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Science 19 February 1993: Vol. 259. no. 5098, pp. 1157 - 1161 DOI: 10.1126/science.8438166
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Articles
Science, Vol 259, Issue 5098, 1157-1161
Copyright © 1993 by American Association for the Advancement of Science
Identification of a ten-amino acid proline-rich SH3 binding site
R Ren,
BJ Mayer,
P Cicchetti,
and
D Baltimore
Rockefeller University, New York, NY 10021.
The Src homology 3 (SH3) region is a small protein domain present in a very large group of proteins, including cytoskeletal elements and signaling proteins. It is believed that SH3 domains serve as modules that mediate protein-protein associations and, along with Src homology 2 (SH2) domains, regulate cytoplasmic signaling. The SH3 binding sites of two SH3 binding proteins were localized to a nine- or ten-amino acid stretch very rich in proline residues. Similar SH3 binding motifs exist in the formins, proteins that function in pattern formation in embryonic limbs of the mouse, and one subtype of the muscarinic acetylcholine receptor. Identification of the SH3 binding site provides a basis for understanding the interaction between the SH3 domains and their targets.
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- SLP-76 Binding to p56lck: A Role for SLP-76 in CD4-Induced Desensitization of the TCR/CD3 Signaling Complex.
- R. Sanzenbacher, D. Kabelitz, and O. Janssen (1999)
J. Immunol.
163, 3143-3152
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- Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation.
- A. D. Holdorf, J. M. Green, S. D. Levin, M. F. Denny, D. B. Straus, V. Link, P. S. Changelian, P. M. Allen, and A. S. Shaw (1999)
J. Exp. Med.
190, 375-384
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- Possible Involvement of a Novel STAM-associated Molecule "AMSH" in Intracellular Signal Transduction Mediated by Cytokines.
- N. Tanaka, K. Kaneko, H. Asao, H. Kasai, Y. Endo, T. Fujita, T. Takeshita, and K. Sugamura (1999)
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274, 19129-19135
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- Genes Encoding Three New Members of the Leukocyte Antigen 6 Superfamily and a Novel Member of Ig Superfamily, Together with Genes Encoding the Regulatory Nuclear Chloride Ion Channel Protein (hRNCC) and a N{omega}-N{omega}-Dimethylarginine Dimethylaminohydrolase Homologue, Are Found in a 30-kb Segment of the MHC Class III Region.
- G. Ribas, M. Neville, J. L. Wixon, J. Cheng, and R. D. Campbell (1999)
J. Immunol.
163, 278-287
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- Identification of an Intramolecular Interaction between the SH3 and Guanylate Kinase Domains of PSD-95.
- A. W. McGee and D. S. Bredt (1999)
J. Biol. Chem.
274, 17431-17436
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- Herpesvirus Ateles Gene Product Tio Interacts with Nonreceptor Protein Tyrosine Kinases.
- J.-C. Albrecht, U. Friedrich, C. Kardinal, J. Koehn, B. Fleckenstein, S. M. Feller, and B. Biesinger (1999)
J. Virol.
73, 4631-4639
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- Splice Variants of Intersectin Are Components of the Endocytic Machinery in Neurons and Nonneuronal Cells.
- N. K. Hussain, M. Yamabhai, A. R. Ramjaun, A. M. Guy, D. Baranes, J. P. O'Bryan, C. J. Der, B. K. Kay, and P. S. McPherson (1999)
J. Biol. Chem.
274, 15671-15677
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- Strains of Actinomyces naeslundii and Actinomyces viscosus Exhibit Structurally Variant Fimbrial Subunit Proteins and Bind to Different Peptide Motifs in Salivary Proteins.
- T. Li, I. Johansson, D. I. Hay, and N. Stromberg (1999)
Infect. Immun.
67, 2053-2059
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- Identification of profilin and src homology 3 domains as binding partners for Drosophila Enabled.
- S. M. Ahern-Djamali, C. Bachmann, P. Hua, S. K. Reddy, A. S. Kastenmeier, U. Walter, and F. M. Hoffmann (1999)
PNAS
96, 4977-4982
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- Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure.
- M. Salinas, R. Reyes, F. Lesage, M. Fosset, C. Heurteaux, G. Romey, and M. Lazdunski (1999)
J. Biol. Chem.
274, 11751-11760
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- Proline-rich Motifs of the Na+/H+ Exchanger 2 Isoform. BINDING OF Src HOMOLOGY DOMAIN 3 AND ROLE IN APICAL TARGETING IN EPITHELIA.
- C.-W. Chow, M. Woodside, N. Demaurex, F. H. Yu, P. Plant, D. Rotin, S. Grinstein, and J. Orlowski (1999)
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274, 10481-10488
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- Cloning and Characterization of KPL2, a Novel Gene Induced during Ciliogenesis of Tracheal Epithelial Cells.
- L. E. Ostrowski, K. Andrews, P. Potdar, H. Matsuura, A. Jetten, and P. Nettesheim (1999)
Am. J. Respir. Cell Mol. Biol.
20, 675-683
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- Sla1p Is a Functionally Modular Component of the Yeast Cortical Actin Cytoskeleton Required for Correct Localization of Both Rho1p-GTPase and Sla2p, a Protein with Talin Homology.
- K. R. Ayscough, J. J. Eby, T. Lila, H. Dewar, K. G. Kozminski, and D. G. Drubin (1999)
Mol. Biol. Cell
10, 1061-1075
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- Interaction of NE-dlg/SAP102, a Neuronal and Endocrine Tissue-specific Membrane-associated Guanylate Kinase Protein, with Calmodulin and PSD-95/SAP90. A POSSIBLE REGULATORY ROLE IN MOLECULAR CLUSTERING AT SYNAPTIC SITES.
- N. Masuko, K. Makino, H. Kuwahara, K. Fukunaga, T. Sudo, N. Araki, H. Yamamoto, Y. Yamada, E. Miyamoto, and H. Saya (1999)
J. Biol. Chem.
274, 5782-5790
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- The Lck SH3 Domain Is Required for Activation of the Mitogen-activated Protein Kinase Pathway but Not the Initiation of T-cell Antigen Receptor Signaling.
- M. F. Denny, H. C. Kaufman, A. C. Chan, and D. B. Straus (1999)
J. Biol. Chem.
274, 5146-5152
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- GCKR Links the Bcr-Abl Oncogene and Ras to the Stress-Activated Protein Kinase Pathway.
- C.-S. Shi, J. M. Tuscano, O. N. Witte, and J. H. Kehrl (1999)
Blood
93, 1338-1345
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- Activation of the Lbc Rho Exchange Factor Proto-Oncogene by Truncation of an Extended C Terminus That Regulates Transformation and Targeting.
- P. Sterpetti, A. A. Hack, M. P. Bashar, B. Park, S.-D. Cheng, J. H. M. Knoll, T. Urano, L. A. Feig, and D. Toksoz (1999)
Mol. Cell. Biol.
19, 1334-1345
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- SH3P7 Is a Cytoskeleton Adapter Protein and Is Coupled to Signal Transduction from Lymphocyte Antigen Receptors.
- O. Larbolette, B. Wollscheid, J. Schweikert, P. J. Nielsen, and J. Wienands (1999)
Mol. Cell. Biol.
19, 1539-1546
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