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Science 26 March 1993:
Vol. 259. no. 5103, pp. 1896 - 1899
DOI: 10.1126/science.8456314
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Articles

Science, Vol 259, Issue 5103, 1896-1899
Copyright © 1993 by American Association for the Advancement of Science

articles

Similarity of the yeast RAD51 filament to the bacterial RecA filament

T Ogawa, X Yu, A Shinohara, and EH Egelman

Department of Biology, Osaka University, Japan.

The RAD51 protein functions in the processes of DNA repair and in mitotic and meiotic genetic recombination in the yeast Saccharomyces cerevisiae. The protein has adenosine triphosphate-dependent DNA binding activities similar to those of the Escherichia coli RecA protein, and the two proteins have 30 percent sequence homology. RAD51 polymerized on double-stranded DNA to form a helical filament nearly identical in low-resolution, three-dimensional structure to that formed by RecA. Like RecA, RAD51 also appears to force DNA into a conformation of approximately a 5.1-angstrom rise per base pair and 18.6 base pairs per turn. As in other protein families, its structural conservation appears to be stronger than its sequence conservation. Both the structure of the protein polymer formed by RecA and the DNA conformation induced by RecA appear to be general properties of a class of recombination proteins found in prokaryotes as well as eukaryotes.


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   Abstract »    Full Text »    PDF »
Chromosome-Wide Regulation of Meiotic Crossover Formation in Caenorhabditis elegans Requires Properly Assembled Chromosome Axes.
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Mutational analyses of the human Rad51-Tyr315 residue, a site for phosphorylation in leukaemia cells.
Y. Takizawa, T. Kinebuchi, W. Kagawa, S. Yokoyama, T. Shibata, and H. Kurumizaka (2004)
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p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis.
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Domain mapping of the Rad51 paralog protein complexes.
K. A. Miller, D. Sawicka, D. Barsky, and J. S. Albala (2004)
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Y. Akamatsu, D. Dziadkowiec, M. Ikeguchi, H. Shinagawa, and H. Iwasaki (2003)
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The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein.
A. L. Eggler, S. L. Lusetti, and M. M. Cox (2003)
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A Novel Function of Rad54 Protein. STABILIZATION OF THE Rad51 NUCLEOPROTEIN FILAMENT.
A. V. Mazin, A. A. Alexeev, and S. C. Kowalczykowski (2003)
J. Biol. Chem. 278, 14029-14036
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Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair.
L. S. Symington (2002)
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Transcription and Double-Strand Breaks Induce Similar Mitotic Recombination Events in Saccharomyces cerevisiae.
S. Gonzalez-Barrera, M. Garcia-Rubio, and A. Aguilera (2002)
Genetics 162, 603-614
   Abstract »    Full Text »    PDF »
Characterization of RAD51-Independent Break-Induced Replication That Acts Preferentially with Short Homologous Sequences.
G. Ira and J. E. Haber (2002)
Mol. Cell. Biol. 22, 6384-6392
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BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure.
H. Yang, P. D. Jeffrey, J. Miller, E. Kinnucan, Y. Sun, N. H. Thoma, N. Zheng, P.-L. Chen, W.-H. Lee, and N. P. Pavletich (2002)
Science 297, 1837-1848
   Abstract »    Full Text »    PDF »
Genetic Requirements for Spontaneous and Transcription-Stimulated Mitotic Recombination in Saccharomyces cerevisiae.
J. A. Freedman and S. Jinks-Robertson (2002)
Genetics 162, 15-27
   Abstract »    Full Text »    PDF »
Replication Protein A Is Required for Meiotic Recombination in Saccharomyces cerevisiae.
C. Soustelle, M. Vedel, R. Kolodner, and A. Nicolas (2002)
Genetics 161, 535-547
   Abstract »    Full Text »    PDF »
ATP Hydrolysis by Mammalian RAD51 Has a Key Role during Homology-directed DNA Repair.
J. M. Stark, P. Hu, A. J. Pierce, M. E. Moynahan, N. Ellis, and M. Jasin (2002)
J. Biol. Chem. 277, 20185-20194
   Abstract »    Full Text »    PDF »
Homologous Pairing and Ring and Filament Structure Formation Activities of the Human Xrcc2{middle dot}Rad51D Complex.
H. Kurumizaka, S. Ikawa, M. Nakada, R. Enomoto, W. Kagawa, T. Kinebuchi, M. Yamazoe, S. Yokoyama, and T. Shibata (2002)
J. Biol. Chem. 277, 14315-14320
   Abstract »    Full Text »    PDF »
Differential expression and requirements for Schizosaccharomyces pombeRAD52 homologs in DNA repair and recombination.
M. van den Bosch, J. B. M. Zonneveld, K. Vreeken, F. A. T. de Vries, P. H. M. Lohman, and A. Pastink (2002)
Nucleic Acids Res. 30, 1316-1324
   Abstract »    Full Text »    PDF »
Bypass of heterology during strand transfer by Saccharomyces cerevisiae Rad51 protein.
V. F. Holmes, K. R. Benjamin, N. J. Crisona, and N. R. Cozzarelli (2001)
Nucleic Acids Res. 29, 5052-5057
   Abstract »    Full Text »    PDF »
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
J.-Y. Masson, M. C. Tarsounas, A. Z. Stasiak, A. Stasiak, R. Shah, M. J. McIlwraith, F. E. Benson, and S. C. West (2001)
Genes & Dev. 15, 3296-3307
   Abstract »    Full Text »    PDF »
Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.
S. Sigurdsson, S. Van Komen, W. Bussen, D. Schild, J. S. Albala, and P. Sung (2001)
Genes & Dev. 15, 3308-3318
   Abstract »    Full Text »    PDF »
RadA protein from Archaeoglobus fulgidus forms rings, nucleoprotein filaments and catalyses homologous recombination.
M. J. McIlwraith, D. R. Hall, A. Z. Stasiak, A. Stasiak, D. B. Wigley, and S. C. West (2001)
Nucleic Acids Res. 29, 4509-4517
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae Dmc1 Protein Promotes Renaturation of Single-strand DNA (ssDNA) and Assimilation of ssDNA into Homologous Super-coiled Duplex DNA.
E. L. Hong, A. Shinohara, and D. K. Bishop (2001)
J. Biol. Chem. 276, 41906-41912
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DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis. ON THE IMPORTANCE OF NOT GETTING STUCK.
K. P. Rice, A. L. Eggler, P. Sung, and M. M. Cox (2001)
J. Biol. Chem. 276, 38570-38581
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Multiple Interactions Among the Components of the Recombinational DNA Repair System in Schizosaccharomyces pombe.
Y. Tsutsui, F. K. Khasanov, H. Shinagawa, H. Iwasaki, and V. I. Bashkirov (2001)
Genetics 159, 91-105
   Abstract »    Full Text »    PDF »
Historical overview: Searching for replication help in all of the rec places.
M. M. Cox (2001)
PNAS 98, 8173-8180
   Abstract »    Full Text »    PDF »
Manipulating the mammalian genome by homologous recombination.
K. M. Vasquez, K. Marburger, Z. Intody, and J. H. Wilson (2001)
PNAS 98, 8403-8410
   Abstract »    Full Text »    PDF »
Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis.
S. L. Gasior, H. Olivares, U. Ear, D. M. Hari, R. Weichselbaum, and D. K. Bishop (2001)
PNAS 98, 8411-8418
   Abstract »    Full Text »    PDF »
Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA.
X. Yu, S. A. Jacobs, S. C. West, T. Ogawa, and E. H. Egelman (2001)
PNAS 98, 8419-8424
   Abstract »    Full Text »    PDF »
Homologous genetic recombination as an intrinsic dynamic property of a DNA structure induced by RecA/Rad51-family proteins: A possible advantage of DNA over RNA as genomic material.
T. Shibata, T. Nishinaka, T. Mikawa, H. Aihara, H. Kurumizaka, S. Yokoyama, and Y. Ito (2001)
PNAS 98, 8425-8432
   Abstract »    Full Text »    PDF »
Gain- and loss-of-function of Rhp51, a Rad51 homolog in fission yeast, reveals dissimilarities in chromosome integrity.
W. J. Kim, H. Lee, E. J. Park, J. K. Park, and S. D. Park (2001)
Nucleic Acids Res. 29, 1724-1732
   Abstract »    Full Text »    PDF »
Efficient Incorporation of Large (>2 kb) Heterologies Into Heteroduplex DNA: Pms1/Msh2-Dependent and -Independent Large Loop Mismatch Repair in Saccharomyces cerevisiae.
J. A. Clikeman, S. L. Wheeler, and J. A. Nickoloff (2001)
Genetics 157, 1481-1491
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Topological testing of the mechanism of homology search promoted by RecA protein.
L. Cai, U. Marquardt, Z. Zhang, M. J. Taisey, and J. Chen (2001)
Nucleic Acids Res. 29, 1389-1398
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Molecular Dissection of Interactions between Rad51 and Members of the Recombination-Repair Group.
L. Krejci, J. Damborsky, B. Thomsen, M. Duno, and C. Bendixen (2001)
Mol. Cell. Biol. 21, 966-976
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DNA Repair Protein Rad55 Is a Terminal Substrate of the DNA Damage Checkpoints.
V. I. Bashkirov, J. S. King, E. V. Bashkirova, J. Schmuckli-Maurer, and W.-D. Heyer (2000)
Mol. Cell. Biol. 20, 4393-4404
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A Recombination Repair Gene of Schizosaccharomyces pombe, rhp57, Is a Functional Homolog of the Saccharomyces cerevisiae RAD57 Gene and Is Phylogenetically Related to the Human XRCC3 Gene.
Y. Tsutsui, T. Morishita, H. Iwasaki, H. Toh, and H. Shinagawa (2000)
Genetics 154, 1451-1461
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RAD51 Is Required for Propagation of the Germinal Nucleus in Tetrahymena thermophila.
T. C. Marsh, E. S. Cole, K. R. Stuart, C. Campbell, and D. P. Romero (2000)
Genetics 154, 1587-1596
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Rad51 Uses One Mechanism to Drive DNA Strand Exchange in Both Directions.
E. A. Namsaraev and P. Berg (2000)
J. Biol. Chem. 275, 3970-3976
   Abstract »    Full Text »    PDF »
The Saccharomyces cerevisiae DNA Recombination and Repair Functions of the RAD52 Epistasis Group Inhibit Ty1 Transposition.
A. J. Rattray, B. K. Shafer, and D. J. Garfinkel (2000)
Genetics 154, 543-556
   Abstract »    Full Text »
Arrest, Adaptation, and Recovery following a Chromosome Double-strand Break in Saccharomyces cerevisiae.
S.E. LEE, A. PELLICIOLI, J. DEMETER, M.P. VAZE, A.P. GASCH, A. MALKOVA, P.O. BROWN, D. BOTSTEIN, T. STEARNS, M. FOIANI, et al. (2000)
Cold Spring Harb Symp Quant Biol 65, 303-314
   Abstract »    PDF »
Double-strand Break Repair in Human Cells.
S.C. WEST, C. CHAPPELL, L.A. HANAKAHI, J.-Y. MASSON, M.J. MCILWRAITH, and E. VAN DYCK (2000)
Cold Spring Harb Symp Quant Biol 65, 315-322
   Abstract »    PDF »
The Bacterial Replicative Helicase DnaB Evolved from a RecA Duplication.
D. D. Leipe, L. Aravind, N. V. Grishin, and E. V. Koonin (2000)
Genome Res. 10, 5-16
   Abstract »    Full Text »
Single Strand DNA Binding and Annealing Activities in the Yeast Recombination Factor Rad59.
G. Petukhova, S. A. Stratton, and P. Sung (1999)
J. Biol. Chem. 274, 33839-33842
   Abstract »    Full Text »    PDF »
A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variation.
R. McCulloch and J. D. Barry (1999)
Genes & Dev. 13, 2875-2888
   Abstract »    Full Text »
Yeast Rad54 Promotes Rad51-dependent Homologous DNA Pairing via ATP Hydrolysis-driven Change in DNA Double Helix Conformation.
G. Petukhova, S. Van Komen, S. Vergano, H. Klein, and P. Sung (1999)
J. Biol. Chem. 274, 29453-29462
   Abstract »    Full Text »    PDF »
The Essential Functions of Human Rad51 Are Independent of ATP Hydrolysis.
C. Morrison, A. Shinohara, E. Sonoda, Y. Yamaguchi-Iwai, M. Takata, R. R. Weichselbaum, and S. Takeda (1999)
Mol. Cell. Biol. 19, 6891-6897
   Abstract »    Full Text »    PDF »
Human Dmc1 protein binds DNA as an octameric ring.
S. I. Passy, X. Yu, Z. Li, C. M. Radding, J.-Y. Masson, S. C. West, and E. H. Egelman (1999)
PNAS 96, 10684-10688
   Abstract »    Full Text »    PDF »
A New Recombinational DNA Repair Gene From Schizosaccharomyces pombe With Homology to Escherichia coli RecA.
F. K. Khasanov, G. V. Savchenko, E. V. Bashkirova, V. G. Korolev, W.-D. Heyer, and V. I. Bashkirov (1999)
Genetics 152, 1557-1572
   Abstract »    Full Text »
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae.
F. Paques and J. E. Haber (1999)
Microbiol. Mol. Biol. Rev. 63, 349-404
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Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis by DNA Damage.
Y. Huang, S. Nakada, T. Ishiko, T. Utsugisawa, R. Datta, S. Kharbanda, K. Yoshida, R. V. Talanian, R. Weichselbaum, D. Kufe, et al. (1999)
Mol. Cell. Biol. 19, 2986-2997
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The DNA Binding Properties of Saccharomyces cerevisiae Rad51 Protein.
E. M. Zaitseva, E. N. Zaitsev, and S. C. Kowalczykowski (1999)
J. Biol. Chem. 274, 2907-2915
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Human Rad51 Protein Can Form Homologous Joints in the Absence of Net Strand Exchange.
R. C. Gupta, E. Folta-Stogniew, and C. M. Radding (1999)
J. Biol. Chem. 274, 1248-1256
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A Role for RAD51 in the Generation of Immunoglobulin Gene Diversity in Rabbits.
R. A. Barrington, M. Fasullo, and K. L. Knight (1999)
J. Immunol. 162, 911-919
   Abstract »    Full Text »    PDF »
Sequestration of Mammalian Rad51-Recombination Protein into Micronuclei.
T. Haaf, E. Raderschall, G. Reddy, D. C. Ward, C. M. Radding, and E. I. Golub (1999)
J. Cell Biol. 144, 11-20
   Abstract »    Full Text »    PDF »
The Human Rad54 Recombinational DNA Repair Protein Is a Double-stranded DNA-dependent ATPase.
S. M. A. Swagemakers, J. Essers, J. de Wit, J. H. J. Hoeijmakers, and R. Kanaar (1998)
J. Biol. Chem. 273, 28292-28297
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Base pair switching by interconversion of sugar puckers in DNA extended by proteins of RecA-family: A model for homology search in homologous genetic recombination.
T. Nishinaka, A. Shinohara, Y. Ito, S. Yokoyama, and T. Shibata (1998)
PNAS 95, 11071-11076
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Polarity of DNA strand exchange promoted by recombination proteins of the RecA family.
R. C. Gupta, E. I. Golub, M. S. Wold, and C. M. Radding (1998)
PNAS 95, 9843-9848
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