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Science 26 March 1993:
Vol. 259. no. 5103, pp. 1912 - 1915
DOI: 10.1126/science.8096091
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Articles

Science, Vol 259, Issue 5103, 1912-1915
Copyright © 1993 by American Association for the Advancement of Science

articles

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

SC Sun, PA Ganchi, DW Ballard, and WC Greene

Gladstone Institute of Virology and Immunology, University of California, San Francisco.

The eukaryotic transcription factor nuclear factor-kappa B (NF-kappa B) participates in many parts of the genetic program mediating T lymphocyte activation and growth. Nuclear expression of NF-kappa B occurs after its induced dissociation from its cytoplasmic inhibitor I kappa B alpha. Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-kappa B is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression. Transfection studies indicate that the I kappa B alpha gene is specifically induced by the 65-kilodalton transactivating subunit of NF-kappa B. Association of the newly synthesized I kappa B alpha with p65 restores intracellular inhibition of NF-kappa B DNA binding activity and prolongs the survival of this labile inhibitor. Together, these results show that NF-kappa B controls the expression of I kappa B alpha by means of an inducible autoregulatory pathway.


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   Abstract »    Full Text »    PDF »
I{kappa}B-{zeta}, a new anti-inflammatory nuclear protein induced by lipopolysaccharide, is a negative regulator for nuclear factor-{kappa}B.
T. Muta, S. Yamazaki, A. Eto, M. Motoyama, and K. Takeshige (2003)
Innate Immunity 9, 187-191
   Abstract »    PDF »
Hypertonicity Inhibits Lipopolysaccharide-Induced Nitric Oxide Synthase Expression in Smooth Muscle Cells by Inhibiting Nuclear Factor {kappa}B.
S. C. Pingle, J. F. Sanchez, D. M. Hallam, A. L. Williamson, S. B. Maggirwar, and V. Ramkumar (2003)
Mol. Pharmacol. 63, 1238-1247
   Abstract »    Full Text »    PDF »
RANK Ligand-induced Elevation of Cytosolic Ca2+ Accelerates Nuclear Translocation of Nuclear Factor kappa B in Osteoclasts.
S. V. Komarova, M. F. Pilkington, A. F. Weidema, S. J. Dixon, and S. M. Sims (2003)
J. Biol. Chem. 278, 8286-8293
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor-regulated Biphasic Activation of NF-kappa B Is Required for Cytokine-induced Loss of Skeletal Muscle Gene Products.
K. J. Ladner, M. A. Caligiuri, and D. C. Guttridge (2003)
J. Biol. Chem. 278, 2294-2303
   Abstract »    Full Text »    PDF »
Post-activation Turn-off of NF-kappa B-dependent Transcription Is Regulated by Acetylation of p65.
R. Kiernan, V. Bres, R. W. M. Ng, M.-P. Coudart, S. El Messaoudi, C. Sardet, D.-Y. Jin, S. Emiliani, and M. Benkirane (2003)
J. Biol. Chem. 278, 2758-2766
   Abstract »    Full Text »    PDF »
A Requirement of Nuclear Factor-kappa B Activation in Fear-potentiated Startle.
S.-H. Yeh, C.-H. Lin, C.-F. Lee, and P.-W. Gean (2002)
J. Biol. Chem. 277, 46720-46729
   Abstract »    Full Text »    PDF »
Low Intracellular Zinc Impairs the Translocation of Activated NF-kappa B to the Nuclei in Human Neuroblastoma IMR-32 Cells.
G. G. Mackenzie, M. P. Zago, C. L. Keen, and P. I. Oteiza (2002)
J. Biol. Chem. 277, 34610-34617
   Abstract »    Full Text »    PDF »
NF-{kappa}B Activation in Light-Induced Retinal Degeneration in a Mouse Model.
T. Wu, Y. Chen, S. K. S. Chiang, and M. O. M. Tso (2002)
Invest. Ophthalmol. Vis. Sci. 43, 2834-2840
   Abstract »    Full Text »    PDF »
Dehydroepiandrosterone Modulates Nuclear Factor-{kappa}B Activation in Hippocampus of Diabetic Rats.
M. Aragno, R. Mastrocola, E. Brignardello, M. Catalano, G. Robino, R. Manti, M. Parola, O. Danni, and G. Boccuzzi (2002)
Endocrinology 143, 3250-3258
   Abstract »    Full Text »    PDF »
Glucocorticoid-Mediated Suppression of Cytokine-Induced Matrix Metalloproteinase-9 Expression in Rat Mesangial Cells: Involvement of Nuclear Factor-{kappa}B and Ets Transcription Factors.
W. Eberhardt, M. Schulze, C. Engels, E. Klasmeier, and J. Pfeilschifter (2002)
Mol. Endocrinol. 16, 1752-1766
   Abstract »    Full Text »    PDF »
NF-{kappa}B Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions.
J. Caamano and C. A. Hunter (2002)
Clin. Microbiol. Rev. 15, 414-429
   Abstract »    Full Text »    PDF »
Characterization of the Nuclear Import and Export Functions of Ikappa Bepsilon.
S.-H. Lee and M. Hannink (2002)
J. Biol. Chem. 277, 23358-23366
   Abstract »    Full Text »    PDF »
Induction of Macrophage-Inflammatory Protein-3{alpha} Gene Expression by TNF-Dependent NF-{kappa}B Activation.
S. Sugita, T. Kohno, K. Yamamoto, Y. Imaizumi, H. Nakajima, T. Ishimaru, and T. Matsuyama (2002)
J. Immunol. 168, 5621-5628
   Abstract »    Full Text »    PDF »
DNA Binding-Independent Induction of I{kappa}B{alpha} Gene Transcription by PPAR{alpha}.
P. Delerive, K. De Bosscher, W. Vanden Berghe, J.-C. Fruchart, G. Haegeman, and B. Staels (2002)
Mol. Endocrinol. 16, 1029-1039
   Abstract »    Full Text »    PDF »
Multi-parameter analysis of the kinetics of NF-{kappa}B signalling and transcription in single living cells.
G. Nelson, L. Paraoan, D. G. Spiller, G. J. C. Wilde, M. A. Browne, P. K. Djali, J. F. Unitt, E. Sullivan, E. Floettmann, and M. R. H. White (2002)
J. Cell Sci. 115, 1137-1148
   Abstract »    Full Text »    PDF »
Transcription Factor NF-kappa B Is Necessary for Up-regulation of Type 1 Angiotensin II Receptor mRNA in Rat Cardiac Fibroblasts Treated with Tumor Necrosis Factor-alpha or Interleukin-1beta.
R. T. Cowling, D. Gurantz, J. Peng, W. H. Dillmann, and B. H. Greenberg (2002)
J. Biol. Chem. 277, 5719-5724
   Abstract »    Full Text »    PDF »


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