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Science 9 April 1993:
Vol. 260. no. 5105, pp. 181 - 186
DOI: 10.1126/science.8097060

Articles

Science, Vol 260, Issue 5105, 181-186
Copyright © 1993 by American Association for the Advancement of Science


articles

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways

H Bading, DD Ginty, and ME Greenberg

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.

Calcium ions (Ca2+) act as an intracellular second messenger and can enter neurons through various ion channels. Influx of Ca2+ through distinct types of Ca2+ channels may differentially activate biochemical processes. N-Methyl-D-aspartate (NMDA) receptors and L-type Ca2+ channels, two major sites of Ca2+ entry into hippocampal neurons, were found to transmit signals to the nucleus and regulated gene transcription through two distinct Ca2+ signaling pathways. Activation of the multifunctional Ca(2+)-calmodulin-dependent protein kinase (CaM kinase) was evoked by stimulation of either NMDA receptors or L-type Ca2+ channels; however, activation of CaM kinase appeared to be critical only for propagating the L-type Ca2+ channel signal to the nucleus. Also, the NMDA receptor and L-type Ca2+ channel pathways activated transcription by means of different cis-acting regulatory elements in the c-fos promoter. These results indicate that Ca2+, depending on its mode of entry into neurons, can activate two distinct signaling pathways. Differential signal processing may provide a mechanism by which Ca2+ controls diverse cellular functions.


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   Abstract »    Full Text »    PDF »
Repression of Activity-Dependent c-fos and Brain-Derived Neurotrophic Factor mRNA Expression by Pyrethroid Insecticides Accompanying a Decrease in Ca2+ Influx into Neurons.
L. Imamura, H. Hasegawa, K. Kurashina, A. Hamanishi, A. Tabuchi, and M. Tsuda (2000)
J. Pharmacol. Exp. Ther. 295, 1175-1182
   Abstract »    Full Text »
Calcium influx in human uterine epithelial RL95-2 cells triggers adhesiveness for trophoblast-like cells. Model studies on signalling events during embryo implantation.
H. Tinel, H.-W. Denker, and M. Thie (2000)
Mol. Hum. Reprod. 6, 1119-1130
   Abstract »    Full Text »    PDF »
L-Type Calcium Channels Mediate Calcium Oscillations in Early Postnatal Purkinje Neurons.
P. Liljelund, J. G. Netzeband, and D. L. Gruol (2000)
J. Neurosci. 20, 7394-7403
   Abstract »    Full Text »    PDF »
Serotonergic Inhibition of Action Potential Evoked Calcium Transients in NOS-Containing Mesopontine Cholinergic Neurons.
C. S. Leonard, S. R. Rao, and T. Inoue (2000)
J Neurophysiol 84, 1558-1572
   Abstract »    Full Text »    PDF »
CaMKIIalpha 3' Untranslated Region-Directed mRNA Translocation in Living Neurons: Visualization by GFP Linkage.
M. S. Rook, M. Lu, and K. S. Kosik (2000)
J. Neurosci. 20, 6385-6393
   Abstract »    Full Text »    PDF »
Activation of Mitogen-Activated Protein Kinases after Transient Forebrain Ischemia in Gerbil Hippocampus.
T. Sugino, K. Nozaki, Y. Takagi, I. Hattori, N. Hashimoto, T. Moriguchi, and E. Nishida (2000)
J. Neurosci. 20, 4506-4514
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Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase.
S. S. Grewal, A. M. Horgan, R. D. York, G. S. Withers, G. A. Banker, and P. J. S. Stork (2000)
J. Biol. Chem. 275, 3722-3728
   Abstract »    Full Text »    PDF »
Parvalbumin Is Expressed in Normal and Pathological Human Parathyroid Glands.
T. L. Pauls, F. Portis, E. Macrì, B. Belser, P. Heitz, C. Doglioni, and M. R. Celio (2000)
J. Histochem. Cytochem. 48, 105-112
   Abstract »    Full Text »
Essentiality of intron control in the induction of c-fos by glucose and glucoincretin peptides in INS-1 {beta}-cells.
S. SUSINI, G. VAN HAASTEREN, S. LI, M. PRENTKI, and W. SCHLEGEL (2000)
FASEB J 14, 128-136
   Abstract »    Full Text »
Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes.
L. S. Premkumar (1999)
Mol. Pharmacol. 56, 1138-1142
   Abstract »    Full Text »
Distinct Calcium Signaling Pathways Regulate Calmodulin Gene Expression in Tobacco.
A. H. van der Luit, C. Olivari, A. Haley, M. R. Knight, and A. J. Trewavas (1999)
Plant Physiology 121, 705-714
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A Novel Calcium Signaling Pathway Targets the c-fos Intragenic Transcriptional Pausing Site.
V. Coulon, J.-L. Veyrune, N. Tourkine, A. Vie, R. A. Hipskind, and J.-M. Blanchard (1999)
J. Biol. Chem. 274, 30439-30446
   Abstract »    Full Text »    PDF »
Persistent Increased DNA-Binding and Expression of Serum Response Factor Occur with Epilepsy-Associated Long-Term Plasticity Changes.
T. A. Morris, N. Jafari, A. C. Rice, O. Vasconcelos, and R. J. DeLorenzo (1999)
J. Neurosci. 19, 8234-8243
   Abstract »    Full Text »    PDF »
Distinct temporal profiles of activity-dependent calcium increase in pyramidal neurons of the rat visual cortex.
N Kato, T Tanaka, K Yamamoto, and Y Isomura (1999)
J. Physiol. 519, 467-479
   Abstract »    Full Text »    PDF »
Ca2+/Calmodulin-dependent Protein Kinase Cascade in Caenorhabditis elegans. IMPLICATION IN TRANSCRIPTIONAL ACTIVATION.
K. Eto, N. Takahashi, Y. Kimura, Y. Masuho, K.-i. Arai, M.-a. Muramatsu, and H. Tokumitsu (1999)
J. Biol. Chem. 274, 22556-22562
   Abstract »    Full Text »    PDF »
VDCCs and NMDARs Underlie Two Forms of LTP in CA1 Hippocampus In Vivo.
S. L. Morgan and T. J. Teyler (1999)
J Neurophysiol 82, 736-740
   Abstract »    Full Text »    PDF »



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