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Science 12 February 1993: Vol. 259. no. 5097, pp. 971 - 974 DOI: 10.1126/science.8438157
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Articles
Science, Vol 259, Issue 5097, 971-974
Copyright © 1993 by American Association for the Advancement of Science
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2
H Harada,
M Kitagawa,
N Tanaka,
H Yamamoto,
K Harada,
M Ishihara,
and
T Taniguchi
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Interferon regulatory factor-1 (IRF-1), a transcriptional activator, and IRF-2, its antagonistic repressor, have been identified as regulators of type I interferon and interferon-inducible genes. The IRF-1 gene is itself interferon-inducible and hence may be one of the target genes critical for interferon action. When the IRF-2 gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice. This transformed phenotype was reversed by concomitant overexpression of the IRF-1 gene. Thus, restrained cell growth depends on a balance between these two mutually antagonistic transcription factors.
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