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Science 2 April 1993:
Vol. 260. no. 5104, pp. 78 - 82
DOI: 10.1126/science.7682011
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Articles

Science, Vol 260, Issue 5104, 78-82
Copyright © 1993 by American Association for the Advancement of Science

articles

Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis

B Andersen, MD Schonemann, SE Flynn, RV Pearse 2nd, H Singh, and MG Rosenfeld

Eukaryotic Regulatory Biology Program, Howard Hughes Medical Institute, University of California School of Medicine, San Diego, La Jolla 92093.

Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development.


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