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Science 29 January 1993:
Vol. 259. no. 5095, pp. 677 - 680
DOI: 10.1126/science.8430316
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Articles

Science, Vol 259, Issue 5095, 677-680
Copyright © 1993 by American Association for the Advancement of Science

articles

Patchiness and correlations in DNA sequences

S Karlin and V Brendel

Department of Mathematics, Stanford University, CA 94305.

The highly nonrandom character of genomic DNA can confound attempts at modeling DNA sequence variation by standard stochastic processes (including random walk or fractal models). In particular, the mosaic character of DNA consisting of patches of different composition can fully account for apparent long-range correlations in DNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Investigating the Relationship Between Genome Structure, Composition, and Ecology in Prokaryotes.
P. Lio (2002)
Mol. Biol. Evol. 19, 789-800
   Abstract »    Full Text »    PDF »
Characteristic enrichment of DNA repeats in different genomes.
R. Cox and S. M. Mirkin (1997)
PNAS 94, 5237-5242
   Abstract »    Full Text »    PDF »
Analysis of DNA sequences.
B. Weir (1993)
Statistical Methods in Medical Research 2, 225-239
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)