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Science 5 February 1993:
Vol. 259. no. 5096, pp. 816 - 819
DOI: 10.1126/science.8430335
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Articles

Science, Vol 259, Issue 5096, 816-819
Copyright © 1993 by American Association for the Advancement of Science

articles

Tumor suppression in Xiphophorus by an accidentally acquired promoter

D Adam, N Dimitrijevic, and M Schartl

Genzentrum, Max-Planck-Institut fur Biochemie, Martinsried, Germany.

Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologous recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.


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