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Science 22 January 1993:
Vol. 259. no. 5094, pp. 516 - 519
DOI: 10.1126/science.8380940
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Articles

Science, Vol 259, Issue 5094, 516-519
Copyright © 1993 by American Association for the Advancement of Science

articles

Sequence and genome organization of a human small round-structured (Norwalk-like) virus

PR Lambden, EO Caul, CR Ashley, and IN Clarke

Department of Molecular Microbiology, University Medical School, Southampton General Hospital, United Kingdom.

Small round-structured viruses (SRSVs), also known as Norwalk or Norwalk-like viruses, are the major worldwide cause of acute, epidemic nonbacterial gastroenteritis in humans. These viruses, which contain a single-stranded RNA genome, have remained refractory to molecular characterization because of the small amounts of virus in clinical samples and the absence of an animal model and an in vitro culture system. The complete genomic nucleotide sequence of an SRSV, Southampton virus, was determined. The 7696-nucleotide RNA genome encodes three open reading frames whose sequences and organization strongly support proposals that SRVSs are members of the Caliciviridae.


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