Science 9 April 1993: Vol. 260. no. 5105, pp. 207 - 210 DOI: 10.1126/science.8469973

Prev | Table of Contents | Next

Articles

Differential utilization of T cell receptor TCR{alpha}/TCR{delta} locus variable region gene segments is mediated by accessibility.

Y. N. Lee, F. W. Alt, J. Reyes, M. Gleason, A. A. Zarrin, and D. Jung (2009)
PNAS 106, 17487-17492
 |  Abstract »  |  Full Text »  |  PDF »

SCID Dogs: Similar Transplant Potential but Distinct Intra-Uterine Growth Defects and Premature Replicative Senescence Compared with SCID Mice.

K. Meek, A. Jutkowitz, L. Allen, J. Glover, E. Convery, A. Massa, T. Mullaney, B. Stanley, D. Rosenstein, S. M. Bailey, et al. (2009)
J. Immunol. 183, 2529-2536
 |  Abstract »  |  Full Text »  |  PDF »

Histone H1 functions as a stimulatory factor in backup pathways of NHEJ.

B. Rosidi, M. Wang, W. Wu, A. Sharma, H. Wang, and G. Iliakis (2008)
Nucleic Acids Res. 36, 1610-1623
 |  Abstract »  |  Full Text »  |  PDF »

Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway.

X. Cui and K. Meek (2007)
PNAS 104, 17046-17051
 |  Abstract »  |  Full Text »  |  PDF »

Processing of DNA for Nonhomologous End-joining Is Controlled by Kinase Activity and XRCC4/Ligase IV.

J. Budman, S. A. Kim, and G. Chu (2007)
J. Biol. Chem. 282, 11950-11959
 |  Abstract »  |  Full Text »  |  PDF »

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.

S. Zha, F. W. Alt, H.-L. Cheng, J. W. Brush, and G. Li (2007)
PNAS 104, 4518-4523
 |  Abstract »  |  Full Text »  |  PDF »

The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.

K. Kiefer, J. Oshinsky, J. Kim, P. B. Nakajima, G. C. Bosma, and M. J. Bosma (2007)
PNAS 104, 2843-2848
 |  Abstract »  |  Full Text »  |  PDF »

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.

M. Wang, W. Wu, W. Wu, B. Rosidi, L. Zhang, H. Wang, and G. Iliakis (2006)
Nucleic Acids Res. 34, 6170-6182
 |  Abstract »  |  Full Text »  |  PDF »

B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responses.

M.-C. Hsu, K.-M. Toellner, C. G. Vinuesa, and I. C. M. MacLennan (2006)
PNAS 103, 5905-5910
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Pathways for the Repair of RAG-Induced DNA Breaks.

D. M. Weinstock and M. Jasin (2006)
Mol. Cell. Biol. 26, 131-139
 |  Abstract »  |  Full Text »  |  PDF »

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.

M. Di Virgilio and J. Gautier (2005)
J. Cell Biol. 171, 765-771
 |  Abstract »  |  Full Text »  |  PDF »

More than just strand breaks: the recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit.

R. Dip and H. Naegeli (2005)
FASEB J 19, 704-715
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Illegitimate V(D)J Recombination or Microhomology-Mediated Nonhomologous End-Joining in the Formation of Intragenic Deletions of the Notch1 Gene in Mouse Thymic Lymphomas.

H. Tsuji, H. Ishii-Ohba, T. Katsube, H. Ukai, S. Aizawa, M. Doi, K. Hioki, and T. Ogiu (2004)
Cancer Res. 64, 8882-8890
 |  Abstract »  |  Full Text »  |  PDF »

Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks.

B. Min, B. T. Weinert, and D. C. Rio (2004)
PNAS 101, 8906-8911
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Processing of the 3'-Overhanging DNA in the Postcleavage Complex Involved in V(D)J Joining.

T. Nishihara, F. Nagawa, H. Nishizumi, M. Kodama, S. Hirose, R. Hayashi, and H. Sakano (2004)
Mol. Cell. Biol. 24, 3692-3702
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of T-cell receptor D{beta}1 promoter by KLF5 through reiterated GC-rich motifs.

X. O. Yang, R. T. Doty, J. S. Hicks, and D. M. Willerford (2003)
Blood 101, 4492-4499
 |  Abstract »  |  Full Text »  |  PDF »

Impact of DNA ligase IV on the fidelity of end joining in human cells.

J. Smith, E. Riballo, B. Kysela, C. Baldeyron, K. Manolis, C. Masson, M. R. Lieber, D. Papadopoulo, and P. Jeggo (2003)
Nucleic Acids Res. 31, 2157-2167
 |  Abstract »  |  Full Text »  |  PDF »

Nonhomologous end joining and V(D)J recombination require an additional factor.

Y. Dai, B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo, M. Stumm, T. O. Harville, S. C. West, M. A. Oettinger, and P. A. Jeggo (2003)
PNAS 100, 2462-2467
 |  Abstract »  |  Full Text »  |  PDF »

Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells.

S. Rooney, F. W. Alt, D. Lombard, S. Whitlow, M. Eckersdorff, J. Fleming, S. Fugmann, D. O. Ferguson, D. G. Schatz, and J. Sekiguchi (2003)
J. Exp. Med. 197, 553-565
 |  Abstract »  |  Full Text »  |  PDF »

Ku-Dependent and Ku-Independent End-Joining Pathways Lead to Chromosomal Rearrangements During Double-Strand Break Repair in Saccharomyces cerevisiae.

X. Yu and A. Gabriel (2003)
Genetics 163, 843-856
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Targeting of V{beta} to D{beta} Rearrangement by RSSs Can Be Mediated by the V(D)J Recombinase in the Absence of Additional Lymphoid-Specific Factors.

R. E. Tillman, A. L. Wooley, B. Khor, T. D. Wehrly, C. A. Little, and B. P. Sleckman (2003)
J. Immunol. 170, 5-9
 |  Abstract »  |  Full Text »  |  PDF »

An Antisense Oligonucleotide Targeted to Human Ku86 Messenger RNA Sensitizes M059K Malignant Glioma Cells to Ionizing Radiation, Bleomycin, and Etoposide but not DNA Cross-Linking Agents.

A. I. Belenkov, J.-P. Paiement, L. C. Panasci, B. P. Monia, and T. Y. K. Chow (2002)
Cancer Res. 62, 5888-5896
 |  Abstract »  |  Full Text »  |  PDF »

Variable Diversity Joining Recombination: Nonhairpin Coding Ends in Thymocytes of SCID and Wild-Type Mice.

P. B. Nakajima and M. J. Bosma (2002)
J. Immunol. 169, 3094-3104
 |  Abstract »  |  Full Text »  |  PDF »

Cancer predisposition and hematopoietic failure in Rad50S/S mice.

C. F. Bender, M. L. Sikes, R. Sullivan, L. E. Huye, M. M. Le Beau, D. B. Roth, O. K. Mirzoeva, E. M. Oltz, and J. H. J. Petrini (2002)
Genes & Dev. 16, 2237-2251
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification.

M. J. Difilippantonio, S. Petersen, H. T. Chen, R. Johnson, M. Jasin, R. Kanaar, T. Ried, and A. Nussenzweig (2002)
J. Exp. Med. 196, 469-480
 |  Abstract »  |  Full Text »  |  PDF »

Sensing and repairing DNA double-strand breaks.

S. P. Jackson (2002)
Carcinogenesis 23, 687-696
 |  Abstract »  |  Full Text »  |  PDF »

Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination.

M. L. Brown, D. Franco, A. Burkle, and Y. Chang (2002)
PNAS 99, 4532-4537
 |  Abstract »  |  Full Text »  |  PDF »

Radiation-induced Genomic Rearrangements Formed by Nonhomologous End-Joining of DNA Double-Strand Breaks.

K. Rothkamm, M. Kühne, P. A. Jeggo, and M. Löbrich (2001)
Cancer Res. 61, 3886-3893
 |  Abstract »  |  Full Text »

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.

H. Wang, Z.-C. Zeng, A. R. Perrault, X. Cheng, W. Qin, and G. Iliakis (2001)
Nucleic Acids Res. 29, 1653-1660
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase.

M. M. Purugganan, S. Shah, J. F. Kearney, and D. B. Roth (2001)
Nucleic Acids Res. 29, 1638-1646
 |  Abstract »  |  Full Text »  |  PDF »

Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors.

C. J. Williams, I. Grandal, D. J. Vesprini, U. Wojtyra, J. S. Danska, and C. J. Guidos (2001)
Mol. Cell. Biol. 21, 400-413
 |  Abstract »  |  Full Text »

Response to RAG-Mediated V(D)J Cleavage by NBS1 and {gamma}-H2AX.

H. T. Chen, A. Bhandoola, M. J. Difilippantonio, J. Zhu, M. J. Brown, X. Tai, E. P. Rogakou, T. M. Brotz, W. M. Bonner, T. Ried, et al. (2000)
Science 290, 1962-1964
 |  Abstract »  |  Full Text »

Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells.

C. Richardson and M. Jasin (2000)
Mol. Cell. Biol. 20, 9068-9075
 |  Abstract »  |  Full Text »

A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells.

E. Marangoni, N. Foray, M. O'Driscoll, S. Douc-Rasy, J. Bernier, J. Bourhis, and P. Jeggo (2000)
Nucleic Acids Res. 28, 4778-4782
 |  Abstract »  |  Full Text »  |  PDF »

Activation of V(D)J Recombination Induces the Formation of Interlocus Joints and Hybrid Joints in scid Pre-B-Cell Lines.

S. Lew, D. Franco, and Y. Chang (2000)
Mol. Cell. Biol. 20, 7170-7177
 |  Abstract »  |  Full Text »

Signal Joint Formation Is Also Impaired in DNA-Dependent Protein Kinase Catalytic Subunit Knockout Cells.

R. Fukumura, R. Araki, A. Fujimori, Y. Tsutsumi, A. Kurimasa, G. C. Li, D. J. Chen, K. Tatsumi, and M. Abe (2000)
J. Immunol. 165, 3883-3889
 |  Abstract »  |  Full Text »  |  PDF »

DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining.

E. Feldmann, V. Schmiemann, W. Goedecke, S. Reichenberger, and P. Pfeiffer (2000)
Nucleic Acids Res. 28, 2585-2596
 |  Abstract »  |  Full Text »  |  PDF »

The DNA-bending protein, HMG1, is required for correct cleavage of 23 bp recombination signal sequences by recombination activating gene proteins in vitro.

T. Yoshida, A. Tsuboi, K.-i. Ishiguro, F. Nagawa, and H. Sakano (2000)
Int. Immunol. 12, 721-729
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Class-Specific Factors in Immunoglobulin Isotype Switching.

A. Shanmugam, M.-J. Shi, L. Yauch, J. Stavnezer, and A. L. Kenter (2000)
J. Exp. Med. 191, 1365-1380
 |  Abstract »  |  Full Text »  |  PDF »

Metabolism of Recombination Coding Ends in scid Cells.

M. L. Brown and Y. Chang (2000)
J. Immunol. 164, 4135-4142
 |  Abstract »  |  Full Text »  |  PDF »

A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p.

D. Moshous, L. Li, R. d. Chasseval, N. Philippe, N. Jabado, M. J. Cowan, A. Fischer, and J.-P. d. Villartay (2000)
Hum. Mol. Genet. 9, 583-588
 |  Abstract »  |  Full Text »  |  PDF »

The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication.

J. Guan, S. DiBiase, and G. Iliakis (2000)
Nucleic Acids Res. 28, 1183-1192
 |  Abstract »  |  Full Text »  |  PDF »

Analyses of TCRB Rearrangements Substantiate a Profound Deficit in Recombination Signal Sequence Joining in SCID Foals: Implications for the Role of DNA-Dependent Protein Kinase in V(D)J Recombination.

E. K. Shin, T. Rijkers, A. Pastink, and K. Meek (2000)
J. Immunol. 164, 1416-1424
 |  Abstract »  |  Full Text »  |  PDF »

Recombination between Two Chromosomes: Implications for Genomic Integrity in Mammalian Cells.

C. RICHARDSON and M. JASIN (2000)
Cold Spring Harb Symp Quant Biol 65, 553-560
 |  Abstract »  |  PDF »

Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage.

G. J. Vanasse, P. Concannon, and D. M. Willerford (1999)
Blood 94, 3997-4010
 |  Full Text »  |  PDF »

Gamma-Irradiation Directly Affects the Formation of Coding Joints in SCID Cell Lines.

A. Binnie, S. Olson, G. E. Wu, and S. M. Lewis (1999)
J. Immunol. 163, 5418-5426
 |  Abstract »  |  Full Text »  |  PDF »

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.

A. J. Pierce, R. D. Johnson, L. H. Thompson, and M. Jasin (1999)
Genes & Dev. 13, 2633-2638
 |  Abstract »  |  Full Text »

Switch Recombination in a Transfected Plasmid Occurs Preferentially in a B Cell Line That Undergoes Switch Recombination of Its Chromosomal Ig Heavy Chain Genes.

J. Stavnezer, S. P. Bradley, N. Rousseau, T. Pearson, A. Shanmugam, D. J. Waite, P. R. Rogers, and A. L. Kenter (1999)
J. Immunol. 163, 2028-2040
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Terminal Deoxynucleotidyltransferase Activity by the DNA-Dependent Protein Kinase.

S. Mickelsen, C. Snyder, K. Trujillo, M. Bogue, D. B. Roth, and K. Meek (1999)
J. Immunol. 163, 834-843
 |  Abstract »  |  Full Text »  |  PDF »

Combined Immunodeficiency Associated with Increased Apoptosis of Lymphocytes and Radiosensitivity of Fibroblasts.

J. Peake, A. Waugh, F. Le Deist, A. Priestley, F. Rieux-Laucat, N. Foray, E. Capulas, B. K. Singleton, J.-P. de Villartay, A. Cant, et al. (1999)
Cancer Res. 59, 3454-3460
 |  Abstract »  |  Full Text »  |  PDF »

The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit.

B. K. Singleton, M. I. Torres-Arzayus, S. T. Rottinghaus, G. E. Taccioli, and P. A. Jeggo (1999)
Mol. Cell. Biol. 19, 3267-3277
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining.

A. Kurimasa, S. Kumano, N. V. Boubnov, M. D. Story, C.-S. Tung, S. R. Peterson, and D. J. Chen (1999)
Mol. Cell. Biol. 19, 3877-3884
 |  Abstract »  |  Full Text »  |  PDF »

Promoter Element for Transcription of Unrearranged T-Cell Receptor beta -Chain Gene in Pro-T Cells.

R. T. Doty, D. Xia, S. P. Nguyen, T. R. Hathaway, and D. M. Willerford (1999)
Blood 93, 3017-3025
 |  Abstract »  |  Full Text »  |  PDF »

The DNA-dependent protein kinase.

G. C.M. Smith and S. P. Jackson (1999)
Genes & Dev. 13, 916-934
 |  Full Text »

A Role for RAD51 in the Generation of Immunoglobulin Gene Diversity in Rabbits.

R. A. Barrington, M. Fasullo, and K. L. Knight (1999)
J. Immunol. 162, 911-919
 |  Abstract »  |  Full Text »  |  PDF »

Nonhomologous End-joining Proteins Are Required for V(D)J Recombination, Normal Growth, and Neurogenesis.

J.M. SEKIGUCHI, Y. GAO, Y. GU, K. FRANK, Y. SUN, J. CHAUDHURI, C. ZHU, H.-L. CHENG, J. MANIS, D. FERGUSON, et al. (1999)
Cold Spring Harb Symp Quant Biol 64, 169-182
 |  Abstract »  |  PDF »

Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.

M. A. Bogue, C. Jhappan, and D. B. Roth (1998)
PNAS 95, 15559-15564
 |  Abstract »  |  Full Text »  |  PDF »

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations.

C. Richardson, M. E. Moynahan, and M. Jasin (1998)
Genes & Dev. 12, 3831-3842
 |  Abstract »  |  Full Text »

DNA end-joining catalyzed by human cell-free extracts.

P. Baumann and S. C. West (1998)
PNAS 95, 14066-14070
 |  Abstract »  |  Full Text »  |  PDF »

Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini.

R. B. West, M. Yaneva, and M. R. Lieber (1998)
Mol. Cell. Biol. 18, 5908-5920
 |  Abstract »  |  Full Text »

A Human Severe Combined Immunodeficiency (SCID) Condition with Increased Sensitivity to Ionizing Radiations and Impaired V(D)J Rearrangements Defines a New DNA Recombination/Repair Deficiency.

N. Nicolas, D. Moshous, M. Cavazzana-Calvo, D. Papadopoulo, R. de Chasseval, F. Le Deist, A. Fischer, and J.-P. de Villartay (1998)
J. Exp. Med. 188, 627-634
 |  Abstract »  |  Full Text »  |  PDF »

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching.

J. P. Manis, Y. Gu, R. Lansford, E. Sonoda, R. Ferrini, L. Davidson, K. Rajewsky, and F. W. Alt (1998)
J. Exp. Med. 187, 2081-2089
 |  Abstract »  |  Full Text »  |  PDF »

Murine Cell Line SX9 Bearing a Mutation in the dna-pkcs Gene Exhibits Aberrant V(D)J Recombination Not Only in the Coding Joint but Also in the Signal Joint.

R. Fukumura, R. Araki, A. Fujimori, M. Mori, T. Saito, F. Watanabe, M. Sarashi, H. Itsukaichi, K. Eguchi-Kasai, K. Sato, et al. (1998)
J. Biol. Chem. 273, 13058-13064
 |  Abstract »  |  Full Text »  |  PDF »

The Transmission of Fragmented Chromosomes in Drosophila melanogaster.

K. Ahmad and K. G. Golic (1998)
Genetics 148, 775-792
 |  Abstract »  |  Full Text »  |  PDF »

The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase.

R. Leber, T. W. Wise, R. Mizuta, and K. Meek (1998)
J. Biol. Chem. 273, 1794-1801
 |  Abstract »  |  Full Text »  |  PDF »

Footprint Analysis of the RAG Protein Recombination Signal Sequence Complex for V(D)J Type Recombination.

F. Nagawa, K.-i. Ishiguro, A. Tsuboi, T. Yoshida, A. Ishikawa, T. Takemori, A. J. Otsuka, and H. Sakano (1998)
Mol. Cell. Biol. 18, 655-663
 |  Abstract »  |  Full Text »

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development.

A. Nussenzweig, K. Sokol, P. Burgman, L. Li, and G. C. Li (1997)
PNAS 94, 13588-13593
 |  Abstract »  |  Full Text »  |  PDF »

Double Strand Break Repair.

G. Chu (1997)
J. Biol. Chem. 272, 24097-24100
 |  Full Text »  |  PDF »

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo.

H. Ouyang, A. Nussenzweig, A. Kurimasa, V. d. C. Soares, X. Li, C. Cordon-Cardo, W.-h. Li, N. Cheong, M. Nussenzweig, G. Iliakis, et al. (1997)
J. Exp. Med. 186, 921-929
 |  Abstract »  |  Full Text »  |  PDF »

Loss of heterozygosity induced by a chromosomal double-strand break.

M. E. Moynahan and M. Jasin (1997)
PNAS 94, 8988-8993
 |  Abstract »  |  Full Text »  |  PDF »

The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

N. Liu, J. E. Lamerdin, J. D. Tucker, Z.-Q. Zhou, C. A. Walter, J. S. Albala, D. B. Busch, and L. H. Thompson (1997)
PNAS 94, 9232-9237
 |  Abstract »  |  Full Text »  |  PDF »

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Y. Gu, S. Jin, Y. Gao, D. T. Weaver, and F. W. Alt (1997)
PNAS 94, 8076-8081
 |  Abstract »  |  Full Text »  |  PDF »

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae.

G. Barnes and D. Rio (1997)
PNAS 94, 867-872
 |  Abstract »  |  Full Text »  |  PDF »

Inducing the Loss of Immunoglobulin &lgr;Light Chain Production and the Rearrangement of a Previously Excluded Allele in Human Plasma B Cell Lines with Concanavalin A.

H. Tachibana, Y. Ushio, C. Krungkasem, and S. Shirahata (1996)
J. Biol. Chem. 271, 17404-17410
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Ku86 Variant Protein That Results in Altered DNA Binding and Diminished DNA-dependent Protein Kinase Activity.

Z. Han, C. Johnston, W. H. Reeves, T. Carter, J. H. Wyche, and E. A. Hendrickson (1996)
J. Biol. Chem. 271, 14098-14104
 |  Abstract »  |  Full Text »  |  PDF »

Ku80-deficient Cells Exhibit Excess Degradation of Extrachromosomal DNA.

F. Liang and M. Jasin (1996)
J. Biol. Chem. 271, 14405-14411
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Saccharomyces cerevisiae HDF1 Gene in DNA Double-strand Break Repair and Recombination.

G. J. Mages, H. M. Feldmann, and E.-L. Winnacker (1996)
J. Biol. Chem. 271, 7910-7915
 |  Abstract »  |  Full Text »  |  PDF »

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes..

M A Bogue, C Zhu, E Aguilar-Cordova, L A Donehower, and D B Roth (1996)
Genes & Dev. 10, 553-565
 |  Abstract »  |  PDF »

High Frequency and Error-prone DNA Recombination in Ataxia Telangiectasia Cell Lines.

C.-M. Luo, W. Tang, K. L. Mekeel, J. S. DeFrank, P. R. Anné, and S. N. Powell (1996)
J. Biol. Chem. 271, 4497-4503
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Defective DNA Transfer Activity in Recombination Deficient SCID Cell Extracts by a 72-kDa Protein from Wild-type Thymocytes.

R. Jessberger, B. Riwar, A. Rolink, and H.-R. Rodewald (1995)
J. Biol. Chem. 270, 6788-6797
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.

C. Kirchgessner, C. Patil, J. Evans, C. Cuomo, L. Fried, T Carter, M. Oettinger, and J. Brown (1995)
Science 267, 1178-1183
 |  Abstract »  |  PDF »

Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents.

J. Danska, F Pflumio, C. Williams, O Huner, J. Dick, and C. Guidos (1994)
Science 266, 450-455
 |  Abstract »  |  PDF »

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

V Smider, W. Rathmell, M. Lieber, and G Chu (1994)
Science 266, 288-291
 |  Abstract »  |  PDF »

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.

G. Taccioli, T. Gottlieb, T Blunt, A Priestley, J Demengeot, R Mizuta, A. Lehmann, F. Alt, S. Jackson, and P. Jeggo (1994)
Science 265, 1442-1445
 |  Abstract »  |  PDF »

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice..

E Spanopoulou, C A Roman, L M Corcoran, M S Schlissel, D P Silver, D Nemazee, M C Nussenzweig, S A Shinton, R R Hardy, and D Baltimore (1994)
Genes & Dev. 8, 1030-1042
 |  Abstract »  |  PDF »

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated..

M Schlissel, A Constantinescu, T Morrow, M Baxter, and A Peng (1993)
Genes & Dev. 7, 2520-2532
 |  Abstract »  |  PDF »

Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation.

W. Lin and S Desiderio (1993)
Science 260, 953-959
 |  Abstract »  |  PDF »

Cellular and Biochemical Impact of a Mutation in DNA Ligase IV Conferring Clinical Radiosensitivity.

E. Riballo, A. J. Doherty, Y. Dai, T. Stiff, M. A. Oettinger, P. A. Jeggo, and B. Kysela (2001)
J. Biol. Chem. 276, 31124-31132
 |  Abstract »  |  Full Text »  |  PDF »

Effect of HIV integrase inhibitors on the RAG1/2 recombinase.

M. Melek, J. M. Jones, M. H. O'Dea, G. Pais, T. R. Burke Jr., Y. Pommier, N. Neamati, and M. Gellert (2002)
PNAS 99, 134-137
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining.

F. Xia, D. G. Taghian, J. S. DeFrank, Z.-C. Zeng, H. Willers, G. Iliakis, and S. N. Powell (2001)
PNAS 98, 8644-8649
 |  Abstract »  |  Full Text »  |  PDF »

Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends.

J. M. Jones and M. Gellert (2001)
PNAS 98, 12926-12931
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products