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Science 16 April 1993:
Vol. 260. no. 5106, pp. 355 - 358
DOI: 10.1126/science.7682337

Articles

Science, Vol 260, Issue 5106, 355-358
Copyright © 1993 by American Association for the Advancement of Science


articles

Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta

DD Taub, K Conlon, AR Lloyd, JJ Oppenheim, and DJ Kelvin

Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick Cancer Research and Development Center (FCRDC), MD 21702.

Recombinant human macrophage inflammatory protein-1 alpha (rhMIP-1 alpha) and rhMIP-1 beta were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1 beta, whereas rhMIP-1 alpha induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naive and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.


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Cutaneous Injection of Human Subjects with Macrophage Inflammatory Protein-1{alpha} Induces Significant Recruitment of Neutrophils and Monocytes.
S. C. Lee, M. E. Brummet, S. Shahabuddin, T. G. Woodworth, S. N. Georas, K. M. Leiferman, S. C. Gilman, C. Stellato, R. P. Gladue, R. P. Schleimer, et al. (2000)
J. Immunol. 164, 3392-3401
   Abstract »    Full Text »    PDF »
The parting of the endothelium: miracle, or simply a junctional affair?.
C Johnson-Leger, M Aurrand-Lions, and B. Imhof (2000)
J. Cell Sci. 113, 921-933
   Abstract »    PDF »
Activation of C-C beta -chemokines in human peripheral blood gamma delta T cells by isopentenyl pyrophosphate and regulation by cytokines.
B. Cipriani, G. Borsellino, F. Poccia, R. Placido, D. Tramonti, S. Bach, L. Battistini, and C. F. Brosnan (2000)
Blood 95, 39-47
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Differential Chemokine Gene Expression in Corneal Transplant Rejection.
S. Yamagami, D. Miyazaki, S. J. Ono, and M. R. Dana (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2892-2897
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Strong Cytotoxic T Lymphocyte Responses to a Macrophage Inflammatory Protein 1{{alpha}}-expressing Tumor: Linkage between Inflammation and Specific Immunity.
M. Maric and Y. Liu (1999)
Cancer Res. 59, 5549-5553
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Chemokine Amplification in Mesangial Cells.
Y. Luo, C. Lloyd, J.-C. Gutierrez-Ramos, and M. E. Dorf (1999)
J. Immunol. 163, 3985-3992
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Cytokines in asthma.
K F Chung and P J Barnes (1999)
Thorax 54, 825-857
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A One-Tube Polymerase Chain Reaction Protocol Demonstrates CC Chemokine Overexpression in Graves' Disease Glands.
Y. Ashhab, O. Dominguez, M. Sospedra, C. Roura-Mir, A. Lucas-Martín, and R. Pujol-Borrell (1999)
J. Clin. Endocrinol. Metab. 84, 2873-2882
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Human Polymorphonuclear Leukocytes Produce IL-12, TNF-{alpha}, and the Chemokines Macrophage-Inflammatory Protein-1{alpha} and -1{beta} in Response to Toxoplasma gondii Antigens.
S. K. Bliss, A. J. Marshall, Y. Zhang, and E. Y. Denkers (1999)
J. Immunol. 162, 7369-7375
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Respiratory Syncytical Virus-induced Chemokine Expression in the Lower Airways . Eosinophil Recruitment and Degranulation.
A. M. HARRISON, C. A. BONVILLE, H. F. ROSENBERG, and J. B. DOMACHOWSKE (1999)
Am. J. Respir. Crit. Care Med. 159, 1918-1924
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Neutralization of Macrophage Inflammatory Protein 2 (MIP-2) and MIP-1alpha Attenuates Neutrophil Recruitment in the Central Nervous System during Experimental Bacterial Meningitis.
A. Diab, H. Abdalla, H. L. Li, F. D. Shi, J. Zhu, B. Hojberg, L. Lindquist, B. Wretlind, M. Bakhiet, and H. Link (1999)
Infect. Immun. 67, 2590-2601
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CD8+ T Cells Are a Biologically Relevant Source of Macrophage Inflammatory Protein-1{alpha} In Vivo.
D. N. Cook, O. Smithies, R. M. Strieter, J. A. Frelinger, and J. S. Serody (1999)
J. Immunol. 162, 5423-5428
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Antigen Receptor Engagement Selectively Induces Macrophage Inflammatory Protein-1{alpha} (MIP-1{alpha}) and MIP-1{beta} Chemokine Production in Human B Cells.
R. Krzysiek, E. A. Lefevre, W. Zou, A. Foussat, J. Bernard, A. Portier, P. Galanaud, and Y. Richard (1999)
J. Immunol. 162, 4455-4463
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Role of the C-C Chemokine, TCA3, in the Protective Anticryptococcal Cell-Mediated Immune Response.
H. A. Doyle and J. W. Murphy (1999)
J. Immunol. 162, 4824-4833
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A Critical Role for a Peritumoral Stromal Reaction in the Induction of T-Cell Migration Responsible for Interleukin-12-induced Tumor Regression.
M. Ogawa, K. Umehara, W.-G. Yu, Y. Uekusa, C. Nakajima, T. Tsujimura, T. Kubo, H. Fujiwara, and T. Hamaoka (1999)
Cancer Res. 59, 1531-1538
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Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling.
R. L. Rabin, M. K. Park, F. Liao, R. Swofford, D. Stephany, and J. M. Farber (1999)
J. Immunol. 162, 3840-3850
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Activation of Peripheral Blood T Cells by Interaction and Migration Through Endothelium: Role of Lymphocyte Function Antigen-1/Intercellular Adhesion Molecule-1 and Interleukin-15.
D. Sancho, M. Yanez-Mo, R. Tejedor, and F. Sanchez-Madrid (1999)
Blood 93, 886-896
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TCR Activation Inhibits Chemotaxis Toward Stromal Cell-Derived Factor-1: Evidence for Reciprocal Regulation Between CXCR4 and the TCR.
J. W. Peacock and F. R. Jirik (1999)
J. Immunol. 162, 215-223
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Murine T Lymphocytes Incapable of Producing Macrophage Inhibitory Protein-1alpha Are Impaired in Causing Graft-Versus-Host Disease Across a Class I But Not Class II Major Histocompatibility Complex Barrier.
J. S. Serody, D. N. Cook, S. L. Kirby, E. Reap, T. C. Shea, and J. A. Frelinger (1999)
Blood 93, 43-50
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Inflammatory Mediators of Asthma: An Update.
P. J. Barnes, K. F. Chung, and C. P. Page (1998)
Pharmacol. Rev. 50, 515-596
   Abstract »    Full Text »    PDF »
Regulation of T Lymphocyte Trafficking into Lymph Nodes During an Immune Response by the Chemokines Macrophage Inflammatory Protein (MIP)-1{alpha} and MIP-1{beta}.
N. Tedla, H.-W. Wang, H. P. McNeil, N. Di Girolamo, T. Hampartzoumian, D. Wakefield, and A. Lloyd (1998)
J. Immunol. 161, 5663-5672
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Essential Role of Nuclear Factor {kappa}B in the Induction of Eosinophilia in Allergic Airway Inflammation.
L. Yang, L. Cohn, D.-H. Zhang, R. Homer, A. Ray, and P. Ray (1998)
J. Exp. Med. 188, 1739-1750
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Cutting Edge Commentary: Chemokine Regulation of Experimental Autoimmune Encephalomyelitis: Temporal and Spatial Expression Patterns Govern Disease Pathogenesis.
W. J. Karpus and R. M. Ransohoff (1998)
J. Immunol. 161, 2667-2671
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TNF-{alpha} Released by Comigrating Monocytes Promotes Transendothelial Migration of Activated Lymphocytes.
D. M. Green, J. Trial, and H. H. Birdsall (1998)
J. Immunol. 161, 2481-2489
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Intestinal Intraepithelial Lymphocytes Are Primed for Gamma Interferon and MIP-1beta Expression and Display Antiviral Cytotoxic Activity despite Severe CD4+ T-Cell Depletion in Primary Simian Immunodeficiency Virus Infection.
J. J. Mattapallil, Z. Smit-McBride, M. McChesney, and S. Dandekar (1998)
J. Virol. 72, 6421-6429
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Induction of Acute Inflammation In Vivo by Staphylococcal Superantigens. II. Critical Role for Chemokines, ICAM-1, and TNF-{alpha}.
P. A. Tessier, P. H. Naccache, K. R. Diener, R. P. Gladue, K. S. Neote, I. Clark-Lewis, and S. R. McColl (1998)
J. Immunol. 161, 1204-1211
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Epstein-Barr Virus-induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells.
V. N. Ngo, H. Lucy Tang, and J. G. Cyster (1998)
J. Exp. Med. 188, 181-191
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