackert (2004)
Cancer Res. 64, 864-870
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Factors and Microsatellite Instability in Sporadic Colon Carcinomas.

B. Diergaarde, H. Braam, G. N. P. van Muijen, M. J. L. Ligtenberg, F. J. Kok, and E. Kampman (2003)
Cancer Epidemiol. Biomarkers Prev. 12, 1130-1136
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal Imbalances in the Colorectal Carcinomas with Microsatellite Instability.

L. S. Li, N.-G. Kim, S. H. Kim, C. Park, H. Kim, H. J. Kang, K. H. Koh, S. N. Kim, W. H. Kim, N. K. Kim, et al. (2003)
Am. J. Pathol. 163, 1429-1436
 |  Abstract »  |  Full Text »  |  PDF »

Tumor-specific Immunological Recognition of Frameshift-mutated Peptides in Colon Cancer with Microsatellite Instability.

T. Ishikawa, T. Fujita, Y. Suzuki, S. Okabe, Y. Yuasa, T. Iwai, and Y. Kawakami (2003)
Cancer Res. 63, 5564-5572
 |  Abstract »  |  Full Text »  |  PDF »

Automated, Multiplex Assay for High-Frequency Microsatellite Instability in Colorectal Cancer.

G.M. Nash, M. Gimbel, J. Shia, A.T. Culliford, D.R. Nathanson, M. Ndubuisi, Y. Yamaguchi, Z.S. Zeng, F. Barany, and P.B. Paty (2003)
J. Clin. Oncol. 21, 3105-3112
 |  Abstract »  |  Full Text »  |  PDF »

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