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Science 12 March 1993:
Vol. 259. no. 5101, pp. 1616 - 1619
DOI: 10.1126/science.8456284
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Articles

Science, Vol 259, Issue 5101, 1616-1619
Copyright © 1993 by American Association for the Advancement of Science

articles

Ultrastructural evidence for hair cell regeneration in the mammalian inner ear

A Forge, L Li, JT Corwin, and G Nevill

Institute of Laryngology and Otology, University College London, United Kingdom.

It has long been thought that hair cell loss from the inner ears of mammals is irreversible. This report presents scanning electron micrographs and thin sections of the utricles from the inner ears of guinea pigs that show that, after hair cell loss caused by treatment with the aminoglycoside gentamicin, hair cells reappeared. Four weeks after the end of treatment, a large number of cells with immature hair bundles in multiple stages of development could be identified in the utricle. Thin sections showed that lost type 1 hair cells were replaced by cells with a morphology similar to that of type 2 hair cells. These results indicate an unexpected capacity for hair cell regeneration in vivo in the mature mammalian inner ear.


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