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Science 1 January 1993:
Vol. 259. no. 5091, pp. 77 - 79
DOI: 10.1126/science.8418498
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Articles

Science, Vol 259, Issue 5091, 77-79
Copyright © 1993 by American Association for the Advancement of Science

articles

Mediation by G proteins of signals that cause collapse of growth cones

M Igarashi, SM Strittmatter, T Vartanian, and MC Fishman

Developmental Biology Laboratory, Massachusetts General Hospital-East, Charlestown 02129.

During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.


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